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1. Full Text Essential thrombocytosis with recurrent spontaneous abortion in the mid trimester A case report
by Yu, Y and Zhang, XY and Shi, QY and Wang, MY and Jing, JL and Liu, YH
MEDICINE, ISSN 0025-7974, 06/2019, Volume 98, Issue 26, p. e16203
Rationale: Essential thrombocytosis (ET) is a myeloproliferative neoplasm characterized by clonal proliferation of the megakaryocytic lineage within the bone... 
MEDICINE, GENERAL & INTERNAL | essential thrombocytosis | arrested embryonic development | recurrent spontaneous abortion | mid trimester | PREGNANCY | Abortion, Spontaneous - pathology | Diagnosis, Differential | Abortion, Spontaneous - genetics | Humans | Thrombocythemia, Essential - pathology | Thrombocythemia, Essential - genetics | Pregnancy Trimester, First | Pregnancy | Cesarean Section | Thrombocythemia, Essential - diagnosis | Abortion, Spontaneous - diagnosis | Bone Marrow - pathology | Thrombocythemia, Essential - therapy | Adult | Female | Thrombocythemia | Case studies | Complications and side effects | Thrombocytosis | Diagnosis | Abortion, Habitual | Risk factors
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2. Full Text New insights into mechanisms behind miscarriage
by Larsen, Elisabeth Clare and Christiansen, Ole Bjarne and Kolte, Astrid Marie and Macklon, Nick
BMC Medicine, ISSN 1741-7015, 06/2013, Volume 11, Issue 1, p. 154
Sporadic miscarriage is the most common complication of early pregnancy. Two or three consecutive pregnancy losses is a less common phenomenon, and this is... 
Immunology | Sperm DNA Integrity | Genetics | Recurrent Miscarriage | Embryo Selection | Miscarriage | Epidemiology | NATURAL-KILLER-CELLS | CONGENITAL UTERINE ANOMALIES | CHROMOSOME ANALYSIS | MATERNAL AGE | WOMEN | MEDICINE, GENERAL & INTERNAL | FETAL LOSS | RECURRENT PREGNANCY LOSS | 1ST TRIMESTER | CLASS-II ALLELES | MOLECULAR-BASIS | Abortion, Spontaneous - genetics | Abortion, Habitual - epidemiology | Humans | Embryo Implantation - genetics | Pregnancy | Abortion, Spontaneous - epidemiology | Animals | Abortion, Spontaneous - diagnosis | Abortion, Habitual - diagnosis | DNA Fragmentation | Abortion, Habitual - genetics | Female | Polymorphism, Genetic - genetics | Polycystic ovary syndrome | Embryology | Ultrasonic imaging | Hospitals | Menstruation | Womens health | Fetuses | Quality control | Embryos
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3. Full Text Mutations in NLRP5 are associated with reproductive wastage and multilocus imprinting disorders in humans
by Docherty, Louise E and Rezwan, Faisal I and Poole, Rebecca L and Turner, Claire L. S and Kivuva, Emma and Maher, Eamonn R and Smithson, Sarah F and Hamilton-Shield, Julian P and Patalan, Michal and Gizewska, Maria and Peregud-Pogorzelski, Jaroslaw and Beygo, Jasmin and Buiting, Karin and Horsthemke, Bernhard and Soellner, Lukas and Begemann, Matthias and Eggermann, Thomas and Baple, Emma and Mansour, Sahar and Temple, I. Karen and MacKay, Deborah J. G
Nature Communications, ISSN 2041-1723, 09/2015, Volume 6, Issue 1, p. 8086
Human-imprinting disorders are congenital disorders of growth, development and metabolism, associated with disturbance of parent of origin-specific DNA... 
METHYLATION ANALYSIS | HYDATIDIFORM MOLE | MULTIDISCIPLINARY SCIENCES | HYPOMETHYLATION
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4. Full Text Comparative Genomic Hybridization–Array Analysis Enhances the Detection of Aneuploidies and Submicroscopic Imbalances in Spontaneous Miscarriages
by Schaeffer, Anthony J and Chung, June and Heretis, Konstantina and Wong, Andrew and Ledbetter, David H and Lese Martin, Christa
The American Journal of Human Genetics, ISSN 0002-9297, 2004, Volume 74, Issue 6, pp. 1168 - 1174
Miscarriage is a condition that affects 10%–15% of all clinically recognized pregnancies, most of which occur in the first trimester. Approximately 50% of... 
