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chemistry, medicinal (210) 210
pharmacology & pharmacy (194) 194
animals (152) 152
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chemistry, multidisciplinary (137) 137
humans (135) 135
acetals - chemistry (120) 120
acetals (112) 112
acetals - pharmacology (97) 97
chemistry, organic (93) 93
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chemistry (72) 72
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acetal (50) 50
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Chemical Reviews, ISSN 0009-2665, 05/2013, Volume 113, Issue 5, pp. 3632 - 3685
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 07/2011, Volume 18, Issue 21, pp. 3234 - 3251
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 04/2012, Volume 159, Issue 2, pp. 290 - 301
The design of improved polymeric carriers to be used in the next generation of polymer therapeutics is an ongoing challenge. Biodegradable systems present... 
pH-dependent degradation | Polyacetals | Solution conformation | SANS | Prostate cancer | Polymer therapeutics | DRUG-DELIVERY | SURFACTANTS | DLS | MICROSCOPY | CHEMISTRY, MULTIDISCIPLINARY | IN-VITRO | NANOMEDICINES | PHARMACOLOGY & PHARMACY | BINDING | TEM | ANGLE NEUTRON-SCATTERING | Molecular Weight | Stereoisomerism | Antineoplastic Agents - chemical synthesis | Humans | Molecular Conformation | Male | Antineoplastic Agents - administration & dosage | Diethylstilbestrol - administration & dosage | Drug Carriers - chemistry | Endocytosis | Diethylstilbestrol - pharmacology | Solutions | Drug Design | Antineoplastic Agents - pharmacology | Acetals - chemistry | Diethylstilbestrol - chemistry | Prostatic Neoplasms - drug therapy | Cell Survival - drug effects | Diethylstilbestrol - chemical synthesis | Prostatic Neoplasms - pathology | Polymers - chemical synthesis | Drug Stability | Solubility | Drug Carriers - chemical synthesis | Antineoplastic Agents - chemistry | Acetals - pharmacology | Drug Carriers - pharmacology | Microscopy, Confocal | Acetals - chemical synthesis | Polymers - pharmacology | Cell Line, Tumor | Polymers - chemistry | Hydrogen-Ion Concentration | Cell culture | Biodegradability | Estrogens | Permeability | pH effects | Molecular weight | N.M.R | Neutron scattering | Diethylstilbestrol | Controlled release | Conformation | Tumors
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 10/2017, Volume 25, Issue 19, pp. 5077 - 5083
Journal Article
Drug Design, Development and Therapy, ISSN 1177-8881, 06/2018, Volume 12, pp. 1785 - 1798
Background: Over the years, pyrazolopyrimidine derivatives have been recognized as having antimicrobial activities. Recently, we reported different synthetic... 
5-aminopyrazoles | Docking studies | 2-(hydroxymethylene)-1-cycloalkanones | Antifungal | Pyrazolo[1,5-a]pyrimidines | Antibacterial | 2-formylcycloalkanones | ACRYLAMIDE THIOGLYCOSIDES | docking studies | CHEMISTRY, MEDICINAL | pyrazolo[1,5-a]pyrimidines | PYRAZOLOPYRIMIDINES | PYRAZOLE DERIVATIVES | ESCHERICHIA-COLI | antibacterial | 5-AMINOPYRAZOLE | ANTITUMOR ACTIVITIES | CYANOKETENE N,S-ACETALS | DIRECT ROUTE | CONVERSIONS | antifungal | SCHIFF-BASES | PHARMACOLOGY & PHARMACY | Gram-Positive Bacteria - drug effects | Pyrazoles - chemical synthesis | Pyrimidines - chemical synthesis | Antifungal Agents - chemical synthesis | Structure-Activity Relationship | Candida albicans - growth & development | Spectroscopy, Fourier Transform Infrared | Candida albicans - drug effects | Proton Magnetic Resonance Spectroscopy | Mass Spectrometry | Drug Design | Molecular Structure | Gram-Positive Bacteria - growth & development | Pyrazoles - pharmacology | Antifungal Agents - pharmacology | Cycloparaffins - pharmacology | Aspergillus flavus - drug effects | Pyrimidines - pharmacology | Anti-Bacterial Agents - chemical synthesis | Gram-Negative Bacteria - drug effects | Aspergillus flavus - growth & development | Disk Diffusion Antimicrobial Tests | Gram-Negative Bacteria - growth & development | Cycloparaffins - chemical synthesis | Anti-Bacterial Agents - pharmacology | Molecular Docking Simulation | Alkaloids | Pyrimidines | Antibacterial agents | Antifungal agents | Infrared spectroscopy | Salts | Nuclear magnetic resonance--NMR | Ketones | Fungicides | Sodium salts | Mass spectroscopy | Antimicrobial agents | Derivatives | Pyrazolopyrimidines | Anticancer properties | Analogs | Antifungal activity | Sodium | Ampicillin | Docking | Infections | Drug resistance | E coli | Antibiotics | Bacteria | Mutation | Cancer | antimicrobial | Pyrazolo | 5-a]pyrimidines
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 05/2018, Volume 26, Issue 9, pp. 2199 - 2220
The quinazolinone-containing 2,3-disubstituted piperidines febrifugine and isofebrifugine have been the subject of significant research efforts since their... 
