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1. Full Text Ion-exchange selectivity of diclofenac, ibuprofen, ketoprofen, and naproxen in ureolyzed human urine
by Landry, Kelly A and Sun, Peizhe and Huang, Ching-Hua and Boyer, Treavor H
Water Research, ISSN 0043-1354, 01/2015, Volume 68, pp. 510 - 521
This research advances the knowledge of ion-exchange of four non-steroidal anti-inflammatory drugs (NSAIDs) – diclofenac (DCF), ibuprofen (IBP), ketoprofen... 
Ion-exchange | Urine source separation | van der Waals forces | Coulombic interactions | Non-steroidal anti-inflammatory drugs | Pharmaceuticals | Van der Waals forces | WASTE-WATER TREATMENT | SOURCE-SEPARATED URINE | SORPTION | WATER RESOURCES | ADSORPTION | RESINS | ENVIRONMENTAL SCIENCES | REMOVAL | PRECIPITATION | ENGINEERING, ENVIRONMENTAL | ORGANIC-COMPOUNDS | MICROPOLLUTANTS | Ketoprofen - urine | Chemistry, Pharmaceutical - methods | Diclofenac - isolation & purification | Humans | Naproxen - urine | Ibuprofen - isolation & purification | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Diclofenac - urine | Anti-Inflammatory Agents, Non-Steroidal - isolation & purification | Diclofenac - chemistry | Water Pollutants, Chemical - urine | Ketoprofen - chemistry | Water Pollutants, Chemical - isolation & purification | Ibuprofen - chemistry | Acetaminophen - isolation & purification | Ion Exchange | Urea - metabolism | Molecular Structure | Naproxen - isolation & purification | Acetaminophen - chemistry | Anion Exchange Resins - chemistry | Water Pollutants, Chemical - chemistry | Acetaminophen - urine | Static Electricity | Naproxen - chemistry | Ketoprofen - isolation & purification | Waste Disposal, Fluid - methods | Hydrogen Bonding | Ibuprofen - urine | Anti-Inflammatory Agents, Non-Steroidal - urine | Kinetics | Nonsteroidal anti-inflammatory drugs | Analgesics | Fluocinolone acetonide | Analysis | Green technology | Urine | Regeneration | Naproxen | Ibuprofen | Selectivity | Functional groups | Diclofenac
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2. Full Text Matrix Effect Compensation in Small-Molecule Profiling for an LC-TOF Platform Using Multicomponent Postcolumn Infusion
by González, Oskar and Van Vliet, Michael and Damen, Carola W. N and Van Der Kloet, Frans M and Vreeken, Rob J and Hankemeier, Thomas
Analytical Chemistry, ISSN 0003-2700, 06/2015, Volume 87, Issue 12, pp. 5921 - 5929
The possible presence of matrix effect is one of the main concerns in liquid chromatography mass spectrometry (LC-MS)-driven bioanalysis due to its impact on... 
INTERNAL STANDARD | CHEMISTRY, ANALYTICAL | SOURCE DESIGN | SIGNAL SUPPRESSION/ENHANCEMENT | PERFORMANCE | QUANTIFICATION | PESTICIDE-RESIDUES | ESI-MS/MS | TANDEM MASS-SPECTROMETRY | ELECTROSPRAY-IONIZATION | Tetrazoles - urine | Humans | Chromatography, High Pressure Liquid - instrumentation | Acetaminophen - urine | Clomipramine - urine | Dihydropyridines - urine | Mass Spectrometry - instrumentation | Enkephalin, Leucine - urine | Time Factors | Simvastatin - urine | Benzimidazoles - urine | Pharmaceutical Preparations - urine | Benzoates - urine | Nifedipine - urine | Matrix isolation | Molecules | Usage | Ionization | Analysis | Liquid chromatography | Mass spectrometry
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3. Full Text Simultaneous quantification of acetaminophen and five acetaminophen metabolites in human plasma and urine by high-performance liquid chromatography–electrospray ionization–tandem mass spectrometry: Method validation and application to a neonatal pharmacokinetic study
by Cook, Sarah F and King, Amber D and van den Anker, John N and Wilkins, Diana G
Journal of Chromatography B, ISSN 1570-0232, 12/2015, Volume 1007, pp. 30 - 42
Drug metabolism plays a key role in acetaminophen (paracetamol)-induced hepatotoxicity, and quantification of acetaminophen metabolites provides critical... 