HIGH-RESOLUTION ANALYSIS | CHROMOSOME | ABERRATION | CGH | SPONTANEOUS-ABORTIONS | GENETICS & HEREDITY | PATIENT | MICROARRAYS | TUMORS | CYTOGENETIC ANALYSIS | Nucleic Acid Hybridization | Trisomy | Chromosome Banding | Abortion, Spontaneous - genetics | Oligonucleotide Array Sequence Analysis | Chromosomes, Human - genetics | Humans | Prenatal Diagnosis | Aneuploidy | In Situ Hybridization, Fluorescence | Gene Dosage | Pregnancy | Karyotyping | Chromosome Aberrations | Female | Retrospective Studies | Human genetics | Research
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5. Full Text Comprehensive genetic analysis of pregnancy loss by chromosomal microarrays: outcomes, benefits, and challenges
by Sahoo, Trilochan and Dzidic, Natasa and Strecker, Michelle N and Commander, Sara and Travis, Mary K and Doherty, Charles and Weslie Tyson, R and Mendoza, Arturo E and Stephenson, Mary and Dise, Craig A and Benito, Carlos W and Ziadie, Mandolin S and Hovanes, Karine
Genetics in Medicine, ISSN 1098-3600, 01/2017, Volume 19, Issue 1, pp. 83 - 89
Purpose: Chromosomal microarray analysis (CMA) is currently considered first-tier testing in pediatric care and prenatal diagnosis owing to its high diagnostic... 
products of conception | aneuploidy | chromosome abnormality | chromosomal microarray | recurrent pregnancy loss | CONCEPTION | ABNORMALITIES | IN-SITU HYBRIDIZATION | MISCARRIAGE | COMBINATION | ANALYSIS CMA | PRODUCTS | EARLY SPONTANEOUS-ABORTIONS | GENETICS & HEREDITY | COMPARATIVE GENOMIC HYBRIDIZATION | STILLBIRTH | Genetic Testing | Abortion, Spontaneous - genetics | Age Factors | Humans | Middle Aged | Prenatal Diagnosis | Aneuploidy | Comparative Genomic Hybridization - methods | Karyotyping - methods | Paraffin Embedding | Pregnancy | Abortion, Spontaneous - diagnosis | Chromosome Aberrations | Adult | Female | Polymorphism, Single Nucleotide | In Situ Hybridization, Fluorescence - methods
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6. Full Text The origin of human aneuploidy: Where we have been, where we are going
by Hassold, Terry and Hall, Heather and Hunt, Patricia
Human Molecular Genetics, ISSN 0964-6906, 10/2007, Volume 16, Issue 2, pp. R203 - R208
Aneuploidy is the most common chromosome abnormality in humans, and is the leading genetic cause of miscarriage and congenital birth defects. Since the... 
MATERNAL AGE | STEM-CELLS | REPAIR | BIOCHEMISTRY & MOLECULAR BIOLOGY | FEMALE MICE | GENETICS & HEREDITY | NONDISJUNCTION | MEIOSIS-I | CHROMOSOMES | TRISOMY-21 | NONOBSTRUCTIVE AZOOSPERMIA | MEIOTIC RECOMBINATION | Trisomy | Abortion, Spontaneous - genetics | Humans | Aneuploidy | Pregnancy | Meiosis - genetics | Animals | Congenital Abnormalities - genetics | Recombination, Genetic | Female | Models, Animal | Mice | Models, Genetic | Chromosome Disorders - genetics | Infant, Newborn
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7. Full Text Relationship between VEGFA polymorphisms and serum VEGF protein levels and recurrent spontaneous miscarriage
by Almawi, Wassim Y and Saldanha, Fabiola Lisa and Mahmood, Naeema A and Al-Zaman, Intissar and Sater, Mai S and Mustafa, Fekria E
Human Reproduction, ISSN 0268-1161, 10/2013, Volume 28, Issue 10, pp. 2628 - 2635
STUDY QUESTION Is recurrent spontaneous miscarriage (RSM) associated with changes in vascular endothelial growth factor (VEGF) serum levels, and with... 
