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Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 12/2018, Volume 28, Issue 23-24, pp. 3798 - 3801
A series of nitrate ester analogues of the acetaminophen derivative SCP-1 were prepared by triflic acid catalyzed O-acylation of SCP-1 with chloroalkanoyl... 
Antipyretic activity | Acetaminophen | Hepatotoxicity | Nitrate ester | NO donor | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | Nitration | Dichloropropane | Chlorides | Cytochrome P-450 | Esters | Silver nitrate | Acylation
Journal Article
Journal Article
Journal Article
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, ISSN 1386-1425, 06/2016, Volume 162, pp. 16 - 26
The aim of this investigation was to determine the molecular properties and provide an interpretation of the vibrational mode couplings of these two... 
FT-IR | Kinetics | Rate constant | Acetaminophen | Heat of formation | Density functionals | Hydrogen | Analysis | Isomerization
Journal Article
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 04/2012, Volume 83, Issue 7, pp. 923 - 931
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used anti-inflammatory therapeutic agents, among which the fenamate analogues play important roles in... 
Fenamate analogues | 2-Aminoethoxydiphenyl borate | Calcium channel | TRPC | Non-steroidal anti-inflammatory drugs | NONSELECTIVE CATION CHANNEL | POTASSIUM CURRENTS | MITOCHONDRIAL CA2+ UPTAKE | N-(P-AMYLCINNAMOYL)ANTHRANILIC ACID | FLUFENAMIC ACID | TRPM2 | INHIBITION | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | RABBIT PORTAL-VEIN | ACTIVATED CHLORIDE | Calcium - metabolism | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Structure-Activity Relationship | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Fenamates - pharmacology | Transfection | HEK293 Cells | Fura-2 - chemistry | Cell Culture Techniques | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | TRPC Cation Channels - genetics | Fluorescent Dyes - chemistry | Fenamates - chemistry | Rats | Mitochondria - metabolism | Mitochondria - drug effects | Muscle, Smooth, Vascular - cytology | TRPC Cation Channels - antagonists & inhibitors | Fura-2 - analogs & derivatives | Patch-Clamp Techniques | Animals | Fenamates - chemical synthesis | Microscopy, Fluorescence | Drugs | Calcium channels | Nonsteroidal anti-inflammatory drugs | Anti-inflammatory drugs | Heterocyclic compounds | Potentiation | Aspirin | Calcium (intracellular) | Calcium imaging | Pharmacology | Celecoxib | Drug development | transient receptor potential proteins | Calcium (mitochondrial) | Diclofenac | Nonsteroidal antiinflammatory drugs | Mitochondria | Sodium | Acetaminophen | Mefenamic acid | Perfusion | Ion channels | Indomethacin | Conformation | Index Medicus
Journal Article
Toxicology Letters, ISSN 0378-4274, 08/2018, Volume 292, pp. 31 - 38
Diallyl sulfide (DAS) has been shown to prevent xenobiotic (e.g. ethanol, acetaminophen) induced toxicity and disease (e.g. HIV-1) pathogenesis. DAS imparts... 
HIV-1 | Cytotoxicity | Alcohol | Acetaminophen | Cytochrome P450 2E1 | Diallyl sulfide | Evaluation | Amines | Analysis | Pharmacy | Dimethyl sulfide | Cytochrome P-450 | Drugstores | Thiophene | Xenobiotics | HIV (Viruses) | Index Medicus
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 10/2013, Volume 54, Issue 42, pp. 5718 - 5720
Acetaminophen analogues containing α-amino acid and fatty acids were easily synthesized in 77–99% yields from the corresponding mixed carbonic carboxylic... 
α-Amino acid | Acetaminophen | Fatty acid | Mixed carbonic carboxylic anhydride | Anilide | alpha-Amino acid | CHEMISTRY, ORGANIC | CHLOROFORMATE | PEPTIDE-SYNTHESIS
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 05/2017, Volume 486, Issue 3, pp. 639 - 644
Journal Article
Redox Biology, ISSN 2213-2317, 04/2015, Volume 4, Issue C, pp. 308 - 320
Oxidative stress plays a major part in the pathogenesis of drug-induced liver injury. Yet, overcoming it with other xenobiotics impose additional risks. In... 
Drug-induced liver injury | Tocotrienol | Tocopherol | Antioxidant | UNITED-STATES | OXIDATIVE STRESS | ALPHA-TOCOTRIENOL | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACETAMINOPHEN HEPATOTOXICITY | NRF2 KNOCKOUT MICE | NATURAL VITAMIN-E | ANTIOXIDANT PROPERTIES | CELL-DEATH | GLUTATHIONE | TOCOPHEROLS | Tumor Necrosis Factor-alpha - metabolism | Reactive Oxygen Species - metabolism | Tumor Necrosis Factor-alpha - genetics | Caspase 3 - metabolism | Tocopherols - pharmacology | bcl-X Protein - genetics | Hepatocytes - metabolism | Hepatocytes - cytology | Proliferating Cell Nuclear Antigen - genetics | Protective Agents - pharmacology | Caspase 3 - genetics | Lipid Peroxidation - drug effects | Interleukin-6 - metabolism | Hepatocytes - drug effects | Hydrogen Peroxide - toxicity | Cell Survival - drug effects | Interleukin-6 - genetics | Signal Transduction | Acetaminophen - toxicity | Acetaminophen - antagonists & inhibitors | Gene Expression Regulation | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Reactive Oxygen Species - antagonists & inhibitors | Animals | Nitric Oxide Synthase Type II - genetics | Mice | Oxidative Stress - drug effects | Proliferating Cell Nuclear Antigen - metabolism | bcl-X Protein - metabolism | Hydrogen Peroxide - antagonists & inhibitors | Cell Line, Transformed | Nitric Oxide Synthase Type II - metabolism | Vitamin E - pharmacology | Index Medicus
Journal Article
Chemical Research in Toxicology, ISSN 0893-228X, 06/2017, Volume 30, Issue 6, pp. 1286 - 1301
Several chemical routes related to the toxicity of paracetamol (APAP, also known as acetaminophen), its analogue Nacetyl-m-aminophenol (AMAP), and their... 
CYSTEINE PK(A) VALUES | HYDROGEN ABSTRACTION | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | ACTIVE-SITE | ELECTRON REDOX POTENTIALS | CHEMISTRY, MULTIDISCIPLINARY | PROSTAGLANDIN-H SYNTHASE | P-BENZOQUINONE IMINE | ABSORPTION FINE-STRUCTURE | TOXICOLOGY | GLUTATHIONE-S-TRANSFERASE | PROTEIN-TYROSINE-PHOSPHATASE |