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acetate-coa ligase - metabolism (377) 377
science & technology (317) 317
life sciences & biomedicine (269) 269
acetate-coa ligase - genetics (166) 166
animals (152) 152
biochemistry & molecular biology (119) 119
microbiology (108) 108
biological and medical sciences (100) 100
acetates - metabolism (99) 99
fundamental and applied biological sciences. psychology (91) 91
acetate-coa ligase - chemistry (86) 86
humans (81) 81
kinetics (78) 78
enzymes (72) 72
ligases (69) 69
molecular sequence data (67) 67
research (63) 63
amino acid sequence (61) 61
acetyl coenzyme a - metabolism (57) 57
male (55) 55
acetylation (53) 53
coenzyme a ligases - metabolism (52) 52
physiological aspects (51) 51
rats (50) 50
bacteria (48) 48
mice (47) 47
bacteriology (44) 44
escherichia coli - genetics (44) 44
gene expression (43) 43
metabolism (43) 43
mutation (43) 43
acetates (41) 41
cell biology (40) 40
proteins (40) 40
substrate specificity (38) 38
bacterial proteins - metabolism (37) 37
research article (37) 37
chemistry (36) 36
glucose - metabolism (36) 36
physical sciences (35) 35
aldehyde oxidoreductases - metabolism (34) 34
biotechnology & applied microbiology (34) 34
female (34) 34
acetyl-coa synthetase (33) 33
analysis (33) 33
binding sites (33) 33
acetic acid (32) 32
science & technology - other topics (31) 31
catalysis (30) 30
multidisciplinary sciences (30) 30
saccharomyces cerevisiae - enzymology (30) 30
acetate-coa ligase (29) 29
bacterial proteins - genetics (29) 29
base sequence (29) 29
biotechnology (29) 29
fatty acids (28) 28
genes (28) 28
acetate (27) 27
cloning, molecular (26) 26
escherichia coli - metabolism (26) 26
gene expression regulation, bacterial (25) 25
genetic aspects (25) 25
glucose (25) 25
multienzyme complexes - metabolism (25) 25
ethanol - metabolism (24) 24
oxidation-reduction (24) 24
transcription, genetic (24) 24
acetate-coa ligase - biosynthesis (23) 23
acetate-coa ligase - isolation & purification (23) 23
adenosine triphosphate - metabolism (23) 23
atp citrate-lyase - metabolism (22) 22
nickel - chemistry (22) 22
biochemistry (21) 21
escherichia coli (21) 21
lipid metabolism (21) 21
liver - enzymology (21) 21
signal transduction (21) 21
acetyl coenzyme a - biosynthesis (20) 20
fatty acids - metabolism (20) 20
liver - metabolism (20) 20
models, biological (20) 20
mycology (20) 20
biosynthesis (19) 19
cell line, tumor (19) 19
escherichia coli - enzymology (19) 19
fermentation (19) 19
life sciences (19) 19
saccharomyces cerevisiae - genetics (19) 19
acetate-coa ligase - antagonists & inhibitors (18) 18
acetyl-coa synthase (18) 18
hydrogen-ion concentration (18) 18
sequence homology, amino acid (18) 18
carbon dioxide - metabolism (17) 17
fatty acids - biosynthesis (17) 17
lipids (17) 17
mitochondria - enzymology (17) 17
molecular weight (17) 17
multienzyme complexes - chemistry (17) 17
phylogeny (17) 17
sirtuins - metabolism (17) 17
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1. Full Text Acetate Dependence of Tumors
by Comerford, Sarah A and Huang, Zhiguang and Du, Xinlin and Wang, Yun and Cai, Ling and Witkiewicz, Agnes K and Walters, Holly and Tantawy, Mohammed N and Fu, Allie and Manning, H. Charles and Horton, Jay D and Hammer, Robert E and McKnight, Steven L and Tu, Benjamin P
Cell (Cambridge), ISSN 0092-8674, 12/2014, Volume 159, Issue 7, pp. 1591 - 1602
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Immunohistochemistry | Neoplasms - metabolism | Acetates - metabolism | Humans | Positron-Emission Tomography | Acetyl Coenzyme A - metabolism | Acetate-CoA Ligase - analysis | Neoplasms - chemistry | Triple Negative Breast Neoplasms - chemistry | Animals | Acetate-CoA Ligase - genetics | Acetate-CoA Ligase - metabolism | Liver Neoplasms - metabolism | Triple Negative Breast Neoplasms - pathology | Mice | Neoplasms - pathology | Metabolites | Molecular genetics | Ligases | Physiological aspects | Histones | Lipids | Gene expression | Acetates | Tumors | Index Medicus
