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1. Full Text Biotransformation and bioactivation reactions - 2015 literature highlights
by Baillie, Thomas A and Dalvie, Deepak and Rietjens, Ivonne M. C. M and Cyrus Khojasteh, S
Drug metabolism reviews, ISSN 0360-2532, 04/2016, Volume 48, Issue 2, pp. 113 - 138
2015 review | literature highlights | biotransformation | metabolism | Bioactivation | Niacinamide - analogs & derivatives | Triazoles - adverse effects | Humans | Pyridines - pharmacokinetics | Imidazoles - pharmacokinetics | Peroxides - pharmacokinetics | Anisoles - pharmacokinetics | Nitrosamines - pharmacokinetics | Biotransformation | Niacinamide - pharmacokinetics | Triazoles - pharmacokinetics | Pyrazoles - pharmacokinetics | Nitroimidazoles - pharmacokinetics | Pyridazines - adverse effects | Benzbromarone - pharmacokinetics | Pyridones - pharmacokinetics | Oxazolidinones - pharmacokinetics | Oxazoles - pharmacokinetics | Aniline Compounds - pharmacokinetics | Thiophenes - pharmacokinetics | Animals | Pyrimidinones - pharmacokinetics | Pyrazines - pharmacokinetics | Pyridazines - pharmacokinetics | Acetaminophen - pharmacokinetics | Index Medicus
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2. Full Text Acute pain management pharmacology for the patient with concurrent renal or hepatic disease
by Murphy, E.J
Anaesthesia and intensive care, ISSN 0310-057X, 06/2005, Volume 33, Issue 3, pp. 311 - 322
Analgesia: renal failure, renal function, hepatic failure, hepatic function, review | Acute pain | Anesthesiology | Life Sciences & Biomedicine | Critical Care Medicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | Anesthesia | Medical sciences | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy | Kidney Failure, Chronic - physiopathology | Analgesics - therapeutic use | Pain - drug therapy | Humans | Half-Life | Biological Availability | Metabolic Clearance Rate | Analgesics - pharmacokinetics | Liver Diseases - physiopathology | Liver Diseases - metabolism | Contraindications | Kidney Failure, Chronic - metabolism | Methadone, pharmacokinetics | Anti-Inflammatory Agents, Non-Steroidal, adverse effects | Piperidines, pharmacokinetics | Hydrocodone, pharmacokinetics | Fentanyl, pharmacokinetics | Pain, complications | Buprenorphine, pharmacokinetics | Hydrocodone, administration and dosage | Carbamazepine, pharmacokinetics | Acute Disease | Ketamine, pharmacokinetics | Sufentanil, pharmacokinetics | Propoxyphene, pharmacokinetics | Acetaminophen, adverse effects | Clonidine, administration and dosage | Morphine, administration and dosage | Oxycodone, administration and dosage | Propoxyphene, administration and dosage | Hydromorphone, administration and dosage | Methadone, administration and dosage | Alfentanil, pharmacokinetics | Buprenorphine, administration and dosage | Codeine, pharmacokinetics | Meperidine, pharmacokinetics | Sufentanil, administration and dosage | Anesthetics, Local, therapeutic use | Codeine, administration and dosage | Mexiletine, pharmacokinetics | Mexiletine, administration and dosage | Anti-Inflammatory Agents, Non-Steroidal, therapeutic use | Liver Failure, complications | Alfentanil, administration and dosage | Piperidines, administration and dosage | Pain, drug therapy | Ketamine, administration and dosage | Fentanyl, administration and dosage | Carbamazepine, administration and dosage | Hydromorphone, pharmacokinetics | Ketorolac, pharmacokinetics | Analgesics, Opioid, therapeutic use | Ketorolac, administration and dosage | Tramadol, administration and dosage | Morphine, pharmacokinetics | Valproic Acid, pharmacokinetics | Acetaminophen, administration and dosage | Valproic Acid, administration and dosage | Tramadol, pharmacokinetics | Acetic Acids | Kidney Failure, complications | Antidepressive Agents, Tricyclic, therapeutic use | Meperidine, administration and dosage | Clonidine, pharmacokinetics | Analgesics, Non-Narcotic, therapeutic use | Oxycodone, pharmacokinetics | Valproic Acid, adverse effects | Index Medicus
