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Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2016, Volume 59, Issue 4, pp. 1271 - 1298
Bromodomains, small protein modules that recognize acetylated lysine on histones, play a significant role in the epigenome, where they function as "readers"... 
CHEMISTRY, MEDICINAL | SWI/SNF COMPLEXES | SMALL-MOLECULE INHIBITORS | PROSTATE-CANCER | SELECTIVE INHIBITORS | GENE-EXPRESSION | CHEMICAL PROBE | TUMOR-SUPPRESSOR | BET INHIBITORS | HISTONE ACETYLTRANSFERASE | PHD FINGER | Small Molecule Libraries - pharmacology | Antigens, Nuclear - metabolism | Humans | Drug Discovery - methods | CREB-Binding Protein - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - antagonists & inhibitors | DNA-Binding Proteins - metabolism | CREB-Binding Protein - metabolism | Protein Processing, Post-Translational - drug effects | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lysine - metabolism | Protein-Serine-Threonine Kinases - metabolism | RNA-Binding Proteins - antagonists & inhibitors | Nerve Tissue Proteins - antagonists & inhibitors | ATPases Associated with Diverse Cellular Activities | DNA-Binding Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Carrier Proteins - antagonists & inhibitors | Adenosine Triphosphatases - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Adenosine Triphosphatases - antagonists & inhibitors | DNA Helicases - metabolism | Small Molecule Libraries - chemistry | Acetylation - drug effects | Animals | Carrier Proteins - metabolism | Nuclear Proteins - antagonists & inhibitors | DNA Helicases - antagonists & inhibitors | Histones - metabolism | Adaptor Proteins, Signal Transducing - metabolism | RNA-Binding Proteins - metabolism
Journal Article
Leukemia, ISSN 0887-6924, 04/2014, Volume 28, Issue 11, pp. 2155 - 2164
Journal Article
Journal of Immunology, ISSN 0022-1767, 02/1999, Volume 162, Issue 4, pp. 2095 - 2102
Leflunomide is a novel immunosuppressive and antiinflammatory agent currently being tested for treatment of autoimmune diseases and transplant rejection.... 
AGENT LEFLUNOMIDE | KINASE COMPLEX | TUMOR-NECROSIS-FACTOR | TYROSINE PHOSPHORYLATION | RAT | DIHYDROOROTATE DEHYDROGENASE | BINDING-PROTEIN | IMMUNOLOGY | SIGNAL TRANSDUCTION | T-CELLS | FACTOR-ALPHA | Okadaic Acid - pharmacology | Humans | NF-kappa B - metabolism | Lipopolysaccharides - antagonists & inhibitors | Tetradecanoylphorbol Acetate - antagonists & inhibitors | Cell Nucleus - metabolism | Protein Binding - drug effects | Genes, MDR - drug effects | NF-KappaB Inhibitor alpha | NF-kappa B - antagonists & inhibitors | DNA-Binding Proteins - antagonists & inhibitors | Isoxazoles - antagonists & inhibitors | NF-kappa B p50 Subunit | Isoxazoles - metabolism | Okadaic Acid - antagonists & inhibitors | Immunosuppressive Agents - antagonists & inhibitors | I-kappa B Proteins | Ceramides - antagonists & inhibitors | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - antagonists & inhibitors | Protein Kinase Inhibitors | Lipopolysaccharides - pharmacology | Tumor Necrosis Factor-alpha - physiology | Hydroxybutyrates - pharmacology | Hydrogen Peroxide - antagonists & inhibitors | Protein Kinases - metabolism | Octamer Transcription Factor-1 | Tetradecanoylphorbol Acetate - pharmacology | Transcription Factor RelA | Chloramphenicol O-Acetyltransferase - genetics | Transcription Factor AP-1 - metabolism | DNA-Binding Proteins - metabolism | Mitogen-Activated Protein Kinase Kinases | Biological Transport - drug effects | Tumor Cells, Cultured | Immunosuppressive Agents - pharmacology | Dithiothreitol - pharmacology | Aniline Compounds - antagonists & inhibitors | Aniline Compounds - pharmacology | Hydroxybutyrates - antagonists & inhibitors | Gene Expression Regulation - immunology | Hydrogen Peroxide - pharmacology | Enzyme Activation - drug effects | Ceramides - pharmacology | Chloramphenicol O-Acetyltransferase - antagonists & inhibitors | Gene Expression Regulation - drug effects | Isoxazoles - pharmacology | Transcription Factors - metabolism | Host Cell Factor C1 | NF-kappa B - genetics | NF-kappa B - isolation & purification | Genes, Reporter - drug effects | Cell Nucleus - drug effects | Tumor Necrosis Factor-alpha - antagonists & inhibitors
Journal Article
Journal of Immunology, ISSN 0022-1767, 1999, Volume 163, Issue 12, pp. 6800 - 6809
Silymarin is a polyphenolic flavonoid derived from milk thistle (Silybum marianum) that has anti-inflammatory, cytoprotective, and anticarcinogenic effects,... 