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2. Full Text Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases
by Mashimo, Tomoyuki and Pichumani, Kumar and Vemireddy, Vamsidhara and Hatanpaa, Kimmo J and Singh, Dinesh Kumar and Sirasanagandla, Shyam and Nannepaga, Suraj and Piccirillo, Sara G and Kovacs, Zoltan and Foong, Chan and Huang, Zhiguang and Barnett, Samuel and Mickey, Bruce E and DeBerardinis, Ralph J and Tu, Benjamin P and Maher, Elizabeth A and Bachoo, Robert M
Cell (Cambridge), ISSN 0092-8674, 12/2014, Volume 159, Issue 7, pp. 1603 - 1614
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Acetates - metabolism | Humans | Brain Neoplasms - pathology | Brain Neoplasms - metabolism | Citric Acid Cycle | Brain Neoplasms - secondary | Animals | Acetate-CoA Ligase - genetics | Acetate-CoA Ligase - metabolism | Neoplasm Metastasis - pathology | Glioblastoma - pathology | Glioblastoma - metabolism | Glutamic Acid - metabolism | Mice | Disease Models, Animal | Glucose metabolism | Ligases | Metastasis | Glucose | Acetates | Dextrose | Citric acid | Glutamine | Index Medicus
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3. Full Text Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory
by Mews, Philipp and Donahue, Greg and Drake, Adam M and Luczak, Vincent and Abel, Ted and Berger, Shelley L
Nature (London), ISSN 0028-0836, 06/2017, Volume 546, Issue 7658, pp. 381 - 386
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Chromatin - metabolism | Up-Regulation | Histones - chemistry | Transcriptional Activation | Neurons - cytology | Neuronal Plasticity - genetics | Cell Nucleus - metabolism | Neuronal Plasticity - physiology | Acetate-CoA Ligase - genetics | Hippocampus - enzymology | Cell Differentiation | Neurons - metabolism | Acetylation | Cells, Cultured | Acetyl Coenzyme A - metabolism | Acetate-CoA Ligase - deficiency | Memory Consolidation - physiology | Gene Expression Regulation, Enzymologic | Hippocampus - metabolism | Animals | Acetate-CoA Ligase - metabolism | Chromatin - enzymology | Mice | Histones - metabolism | Hippocampus - physiology | Chromatin - genetics | Memory - physiology | Histones | Hippocampus (Brain) | Health aspects | Memory | Cell culture | Chromatin | Ontology | Transcription | Genes | Gene regulation | Genomics | Cognitive ability | Kinases | Plasticity (neural) | Proteins | Memory tasks | Metabolites | Rodents | Coenzyme A | Enzymes | Neurons | Spatial analysis | Metabolism | Mammals | Gene expression | Epigenetics | Nuclei (cytology) | Genetic engineering | Hippocampus | Spatial memory | Plastic foam | Index Medicus
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4. Full Text ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
by Kathryn E. Wellen and Georgia Hatzivassiliou and Uma M. Sachdeva and Thi V. Bui and Justin R. Cross and Craig B. Thompson
Science (American Association for the Advancement of Science), ISSN 0036-8075, 5/2009, Volume 324, Issue 5930, pp. 1076 - 1080
