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Journal of medicinal chemistry, ISSN 0022-2623, 08/2014, Volume 57, Issue 15, pp. 6289 - 6300
Structures of integral membrane receptors provide valuable models for drug receptor interactions across many important classes of drug targets and have become much more widely available in recent years... 
AGONIST BINDING-SITE | CATION-PI INTERACTIONS | CHEMISTRY, MEDICINAL | ACID | IONIC HYDROGEN-BONDS | LIGAND RECOGNITION | X-RAY-STRUCTURE | SMOKING-CESSATION DRUGS | NICOTINIC ACETYLCHOLINE-RECEPTORS | RESIDUES | SUBUNIT | Receptors, Serotonin, 5-HT3 - chemistry | Humans | Serotonin 5-HT3 Receptor Agonists - chemistry | Serotonin 5-HT3 Receptor Agonists - pharmacology | Amino Acids - genetics | Nicotinic Agonists - chemistry | Protein Subunits - metabolism | Receptors, Glycine - agonists | Receptors, Nicotinic - chemistry | Receptors, Cell Surface - chemistry | Receptors, Glycine - chemistry | Receptors, Glycine - metabolism | Binding Sites | Nicotinic Agonists - pharmacology | Protein Subunits - genetics | Receptors, Nicotinic - metabolism | GABA Agonists - chemistry | Receptors, Serotonin, 5-HT3 - genetics | Receptors, GABA - genetics | Receptors, Cell Surface - metabolism | Pharmaceutical Preparations - metabolism | Animals | Receptors, GABA - chemistry | Receptors, Serotonin, 5-HT3 - metabolism | GABA Agonists - pharmacology | Pharmaceutical Preparations - chemistry | Receptors, GABA - metabolism | Ligands | Protein Conformation | Protein Subunits - chemistry | Mutation | Ion Channel Gating | Receptors, Glycine - genetics | Receptors, Nicotinic - genetics | Receptors, Cell Surface - genetics | Index Medicus
Journal Article
Book
Neuroscience, ISSN 0306-4522, 2010, Volume 169, Issue 4, pp. 1610 - 1620
... [Lucas-Meunier E, Monier C, Amar M, Baux G, Frégnac Y, Fossier P (2009) Cereb Cortex 19:2411–2427]. Our aim is now to establish a functional basis for the role of the different types of muscarinic receptors... 
Neurology | pyramidal neuron | acetylcholine | M1- M2- M3- M4- M5-muscarinic receptors | cortical network | Acetylcholine | Cortical network | Pyramidal neuron | GABAERGIC TRANSMISSION | SYNAPTIC-TRANSMISSION | NEUROSCIENCES | ACETYLCHOLINE-RECEPTOR | CEREBRAL-CORTEX | IN-VITRO | CORTICAL-NEURONS | M1-M2-M3-M4-M5-muscarinic receptors | AUDITORY-CORTEX | CHOLINERGIC MODULATION | POSTNATAL-DEVELOPMENT | HIPPOCAMPAL PYRAMIDAL CELLS | Pyramidal Cells - metabolism | Rats, Wistar | Receptor, Muscarinic M4 - physiology | Receptor, Muscarinic M1 - antagonists & inhibitors | Receptor, Muscarinic M3 - physiology | Receptors, Muscarinic - metabolism | Receptor, Muscarinic M1 - physiology | Excitatory Postsynaptic Potentials - drug effects | Receptor, Muscarinic M2 - physiology | Visual Cortex - physiology | Excitatory Postsynaptic Potentials - physiology | Neural Inhibition - physiology | Muscarinic Antagonists - pharmacology | Pyramidal Cells - physiology | Receptor, Muscarinic M2 - antagonists & inhibitors | Glutamic Acid - secretion | Pyramidal Cells - drug effects | Organ Culture Techniques | Inhibitory Postsynaptic Potentials - physiology | Rats | Receptor, Muscarinic M3 - antagonists & inhibitors | Animals | Glutamic Acid - metabolism | Visual Cortex - drug effects | Neural Inhibition - drug effects | Receptor, Muscarinic M4 - antagonists & inhibitors | Inhibitory Postsynaptic Potentials - drug effects | Receptors, Muscarinic - physiology | Methyl aspartate | Cell research | Neurosciences | Neurons | GABA | Glutamate | Benzodiazepines | Acetylcholine receptors (muscarinic) | Neural Inhibition | Neurons and Cognition | Visual Cortex | Muscarinic Antagonists | Receptor, Muscarinic M1 | Receptor, Muscarinic M2 | Receptor, Muscarinic M3 | Receptor, Muscarinic M4 | Glutamic Acid | Life Sciences | Receptors, Muscarinic | Excitatory Postsynaptic Potentials | Pyramidal Cells | Inhibitory Postsynaptic Potentials
Journal Article
2002, Molecular and cellular neurobiology series., ISBN 9780192632241, xii, 222
... up the most important ion channels and receptor families, fundamental to synaptic function. Improved understanding of these processes is expected to reveal novel therapeutic targets relevant to a range of disease states... 
