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Free Radical Biology and Medicine, ISSN 0891-5849, 2004, Volume 36, Issue 8, pp. 994 - 1010
As rat spermatozoa undergo epididymal maturation, they acquire the ability to exhibit a spontaneous burst of luminol-peroxidase-dependent chemiluminescence... 
Epididymis | Peroxynitrite | Free radicals | Sperm | Nitric oxide | Luminol | Peroxidase | NADPH OXIDASE | nitric oxide | free radicals | LUMINOL CHEMILUMINESCENCE | peroxynitrite | LIPID-PEROXIDATION | peroxidase | NITRIC-OXIDE SYNTHASE | MOUSE SPERMATOZOA | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN SPERM FUNCTION | PROTEIN-TYROSINE PHOSPHORYLATION | epididytnis | sperm | SUPEROXIDE ANION | ENDOCRINOLOGY & METABOLISM | HYDROGEN-PEROXIDE | CELLULAR MECHANISMS | luminol | Catalase - pharmacology | Epididymis - metabolism | Temperature | Reactive Oxygen Species | Uncoupling Agents - pharmacology | Rats, Wistar | Calcium - metabolism | Capsaicin - pharmacology | Nitric Oxide Synthase - antagonists & inhibitors | Male | Spermatozoa - metabolism | Culture Media - metabolism | Acrosome Reaction | Time Factors | Indicators and Reagents - pharmacology | Rotenone - pharmacology | Bicarbonates - chemistry | NADH, NADPH Oxidoreductases - metabolism | Diterpenes - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Deferoxamine - pharmacology | Superoxide Dismutase - pharmacology | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Rats | Onium Compounds - pharmacology | Arginine - chemistry | Luminol - pharmacology | Microscopy, Confocal | Animals | Iron Chelating Agents - pharmacology | Models, Biological | Acridines - pharmacology | Glucose - chemistry | 4-Chloromercuribenzenesulfonate - pharmacology | Fructose - chemistry | Microscopy, Fluorescence | Peroxidase - metabolism
Journal Article
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 2/2007, Volume 59, Issue 2, pp. 157 - 164
The inhibition of kinesin Eg5 by small molecules such as monastrol is currently evaluated as an approach to develop a novel class of antiproliferative drugs... 
Biomedicine | Chemosensitivity | Oncology | Cancer Research | Confocal microscopy | Human glioblastoma cells | Pharmacology/Toxicology | Kinesin inhibitors | Monastrol analogues | monastrol analogues | PROTEIN | P-GLYCOPROTEIN | PACLITAXEL | kinesin inhibitors | POTENT | ONCOLOGY | confocal microscopy | IN-VIVO | BIOLOGICAL EVALUATION | human glioblastoma cells | PHARMACOLOGY & PHARMACY | chemosensitivity | MULTIDRUG-RESISTANCE | BRAIN | Fluoresceins - pharmacology | Cysteine - analogs & derivatives | Flow Cytometry - methods | Paclitaxel - pharmacology | Tubulin Modulators - pharmacology | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Pyrimidines - chemistry | Dose-Response Relationship, Drug | Tubulin - metabolism | Spindle Apparatus - metabolism | Time Factors | Cysteine - pharmacology | Rotenone - pharmacology | Glioblastoma - metabolism | Molecular Structure | Kinesin - antagonists & inhibitors | Quinazolines - chemistry | Insecticides - pharmacology | Cell Survival - drug effects | Tetrahydroisoquinolines - pharmacology | Thiones - chemistry | Pyrimidines - pharmacology | Kinesin - metabolism | Acridines - pharmacology | Glioblastoma - pathology | Cell Line, Tumor | Cell Proliferation - drug effects | Spindle Apparatus - drug effects | Vinblastine - pharmacology | Thiones - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Quinazolines - pharmacology | Brain tumors
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 08/2009, Volume 26, Issue 8, pp. 1816 - 1831
To study the inhibition patterns of the three major human ABC transporters P-gp (ABCB1), BCRP (ABCG2) and MRP2 (ABCC2), using a dataset of 122 structurally... 
