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Medicinal Research Reviews, ISSN 0198-6325, 01/2013, Volume 33, Issue 1, pp. 139 - 189
With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes an overwhelming health, social, economic, and political problem to... 
antioxidant drugs | CDK5 inhibitors | anti‐inflammatory drugs | AChE peripheral anionic site | CK‐1 inhibitors | ERK2‐inhibitors | Ca2+ dyshomeostasis | BACE‐1 inhibitors | amyloid–β antiaggregating agents | NSAIDs | neuroprotection | multitarget drugs | GSK‐3β inhibitors | dual AChE inhibitors | metal chelators | Alzheimer's disease | Ca2+ overload | oxidative stress | multiactive compounds | 1,4‐dihydropyridines | voltage‐dependent calcium channels | Neuroprotection | Oxidative stress | Dual AChE inhibitors | Anti-inflammatory drugs | GSK-3β inhibitors | Antioxidant drugs | overload | Metal chelators | Multitarget drugs | Voltage-dependent calcium channels | CK-1 inhibitors | BACE-1 inhibitors | dyshomeostasis | 1,4-dihydropyridines | ERK2-inhibitors | Multiactive compounds | Amyloid-β antiaggregating agents | Ca | GSK-3 ss inhibitors | anti-inflammatory drugs | voltage-dependent calcium channels | TYROSINE KINASE INHIBITOR | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | POTENT ACETYLCHOLINESTERASE INHIBITORS | amyloid-ss antiaggregating agents | M1 MUSCARINIC AGONISTS | CHEMISTRY, MEDICINAL | AMYLOID PRECURSOR PROTEIN | MOLECULAR MODELING INVESTIGATIONS | HERPES-SIMPLEX-VIRUS | TACRINE-DIHYDROPYRIDINE HYBRIDS | PERIPHERAL ANIONIC SITE | NMDA RECEPTOR ANTAGONIST | Calcium Channels - metabolism | Humans | Enzyme Inhibitors - pharmacology | Alzheimer Disease - drug therapy | tau Proteins - metabolism | Receptors, N-Methyl-D-Aspartate | Alzheimer Disease - enzymology | Enzyme Inhibitors - therapeutic use | Disease Progression | Alzheimer Disease - pathology | Amyloid Precursor Protein Secretases - metabolism | Butyrylcholinesterase - metabolism | Amyloid beta-Peptides - metabolism | Ligands | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Binding Sites | Acetylcholinesterase - metabolism | Care and treatment | Calcium channels | Glycogen | Development and progression | Glutamate | Target marketing | Antioxidants | Methyl aspartate | Enzyme inhibitors | Synthesis | Surface active agents | Drug therapy | Cancer
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2019, Volume 177, pp. 221 - 234
Alzheimer's disease (AD) is a multifactorial neurological disorder involving complex pathogenesis. Single target directed drugs proved ineffective and since... 
Acetylcholinesterase inhibitors | Diphenylpyrimidine | MAO inhibitors | Alzheimer's disease | Dual inhibitors | Neurological disorders | Acetylchollnesterase inhibitors | DESIGN | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | CHOLINESTERASE-INHIBITORS | NEUROPROTECTION | MULTITARGET-DIRECTED LIGANDS | DONEPEZIL | BIOLOGICAL EVALUATION | POTENTIAL TREATMENT | MULTIPOTENT MAO | HYBRIDS | Alkynes - chemical synthesis | Cholinesterase Inhibitors - toxicity | Pyrimidines - chemical synthesis | Humans | Cholinesterase Inhibitors - chemistry | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Monoamine Oxidase Inhibitors - chemical synthesis | Pyrimidines - chemistry | Monoamine Oxidase - chemistry | Pyrimidines - toxicity | Drug Design | Alkynes - pharmacology | Molecular Structure | Monoamine Oxidase Inhibitors - pharmacology | Catalytic Domain | Alzheimer Disease - drug therapy | Alkynes - chemistry | Acetylcholinesterase - chemistry | Pyrimidines - pharmacology | Molecular Dynamics Simulation | Monoamine Oxidase Inhibitors - toxicity | Cholinesterase Inhibitors - pharmacology | Alkynes - toxicity | Cell Line, Tumor | Molecular Docking Simulation | Monoamine Oxidase Inhibitors - chemistry | Kinetics | Oxidases | Molecular dynamics | Development and progression | Nervous system diseases | Enzyme inhibitors
Journal Article
Current Alzheimer Research, ISSN 1567-2050, 04/2009, Volume 6, Issue 2, pp. 86 - 96
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 01/2015, Volume 22, Issue 3, pp. 373 - 404
Journal Article
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 07/2015, Volume 58, Issue 14, pp. 5561 - 5578
Journal Article
1970, 1st ed., International encyclopedia of pharmacology and therapeutics, ISBN 008006633X, Volume section 13., v.
Book
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 02/2017, Volume 25, Issue 3, pp. 1030 - 1041
A series of 4′-aminochalcone-revastigmine hybrids were designed, synthesized and evaluated as multifunctional agents for the treatment of Alzheimer’s disease.... 
Acetylcholinesterase inhibitors | Monoamine oxidase B inhibitors | Aβ aggregation inhibitors | Multifunctional agents | Chalcone carbamate derivatives | Alzheimer’s disease | Alzheimer's disease | CHEMISTRY, MEDICINAL | ANALOGS | TACRINE-COUMARIN HYBRIDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARBAMATE DERIVATIVES | CHEMISTRY, ORGANIC | B INHIBITION | CHOLINESTERASE-INHIBITORS | CHALCONE DERIVATIVES | ANTIOXIDANT | MONOAMINE-OXIDASE INHIBITORS | A beta aggregation inhibitors | PHARMACOLOGICAL EVALUATION | Chalcones - chemistry | Monoamine Oxidase Inhibitors - pharmacology | Humans | Cholinesterase Inhibitors - chemistry | Alzheimer Disease - drug therapy | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Monoamine Oxidase Inhibitors - chemical synthesis | Blood-Brain Barrier - drug effects | Blood-Brain Barrier - metabolism | Dose-Response Relationship, Drug | Animals | Rivastigmine - pharmacology | Cholinesterase Inhibitors - pharmacology | Swine | Chalcones - pharmacology | Drug Design | Molecular Docking Simulation | Molecular Structure | Monoamine Oxidase Inhibitors - chemistry | Rivastigmine - chemistry | Acetylcholinesterase - metabolism | Monoamine Oxidase - metabolism | Drug therapy | Analysis | Drugs | Drug delivery systems | Monoamine oxidase | Enzyme inhibitors | Surface active agents | Carbamates | Vehicles
Journal Article
Journal Article