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Chemico-Biological Interactions, ISSN 0009-2797, 12/2018, Volume 296, pp. 117 - 123
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 01/2015, Volume 78, pp. 202 - 212
The transcription factor Nrf2 regulates the basal and inducible expression of a battery of cytoprotective genes. Whereas numerous Nrf2-inducing small molecules... 
Brusatol | Free radicals | Hepatocyte | Nrf2 | Toxicity | Keap1 | Chemical stress | Cell defense | OXIDATIVE STRESS | ACTIVATION | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-SYNTHESIS INHIBITION | CANCER | TRANSCRIPTION FACTOR NRF2 | DEFENSE PATHWAY | ACETAMINOPHEN | ENDOCRINOLOGY & METABOLISM | DEGRADATION | RNA, Small Interfering - genetics | NF-E2-Related Factor 2 - antagonists & inhibitors | Oxidative Stress | Apoptosis - drug effects | Humans | Hepatocytes - metabolism | Autophagy | Quassins - pharmacology | Hepatocytes - cytology | Carcinoma, Hepatocellular - drug therapy | Liver Neoplasms - pathology | NF-E2-Related Factor 2 - genetics | Real-Time Polymerase Chain Reaction | Hepatocytes - drug effects | Oxidation-Reduction | RNA, Messenger - genetics | Cells, Cultured | Liver Neoplasms - drug therapy | Reverse Transcriptase Polymerase Chain Reaction | Brucea - chemistry | Blotting, Western | Gene Expression Regulation - drug effects | Animals | Signal Transduction - drug effects | NF-E2-Related Factor 2 - metabolism | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Proliferation - drug effects | Mice | Carcinoma, Hepatocellular - metabolism | Chemical inhibitors | Metabolites | Proteolysis | Health aspects | Quinone | Cells | Index Medicus | Gclm, glutamate–cysteine ligase regulatory subunit | NEM, N-ethylmaleimide | NAPQI, N-acetyl-p-benzoquinone imine | IAA, iodoacetamide | Nrf2, nuclear factor erythroid 2-related factor 2 | Original Contribution | Keap1, Kelch-like ECH-associated protein 1 | DNCB, 2,4-dinitrochlorobenzene | Nqo1, NAD(P)H dehydrogenase quinone 1 | CDDO-Me, methyl-2-cyano-3,12-dioxooleana-1, 9dien-28-oate | HIF-1α, hypoxia-inducible factor 1α | RT-qPCR, real-time quantitative PCR | AMC, 7-amino-4-methylcoumarin
Journal Article
Journal Article
Comparative Biochemistry and Physiology, Part C, ISSN 1532-0456, 11/2013, Volume 158, Issue 4, pp. 216 - 224
Journal Article
Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, 11/2018, Volume 123, Issue 5, pp. 589 - 593
Paracetamol overdosing may cause liver injury including fulminant liver failure due to generation of the toxic metabolites, N ‐acetyl‐p‐benzoquinone imine (... 
OXIDATIVE STRESS | AMINOPHENOL | INDUCED HEPATIC-NECROSIS | ISOPHTHALAMIDE | GLUTATHIONE | PHARMACOLOGY & PHARMACY | N-ACETYLCYSTEINE | MECHANISMS | MICE | TOXICOLOGY | ACETAMINOPHEN HEPATOTOXICITY | FAILURE | Acetaminophen - adverse effects | Antidotes - pharmacology | Chemical and Drug Induced Liver Injury - prevention & control | Benzene Derivatives - metabolism | Administration, Oral | Benzene Derivatives - therapeutic use | Analgesics, Non-Narcotic - pharmacology | Imines - pharmacokinetics | Benzoquinones - pharmacokinetics | Sulfhydryl Compounds - metabolism | Animals | Chemical and Drug Induced Liver Injury - metabolism | Analgesics, Non-Narcotic - adverse effects | Acetylcysteine - pharmacology | Mice | Sulfhydryl Compounds - therapeutic use | Acetaminophen - pharmacokinetics | Chelating Agents - metabolism | Chelating Agents - therapeutic use | Chemical and Drug Induced Liver Injury - etiology | Disease Models, Animal | Alanine | Liver diseases | Toxicity | Liver | Oral administration | Acetylcysteine | Benzoquinone | Necrosis | Quinones | Transient receptor potential proteins | Paracetamol | Injury prevention | Metabolites | Analgesics | Alanine transaminase | Chelation | Ankyrin | Index Medicus | Basic Medicine | Farmakologi och toxikologi | Medical and Health Sciences | Pharmacology and Toxicology | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article