POTENT INHIBITOR | CELLS | TUMOR-NECROSIS-FACTOR | OXIDATIVE STRESS | LIPID-PEROXIDATION | MESSENGER-RNA | IMMUNOLOGY | EXPRESSION | FLAVONOID ANTIOXIDANT SILYMARIN | FACTOR-ALPHA | FACTOR-KB | Okadaic Acid - pharmacology | Reactive Oxygen Species - metabolism | Tetradecanoylphorbol Acetate - pharmacology | Apoptosis - drug effects | Humans | Protein-Serine-Threonine Kinases | Transcription Factor RelA | NF-kappa B - metabolism | Chloramphenicol O-Acetyltransferase - genetics | Lipopolysaccharides - antagonists & inhibitors | Tetradecanoylphorbol Acetate - antagonists & inhibitors | Transcription Factor AP-1 - metabolism | DNA-Binding Proteins - metabolism | U937 Cells | Lipid Peroxidation - drug effects | JNK Mitogen-Activated Protein Kinases | Silymarin - pharmacology | Phosphorylation - drug effects | MAP Kinase Kinase Kinases - antagonists & inhibitors | Immunosuppressive Agents - pharmacology | Binding Sites - drug effects | NF-KappaB Inhibitor alpha | NF-kappa B - antagonists & inhibitors | DNA-Binding Proteins - antagonists & inhibitors | Jurkat Cells | NF-kappa B p50 Subunit | Okadaic Acid - antagonists & inhibitors | I-kappa B Proteins | Ceramides - antagonists & inhibitors | MAP Kinase Kinase Kinases - metabolism | DNA - metabolism | Enzyme Activation - drug effects | DNA - antagonists & inhibitors | Ceramides - pharmacology | Transcription Factor AP-1 - antagonists & inhibitors | Mitogen-Activated Protein Kinases - antagonists & inhibitors | NF-kappa B - genetics | Lipopolysaccharides - pharmacology | Tumor Necrosis Factor-alpha - physiology | Enzyme Repression - genetics | Genes, Reporter - drug effects | Enzyme Repression - drug effects | HeLa Cells | Chloramphenicol O-Acetyltransferase - biosynthesis | MAP Kinase Kinase Kinase 1 | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Mitogen-Activated Protein Kinases - metabolism
Journal Article
Cell Reports, ISSN 2211-1247, 04/2018, Volume 23, Issue 4, pp. 1138 - 1151
The mechanisms by which the mammalian airway detects invading viral pathogens to trigger protective innate neutrophilic inflammation are incompletely... 
bromodomain containing protein 4 | airway inflammation | NF-κB | histone acetyltransferase activity | innate immune response | CELLS | OBSTRUCTIVE PULMONARY-DISEASE | DOUBLE-STRANDED-RNA | ACTIVATION | SYNCYTIAL VIRUS-INFECTION | PHOSPHORYLATION | KINASE | LUNG-FUNCTION | TRANSCRIPTIONAL ELONGATION | BRD4 | CELL BIOLOGY
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 07/2010, Volume 30, Issue 14, pp. 3582 - 3595
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
ACETYLTRANSFERASE COMPLEX | ATM FUNCTION | TELOMERE STABILITY | GENOMIC STABILITY | DROSOPHILA MSL COMPLEX | DOSAGE COMPENSATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ATAXIA-TELANGIECTASIA CELLS | IONIZING-RADIATION | MAMMALIAN-CELLS | DEFICIENT CELLS | CELL BIOLOGY | Chromatin - metabolism | RNA, Small Interfering - genetics | Tumor Suppressor Proteins - antagonists & inhibitors | Histones - chemistry | Humans | DNA Repair - physiology | Histone Acetyltransferases - genetics | Male | DNA Breaks, Double-Stranded | Cell Cycle Proteins - antagonists & inhibitors | DNA-Binding Proteins - metabolism | RNA Interference | Base Sequence | DNA-Activated Protein Kinase - metabolism | Histone Acetyltransferases - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Acetylation | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Nuclear Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins | Synaptonemal Complex - metabolism | Chromatin - radiation effects | Histone Acetyltransferases - antagonists & inhibitors | HL-60 Cells | Histone Deacetylase Inhibitors - pharmacology | DNA Damage | Histones - metabolism | Lysine - chemistry | Index Medicus | Life Sciences
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2016, Volume 59, Issue 11, pp. 5391 - 5402
Journal Article
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 04/2007, Volume 67, Issue 8, pp. 3936 - 3944
Journal Article