Proteins | Ion channels | Physiological transport | Neurons | Neurotransmitter receptors | Molecular and Cellular Systems | Molecular neurobiology | Cation channels | Multimeric proteins | Acetylcholine receptors | Synaptic function | Disease states | Receptor families | Amino acid receptors | Protein complexes
Book
Journal of psychopharmacology (Oxford), ISSN 1461-7285, 2008, Volume 23, Issue 1, pp. 65 - 73
.... We determined and compared the human receptor binding affinities and functional characteristics of asenapine and several antipsychotic drugs... 
Schizophrenia | Affinity | Bipolar disorder | Asenapine | Human receptor | NEGATIVE SYMPTOMS | PSYCHIATRY | FOCUS | SEROTONIN RECEPTORS | DISORDERS | RISPERIDONE | schizophrenia | COGNITION | NEUROSCIENCES | CLINICAL NEUROLOGY | bipolar disorder | DOPAMINE D-3 RECEPTOR | PSYCHOSIS | ATYPICAL ANTIPSYCHOTIC-DRUG | PHARMACOLOGY & PHARMACY | asenapine | human receptor | affinity | Humans | Receptors, Serotonin - drug effects | Substrate Specificity | Receptors, Serotonin - genetics | Heterocyclic Compounds, 4 or More Rings - pharmacology | Psychotropic Drugs - therapeutic use | Receptors, Dopamine - drug effects | Clozapine - pharmacology | Histamine Release - genetics | Receptors, Muscarinic - drug effects | Heterocyclic Compounds, 4 or More Rings - therapeutic use | Receptors, Adrenergic - drug effects | Psychotropic Drugs - pharmacology | Cloning, Molecular | Receptors, Adrenergic - genetics | Receptors, Dopamine D2 - drug effects | Inhibitory Concentration 50 | Molecular Structure | Radioligand Assay | Histamine Release - drug effects | Receptors, Muscarinic - genetics | Benzodiazepines - pharmacology | Heterocyclic Compounds, 4 or More Rings - chemistry | Clinical Trials as Topic | Psychotropic Drugs - chemistry | Bipolar Disorder - drug therapy | Receptors, Dopamine D2 - physiology | Schizophrenia - drug therapy | Receptors, Dopamine - genetics | Histamine receptors | Drugs | Neuroleptics | Olanzapine | Acetylcholine receptors (muscarinic) | Mental disorders | Dopamine D4 receptors | Serotonin S1 receptors | Serotonin S7 receptors | Psychotropic drugs | Receptors | Histamine H2 receptors | Risperidone | Dopamine D2 receptors | Binding | Dopamine | Serotonin | Dopamine D3 receptors | Serotonin S6 receptors | Serotonin S2 receptors | Histamine | Dopamine D1 receptors | Serotonin receptors | Receptors (physiology) | Index Medicus
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 4/2009, Volume 379, Issue 4, pp. 389 - 395
Journal Article
The Journal of neuroscience, ISSN 1529-2401, 2007, Volume 27, Issue 14, pp. 3663 - 3676
Journal Article
PloS one, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e46039
...(2) adrenergic receptor (beta(2)AR), a G-protein coupled receptor (GPCR) for catecholamines. We demonstrate that the N-terminal fused T4L is sufficiently rigid... 
