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Clinical and Experimental Pharmacology and Physiology, ISSN 1440-1681, 01/2009, Volume 36, Issue 1, pp. 35 - 42
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2009, Volume 106, Issue 34, pp. 14728 - 14733
We provide a demonstration in humans of the principle of pharmacometabonomics by showing a dear connection between an individual's metabolic phenotype, in the... 
Urine | Metabolomics | Excretion | Pharmacogenetics | Metabolites | Metabolic diseases | Bacteria | Glucuronides | Sulfates | Metabolism | Sulfate | Acetaminophen | p-cresol | Glucuronide | DNA-ADDUCTS | sulfate | QUINONE METHIDE | bacteria | MULTIDISCIPLINARY SCIENCES | ACETAMINOPHEN HEPATOTOXICITY | MYELIN BASIC-PROTEIN | acetaminophen | AUTISTIC-CHILDREN | GUT MICROFLORA | glucuronide | LOW-DOSE PARACETAMOL | PHARMACOGENOMICS | P-CRESOL SULFATE | HUMAN SULFOTRANSFERASES | Acetaminophen - metabolism | Analgesics, Non-Narcotic - pharmacokinetics | Humans | Middle Aged | Male | Sulfuric Acid Esters - metabolism | Young Adult | Bacteria - growth & development | Cresols - urine | Adult | Bacteria - metabolism | Acetaminophen - analogs & derivatives | Sulfates - metabolism | Magnetic Resonance Spectroscopy | Administration, Oral | Gastrointestinal Tract - microbiology | Acetaminophen - urine | Analgesics, Non-Narcotic - administration & dosage | Analgesics, Non-Narcotic - metabolism | Cresols - metabolism | Gastrointestinal Tract - metabolism | Host-Pathogen Interactions | Sulfuric Acid Esters - urine | Adolescent | Acetaminophen - pharmacokinetics | Host-bacteria relationships | Drug metabolism | Metabonomic analysis | Research | Competition | Drugs | biomarkers | Cresol | Magnetic resonance spectroscopy | p-Cresol | Analgesics | Sulfonation | Xenobiotics | Digestive tract | Pharmaceuticals | Biological Sciences
Journal Article
Journal Article
Pharmaceutical research, ISSN 1573-904X, 2013, Volume 30, Issue 9, pp. 2174 - 2187
Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic doses, overdose causes mitochondrial dysfunction and centrilobular... 
Biochemistry, general | Biomedical Engineering | drug transporters | nuclear receptors | acetaminophen | Biomedicine | Pharmacy | hepatotoxicity | drug metabolism | Medical Law | Pharmacology/Toxicology | ACUTE LIVER-FAILURE | PREGNANE-X RECEPTOR | APOPTOSIS-INDUCING FACTOR | COVALENT BINDING | MITOCHONDRIAL OXIDANT STRESS | CHEMISTRY, MULTIDISCIPLINARY | S-TRANSFERASE-PI | INDUCED HEPATIC-NECROSIS | CULTURED MOUSE HEPATOCYTES | BILIARY-EXCRETION | PHARMACOLOGY & PHARMACY | GLUTATHIONE DEPLETION | Acetaminophen - metabolism | Analgesics, Non-Narcotic - blood | Analgesics, Non-Narcotic - pharmacokinetics | Acetaminophen - toxicity | Humans | Liver - metabolism | Antipyretics - toxicity | Cytochrome P-450 Enzyme System - metabolism | Glutathione Transferase - metabolism | Analgesics, Non-Narcotic - metabolism | Chemical and Drug Induced Liver Injury - diagnosis | Acetaminophen - blood | Animals | Antipyretics - pharmacokinetics | Analgesics, Non-Narcotic - toxicity | Liver - drug effects | Chemical and Drug Induced Liver Injury - metabolism | Protein Binding | Acetaminophen - pharmacokinetics | Antipyretics - blood | Antipyretics - metabolism | Cellular proteins | Metabolites | Acetaminophen | Transferases | Cytochrome P-450 | Physiological aspects | Sulfates | Protein binding | Metabolism | Medical diagnosis | Hepatology | Index Medicus
Journal Article
Separation and purification technology, ISSN 1383-5866, 11/2018, Volume 206, p. 343
The presence of acetaminophen (APAP) in water and wastewater indicates its low susceptibility to conventional treatment. The application of new TiO.sub.2... 
Acetaminophen
Journal Article
Cochrane Database of Systematic Reviews, ISSN 1469-493X, 02/2018, Volume 2018, Issue 2, pp. CD003328 - CD003328
Background Paracetamol (acetaminophen) is the most widely used non‐prescription analgesic in the world. Paracetamol is commonly taken in overdose either... 
Liver Transplantation | Medical interventions | Antidotes | Haemoperfusion | Analgesics, Non‐Narcotic | Drug Overdose | Liver Failure, Acute | Gastroenterology & hepatology | Methionine | Liver disorders | Acetylcysteine | Cysteamine | Dimercaprol | TOXIC LIVER DISEASE DUE TO PARACETAMOL (ACETAMINOPHEN) (K71.9) (Y45.5) | Paracetamol (acetaminophen) overdose | Intestinal Absorption | Randomized Controlled Trials as Topic | Surgical interventions | Treatment | Acetaminophen | Charcoal haemoperfusion | Gastric Lavage | Medicine General & Introductory Medical Sciences | Charcoal | Liver Failure, Acute [chemically induced; surgery] | ACUTE LIVER-FAILURE | ACTIVATED-CHARCOAL | Analgesics, Non-Narcotic [pharmacokinetics; poisoning] | Acetaminophen [pharmacokinetics; poisoning] | Antidotes [therapeutic use] | DESIGN CHARACTERISTICS | Humans | Charcoal [therapeutic use] | ADVERSE-REACTIONS | TRIAL SEQUENTIAL-ANALYSIS | COLLABORATION RANDOMIZED-TRIAL | MEDICINE, GENERAL & INTERNAL | Drug Overdose [therapy] | EMPIRICAL-EVIDENCE | FULMINANT HEPATIC-FAILURE | LOADING INFUSION RATES | INTRAVENOUS N-ACETYLCYSTEINE | Analgesics, Non-Narcotic - pharmacokinetics | Drug Overdose - therapy | Drug Overdose - mortality | Charcoal - therapeutic use | Liver Failure, Acute - chemically induced | Liver Failure, Acute - epidemiology | Methionine - therapeutic use | Dimercaprol - therapeutic use | Acetaminophen - poisoning | Cysteamine - therapeutic use | Liver Failure, Acute - surgery | Acetaminophen - pharmacokinetics | Acetylcysteine - therapeutic use | Analgesics, Non-Narcotic - poisoning | Antidotes - therapeutic use | Index Medicus
Journal Article