Human plasma | Metabolites | Acetaminophen/Paracetamol | LC–MS/MS | Human urine | LC-MS/MS | UNITED-STATES | CHEMISTRY, ANALYTICAL | ADULT-POPULATION | OVERDOSE | BIOCHEMICAL RESEARCH METHODS | PARACETAMOL | HUMAN SERUM | INDUCED LIVER-INJURY | MEDICATION USE | NECROSIS | HEPATOTOXICITY | SLONE SURVEY | Limit of Detection | Reference Standards | Acetaminophen - blood | Chromatography, High Pressure Liquid - methods | Humans | Acetaminophen - urine | Acetaminophen - pharmacokinetics | Calibration | Tandem Mass Spectrometry - methods | Infant, Newborn | Quality Control | Infants (Newborn) | Acetaminophen | Mass spectrometry | Methods | High performance liquid chromatography | Index Medicus
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4. Full Text Differential pulse voltammetric determination of paracetamol in tablet and urine samples at a micro-crystalline natural graphite–polystyrene composite film modified electrode
by Khaskheli, Abdul Rauf and Fischer, Jan and Barek, Jiří and Vyskočil, Vlastimil and Sirajuddin and Bhanger, Muhammad Iqbal
Electrochimica Acta, ISSN 0013-4686, 07/2013, Volume 101, pp. 238 - 242
► Voltammetric determination of drug paracetamol. ► Utilization of a carbon film modified electrode. ► Determination of the paracetamol in tablet samples and... 
Paracetamol | Modified electrode | Graphite–polystyrene composite | Determination | Differential pulse voltammetry | Tablet samples | Human urine samples | Graphite-polystyrene composite | ELECTROCHEMISTRY | ACID | P-AMINOPHENOL | BEHAVIOR | CAFFEINE | ELECTROCHEMICAL OXIDATION | CARBON-PASTE ELECTRODE | PHARMACEUTICAL FORMULATIONS | AMPEROMETRIC DETERMINATION | ACETAMINOPHEN | CYCLIC VOLTAMMETRY | Electrochemistry | Electrochemical reactions | Polystyrene | Acetaminophen | Graphite
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5. Full Text Sol–gel thin-film based mesoporous silica and carbon nanotubes for the determination of dopamine, uric acid and paracetamol in urine
by Canevari, Thiago C and Raymundo-Pereira, Paulo A and Landers, Richard and Benvenutti, Edilson V and Machado, Sérgio A.S
Talanta, ISSN 0039-9140, 11/2013, Volume 116, pp. 726 - 735
This work describes the preparation, characterization and application of a hybrid material composed of disordered mesoporous silica (SiO ) modified with... 
Carbon nanotubes | Paracetamol | Dopamine | Uric acid | Electrochemical sensor | Mesoporous silica | CHEMISTRY, ANALYTICAL | PYROLYTIC-GRAPHITE ELECTRODE | SENSITIVE DETERMINATION | ASCORBIC-ACID | PASTE ELECTRODE | SIMULTANEOUS ELECTROCHEMICAL DETERMINATION | ACETAMINOPHEN | BIOSENSORS | SURFACE | FUNCTIONAL-GROUPS | MODIFIED GCE | Limit of Detection | Microscopy, Electron, Scanning | Electrochemical Techniques | Oxidation-Reduction | Humans | Silicon Dioxide - chemistry | Nanotubes, Carbon - ultrastructure | Acetaminophen - urine | Phase Transition | Electrodes | Hydrofluoric Acid - chemistry | Uric Acid - urine | Dopamine - urine | Nanotubes, Carbon - chemistry | Porosity | Hydrogen-Ion Concentration | Thin films | Phosphates | Adsorption | Acetaminophen | Nanotubes | Phenols | X-ray spectroscopy | Dielectric films | Raman spectroscopy | Silica | Sol gel process | Oxidation | Statistical methods | Glassy carbon | Silicon dioxide
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6. Full Text Physical-chemical interactions between pharmaceuticals and biochar in synthetic and real urine
by Solanki, Avni and Boyer, Treavor H
Chemosphere, ISSN 0045-6535, 03/2019, Volume 218, pp. 818 - 826
This research advances the knowledge of the pharmaceutical removal interactions by biochar in synthetic and real urine through the use of reference adsorbents... 
