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1. Full Text N-Heteroarylmethyl-5-hydroxy-1,2,5,6-tetrahydropyridine-3-carboxyl ic acid a novel scaffold for the design of uncompetitive I--glucosidase inhibitors
by Long, Sha and Stefani, Francesca and Biondi, Stefano and Ghiselli, Giancarlo and Panunzio, Mauro
Bioorganic & medicinal chemistry, ISSN 0968-0896, 09/2013, Volume 21, Issue 18, pp. 5811 - 5822
Acarbose
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2. Full Text Potent [alpha]-glucosidase inhibitors from the roots of Panax japonicus C. A. Meyer var. major
by Chan, Hsiu-Hui and Sun, Han-Dong and Reddy, Mopur Vijaya Bhaskar and Wu, Tian-Shung
Phytochemistry (Oxford), ISSN 0031-9422, 08/2010, Volume 71, Issue 11-12, p. 1360
Acarbose
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3. Full Text Polyneuropathy with impaired glucose tolerance: Implication for diagnosis and therapy
by Singleton, J. Robinson and Smith, A. Gordon and Russell, James and Feldman, Eva L
Current treatment options in neurology, ISSN 1092-8480, 2005, Volume 7, Issue 1, pp. 33 - 42
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4. Full Text Acarbose improves health and lifespan in aging HET3 mice
by Harrison, David E and Strong, Randy and Alavez, Silvestre and Astle, Clinton Michael and DiGiovanni, John and Fernandez, Elizabeth and Flurkey, Kevin and Garratt, Michael and Gelfond, Jonathan A. L and Javors, Martin A and Levi, Moshe and Lithgow, Gordon J and Macchiarini, Francesca and Nelson, James F and Sukoff Rizzo, Stacey J and Slaga, Thomas J and Stearns, Tim and Wilkinson, John Erby and Miller, Richard A
Aging cell, ISSN 1474-9718, 04/2019, Volume 18, Issue 2, pp. e12898 - n/a
lifespan | acarbose | heterogeneous mice | health measures | Life Sciences & Biomedicine | Geriatrics & Gerontology | Science & Technology | Cell Biology | Acarbose - pharmacology | Acarbose - administration & dosage | Longevity - drug effects | Mice, Inbred C57BL | Male | Acarbose - analysis | Mice, Inbred C3H | Animals | Mice, Mutant Strains | Healthy Aging - drug effects | Female | Mice | Mice, Inbred BALB C | Acarbose | Gerontology | Hyperglycemia | Rankings | Blood sugar | Lung cancer | Body fat | Liver | Benzothiazole | Sex differences | Longevity | Glucose | Males | Life span | Aging | Ursolic acid | Degeneration | Females | Tumors | Cancer | Index Medicus | Original Paper
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5. Full Text α-Glucosidase inhibition by flavonoids: an in vitro and in silico structure-activity relationship study
by Proença, Carina and Freitas, Marisa and Ribeiro, Daniela and Oliveira, Eduardo F. T and Sousa, Joana L. C and Tomé, Sara M and Ramos, Maria J and Silva, Artur M. S and Fernandes, Pedro A and Fernandes, Eduarda
Journal of enzyme inhibition and medicinal chemistry, ISSN 1475-6366, 01/2017, Volume 32, Issue 1, pp. 1216 - 1228
α-glucosidase inhibition | Diabetes | in silico | flavonoids | in vitro | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Acarbose - pharmacology | Structure-Activity Relationship | Glycoside Hydrolase Inhibitors - chemistry | Glycoside Hydrolase Inhibitors - pharmacology | Acarbose - chemistry | Dose-Response Relationship, Drug | Computer Simulation | Saccharomyces cerevisiae - enzymology | Flavonoids - pharmacology | Molecular Docking Simulation | Molecular Structure | Flavonoids - chemistry | alpha-Glucosidases - metabolism | Flavonoids | Acarbose | Hyperglycemia | α-Glucosidase | Catechol | Diabetes mellitus (non-insulin dependent) | Index Medicus
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6. Full Text Pentacyclic triterpenes as α-glucosidase and α-amylase inhibitors: Structure-activity relationships and the synergism with acarbose
by Zhang, Bo-wei and Xing, Yan and Wen, Chen and Yu, Xiao-xia and Sun, Wen-long and Xiu, Zhi-long and Dong, Yue-sheng
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 11/2017, Volume 27, Issue 22, pp. 5065 - 5070