COMPLEX | ANTAGONIST | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | GPCR | BETA-ADRENERGIC RECEPTOR | MUSCARINIC ACETYLCHOLINE-RECEPTOR | Protein Engineering - methods | Receptors, G-Protein-Coupled - metabolism | Humans | Molecular Sequence Data | Crystallography, X-Ray | Tritium | Recombinant Fusion Proteins - metabolism | Viral Proteins - metabolism | Receptors, Adrenergic, beta-2 - chemistry | Sf9 Cells | Bacteriophage T4 - enzymology | Binding Sites | Binding, Competitive | Protein Structure, Tertiary | Amino Acid Sequence | Protein Structure, Secondary | Muramidase - chemistry | Receptors, Adrenergic, beta-2 - genetics | Viral Proteins - chemistry | Muramidase - genetics | Crystallization | Models, Molecular | Viral Proteins - genetics | Muramidase - metabolism | Recombinant Fusion Proteins - chemistry | Receptors, Adrenergic, beta-2 - metabolism | Animals | Dihydroalprenolol - metabolism | Protein Binding | Recombinant Fusion Proteins - genetics | Dihydroalprenolol - chemistry | Protein Conformation | Receptors, G-Protein-Coupled - genetics | Mutation | Receptors, G-Protein-Coupled - chemistry | Proteins | Lysozyme | G proteins | Protein engineering | G protein-coupled receptors | Crystal lattices | Science | Catecholamines | Crystallography | Medicine | Signaling | N-Terminus | Chemical bonds | Adrenergic receptors | Physiology | Crystal structure
Journal Article
Pflügers Archiv - European Journal of Physiology, ISSN 0031-6768, 4/2003, Volume 446, Issue 1, pp. 17 - 29
Acetylcholine (ACh) is an important neurotransmitter of the CNS that binds both nicotinic and muscarinic receptors to exert its action... 
Acetylcholine Cortical network Excitation Inhibition Nicotinic and muscarinic receptors | Acetylcholine | Cortical network | Excitation | Inhibition | Nicotinic and muscarinic receptors | PHYSIOLOGY | RAT CEREBRAL-CORTEX | inhibition | M2 MUSCARINIC RECEPTOR | NICOTINIC ACETYLCHOLINE-RECEPTORS | nicotinic and muscarinic receptors | NUCLEUS BASALIS-MAGNOCELLULARIS | PHASEOLUS-VULGARIS LEUCOAGGLUTININ | SUBUNIT MESSENGER-RNAS | excitation | VASOACTIVE INTESTINAL POLYPEPTIDE | cortical network | CENTRAL-NERVOUS-SYSTEM | acetylcholine | GAMMA-AMINOBUTYRIC-ACID | PROGRESSIVE SUPRANUCLEAR PALSY | Cholinergic Fibers - physiology | Receptors, Nicotinic - metabolism | Synaptic Transmission - physiology | Calcium - metabolism | Cholinergic Agents - pharmacology | Humans | Receptors, Muscarinic - metabolism | Acetylcholine - metabolism | Receptors, Muscarinic - chemistry | Animals | Ion Channels - metabolism | Receptors, Nicotinic - chemistry | Receptors, Nicotinic - physiology | Receptors, GABA - metabolism | Cognition - physiology | Cerebral Cortex - physiology | Cerebral Cortex - drug effects | Acetylcholine - physiology | Receptors, Muscarinic - physiology | Receptors, Nicotinic | Calcium | Ion Channels | Neurons and Cognition | Cerebral Cortex | Cognition | Synaptic Transmission | Cholinergic Fibers | Life Sciences | Receptors, Muscarinic | Cholinergic Agents | Receptors, GABA
Journal Article
Cellular signalling, ISSN 0898-6568, 2017, Volume 35, pp. 188 - 196
Journal Article