Drug transport | ABC transporters | Transport proteins | Inhibition | Structure-activity relationships | COMPUTATIONAL MODELS | GLYCOPROTEIN INHIBITORS | drug transport | inhibition | CELL-LINES | BLOOD-BRAIN-BARRIER | CHEMISTRY, MULTIDISCIPLINARY | NORMAL HUMAN-TISSUES | IN-VITRO | structure-activity relationships | PHARMACOLOGY & PHARMACY | FUMITREMORGIN-C | MULTIDRUG-RESISTANCE | transport proteins | CANCER RESISTANCE PROTEIN | PHARMACOPHORE MODEL | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Propionates - pharmacology | Cell Line | Tetrahydroisoquinolines - pharmacology | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Neoplasm Proteins - antagonists & inhibitors | Adenosine - pharmacology | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | Diketopiperazines | Quinolines - pharmacology | Heterocyclic Compounds, 4 or More Rings | Acridines - pharmacology | Adenosine - analogs & derivatives | Adenosine Triphosphate - metabolism | Computer Simulation | ATP-Binding Cassette Transporters - metabolism | Multidrug Resistance-Associated Proteins - metabolism | ATP-Binding Cassette Transporters - antagonists & inhibitors | Drugs | Universities and colleges | Carrier proteins | Analysis | Pharmacy | Comparative studies | Medical research | Pharmacology | Inhibitor drugs | Binding sites | Pharmaceutical Sciences | Basic Medicine | PHARMACY | Medical and Health Sciences | Medicin och hälsovetenskap | Farmaceutiska vetenskaper | Medicinska och farmaceutiska grundvetenskaper | FARMACI
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2013, Volume 8, Issue 8, p. e69394
We have reported that the P-gp substrate digoxin required basolateral and apical uptake transport in excess of that allowed by digoxin passive permeability (as... 
MEMBRANE TRANSPORTERS | IN-VITRO | EFFLUX | MULTIDISCIPLINARY SCIENCES | CONFLUENT MONOLAYER | GLYCOPROTEIN | CANDIDATES | PHARMACEUTICAL DRUGS | IDENTIFICATION | CACO-2 CELLS | MDCKII-HMDR1 CELLS | Vinblastine - metabolism | Digoxin - metabolism | Cyclosporine - pharmacology | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Ketoconazole - metabolism | Ketoconazole - pharmacology | Carbamates - metabolism | Madin Darby Canine Kidney Cells | Digoxin - antagonists & inhibitors | Cyclosporine - metabolism | Carbamates - pharmacology | Caco-2 Cells | Quinidine - metabolism | Tetrahydroisoquinolines - pharmacology | Gene Expression | Acridines - metabolism | Loperamide - pharmacology | Quinidine - pharmacology | Sulfonamides - pharmacology | Animals | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Tetrahydroisoquinolines - metabolism | Acridines - pharmacology | Cell Membrane Permeability - drug effects | Dogs | Sulfonamides - metabolism | Protein Binding | Loperamide - metabolism | Vinblastine - pharmacology | Kinetics | Loperamide | Permeability | Ketoconazole | Digoxin | Analysis | Monomolecular films | Drugs | Biotechnology | Cyclosporins | Membrane permeability | Biochemistry | Biology | Kinases | MDR1 protein | Inhibition | P-Glycoprotein | Dimerization | Efflux | Enzymes | Vinblastine | Glycoproteins | Metabolism | Substrates | Quinidine | Cell lines | Verapamil | Transport | Amprenavir | Transporter | Cancer | Pharmaceuticals
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 02/2016, Volume 101, pp. 40 - 53
P-glycoprotein (P-gp) is a member of the ATP-binding cassette transporter superfamily. This multidrug transporter utilizes energy from ATP hydrolysis for the... 
Drug-binding site | ABC transporter | Multidrug resistance | Modulators | Structural motifs | ABCB1 | TURNOVER | PHARMACOLOGY & PHARMACY | BINDING | TARIQUIDAR | RESIDUES | CATALYTIC CYCLE | Dibenzocycloheptenes - chemistry | Membrane Transport Modulators - chemistry | Hydrolysis - drug effects | Humans | Molecular Conformation | ATP Binding Cassette Transporter, Sub-Family B - chemistry | Quinolines - pharmacology | Tetrahydroisoquinolines - chemistry | Biocatalysis - drug effects | Dibenzocycloheptenes - metabolism | Adenosine Triphosphate - metabolism | Membrane Transport Modulators - pharmacology | Dibenzocycloheptenes - pharmacology | ATP Binding Cassette Transporter, Sub-Family B - antagonists & inhibitors | Binding Sites | Mutant Proteins - antagonists & inhibitors | Acridines - chemistry | Recombinant Proteins - metabolism | Tetrahydroisoquinolines - pharmacology | Acridines - metabolism | Quinolines - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Amino Acid Motifs | Quinolines - metabolism | Membrane Transport Modulators - metabolism | Animals | Hydrogen Bonding | Tetrahydroisoquinolines - metabolism | Acridines - pharmacology | Mutant Proteins - chemistry | Lepidoptera | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Ligands | Molecular Docking Simulation | HeLa Cells | Adenosine Triphosphate - chemistry | ATP Binding Cassette Transporter, Sub-Family B - genetics | Amino Acid Substitution | Hydrolysis | Hydrogen | Cells | Protein binding | multidrug resistance | structural motifs | modulators | drug-binding site
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 01/2014, Volume 274, Issue 2, pp. 319 - 327
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 08/2014, Volume 90, Issue 3, pp. 320 - 330
Vorinostat, which is an extensively studied inhibitor against histone deacetylase (HDAC), shows limited clinical activity to solid tumors. WJ35435, a new... 