Acarbose | Synergistic inhibition | α-Amylase | α-Glucosidase | Pentacyclic triterpenes | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | alpha-Amylases - antagonists & inhibitors | Acarbose - metabolism | Structure-Activity Relationship | alpha-Amylases - metabolism | Pentacyclic Triterpenes - chemistry | Acarbose - chemistry | Drug Synergism | Triterpenes - chemistry | Oleanolic Acid - metabolism | Oleanolic Acid - chemistry | Inhibitory Concentration 50 | Kinetics | Pentacyclic Triterpenes - metabolism | Triterpenes - metabolism | alpha-Glucosidases - metabolism | alpha-Glucosidases - chemistry | Index Medicus
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7. Full Text Dietary Flavonoids and Acarbose Synergistically Inhibit α‑Glucosidase and Lower Postprandial Blood Glucose
by Zhang, Bo-wei and Li, Xia and Sun, Wen-long and Xing, Yan and Xiu, Zhi-long and Zhuang, Chun-lin and Dong, Yue-sheng
Journal of agricultural and food chemistry, ISSN 0021-8561, 09/2017, Volume 65, Issue 38, pp. 8319 - 8330
α-glucosidase | baicalein | synergistic inhibition | postprandial blood glucose | acarbose | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Applied | Food Science & Technology | Agriculture, Multidisciplinary | Agriculture | Science & Technology | Diabetes Mellitus - enzymology | Acarbose - administration & dosage | Humans | Diabetes Mellitus - drug therapy | Diabetes Mellitus - metabolism | Rats | Hypoglycemic Agents - chemistry | Glycoside Hydrolase Inhibitors - chemistry | Acarbose - chemistry | Rats, Sprague-Dawley | Glycoside Hydrolase Inhibitors - administration & dosage | Drug Synergism | Animals | Hypoglycemic Agents - administration & dosage | Swine | Flavonoids - administration & dosage | Mice | Molecular Docking Simulation | Postprandial Period - drug effects | Kinetics | Blood Glucose - metabolism | Flavonoids - chemistry | alpha-Glucosidases - chemistry | Index Medicus
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8. Full Text Hepatoxixicty associated with acarbose therapy
by Hsiao, Shu-Hwa and Liao, Li-Hsiang and Cheng, Pin-Nan and Wu, Ta-Jen
The Annals of pharmacotherapy, ISSN 1060-0280, 01/2006, Volume 40, Issue 1, pp. 151 - 154
Acarbose | Hepatotoxicity
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9. Full Text Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer
by Strong, Randy and Miller, Richard A and Antebi, Adam and Astle, Clinton M and Bogue, Molly and Denzel, Martin S and Fernandez, Elizabeth and Flurkey, Kevin and Hamilton, Karyn L and Lamming, Dudley W and Javors, Martin A and Magalhães, de, João Peo and Martinez, Paul Anthony and McCord, Joe M and Miller, Benjamin F and Müller, Michael and Nelson, James F and Ndukum, Juliet and Rainger, G.E and Richardson, Arlan and Sabatini, David M and Salmon, Adam B and Simpkins, James W and Steegenga, Wilma T and Nadon, Nancy L and Harrison, David E
Aging cell, ISSN 1474-9718, 2016, Volume 15, Issue 5, pp. 872 - 884
NDGA | acarbose | fish oil | 17-α-estradiol | metformin | UDCA | Protandim | rapamycin | 17‐α‐estradiol | Acarbose | Rapamycin | Metformin | Fish oil | Acarbose - pharmacology | Masoprocol - pharmacology | Longevity - drug effects | Metformin - pharmacology | Drugs, Chinese Herbal - pharmacology | Male | Antioxidants - pharmacology | Fish Oils - pharmacology | Glycoside Hydrolase Inhibitors - pharmacology | Sirolimus - pharmacology | Ursodeoxycholic Acid - pharmacology | Rotarod Performance Test | Animals | NF-E2-Related Factor 2 - metabolism | Survival Analysis | Mice | Estradiol - pharmacology | Hand Strength | alpha-Glucosidases - metabolism | Index Medicus | Original
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10. Full Text Acarbose, 17‐α‐estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males
by Harrison, David E and Strong, Randy and Allison, David B and Ames, Bruce N and Astle, Clinton M and Atamna, Hani and Fernandez, Elizabeth and Flurkey, Kevin and Javors, Martin A and Nadon, Nancy L and Nelson, James F and Pletcher, Scott and Simpkins, James W and Smith, Daniel and Wilkinson, J. Erby and Miller, Richard A
Aging cell, ISSN 1474-9718, 04/2014, Volume 13, Issue 2, pp. 273 - 282
