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Biomaterials, ISSN 0142-9612, 2011, Volume 33, Issue 7, pp. 2372 - 2387
Abstract In this study, the aminated gelatin was grafted with carboxylic end-capped poly( N -isopropylacrylamide) (PN) via a carbodiimide-mediated coupling... 
Advanced Basic Science | Dentistry | Intracameral delivery system | Pilocarpine | Biodegradable in situ forming gel | Gelatin- g-PNIPAAm | Glaucoma therapy | Gelatin-g-PNIPAAm | MATERIALS SCIENCE, BIOMATERIALS | POLY(N-ISOPROPYLACRYLAMIDE) HYDROGELS | ENGINEERING, BIOMEDICAL | HYALURONIC-ACID HYDROGELS | CONTROLLED-RELEASE | CELL SHEET | OCULAR DRUG-DELIVERY | LINKED GELATIN MEMBRANES | N-ISOPROPYLACRYLAMIDE | OPHTHALMIC DELIVERY | EPITHELIAL-CELLS | ARTIFICIAL EXTRACELLULAR-MATRIX | Biocompatible Materials - metabolism | Intraocular Pressure - drug effects | Miotics - therapeutic use | Biocompatible Materials - chemistry | Humans | Spectroscopy, Fourier Transform Infrared | Drug Carriers - chemistry | Miotics - pharmacology | Pilocarpine - pharmacokinetics | Biocompatible Materials - chemical synthesis | Pilocarpine - therapeutic use | Miotics - pharmacokinetics | Miotics - administration & dosage | Acrylamides - metabolism | Acrylic Resins | Molecular Structure | Pilocarpine - administration & dosage | Gelatin - chemistry | Rabbits | Drug Carriers - metabolism | Polymers - chemical synthesis | Ophthalmic Solutions - administration & dosage | Ophthalmic Solutions - therapeutic use | Glaucoma - drug therapy | Materials Testing | Drug Carriers - chemical synthesis | Acrylamides - chemistry | Animals | Gelatin - chemical synthesis | Pilocarpine - pharmacology | Polymers - chemistry | Gelatin - metabolism | Drug Delivery Systems - methods | Acrylamides - chemical synthesis | Polymers - metabolism | Glaucoma | Biological products | Ophthalmology | Universities and colleges | Analysis | Biomedical engineering | Drugs | Biodegradability | Delivery systems | Forming | Gelatins | Grafting | Density
Journal Article
Cancer Discovery, ISSN 2159-8274, 12/2013, Volume 3, Issue 12, pp. 1404 - 1415
Patients with non-small cell lung cancer (NSCLC) with activating EGF receptor (EGFR) mutations initially respond to first-generation reversible EGFR tyrosine... 
CELL LUNG-CANCER | MET AMPLIFICATION | ONCOLOGY | FACTOR RECEPTOR MUTATIONS | ACQUIRED-RESISTANCE | TYROSINE KINASE INHIBITOR | T790M MUTATION | OPEN-LABEL | AKT INHIBITOR | GEFITINIB RESISTANCE | AXL KINASE | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Humans | Drug Resistance, Neoplasm | Epithelial-Mesenchymal Transition - drug effects | Lung Neoplasms - pathology | Antineoplastic Agents - administration & dosage | Molecular Targeted Therapy | Receptor, Epidermal Growth Factor - metabolism | HEK293 Cells | Female | Antineoplastic Agents - pharmacology | Acrylamides - pharmacology | Mutant Proteins - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Administration, Oral | Carcinoma, Non-Small-Cell Lung - genetics | Pyrimidines - administration & dosage | Mice, Transgenic | Mutant Proteins - metabolism | Pyrimidines - pharmacology | Xenograft Model Antitumor Assays | Protein Kinase Inhibitors - administration & dosage | Animals | Acrylamides - administration & dosage | Mice, Nude | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Drug Screening Assays, Antitumor | T790M | drug resistance | NSCLC | EMT | EGFR
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 04/2015, Volume 372, Issue 18, pp. 1689 - 1699
AZD9291, an irreversible inhibitor of epidermal growth factor receptor, was associated with tumor responses in the majority of patients with advanced... 