Isotherm | Paracetamol | XPS | Biochar | Naproxen | Graphite | AQUEOUS-SOLUTIONS | DICLOFENAC | ION-EXCHANGE | ADSORPTION | INACTIVATION | IBUPROFEN | ENVIRONMENTAL SCIENCES | REMOVAL | TEMPERATURE | ACTIVATED CARBON | MICROPOLLUTANTS | Naproxen - chemical synthesis | Pharmaceutical Preparations - isolation & purification | Naproxen - isolation & purification | Acetaminophen - chemistry | Naproxen - urine | Urine - chemistry | Acetaminophen - urine | Charcoal - chemistry | Water Pollutants, Chemical - analysis | Adsorption | Acetaminophen - isolation & purification | Pharmaceutical Preparations - chemistry | Pharmaceutical Preparations - urine | Kinetics | Index Medicus
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7. Full Text N-acetyl-4-aminophenol (paracetamol) in urine samples of 6–11-year-old Danish school children and their mothers
by Nielsen, Jeanette K.S and Nielsen, Flemming and Modick, Hendrik and Mørck, Thit A and Jensen, Janne F and Koch, Holger M and Knudsen, Lisbeth E
International Journal of Hygiene and Environmental Health, ISSN 1438-4639, 01/2015, Volume 218, Issue 1, pp. 28 - 33
Recent studies indicate an association between the use of paracetamol during pregnancy and reproductive disorders in male offspring. Furthermore,... 
Urine | N-acetyl-4-aminophenol | Paracetamol | Biomonitoring | Aniline | Human exposure | INFECTIOUS DISEASES | METABOLITES | INDOMETHACIN | EXCRETION | ASPIRIN | PREGNANCY | GENERAL-POPULATION | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | ACETAMINOPHEN | PHARMACOKINETICS | EXPOSURE | Pregnancy | Environmental Monitoring | Prenatal Exposure Delayed Effects | Humans | Adult | Body Burden | Female | Male | Acetaminophen - urine | Acetaminophen - pharmacokinetics | Acetaminophen - therapeutic use | Child | Elementary school students | Acetaminophen | Analysis | Public health
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8. Full Text Advancing NMR Sensitivity for LC-NMR-MS Using a Cryoflow Probe:  Application to the Analysis of Acetaminophen Metabolites in Urine
by Spraul, M and Freund, A. S and Nast, R. E and Withers, R. S and Maas, W. E and Corcoran, O
Analytical Chemistry, ISSN 0003-2700, 03/2003, Volume 75, Issue 6, pp. 1536 - 1541
Cryogenic cooling of the NMR radio frequency coils and electronics to give greatly enhanced sensitivity is arguably the most significant recent advance in NMR... 
HPLC-NMR | CHEMISTRY, ANALYTICAL | SPECTROSCOPY | CHROMATOGRAPHY | IDENTIFICATION | SPECTROMETRY | Acetaminophen - metabolism | Cold Temperature | Magnetic Resonance Spectroscopy - methods | Humans | Acetaminophen - administration & dosage | Glucuronides - urine | Acetaminophen - urine | Magnetic Resonance Spectroscopy - instrumentation | Sulfates - urine | Mass Spectrometry - instrumentation | Adult | Female | Mass Spectrometry - methods | Urine | Measurement | Chemistry, Analytic | Metabolites | Acetaminophen | Analysis | Methods
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9. Full Text Quantification of acetaminophen (paracetamol) in human plasma and urine by stable isotope-dilution GC–MS and GC–MS/MS as pentafluorobenzyl ether derivative
by Trettin, Arne and Zoerner, Alexander A and Böhmer, Anke and Gutzki, Frank-Mathias and Stichtenoth, Dirk O and Jordan, Jens and Tsikas, Dimitrios
Journal of Chromatography B, ISSN 1570-0232, 2011, Volume 879, Issue 23, pp. 2274 - 2280
We report on the quantitative determination of acetaminophen (paracetamol; NAPAP-d ) in human plasma and urine by GC–MS and GC–MS/MS in the electron-capture... 