haplotypes | miscarriage | polymorphisms | vascular endothelial growth factor | METAANALYSIS | GENOTYPE | FACTOR GENE POLYMORPHISMS | PREGNANCY LOSS | OBSTETRICS & GYNECOLOGY | WOMEN | REPRODUCTIVE BIOLOGY | SPONTANEOUS-ABORTION | RECEPTORS | ASSOCIATION | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | Abortion, Spontaneous - genetics | Genetic Association Studies | Neovascularization, Physiologic - genetics | Gene Frequency | Humans | Vascular Endothelial Growth Factor A - blood | Genotype | Vascular Endothelial Growth Factor A - genetics | Linkage Disequilibrium | Adult | Female | Polymorphism, Single Nucleotide | Retrospective Studies
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8. Full Text Genetic Polymorphisms and Recurrent Spontaneous Abortions: An Overview of Current Knowledge
by Daher, Silvia and Mattar, Rosiane and Gueuvoghlanian‐Silva, Bárbara Y and Torloni, Maria R
American Journal of Reproductive Immunology, ISSN 1046-7408, 04/2012, Volume 67, Issue 4, pp. 341 - 347
The relevance of gene polymorphisms in the development of unexplained recurrent spontaneous abortion is still unclear. Cytokines, angiogenic mediators, and... 
cytokine | genetic | Angiogenesis | habitual abortion | hormones | recurrent spontaneous abortions | polymorphism | Recurrent spontaneous abortions | Habitual abortion | Cytokine | Genetic | Hormones | Polymorphism | RISK | IMMUNOLOGY | PREGNANCY LOSS | WOMEN | REPRODUCTIVE BIOLOGY | X-CHROMOSOME INACTIVATION | PROGESTERONE-RECEPTOR | PROMOTER | ASSOCIATION | INTERLEUKIN-6 GENE | ENDOTHELIAL GROWTH-FACTOR | SINGLE NUCLEOTIDE POLYMORPHISMS | Pregnancy | Angiogenic Proteins - genetics | Abortion, Spontaneous - genetics | Humans | Abortion, Habitual - genetics | Female | Polymorphism, Genetic - genetics | Cytokines - genetics | Infant, Newborn | Pregnancy Outcome - genetics | Reproduction | Reviews | Cytokines | Abortion | Gene polymorphism | Obstetrics
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9. Full Text The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis
by Robinson, Lynne and Gallos, Ioannis D and Conner, Sarah J and Rajkhowa, Madhurima and Miller, David and Lewis, Sheena and Kirkman-Brown, Jackson and Coomarasamy, Arri
Human Reproduction, ISSN 0268-1161, 10/2012, Volume 27, Issue 10, pp. 2908 - 2917
STUDY QUESTION Is there an association between high levels of sperm DNA damage and miscarriage? SUMMARY ANSWER Miscarriage rates are positively correlated with... 
pregnancy loss | spermatozoa | miscarriage | male infertility | DNA fragmentation | HUMAN SPERMATOZOA | OXIDATIVE STRESS | DEOXYRIBONUCLEIC-ACID FRAGMENTATION | CHROMATIN-STRUCTURE ASSAY | OBSTETRICS & GYNECOLOGY | MALE-INFERTILITY | EMBRYO DEVELOPMENT | REPRODUCTIVE BIOLOGY | SPONTANEOUS-ABORTION | PREGNANCY RATES | PATERNAL AGE | IN-VITRO FERTILIZATION | In Situ Nick-End Labeling | Abortion, Spontaneous - genetics | Risk Assessment | United States | Humans | Male | Comet Assay | Pregnancy | Sperm Injections, Intracytoplasmic | Abortion, Spontaneous - epidemiology | Fertilization in Vitro | DNA Fragmentation | Female | Spermatozoa - physiology | Odds Ratio | Cohort Studies
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10. Full Text Effectiveness of in vitro fertilization with preimplantation genetic screening: a reanalysis of United States assisted reproductive technology data 2011–2012
by Kushnir, Vitaly A., M.D and Darmon, Sarah K., Ph.D and Albertini, David F., Ph.D and Barad, David H., M.D and Gleicher, Norbert, M.D
Fertility and Sterility, ISSN 0015-0282, 2016, Volume 106, Issue 1, pp. 75 - 79
Objective To assess effectiveness of preimplantation genetic screening (PGS) in fresh IVF cycles. Design Reanalysis of retrospective US national data. Setting... 