MEDICINE, GENERAL & INTERNAL | GEFITINIB | PLACEBO | PHASE-III | ACQUIRED-RESISTANCE | OPEN-LABEL | MUTATIONS | AFATINIB | IRREVERSIBLE EGFR | CHEMOTHERAPY | ERLOTINIB | Lung Neoplasms - drug therapy | Humans | Middle Aged | ErbB Receptors - genetics | Male | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Acrylamides - pharmacokinetics | Dose-Response Relationship, Drug | Antineoplastic Agents - adverse effects | Aged, 80 and over | Adult | Female | Aniline Compounds - administration & dosage | Lung Neoplasms - genetics | Protein Kinase Inhibitors - pharmacokinetics | ErbB Receptors - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - genetics | Aniline Compounds - pharmacokinetics | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Drug Resistance, Neoplasm - genetics | Acrylamides - administration & dosage | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Aniline Compounds - adverse effects | Acrylamides - adverse effects | Clinical trials | Care and treatment | Usage | Diagnosis | Lung cancer, Non-small cell | Patient outcomes | Tyrosine | Appetite | Inhibitor drugs | Epidermal growth factor receptors | Lung cancer | Diarrhea | Nausea | Drug resistance | Kinases | Patients | Epidermal growth factor | Pharmacokinetics | Protein-tyrosine kinase | Index Medicus | Abridged Index Medicus
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 04/2015, Volume 372, Issue 18, pp. 1700 - 1709
Patients with non–small-cell lung cancer and mutated epidermal growth factor receptors who develop resistance to EGFR inhibitors through a particular mutation... 
TYROSINE KINASE INHIBITORS | MEDICINE, GENERAL & INTERNAL | PHASE-II TRIAL | GEFITINIB | ADENOCARCINOMA | ACQUIRED-RESISTANCE | MUTATIONS | AFATINIB | ERLOTINIB | CHEMOTHERAPY | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Acrylamides - pharmacokinetics | Dose-Response Relationship, Drug | Hyperglycemia - chemically induced | Antineoplastic Agents - adverse effects | Female | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Protein Kinase Inhibitors - pharmacokinetics | Carcinoma, Non-Small-Cell Lung - genetics | Pyrimidines - administration & dosage | Protein Kinase Inhibitors - administration & dosage | Drug Resistance, Neoplasm - genetics | Acrylamides - administration & dosage | Pyrimidines - adverse effects | Pyrimidines - pharmacokinetics | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Acrylamides - adverse effects | Clinical trials | Care and treatment | Usage | Diagnosis | Lung cancer, Non-small cell | Hyperglycemia | Chemotherapy | Epidermal growth factor | Inhibitor drugs | Epidermal growth factor receptors | Lung cancer | Genes | Non-small cell lung carcinoma | Antitumor activity | Pharmacokinetics | Patients | Index Medicus | Abridged Index Medicus
Journal Article
FASEB Journal, ISSN 0892-6638, 10/2015, Volume 29, Issue 10, pp. 4285 - 4298
Transient receptor potential vanilloid 1 (TRPV1) is involved in sensory nerve nociceptive signaling. Recently, it has been discovered that TRPV1 receptors also... 
Brown adipose tissue | Thermogenesis | TRPV1 | THYROID-HORMONE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADRENERGIC-RECEPTOR | BROWN ADIPOSE-TISSUE | CELL BIOLOGY | CAPSAICIN RECEPTOR | thermogenesis | brown adipose tissue | COLD-EXPOSURE | ADAPTIVE THERMOGENESIS | BIOLOGY | 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA | INFLAMMATORY RESPONSE | D-AMPHETAMINE | TRPV1 ANTAGONIST | Telemetry - methods | Humans | Male | Mice, 129 Strain | Body Temperature - physiology | Sympathetic Nervous System - metabolism | Adrenergic alpha-1 Receptor Antagonists - administration & dosage | Fever - physiopathology | Prazosin - administration & dosage | Adrenergic beta-Antagonists - pharmacology | Propranolol - pharmacology | Sympathetic Nervous System - physiology | Adrenergic alpha-1 Receptor Antagonists - pharmacology | Prazosin - pharmacology | Propranolol - administration & dosage | TRPV Cation Channels - antagonists & inhibitors | Injections, Subcutaneous | Acrylamides - pharmacology | Adrenergic beta-Antagonists - administration & dosage | Receptors, Adrenergic, alpha-1 - physiology | TRPV Cation Channels - physiology | Body Temperature Regulation - physiology | Mice, Inbred C57BL | Injections, Intraperitoneal | Bridged Bicyclo Compounds, Heterocyclic - administration & dosage | Receptors, Adrenergic, beta - physiology | Labetalol - pharmacology | TRPV Cation Channels - genetics | Mice, Knockout | Labetalol - administration & dosage | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Acrylamides - administration & dosage | Body Temperature - genetics | Fever - genetics | Body Temperature Regulation - genetics | Research Communication
Journal Article
ACS Applied Materials and Interfaces, ISSN 1944-8244, 05/2015, Volume 7, Issue 17, pp. 9235 - 9246
Journal Article
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 01/2016, Volume 222, pp. 67 - 77
Journal Article
Journal Article