Validation | Pentafluorobenzyl bromide | Quantification | Derivatization | Biological samples | Stable-isotope dilution | CHEMISTRY, ANALYTICAL | METABOLITES | ASSAY | BIOCHEMICAL RESEARCH METHODS | CAFFEINE | CHLORPHENIRAMINE | THEOPHYLLINE | TANDEM MASS-SPECTROMETRY | QUANTITATIVE-DETERMINATION | PHENACETIN | HPLC-MS/MS | Gas Chromatography-Mass Spectrometry - methods | Acetaminophen - blood | Radioisotope Dilution Technique | Humans | Ethers - chemistry | Acetaminophen - urine | Fluorobenzenes - chemistry | Tandem Mass Spectrometry - methods | Esters | Acetaminophen | Ionization | Toluene | Acetonitrile
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10. Full Text Simpler spectrophotometric assay of paracetamol in tablets and urine samples
by Sirajuddin and Khaskheli, Abdul Rauf and Shah, Afzal and Bhanger, Muhammad Iqbal and Niaz, Abdul and Mahesar, Sarfaraz
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, ISSN 1386-1425, 2007, Volume 68, Issue 3, pp. 747 - 751
A very fast, economical and simpler direct spectrophotometric method was investigated for paracetamol (PC) determination in aqueous medium without using any... 
FTIR studies | UV/visible spectrophotometry | Urine samples | Paracetamol | Tablets | urine samples | paracetamol | SPECTROSCOPY | tablets | Water | Solvents | Temperature | Humans | Acetaminophen - urine | Spectrophotometry - methods | Calibration | Spectroscopy, Fourier Transform Infrared | Acids | Analgesics | Solutions | Time Factors | Tablets - chemistry | Hydrogen-Ion Concentration | Acetaminophen
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11. Full Text Ubiquitous presence of paracetamol in human urine: Sources and implications
by Modick, Hendrik and Weiss, Tobias and Dierkes, Georg and Brüning, Thomas and Koch, Holger M
Reproduction, ISSN 1470-1626, 2014, Volume 147, Issue 4, pp. R105 - R117
N-acetyl-4-aminophenol (acetaminophen/paracetamol, NA4AP) is one of the most commonly used over-the-counter analgesic and antipyretic drugs. Recent studies... 
ACETYLSALICYLIC-ACID | REPRODUCTIVE BIOLOGY | LIQUID-CHROMATOGRAPHY | ACETAMINOPHEN | FETAL TESTIS | THE-COUNTER MEDICATIONS | DEVELOPMENTAL BIOLOGY | CRYPTORCHIDISM | TANDEM MASS-SPECTROMETRY | AROMATIC-AMINES | BREAST-MILK | PREGNANCY | Pregnancy | Veterinary Drugs - therapeutic use | Humans | Environmental Pollutants - urine | Female | Male | Acetaminophen - urine | Anti-Inflammatory Agents, Non-Steroidal - urine | Meat Products | Meat-Packing Industry
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12. Full Text Flow injection tyrosinase biosensor for direct determination of acetaminophen in human urine
by Frangu, Arbër and Pravcová, Kateřina and Šilarová, Petra and Arbneshi, Tahir and Sýs, Milan
Analytical and Bioanalytical Chemistry, ISSN 1618-2642, 4/2019, Volume 411, Issue 11, pp. 2415 - 2424
An amperometric biosensor compatible with a flow injection analysis (FIA) for highly selective determination of acetaminophen (APAP) in a sample of human urine... 
