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Journal of the National Cancer Institute, ISSN 0027-8874, 11/2011, Volume 103, Issue 22, pp. 1665 - 1675
Recent advances in tumor biology have made remarkable achievements in the development of therapy for metastatic castrate-resistant prostate cancer. These... 
GROWTH-FACTOR RECEPTOR | CONTROLLED-TRIAL | ANTIANGIOGENIC THERAPY | ONCOLOGY | RANDOMIZED PHASE-II | BONE METASTASES | C-MET | SIPULEUCEL-T APC8015 | ABIRATERONE ACETATE | TUMOR MICROENVIRONMENT | ANGIOGENESIS INHIBITION | Cancer Vaccines - pharmacology | Humans | Male | Antineoplastic Agents - therapeutic use | Bevacizumab | Prostatic Neoplasms - immunology | RANK Ligand - pharmacology | Receptors, Androgen - drug effects | Treatment Failure | Prostatic Neoplasms - drug therapy | Phenylthiohydantoin - pharmacology | Tumor Microenvironment - drug effects | Dasatinib | Antibodies, Monoclonal - pharmacology | Angiogenesis Inhibitors - pharmacology | Clusterin - pharmacology | Pyrimidines - pharmacology | Denosumab | Prostate-Specific Antigen - blood | Orchiectomy | Signal Transduction - drug effects | Anilides - pharmacology | Mice | Receptor Cross-Talk - drug effects | Endothelin-1 - antagonists & inhibitors | Immunotherapy - methods | Taxoids - pharmacology | Ipilimumab | Tissue Extracts - pharmacology | Bone Remodeling - drug effects | Pyrrolidines - pharmacology | Antibodies, Monoclonal, Humanized - pharmacology | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Molecular Targeted Therapy - methods | Prostatic Neoplasms - pathology | Antineoplastic Agents, Hormonal - pharmacology | Androstenols - pharmacology | Androstenes | Clinical Trials as Topic | Mice, SCID | Phenylthiohydantoin - analogs & derivatives | Biomarkers, Tumor - blood | Xenograft Model Antitumor Assays | Cancer Vaccines - immunology | Pyrroles - pharmacology | Animals | RANK Ligand - antagonists & inhibitors | Pyridines - pharmacology | Thiazoles - pharmacology | Immune response | Development and progression | Cellular signal transduction | Research | Drug therapy | Health aspects | Prostate cancer | Risk factors | Review
Journal Article
Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 4, pp. 425 - 429
Journal Article
Pain, ISSN 0304-3959, 2005, Volume 117, Issue 1, pp. 171 - 181
Protein kinase C (PKC) is able to phosphorylate several cellular components that serve as key regulatory components in signal transduction pathways of... 
Nociception | Protein kinase C | Substance P | Phorbol ester | MAP kinase | Mice | Glutamate | phorbol ester | PRIMARY AFFERENT NEURONS | INFLAMMATORY HYPERALGESIA | nociception | VANILLOID RECEPTOR | NECROSIS-FACTOR-ALPHA | RAT SENSORY NEURONS | mice | NEUROSCIENCES | CLINICAL NEUROLOGY | NERVE GROWTH-FACTOR | IN-VITRO | SCIATIC-NERVE | ANESTHESIOLOGY | substance P | UP-REGULATION | protein kinase C | glutamate | Bradykinin - analogs & derivatives | Analgesics - pharmacology | Tetradecanoylphorbol Acetate - pharmacology | Capsaicin - pharmacology | Nociceptors - physiology | Tetradecanoylphorbol Acetate - analogs & derivatives | Male | Peptide Fragments - pharmacology | Extracellular Signal-Regulated MAP Kinases - metabolism | Pain - chemically induced | Dose-Response Relationship, Drug | Salicylates - pharmacology | Adrenergic beta-Antagonists - pharmacology | Propranolol - pharmacology | Drug Interactions | Pain - enzymology | Time Factors | Pain - drug therapy | Protein Kinase C - metabolism | Sympatholytics - pharmacology | Behavior, Animal - drug effects | Indoles - pharmacology | Bradykinin - pharmacology | Blotting, Western - methods | Protein Kinase C - physiology | Calcitonin Gene-Related Peptide - pharmacology | Dipeptides - pharmacology | Enzyme Inhibitors - pharmacology | Capsaicin - analogs & derivatives | Chelating Agents - pharmacology | Enzyme Activation - drug effects | Antibodies - pharmacology | Pain Measurement - methods | Animals | Egtazic Acid - pharmacology | Ruthenium Red - pharmacology | Dizocilpine Maleate - pharmacology | Excitatory Amino Acid Antagonists | Guanethidine - pharmacology | Nociceptors - drug effects | Methyl aspartate | Nerve growth factor | Cell research | Protein kinases
Journal Article
Circulation Research, ISSN 0009-7330, 10/2004, Volume 95, Issue 7, pp. 726 - 733
Altered gap junction coupling of cardiac myocytes during ischemia may contribute to development of lethal arrhythmias. The phosphoprotein connexin 43 (Cx43) is... 