Internal Medicine | Obstetrics and Gynecology | aneuploidy | embryo selection | preimplantation genetic diagnosis | In vitro fertilization | preimplantation genetic screening | In vitro fertilization | DIAGNOSIS | REPRODUCTIVE BIOLOGY | OUTCOMES | OBSTETRICS & GYNECOLOGY | Preimplantation Diagnosis - adverse effects | Predictive Value of Tests | Genetic Testing | Abortion, Spontaneous - genetics | United States | Humans | Patient Selection | Maternal Age | Fertility | Abortion, Spontaneous - etiology | Adult | Female | Infertility - physiopathology | Retrospective Studies | Infertility - therapy | Pregnancy Rate | Databases, Factual | Fertilization in Vitro - adverse effects | Live Birth | Risk Factors | Quality Indicators, Health Care | Treatment Outcome | Preimplantation Diagnosis - methods | Embryo Implantation | Pregnancy | Infertility - diagnosis | Abortion, Spontaneous - diagnosis | Quality Improvement | Embryo Transfer | Fertilization in vitro | Medical equipment | Physiological apparatus | Genetic screening
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11. Full Text The association of factor V leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: A systematic review and meta-analysis of prospective cohort studies
by Rodger, Marc A and Betancourt, Marisol T and Clark, Peter and Lindqvist, Pelle G and Dizon-Townson, Donna and Said, Joanne and Seligsohn, Uri and Carrier, Marc and Salomon, Ophira and Greer, Ian A
PLoS Medicine, ISSN 1549-1277, 06/2010, Volume 7, Issue 6, p. e1000292
Background: Factor V Leiden (FVL) and prothrombin gene mutation (PGM) are common inherited thrombophilias. Retrospective studies variably suggest a link... 
MEDICINE, GENERAL & INTERNAL | POLYMORPHISMS | VENOUS THROMBOEMBOLISM | RISK-FACTOR | THROMBOSIS | INHERITED THROMBOPHILIA | NULLIPAROUS WOMEN | PREECLAMPSIA | INTRAUTERINE GROWTH RESTRICTION | OUTCOMES | 3-UNTRANSLATED REGION | Pre-Eclampsia - genetics | Thrombophilia - genetics | Abortion, Spontaneous - genetics | Humans | Risk Factors | Stillbirth - genetics | Pregnancy Complications, Hematologic - genetics | Pregnancy | Placenta | Female | Infant, Small for Gestational Age | Prothrombin - genetics | Abruptio Placentae - genetics | Factor V - genetics | Mutation | Odds Ratio | Infant, Newborn | Studies | Medical research | Miscarriage
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12. Full Text LncRNA‐regulated Infection and Inflammation Pathways Associated with Pregnancy Loss: Genome Wide Differential Expression of lncRNAs in Early Spontaneous Abortion
by Wang, Hong and Cao, Qingying and Ge, Jun and Liu, Chunmiao and Ma, Yanhong and Meng, Yuciu and Wang, Yuxin and Zhao, Xiaoli and Liu, Ru and Li, Caixia and Wang, Yu and Zhong, Julia and Ju, Weina and Jenkins, Edmund C and Brown, W. Ted and Zhong, Nanbert
American Journal of Reproductive Immunology, ISSN 1046-7408, 10/2014, Volume 72, Issue 4, pp. 359 - 375
Spontaneous abortion (SA) occurs before 20 gestational weeks. Approximately, half of recurrent SA has no identifiable cause. No report has yet been... 
lnc | Embryonic development | pathogenesis | spontaneous abortion | first trimester | RNA | pathways | long non‐coding | First trimester | Long non-coding RNA (lncRNA) | Pathways | Spontaneous abortion | Pathogenesis | Epigenomics | Abortion, Spontaneous - genetics | Oligonucleotide Array Sequence Analysis | Decidua - cytology | Humans | Gene Expression Profiling | Inflammation - immunology | RNA, Long Noncoding - genetics | Signal Transduction - genetics | Abortion, Induced | Pregnancy | Sequence Analysis, RNA | Gene Expression Regulation, Developmental | Base Sequence | Pregnancy Complications - genetics | Inflammation - genetics | Female | Infections | Inflammation | Abortion
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