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Toxicology and Applied Pharmacology, ISSN 0041-008X, 2004, Volume 201, Issue 3, pp. 226 - 294
Experience with dose response and mechanisms of toxicity has shown that multiple mechanisms may exist for a single agent along the continuum of the full... 
Mechanisms of toxicity | Dose response | Formaldehyde | Zinc | Progesterone/hydroxyflutamide | Propylene oxide | Dose-dependent transitions | Peroxisome proliferator-activated receptor | Acetaminophen | Vinylidene chloride | Butadiene, ethylene glycol | Methylene chloride | Vinyl acetate | Vinyl chloride | Manganese | Progesterone/ hydroxyflutamide | ACETAMINOPHEN-INDUCED HEPATOTOXICITY | propylene oxide | ACTIVATED RECEPTOR-GAMMA | dose-dependent transitions | mechanisms of toxicity | vinylidene chloride | manganese | butadiene | INDUCED HEPATIC-NECROSIS | dose response | ethylene glycol | methylene chloride | PHARMACOLOGY & PHARMACY | TOXICOLOGY | peroxisome proliferator-activated receptor | vinyl acetate | zinc | SISTER-CHROMATID EXCHANGES | SPRAGUE-DAWLEY RATS | MANGANESE OXIDE AEROSOL | formaldehyde | CHRONIC INHALATION TOXICITY | PROTEIN CROSS-LINKS | acetaminophen | vinyl chloride | GLUTATHIONE-S-TRANSFERASE | PARA-BENZOQUINONE IMINE | progesterone/hydroxyflutamide | Analgesics, Non-Narcotic - pharmacokinetics | Progesterone - administration & dosage | Humans | Acetaminophen - administration & dosage | Epoxy Compounds - pharmacokinetics | Dichloroethylenes - toxicity | Manganese - pharmacokinetics | Methylene Chloride - administration & dosage | Analgesics, Non-Narcotic - toxicity | Manganese - administration & dosage | Dichloroethylenes - pharmacokinetics | Dichloroethylenes - administration & dosage | Formaldehyde - toxicity | Androgen Antagonists - toxicity | Ethylene Glycol - toxicity | Butadienes - toxicity | Androgen Antagonists - pharmacokinetics | Progesterone - pharmacokinetics | Oxidation-Reduction | Acetaminophen - toxicity | Vinyl Compounds - administration & dosage | Zinc - toxicity | Androgen Antagonists - administration & dosage | Flutamide - administration & dosage | Vinyl Compounds - toxicity | Zinc - administration & dosage | Peroxisome Proliferator-Activated Receptors - physiology | Drug-Related Side Effects and Adverse Reactions - chemically induced | Flutamide - toxicity | Drug-Related Side Effects and Adverse Reactions - metabolism | Vinyl Compounds - pharmacokinetics | Dose-Response Relationship, Drug | Methylene Chloride - toxicity | Zinc - pharmacokinetics | Epoxy Compounds - administration & dosage | Formaldehyde - administration & dosage | Ethylene Glycol - administration & dosage | Formaldehyde - pharmacokinetics | Ethylene Glycol - pharmacokinetics | Butadienes - pharmacokinetics | Flutamide - analogs & derivatives | Analgesics, Non-Narcotic - administration & dosage | Epoxy Compounds - toxicity | Animals | Butadienes - administration & dosage | Progesterone - toxicity | Methylene Chloride - pharmacokinetics | Acetaminophen - pharmacokinetics | Flutamide - pharmacokinetics | Manganese Poisoning - metabolism
Journal Article
Journal Article
ANAESTHESIA AND INTENSIVE CARE, ISSN 0310-057X, 06/2005, Volume 33, Issue 3, pp. 311 - 322
The clinical utility of most analgesic drugs is altered in the presence of patients with impaired renal or hepatic function not simply because of altered... 