Ischemia | Gap junctions | Glycolysis | Okadaic acid | Protein phosphatases | Connexin43 | Protein phosphorylation | AMP kinase | gap junctions | PROTEIN-KINASE-C | CARDIAC & CARDIOVASCULAR SYSTEMS | connexin43 | PHOSPHORYLATION | GAP JUNCTIONAL COMMUNICATION | glycolysis | CARDIAC MYOCYTES | ACTIN GENE | protein phosphorylation | okadaic acid | ischemia | IN-VITRO | INTERCELLULAR COMMUNICATION | PERIPHERAL VASCULAR DISEASE | JUN KINASE | protein phosphatases | RAT VENTRICULAR MYOCYTES | HEMATOLOGY | ADRENERGIC REGULATION | Okadaic Acid - pharmacology | Tetradecanoylphorbol Acetate - pharmacology | Maleimides - pharmacology | Recombinant Fusion Proteins - physiology | Myocardial Contraction - drug effects | Brefeldin A - pharmacology | Phenanthridines - pharmacology | Antimycin A - pharmacology | Aminoimidazole Carboxamide - pharmacology | Cell Hypoxia | Ribonucleotides - pharmacology | Alkaloids | Protein Processing, Post-Translational - drug effects | Adenosine Triphosphate - metabolism | Deoxyglucose - pharmacology | Tacrolimus - pharmacology | Indoles - pharmacology | Flavonoids - pharmacology | Potassium Cyanide - pharmacology | JNK Mitogen-Activated Protein Kinases - genetics | Phosphorylation - drug effects | Ouabain - pharmacology | Cells, Cultured - drug effects | Connexin 43 - metabolism | Rats | Imidazoles - pharmacology | Cycloheximide - pharmacology | Pyrroles - pharmacology | Animals | Myocytes, Cardiac - drug effects | Aminoimidazole Carboxamide - analogs & derivatives | Benzophenanthridines | JNK Mitogen-Activated Protein Kinases - physiology | Myocytes, Cardiac - metabolism | Cells, Cultured - metabolism | Pyridines - pharmacology | Carbazoles - pharmacology | Staurosporine - pharmacology
Journal Article
The Journal of Physiology, ISSN 0022-3751, 07/2010, Volume 588, Issue 14, pp. 2605 - 2619
In vertebrate retina, melatonin regulates various physiological functions. In this work we investigated the mechanisms underlying melatonin‐induced... 
CIRCADIAN CLOCK | XENOPUS-LAEVIS | BIPOLAR CELLS | PROTEIN-KINASE-C | PHYSIOLOGY | FISH RETINA | PHOSPHOLIPASE-C | VISUAL PATHWAY | FUNCTIONAL-ROLE | MT2 MELATONIN | RECEPTORS | NEUROSCIENCES | Cyclic GMP - pharmacology | Receptor, Melatonin, MT2 - antagonists & inhibitors | Tetradecanoylphorbol Acetate - pharmacology | Maleimides - pharmacology | Male | Calcium - analysis | Melatonin - physiology | Type C Phospholipases - antagonists & inhibitors | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic GMP-Dependent Protein Kinases - physiology | Isoquinolines - pharmacology | Cyclic GMP - analogs & derivatives | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Bridged-Ring Compounds - pharmacology | Egtazic Acid - analogs & derivatives | Indoles - pharmacology | Guanosine Diphosphate - pharmacology | Pertussis Toxin - pharmacology | Retinal Ganglion Cells - physiology | Protein Kinase C - physiology | Retinal Ganglion Cells - enzymology | 8-Bromo Cyclic Adenosine Monophosphate - pharmacology | Rats | Protein Kinase C - antagonists & inhibitors | Receptor, Melatonin, MT2 - physiology | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Animals | Egtazic Acid - pharmacology | Glycine - physiology | Guanosine Diphosphate - analogs & derivatives | Signal Transduction - drug effects | Tetrahydronaphthalenes - pharmacology | Thiones - pharmacology | Carbazoles - pharmacology | Type C Phospholipases - physiology | Melatonin | Phospholipids | Glycine | Ganglion | Gross domestic product | Protein kinases | Kinases | Retina | Physiology | Neuroscience
Journal Article
International Journal of Oncology, ISSN 1019-6439, 12/2013, Volume 43, Issue 6, pp. 1787 - 1798
The highly aggressive adult sarcomas are characterized by high levels of matrix metalloproteinase (MMP)-2 and -9, which play crucial roles in tumor invasion... 
