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Nature Medicine, ISSN 1078-8956, 10/2016, Volume 22, Issue 10, pp. 1108 - 1119
Continuous de novo fatty acid synthesis is a common feature of cancer that is required to meet the biosynthetic demands of a growing tumor. This process is... 
PROSTATE | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | HOMEOSTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA | PHOSPHORYLATION SITES | CELL BIOLOGY | SYNTHASE | METABOLISM | LIPOGENESIS | AMPK | HEPATIC STEATOSIS | Lung Neoplasms - drug therapy | Proto-Oncogene Proteins p21(ras) - genetics | Allosteric Regulation | Humans | Lung Neoplasms - metabolism | Molecular Targeted Therapy | Tumor Suppressor Protein p53 - genetics | Acetyltransferases - antagonists & inhibitors | Lipid Metabolism - genetics | Pyrimidinones - pharmacology | Acetyl-CoA Carboxylase - antagonists & inhibitors | Lung Neoplasms - genetics | Cell Proliferation - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Thiophenes - pharmacology | Mice, Knockout | Xenograft Model Antitumor Assays | Animals | Lipid Metabolism - drug effects | Cell Proliferation - drug effects | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Fatty Acids - biosynthesis | Synthesis | Growth | Cancer cells | Genetic aspects | Models | Research | Lung cancer, Non-small cell | Fatty acids | Carboxylases | Enzymes | Genetically modified organisms | Genetic engineering | Tumor proteins | Tumors | Animal models | p53 Protein | Xenotransplantation | Lung cancer | Non-small cell lung carcinoma | Pharmacology | LKB1 protein | Allosteric properties | Liability | Acetyl-CoA carboxylase | Lungs | Xenografts | Carboplatin | Inhibition | Dimerization | Viability | Cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2016, Volume 113, Issue 13, pp. E1796 - E1805
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2007, Volume 104, Issue 44, pp. 17358 - 17363
Journal Article
Journal Article
Hepatology, ISSN 0270-9139, 12/2018, Volume 68, Issue 6, pp. 2197 - 2211
Journal Article
Cell Metabolism, ISSN 1550-4131, 08/2017, Volume 26, Issue 2, pp. 394 - 406.e6
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, p. e0169566
Tumor cell proliferation and migration processes are regulated by multiple metabolic pathways including glycolysis and de novo lipogenesis. Since acetyl-CoA... 
APOPTOSIS | ACTIVATION | LIPID-METABOLISM | ENZYMES | MULTIDISCIPLINARY SCIENCES | FATTY-ACID | GROWTH | LIVER | C-MYC | ACID SYNTHESIS PATHWAY | ALPHA | Cell Proliferation - genetics | Glioblastoma - enzymology | Apoptosis - drug effects | Humans | Enzyme Inhibitors - pharmacology | Apoptosis - genetics | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Acetyl-CoA Carboxylase - genetics | Glioblastoma - genetics | Lipogenesis - genetics | Oxygen Consumption - drug effects | Oxygen Consumption - genetics | Glioblastoma - pathology | Lipogenesis - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Glioblastoma - drug therapy | Neoplasm Proteins - genetics | Acetyl-CoA Carboxylase - antagonists & inhibitors | Acetyl-CoA Carboxylase - metabolism | Receptor, Epidermal Growth Factor | Care and treatment | Development and progression | Genetic aspects | Gene expression | Glioblastoma multiforme | Health aspects | Carboxylases | Cell proliferation | Metabolic rate | Biotechnology | Brain cancer | Glioblastoma | Acidification | Lipids | Cancer therapies | Mitochondria | Cell growth | Pathways | Bioenergetics | Acetyl-CoA carboxylase | Penicillin | Inhibition | Lipid metabolism | Lipogenesis | Growth factors | Cellular manufacture | Enzymes | Caspase | siRNA | Tumor cell lines | Metabolism | Fatty acids | Inhibitors | Medical prognosis | Cell lines | Glycolysis | Metabolic pathways | Glioblastoma cells | Mutation | Electron transport | Respiration | Viability | Cell migration | Apoptosis | Cancer
Journal Article