acute pain | MORPHINE | ORTHOTOPIC LIVER-TRANSPLANTATION | CONTROLLED ANALGESIA | hepatic function | VALPROATE | CARBAMAZEPINE | FAILURE | DISPOSITION | PLASMA | PHARMACOKINETICS | hepatic failure | review | renal function | ANESTHESIOLOGY | REMIFENTANIL | analgesia : renal failure | CRITICAL CARE MEDICINE | Kidney Failure, Chronic - physiopathology | Analgesics - therapeutic use | Pain - drug therapy | Humans | Half-Life | Biological Availability | Metabolic Clearance Rate | Analgesics - pharmacokinetics | Liver Diseases - physiopathology | Liver Diseases - metabolism | Contraindications | Kidney Failure, Chronic - metabolism | Methadone, pharmacokinetics | Anti-Inflammatory Agents, Non-Steroidal, adverse effects | Piperidines, pharmacokinetics | Hydrocodone, pharmacokinetics | Fentanyl, pharmacokinetics | Pain, complications | Buprenorphine, pharmacokinetics | Hydrocodone, administration and dosage | Carbamazepine, pharmacokinetics | Acute Disease | Ketamine, pharmacokinetics | Sufentanil, pharmacokinetics | Propoxyphene, pharmacokinetics | Acetaminophen, adverse effects | Clonidine, administration and dosage | Morphine, administration and dosage | Oxycodone, administration and dosage | Propoxyphene, administration and dosage | Hydromorphone, administration and dosage | Methadone, administration and dosage | Alfentanil, pharmacokinetics | Buprenorphine, administration and dosage | Codeine, pharmacokinetics | Meperidine, pharmacokinetics | Sufentanil, administration and dosage | Anesthetics, Local, therapeutic use | Codeine, administration and dosage | Mexiletine, pharmacokinetics | Mexiletine, administration and dosage | Anti-Inflammatory Agents, Non-Steroidal, therapeutic use | Liver Failure, complications | Alfentanil, administration and dosage | Piperidines, administration and dosage | Pain, drug therapy | Ketamine, administration and dosage | Fentanyl, administration and dosage | Carbamazepine, administration and dosage | Hydromorphone, pharmacokinetics | Ketorolac, pharmacokinetics | Analgesics, Opioid, therapeutic use | Ketorolac, administration and dosage | Tramadol, administration and dosage | Morphine, pharmacokinetics | Valproic Acid, pharmacokinetics | Acetaminophen, administration and dosage | Valproic Acid, administration and dosage | Tramadol, pharmacokinetics | Acetic Acids | Kidney Failure, complications | Antidepressive Agents, Tricyclic, therapeutic use | Meperidine, administration and dosage | Clonidine, pharmacokinetics | Analgesics, Non-Narcotic, therapeutic use | Oxycodone, pharmacokinetics | Valproic Acid, adverse effects | Analgesia: renal failure, renal function, hepatic failure, hepatic function, review | Acute pain
Journal Article
Journal of Paediatrics and Child Health, ISSN 1034-4810, 01/2008, Volume 44, Issue 1‐2, pp. 3 - 9
Aim:  To undertake a meta‐analysis of all randomised controlled trials (RCTs) on the acute pharmacologic treatment of children and adolescents with migraine... 
paediatrics | therapeutics | evidenced‐based medicine | migraine disorders | Evidenced-based medicine | Migraine disorders | Paediatrics | Therapeutics | AMERICAN-ACADEMY | PRACTICE PARAMETER | evidenced-based medicine | OPEN-LABEL | QUALITY STANDARDS SUBCOMMITTEE | SUBCUTANEOUS SUMATRIPTAN | PHARMACOLOGICAL-TREATMENT | RIZATRIPTAN 5 MG | ADOLESCENTS | SUMATRIPTAN NASAL SPRAY | DOUBLE-BLIND | PEDIATRICS | Triazoles - administration & dosage | Humans | Acetaminophen - administration & dosage | Drug Evaluation | Sumatriptan - administration & dosage | Ibuprofen - administration & dosage | Analgesics, Non-Narcotic - administration & dosage | Oxazolidinones - administration & dosage | Migraine Disorders - drug therapy | Randomized Controlled Trials as Topic | Adolescent | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Placebos | Child | Dihydroergotamine - administration & dosage | Serotonin Receptor Agonists - administration & dosage | Tryptamines - administration & dosage | Oxazolidinones, administration and dosage | Acetaminophen, administration and dosage | Analgesics, Non-Narcotic, administration and dosage | Sumatriptan, administration and dosage | Migraine Disorders, drug therapy | Tryptamines, administration and dosage | Triazoles, administration and dosage | Ibuprofen, administration and dosage | Anti-Inflammatory Agents, Non-Steroidal, administration and dosage | Dihydroergotamine, administration and dosage | Serotonin Agonists, administration and dosage | Drug therapy | Migraine | Analysis | Ibuprofen
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 2014, Volume 106, Issue 2, pp. djt431 - djt431
Journal Article
Journal Article