synovial sarcoma | inhibitors | inducers | chondrosarcoma | cytokines | matrix metalloproteinases | liposarcoma | fibrosarcoma | Chondrosarcoma | Inhibitors | Matrix metalloproteinases | Cytokines | Synovial sarcoma | Liposarcoma | Fibrosarcoma | Inducers | CANCER-CELLS | VITAMIN-C | TUMOR INVASION | ASCORBIC-ACID | GREEN TEA | ONCOLOGY | NUTRIENT MIXTURE | SERUM-LEVELS | SOFT-TISSUE SARCOMA | ENDOTHELIAL GROWTH-FACTOR | Interleukin-1beta - pharmacology | Tetradecanoylphorbol Acetate - pharmacology | Humans | Fibrosarcoma - metabolism | Liposarcoma - metabolism | Matrix Metalloproteinase 9 - metabolism | Carcinogens - pharmacology | Dexamethasone - pharmacology | Antineoplastic Agents - pharmacology | Catechin - pharmacology | Matrix Metalloproteinase 2 - biosynthesis | Tretinoin - pharmacology | Matrix Metalloproteinase 9 - biosynthesis | Anti-Inflammatory Agents - pharmacology | Matrix Metalloproteinase 2 - metabolism | Sarcoma, Synovial - metabolism | Antioxidants - pharmacology | Sarcoma - metabolism | Matrix Metalloproteinase Inhibitors - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Chondrosarcoma - metabolism | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Doxycycline - pharmacology | Anti-Bacterial Agents - pharmacology | Catechin - analogs & derivatives | Dactinomycin - pharmacology | Studies | Tea | Cell growth | Medical prognosis | Collagen | Penicillin | Tumor necrosis factor-TNF | Physiology | Metastasis | Growth factors | Cancer
Journal Article
Journal Article
Oncology Reports, ISSN 1021-335X, 03/2017, Volume 37, Issue 3, pp. 1907 - 1913
Brain tumors are highly aggressive, characterized by the secretion of high levels of matrix metalloproteinase (MMP)-2 and MMP-9 that degrade the extracellular... 
Inhibitors | Matrix metalloproteinases | Cytokines | Glioblastoma T-98G | Inducers | VITAMIN-C | GLIOMA-CELLS | inhibitors | CANCER-RELATED INFLAMMATION | glioblastoma T-98G | N-ACETYLCYSTEINE | LINES | GREEN TEA | BRAIN-TUMOR | IN-VITRO | ONCOLOGY | inducers | GROWTH | cytokines | matrix metalloproteinases | TUMOR MICROENVIRONMENT | Enzyme Activators - pharmacology | Gene Expression Regulation, Enzymologic - drug effects | Glioblastoma - enzymology | Interleukin-1beta - pharmacology | Tetradecanoylphorbol Acetate - pharmacology | Humans | Carcinogens - pharmacology | Cattle | Matrix Metalloproteinase 9 - secretion | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Catechin - pharmacology | Tretinoin - pharmacology | Antioxidants - pharmacology | Matrix Metalloproteinase Inhibitors - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Animals | Glioblastoma - pathology | Lipopolysaccharides - pharmacology | Doxycycline - pharmacology | Matrix Metalloproteinase 2 - secretion | Anti-Bacterial Agents - pharmacology | Catechin - analogs & derivatives | Glioblastoma - drug therapy | Cytokines - pharmacology | Enzymes | Care and treatment | Proteases | Development and progression | Genetic aspects | Regulation | Health aspects | Glioblastoma multiforme | Angiogenesis | Acids | Collagen | Brain cancer | Penicillin | Tumor necrosis factor-TNF | Nervous system | Metastasis | Cancer therapies | Tumors | Apoptosis | Index Medicus
Journal Article
Cardiovascular Research, ISSN 0008-6363, 05/2010, Volume 86, Issue 2, pp. 311 - 320
Journal Article
Journal Article