Biochemistry, general | Food Science | Flow injection analysis | Laboratory Medicine | Chemistry | Analytical Chemistry | Monitoring/Environmental Analysis | Acetaminophen | Biosensor | Human urine | Amperometry | Characterization and Evaluation of Materials | Tyrosinase | OXIDATION | CHEMISTRY, ANALYTICAL | BIOCHEMICAL RESEARCH METHODS | PARACETAMOL | ELECTRODES | GRAPHENE | CARBON NANOTUBES | PEROXIDASE | AMPEROMETRIC BIOSENSOR | Limit of Detection | Urinalysis - instrumentation | Analgesics, Non-Narcotic - urine | Humans | Acetaminophen - urine | Equipment Design | Urinalysis - methods | Flow Injection Analysis - instrumentation | Agaricus - enzymology | Biosensing Techniques - instrumentation | Biosensing Techniques - methods | Flow Injection Analysis - methods | Monophenol Monooxygenase - chemistry | Crosslinked polymers | Graphene | Analysis | High performance liquid chromatography | Detectors | Formulations | Urine | Correlation coefficient | Correlation coefficients | Crosslinking | Liquid chromatography | Injection | High-performance liquid chromatography | Ion exchanging | Electrical measurement | Glutaraldehyde | Analgesics | Mathematical analysis | Biosensors | Pharmaceuticals
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13. Full Text Investigation on the downregulation of dopamine by acetaminophen administration based on their simultaneous determination in urine
by Chandra, Pranjal and Son, Nguyen X and Noh, Hui-Bog and Goyal, Rajendra N and Shim, Yoon-Bo
Biosensors and Bioelectronics, ISSN 0956-5663, 01/2013, Volume 39, Issue 1, pp. 139 - 144
A highly sensitive and selective method is developed for the simultaneous detection of dopamine (DA) and acetaminophen (AP) by reactive blue-4 (RB4) dye... 
Dopamine | Simultaneous detection | Conducting polymer | Downregulation | Acetaminophen | Human urine | ELECTROCHEMISTRY | CHEMISTRY, ANALYTICAL | PARACETAMOL | NANOSCIENCE & NANOTECHNOLOGY | BIOPHYSICS | LIQUID-CHROMATOGRAPHY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ELECTRODE | ELECTROCHEMICAL SENSOR | Naphthalenes - chemistry | Humans | Dopamine - blood | Acetaminophen - urine | Antipyretics - urine | Electrodes | Dopamine - urine | Acetaminophen - blood | Acetaminophen - pharmacology | Sensitivity and Specificity | Biosensing Techniques - methods | Electrochemical Techniques - methods | Triazines - chemistry | Antipyretics - blood | Antipyretics - pharmacology | Dopamine - metabolism | Surface active agents | Metabolites | Analysis | Phenols | Polymers | Investigations
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14. Full Text Determination of acetaminophen and its main metabolites in urine by capillary electrophoresis hyphenated to mass spectrometry
by Lecoeur, Marie and Rabenirina, Guy and Schifano, Nadège and Odou, Pascal and Ethgen, Sabine and Lebuffe, Gilles and Foulon, Catherine
Talanta, ISSN 0039-9140, 12/2019, Volume 205, p. 120108
In this study, a capillary electrophoresis-tandem mass spectrometry method combining efficient separation and sensitive detection has been developed and... 
Acetaminophen (APAP) | Metabolites | Urinary samples | Capillary electrophoresis (CE) | Electrospray ionization interface (ESI) | Mass spectrometry (MS) | CHEMISTRY, ANALYTICAL | HUMAN PLASMA | GLUCURONIDE | QUANTIFICATION | VALIDATION | HARMONIZATION | SFSTP PROPOSAL | PARACETAMOL METABOLITES | SULFATE METABOLITES | QUANTITATIVE ANALYTICAL PROCEDURES | PARTIAL LIVER RESECTION
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15. Full Text First Report for Electrochemical Determination of Levodopa and Cabergoline: Application for Determination of Levodopa and Cabergoline in Human Serum, Urine and Pharmaceutical Formulations
by Tajik, Somayeh and Taher, Mohammad Ali and Beitollahi, Hadi
Electroanalysis, ISSN 1040-0397, 04/2014, Volume 26, Issue 4, pp. 796 - 806
The electrochemical oxidation of levodopa on the surface of a carbon paste electrode modified with graphene nanosheets,... 
Graphene nanosheets | Levodopa | Carbon paste electrode | Electrochemical sensor | Cabergoline | ELECTROCHEMISTRY | CHEMISTRY, ANALYTICAL | VOLTAMMETRIC DETERMINATION | SENSOR | IONIC LIQUID | ASCORBIC-ACID | CARBIDOPA | CARBON-PASTE ELECTRODE | 2,7-BIS(FERROCENYL ETHYL)FLUOREN-9-ONE | NANOTUBE | ACETAMINOPHEN | L-DOPA | Phosphates | Chemical properties | Dopa | Pharmaceutical industry | Graphene | Electric properties | Pastes | Urine | Human | Electrodes | Ionic liquids | Carbon | Electrochemical oxidation
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