methylene blue | NDGA | lifespan | acarbose | heterogeneous mice | estradiol | Acarbose | Heterogeneous mice | Estradiol | Lifespan | Methylene blue | Life Sciences & Biomedicine | Geriatrics & Gerontology | Science & Technology | Cell Biology | Acarbose - pharmacology | Biomarkers - metabolism | Masoprocol - pharmacology | Animals | Body Weight | Longevity - drug effects | Survival Analysis | Female | Male | Methylene Blue | Mice | Estradiol - pharmacology | Index Medicus | Original
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11. Full Text Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial
by Chiasson, Jean-Louis and Josse, Robert G and Gomis, Ramon and Hanefeld, Markolf and Karasik, Avraham and Laakso, Markku and for The STOP-NIDDM Trial Research Group and STOP-NIDDM Trail Research Group
The Lancet (British edition), ISSN 0140-6736, 06/2002, Volume 359, Issue 9323, pp. 2072 - 2077
Biological and medical sciences | Medical sciences | General and cellular metabolism. Vitamins | Pharmacology. Drug treatments | Blood Glucose - drug effects | Hypoglycemic Agents - therapeutic use | Acarbose - therapeutic use | Glucose Intolerance - drug therapy | Humans | Middle Aged | Diabetes Mellitus, Type 2 - prevention & control | Female | Male | Acarbose - adverse effects | Hypoglycemic Agents - adverse effects | Type 2 diabetes | Physiological aspects | Evaluation | Development and progression | Acarbose | Glucose intolerance | Drug therapy | Clinical outcomes | Diabetes | Fasting | Laboratories | Diabetes mellitus | Diarrhea | Lipids | Triglycerides | Glucose | Patients | Conversion | Evidence-based medicine | Cholesterol | Abdomen | Glucose tolerance | Hyperglycemia | Reversion | Randomization | Motivation | Insulin resistance | Diabetes mellitus (non-insulin dependent) | Index Medicus | Abridged Index Medicus
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12. Full Text The glucoamylase inhibitor acarbose has a dietdependent and reversible effect on the murine gut microbiome
by Baxter, Nielsen T and Baxter, Nielsen T and Lesniak, Nicholas A and Sinani, Hamide and Schloss, Patrick D and Koropatkin, Nicole M and Koropatkin, Nicole M
mSphere, 01/2019, Volume 4, Issue 1
starch | gut microbiota | acarbose
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13. Full Text Carbon source dependent biosynthesis of acarviose metabolites in Actinoplanes sp. SE50/110
by Wendler, Sergej and Ortseifen, Vera and Persicke, Marcus and Klein, Andreas and Neshat, Armin and Niehaus, Karsten and Schneiker-Bekel, Susanne and Walter, Frederik and Wehmeier, Udo F and Kalinowski, Jörn and Pühler, Alfred
Journal of biotechnology, ISSN 0168-1656, 12/2014, Volume 191, pp. 113 - 120
Proteome | Acarbose | Acarviose metabolite | Actinoplanes | LC–MS | LC-MS | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Acarbose - therapeutic use | Acarbose - metabolism | Glycosyltransferases - chemistry | Humans | Bacterial Proteins - chemistry | Acarbose - chemistry | Carbon - chemistry | Maltose - chemistry | Galactose - chemistry | Glycosyltransferases - metabolism | Glucose - chemistry | Bacterial Proteins - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Physiological aspects | Chemical properties | Metabolites | Analysis | Genomics | Index Medicus | Media | Biosynthesis | Glucose | Maltose | Galactose | Carbon | Culture
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14. Full Text Acarbose compared with metformin as initial therapy in patients with newly diagnosed type 2 diabetes: an open-label, non-inferiority randomised trial
by Yang, Wenying, Prof and Liu, Jie, Prof and Shan, Zhongyan, Prof and Tian, Haoming, Prof and Zhou, Zhiguang, Prof and Ji, Qiuhe, Prof and Weng, Jianping, Prof and Jia, Weiping, Prof and Lu, Juming, Prof and Liu, Jing, Prof and Xu, Yuan, MD and Yang, Zhaojun, Prof and Chen, Wei, Prof
The lancet. Diabetes & endocrinology, ISSN 2213-8587, 2014, Volume 2, Issue 1, pp. 46 - 55
Endocrinology & Metabolism | Other | Life Sciences & Biomedicine | Science & Technology | Body Mass Index | Hypoglycemic Agents - therapeutic use | Acarbose - therapeutic use | Acarbose - administration & dosage | Metformin - therapeutic use | Glycated Hemoglobin A - metabolism | Humans | Middle Aged | Glycated Hemoglobin A - drug effe