Halofuginone | Anti-fibrotic | Dichroine A and B | 3-hydroxypiperidine | Isomerization | Febrifugine | Quinazolinone | Anti-angiogenic | Isofebrifugine | Anti-protozoal | SEMICYCLIC N,O-ACETALS | CHEMISTRY, MEDICINAL | LEWIS-ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | MACROPHYLLA VAR. OTAKSA | CHEMISTRY, ORGANIC | NUCLEOPHILIC-SUBSTITUTION REACTIONS | HYDRANGEA-CHINENSIS | TRANSFER-RNA SYNTHETASE | ANTIMALARIAL ACTIVITY | CONCISE ENANTIOSELECTIVE SYNTHESIS | PLASMODIUM MALARIA PARASITE | CATALYTIC ASYMMETRIC-SYNTHESIS | Quinazolines - chemical synthesis | Piperidines - chemistry | Stereoisomerism | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Plasmodium falciparum - drug effects | Piperidines - chemical synthesis | Cycloaddition Reaction | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Antimalarials - pharmacology | Quinazolinones - chemical synthesis | Animals | Cyclization | Piperidines - pharmacology | Antimalarials - chemistry | Quinazolinones - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Quinazolines - pharmacology | Quinazolines - chemistry | Antimalarials - chemical synthesis | Quinazolinones - pharmacology | Malaria | Chemical tests and reagents | RNA | Ammonium paratungstate | Aluminum compounds | Fluorides | Biological response modifiers | Transforming growth factors | Muscle proteins | Lipase | Cytokinins | Ammonium compounds | Pyridine | Dimethyl sulfoxide | Interferon | Chemical synthesis | Adenosine triphosphate
Journal Article
Journal Article
Small, ISSN 1613-6810, 06/2015, Volume 11, Issue 24, pp. 2938 - 2945
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 10/2008, Volume 15, Issue 25, pp. 2614 - 2631
Having previously reported the synthesis and anticancer activities of cyclic 5-fluorouracil (5-FU) O,N-acetalic compounds, the decision was made to change 5-FU... 
Antitumour compounds | Purines | Benzoxazepines | Pyrimidines | Benzoxadioxepins | Benzoxathiins | Benzoxathiepins | Breast cancer | ORGANIC-SYNTHESIS | 5-FLUOROURACIL DERIVATIVES | CHEMISTRY, MEDICINAL | CYCLIN D1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ELECTRON-WITHDRAWING GROUPS | breast cancer | KINASE INHIBITORS | benzoxadioxepins | ANTITUMOR-ACTIVITY | benzoxathiepins | BREAST-CANCER CELLS | benzoxathiins | NITROGEN ATOM | IN-VIVO | purines | SELECTIVE INHIBITORS | benzoxazepines | PHARMACOLOGY & PHARMACY | pyrimidines | Cyclin D1 - metabolism | Benzene Derivatives - chemical synthesis | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Heterocyclic Compounds - pharmacology | Heterocyclic Compounds - chemical synthesis | Structure-Activity Relationship | RNA, Messenger - metabolism | Neoplasm Metastasis - prevention & control | Drug Design | Fluorouracil - chemical synthesis | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | Acetals - chemistry | Benzene Derivatives - pharmacology | Purines - chemical synthesis | Fluorouracil - analogs & derivatives | Purines - pharmacology | RNA, Messenger - genetics | Pyrimidines - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Acetals - pharmacology | Cyclin D1 - genetics | Breast Neoplasms - pathology | Neoplasm Metastasis - pathology | Cell Line, Tumor | Cell Proliferation - drug effects | Fluorouracil - pharmacology
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 06/2013, Volume 64, pp. 464 - 476
Journal Article
MOLECULAR CANCER RESEARCH, ISSN 1541-7786, 07/2015, Volume 13, Issue 7, pp. 1073 - 1082
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 12/2012, Volume 164, Issue 3, pp. 314 - 322
Journal Article
Journal Article
Journal Article