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3. Full Text Safety, tolerability, and pharmacokinetics of l‐ornithine phenylacetate in patients with acute liver injury/failure and hyperammonemia
by Stravitz, R. Todd and Gottfried, Michelle and Durkalski, Valerie and Fontana, Robert J and Hanje, A. James and Koch, David and Hameed, Bilal and Ganger, Daniel and Subramanian, Ram M and Bukofzer, Stan and Ravis, William R and Clasen, Kristen and Sherker, Averell and Little, Lanna and Lee, William M and Acute Liver Failure Study Grp and Acute Liver Failure Study Group
Hepatology (Baltimore, Md.), ISSN 0270-9139, 03/2018, Volume 67, Issue 3, pp. 1003 - 1013
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Acetates - blood | Liver - pathology | Liver Failure, Acute - complications | Humans | Middle Aged | Glutamine - metabolism | Ornithine - analogs & derivatives | Male | Kidney Function Tests | Young Adult | Hyperammonemia - drug therapy | Ornithine - adverse effects | Ornithine - pharmacokinetics | Adult | Female | Phenols - blood | Registries | Glutamine - analogs & derivatives | Liver Failure, Acute - drug therapy | Ammonia - blood | Treatment Outcome | Hyperammonemia - complications | Ornithine - administration & dosage | Adolescent | Aged | Creatinine | Urine | Edema | Headache | Excretion | Renal function | Liver diseases | Liver | Hyperammonemia | Nausea | Morbidity | Ammonia | Vomiting | Renal failure | Safety | Pharmacokinetics | Ornithine | Index Medicus | ammonia | intracranial hypertension | acetaminophen | cerebral edema | hepatic encephalopathy
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4. Full Text Enteral Drug Absorption in Patients with Short Small Bowel: A Review
by Rene Severijnen and Nazila Bayat and Hans Bakker and Jules Tolboom and Ger Bongaerts
Clinical pharmacokinetics, ISSN 0312-5963, 2004, Volume 43, Issue 14, pp. 951 - 962
Loperamide, pharmacokinetics | Tricyclic antidepressants, pharmacokinetics | Levonorgestrel, pharmacokinetics | Amitriptyline, pharmacokinetics | Mesalazine, pharmacokinetics | Nortriptyline, pharmacokinetics | Oral contraceptives, pharmacokinetics | Omeprazole, pharmacokinetics | Short bowel syndrome | Warfarin, pharmacokinetics | Procainamide, pharmacokinetics | Hydrochlorothiazide, pharmacokinetics | Norethisterone, pharmacokinetics | Cimetidine, pharmacokinetics | Digoxin, pharmacokinetics | Pindolol, pharmacokinetics | Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions | Short Bowel Syndrome - metabolism | Antidepressive Agents, Tricyclic - pharmacokinetics | Humans | Cardiovascular Agents - pharmacokinetics | Acetaminophen - pharmacokinetics | Gastrointestinal Agents - pharmacokinetics | Pharmacokinetics | Intestinal Absorption | Index Medicus
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5. Full Text O05 Physiologically based pharmacokinetic modelling to characterize acetaminophen pharmacokinetics and NAPQI formation in non-pregnant and pregnant women
by Mian, P and van den Anker, JN and van Calsteren, K and Annaert, P and Tibboel, D and Pfister, M and Allegaert, K and Dallmann, A
Archives of disease in childhood, ISSN 0003-9888, 06/2019, Volume 104, Issue 6, pp. e2 - e3
Pregnancy | Metabolites | Analgesics | Acetaminophen | Models | Pharmacokinetics | Hepatotoxicity
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6. Full Text Population pharmacokinetics of paracetamol across the human age-range from (pre)term neonates, infants, children to adults