Hybrid | DACA | DNA repair | Vorinostat | DNA damage | ACID | ACETYLATION | MECHANISMS | CELL-GROWTH | ANTITUMOR | LUNG-CANCER | CLINICAL-TRIALS | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | CHECKPOINT | DNA-REPAIR | Acridines - adverse effects | Humans | Drugs, Investigational - therapeutic use | Drug Resistance, Neoplasm | Male | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Prostate - pathology | Topoisomerase I Inhibitors - pharmacology | Topoisomerase II Inhibitors - chemistry | Prostate - drug effects | Prostatic Neoplasms - drug therapy | Topoisomerase I Inhibitors - chemistry | Acridines - chemistry | DNA Repair - drug effects | DNA Topoisomerases, Type I - metabolism | Histone Deacetylase Inhibitors - chemistry | Mice, Nude | Prostate - cytology | Cell Line, Tumor | Acridines - therapeutic use | Histone Deacetylase Inhibitors - pharmacology | Hydroxamic Acids - therapeutic use | Histone Deacetylase Inhibitors - therapeutic use | Prostate - enzymology | DNA Damage | Cell Cycle - drug effects | Histone Deacetylase Inhibitors - adverse effects | Drugs, Investigational - adverse effects | Drugs, Investigational - pharmacology | Hydroxamic Acids - adverse effects | DNA Topoisomerases, Type I - chemistry | Hydroxamic Acids - chemistry | Neoplasm Proteins - metabolism | Drugs, Investigational - chemistry | Antineoplastic Agents - adverse effects | Antineoplastic Agents - pharmacology | Hydroxamic Acids - pharmacology | Prostatic Neoplasms - pathology | Histone Deacetylase 6 | Cells, Cultured | Histone Deacetylases - chemistry | Histone Deacetylases - metabolism | Topoisomerase II Inhibitors - adverse effects | Topoisomerase II Inhibitors - pharmacology | Antineoplastic Agents - chemistry | Xenograft Model Antitumor Assays | Topoisomerase I Inhibitors - adverse effects | Animals | Tumor Burden - drug effects | Topoisomerase I Inhibitors - therapeutic use | Acridines - pharmacology | Prostatic Neoplasms - enzymology | Prevention | Medical colleges | Care and treatment | Pharmacy | Drugstores | Metastasis | Prostate cancer | Cancer
Journal Article
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 09/2017, Volume 106, Issue 9, pp. 2632 - 2641
Regorafenib is a multikinase inhibitor orally administered to colorectal cancer patients, and is known to often exhibit dermal toxicity. The purpose of this... 
P-glycoprotein | skin | tissue partition | ABC transporters | transporters | BCRP | MULTICENTER | CHEMISTRY, MEDICINAL | TRANSDERMAL ABSORPTION | CHEMISTRY, MULTIDISCIPLINARY | IN-VITRO | POLYMORPHISMS | COLORECTAL-CANCER | PHASE-3 TRIAL | PHARMACOLOGY & PHARMACY | FOOT SKIN REACTION | EXPRESSION | BRAIN | Diketopiperazines - chemistry | Pyridines - chemistry | Skin - metabolism | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Male | Phenylurea Compounds - toxicity | Heterocyclic Compounds, 4 or More Rings - pharmacology | Breast Neoplasms - metabolism | Antineoplastic Agents - metabolism | Tissue Distribution | Protein Kinase Inhibitors - chemistry | Biological Transport | Tetrahydroisoquinolines - chemistry | Phenylurea Compounds - chemistry | Antineoplastic Agents - pharmacology | Phenylurea Compounds - metabolism | Acridines - chemistry | Tetrahydroisoquinolines - pharmacology | Acridines - metabolism | Heterocyclic Compounds, 4 or More Rings - chemistry | Diketopiperazines - pharmacology | Antineoplastic Agents - chemistry | Breast Neoplasms - drug therapy | Animals | Pyridines - metabolism | Pyridines - toxicity | Tetrahydroisoquinolines - metabolism | Acridines - pharmacology | Heterocyclic Compounds, 4 or More Rings - metabolism | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Diketopiperazines - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Index Medicus
Journal Article