Cellular metabolism | HCT116 cells | Cell lines | Histones | Small interfering RNA | Reports | Gene expression regulation | Acetylation | Adipocytes | Acetates | Cellular differentiation | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Cell metabolism, cell oxidation | Cell Proliferation | Humans | Adipocytes - cytology | Cell Nucleus - enzymology | Intercellular Signaling Peptides and Proteins - metabolism | RNA Interference | Acetate-CoA Ligase - genetics | Transcription, Genetic | Cell Differentiation | ATP Citrate (pro-S)-Lyase - metabolism | Cell Line | Cytoplasm - enzymology | Interleukin-3 - metabolism | Gene Expression Regulation | ATP Citrate (pro-S)-Lyase - genetics | Histone Deacetylases - metabolism | Acetyl Coenzyme A - metabolism | Animals | Acetate-CoA Ligase - metabolism | Adipocytes - metabolism | Cell Line, Tumor | Glucose - metabolism | Glycolysis | Citric Acid - metabolism | Histone Deacetylase Inhibitors | Mice | Histones - metabolism | 3T3 Cells | Cell metabolism | Research | Properties | Adenosine triphosphate | Enzymes | Chromatin | Biochemistry | Glucose | Cellular biology | Metabolism | Index Medicus
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5. Full Text Staphylococcus aureus modulates the activity of acetyl‐Coenzyme A synthetase (Acs) by sirtuin‐dependent reversible lysine acetylation
by Burckhardt, Rachel M and Buckner, Brandi A and Escalante‐Semerena, Jorge C
Molecular microbiology, ISSN 0950-382X, 08/2019, Volume 112, Issue 2, pp. 588 - 604
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Staphylococcus aureus - genetics | Acetate-CoA Ligase - chemistry | Staphylococcus aureus - enzymology | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Amino Acid Motifs | Staphylococcus aureus - chemistry | Lysine - genetics | Acetate-CoA Ligase - genetics | Acetate-CoA Ligase - metabolism | Succinic Acid - metabolism | Bacterial Proteins - metabolism | Lysine - metabolism | Acetylation | Sirtuins - genetics | Sirtuins - metabolism | Staphylococcus aureus - metabolism | Post-translational modification | Thiols | Lysine | Ligases | Physiological aspects | Staphylococcus aureus | Acylation | Propionic acid | Dicarboxylic acids | Metabolism | Organic acids | Proteins | NAD | Domains | Deacetylation | Coenzyme A | Acetyltransferase | Acetic acid | Index Medicus | acetate metabolism | Reversible lysine acetylation | protein acylation | bGNAT | acetyl-CoA synthetase | Sirtuin | AMP-forming acyl:CoA ligases | bacterial GCN5-related acetyltransferases
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6. Full Text Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation
by Bulusu, Vinay and Tumanov, Sergey and Michalopoulou, Evdokia and van den Broek, Niels J and MacKay, Gillian and Nixon, Colin and Dhayade, Sandeep and Schug, Zachary T and Vande Voorde, Johan and Blyth, Karen and Gottlieb, Eyal and Vazquez, Alexei and Kamphorst, Jurre J
Cell reports (Cambridge), ISSN 2211-1247, 01/2017, Volume 18, Issue 3, pp. 647 - 658
acetate | cancer metabolism | hypoxia | acetyl-CoA synthetase 2 | histone deacetylation | lipogenesis | stable isotope tracing | enzyme localization | histone acetylation | metabolite compartmentalization | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Acetates - metabolism | Humans | Metabolome | Acetates - chemistry | Mitochondria - metabolism | Chromatography, High Pressure Liquid | Acetyl Coenzyme A - metabolism | Cell Nucleus - enzymology | Acetate-CoA Ligase - antagonists & inhibitors | Cell Hypoxia | RNA Interference | Acetate-CoA Ligase - genetics | Acetate-CoA Ligase - metabolism | Mass Spectrometry | Cell Line, Tumor | Acetylation | Histones - metabolism | Culture Media - chemistry | Carbon Isotopes - chemistry | Microscopy, Fluorescence | RNA, Small Interfering - metabolism | Serum - chemistry | Index Medicus
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7. Full Text Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress
by Schug, Zachary T and Peck, Barrie and Jones, Dylan T and Zhang, Qifeng and Grosskurth, Shaun and Alam, Israt S and Goodwin, Louise M and Smethurst, Elizabeth and Mason, Susan and Blyth, Karen and McGarry, Lynn and James, Daniel and Shanks, Emma and Kalna, Gabriela and Saunders, Rebecca E and Jiang, Ming and Howell, Michael and Lassailly, Francois and Thin, May Zaw and Spencer-Dene, Bradley and Stamp, Gordon and van den Broek, Niels J.F and Mackay, Gillian and Bulusu, Vinay and Kamphorst, Jurre J and Tardito, Saverio and Strachan, David and Harris, Adrian L and Aboagye, Eric O and Critchlow, Susan E and Wakelam, Michael J.O and Schulze, Almut and Gottlieb, Eyal