by Wang, Chenguang and Allegaert, Karel and Tibboel, Dick and Danhof, Meindert and van der Marel, Caroline D and Mathot, Ron A. A and Knibbe, Catherijne A. J
Journal of clinical pharmacology, ISSN 0091-2700, 2014, Volume 54, Issue 6, pp. 619 - 629
pharmacokinetics | clearance | allometry | paracetamol | pediatric | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Analgesics, Non-Narcotic - pharmacokinetics | Humans | Child, Preschool | Infant | Male | Young Adult | Models, Biological | Infant, Premature | Adult | Acetaminophen - pharmacokinetics | Child | Infant, Newborn | Aging - metabolism | Practice guidelines (Medicine) | Usage | Dosage and administration | Pharmacokinetics | Allometry | Acetaminophen | Index Medicus
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7. Full Text Dose-dependent transitions in mechanisms of toxicity: case studies
by Slikker, William and Andersen, Melvin E and Bogdanffy, Matthew S and Bus, James S and Cohen, Steven D and Conolly, Rory B and David, Raymond M and Doerrer, Nancy G and Dorman, David C and Gaylor, David W and Hattis, Dale and Rogers, John M and Setzer, R. Woodrow and Swenberg, James A and Wallace, Kendall
Toxicology and applied pharmacology, ISSN 0041-008X, 2004, Volume 201, Issue 3, pp. 226 - 294
Mechanisms of toxicity | Dose response | Formaldehyde | Zinc | Progesterone/hydroxyflutamide | Propylene oxide | Dose-dependent transitions | Peroxisome proliferator-activated receptor | Acetaminophen | Vinylidene chloride | Butadiene, ethylene glycol | Methylene chloride | Vinyl acetate | Vinyl chloride | Manganese | Progesterone/ hydroxyflutamide | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Solvents | Biological and medical sciences | Medical sciences | Chemical and industrial products toxicology. Toxic occupational diseases | Metals and various inorganic compounds | Analgesics, Non-Narcotic - pharmacokinetics | Progesterone - administration & dosage | Humans | Acetaminophen - administration & dosage | Epoxy Compounds - pharmacokinetics | Dichloroethylenes - toxicity | Manganese - pharmacokinetics | Methylene Chloride - administration & dosage | Analgesics, Non-Narcotic - toxicity | Manganese - administration & dosage | Dichloroethylenes - pharmacokinetics | Dichloroethylenes - administration & dosage | Formaldehyde - toxicity | Androgen Antagonists - toxicity | Ethylene Glycol - toxicity | Butadienes - toxicity | Androgen Antagonists - pharmacokinetics | Progesterone - pharmacokinetics | Oxidation-Reduction | Acetaminophen - toxicity | Vinyl Compounds - administration & dosage | Zinc - toxicity | Androgen Antagonists - administration & dosage | Flutamide - administration & dosage | Vinyl Compounds - toxicity | Zinc - administration & dosage | Peroxisome Proliferator-Activated Receptors - physiology | Drug-Related Side Effects and Adverse Reactions - chemically induced | Flutamide - toxicity | Drug-Related Side Effects and Adverse Reactions - metabolism | Vinyl Compounds - pharmacokinetics | Dose-Response Relationship, Drug | Methylene Chloride - toxicity | Zinc - pharmacokinetics | Epoxy Compounds - administration & dosage | Formaldehyde - administration & dosage | Ethylene Glycol - administration & dosage | Formaldehyde - pharmacokinetics | Ethylene Glycol - pharmacokinetics | Butadienes - pharmacokinetics | Flutamide - analogs & derivatives | Analgesics, Non-Narcotic - administration & dosage | Epoxy Compounds - toxicity | Animals | Butadienes - administration & dosage | Progesterone - toxicity | Methylene Chloride - pharmacokinetics | Acetaminophen - pharmacokinetics | Flutamide - pharmacokinetics | Manganese Poisoning - metabolism | Index Medicus
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