Cancer cell, ISSN 1535-6108, 01/2015, Volume 27, Issue 1, pp. 57 - 71
Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplasms - metabolism | Neoplasm Transplantation | Cell Proliferation | Humans | Gene Expression Regulation, Neoplastic | Stress, Physiological | Gene Dosage | Disease Progression | Animals | MCF-7 Cells | Neoplasms - genetics | Acetate-CoA Ligase - genetics | Acetate-CoA Ligase - metabolism | Mice, Nude | Cell Line, Tumor | Hypoxia | Mice | Neoplasms - pathology | Fatty Acids - metabolism | Growth | Ligases | Genomics | Development and progression | Stress (Physiology) | Fatty acids | Acetates | Cancer | Index Medicus
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8. Full Text Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy
by Li, Xinjian and Yu, Willie and Qian, Xu and Xia, Yan and Zheng, Yanhua and Lee, Jong-Ho and Li, Wei and Lyu, Jianxin and Rao, Ganesh and Zhang, Xiaochun and Qian, Chao-Nan and Rozen, Steven G and Jiang, Tao and Lu, Zhimin
Molecular cell, ISSN 1097-2765, 06/2017, Volume 66, Issue 5, pp. 684 - 697.e9
ACSS2 | lysosomal biogenesis | autophagy | TFEB | nucleus | AMPK | acetyl-CoA | tumor development | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | alpha Karyopherins - metabolism | AMP-Activated Protein Kinases - metabolism | Glioblastoma - enzymology | Phosphorylation | Humans | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | Stress, Physiological | Male | Autophagy | Cell Nucleus - enzymology | Organelle Biogenesis | Lysosomes - metabolism | Transfection | Glioblastoma - genetics | RNA Interference | Acetate-CoA Ligase - genetics | Cell Nucleus - pathology | Transcription, Genetic | Acetylation | Active Transport, Cell Nucleus | Binding Sites | Promoter Regions, Genetic | Brain Neoplasms - enzymology | Cell Survival | Brain Neoplasms - genetics | Acetyl Coenzyme A - metabolism | Animals | Energy Metabolism | Acetate-CoA Ligase - metabolism | Mice, Nude | Glioblastoma - pathology | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | alpha Karyopherins - genetics | Cell Line, Tumor | Protein Binding | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Mice, Inbred BALB C | Protein Processing, Post-Translational | Histones - metabolism | Medical colleges | Thiols | Brain tumors | Genes | Genetic transcription | Glucose | Dextrose | Gliomas | Ligases | Stem cells | Medical genetics | Genetic aspects | Protein kinases | Resveratrol | Development and progression | Index Medicus
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9. Full Text Nucleocytosolic Acetyl-Coenzyme A Synthetase Is Required for Histone Acetylation and Global Transcription
by Takahashi, Hidekazu and McCaffery, J. Michael and Irizarry, Rafael A and Boeke, Jef D
Molecular cell, ISSN 1097-2765, 2006, Volume 23, Issue 2, pp. 207 - 217
DNA | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Coenzyme A Ligases - genetics | Signal Transduction | Mitochondria - metabolism | Cell Nucleus - enzymology | Cytosol - chemistry | Cytosol - enzymology | Transcription, Genetic - physiology | Acetate-CoA Ligase - genetics | Coenzyme A Ligases - physiology | Histone Acetyltransferases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Cell Nucleus - chemistry | Acetate-CoA Ligase - physiology | Acetylation | Histones - metabolism | Mutation | Glycerin | Chromatin | Lysine | Ligases | Physiological aspects | Glycerol | Gene expression | Acetates | Index Medicus
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