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Nature Chemical Biology, ISSN 1552-4450, 09/2015, Volume 11, Issue 9, pp. 705 - 712
Actin-targeting macrolides comprise a large, structurally diverse group of cytotoxins isolated from remarkably dissimilar micro- and macroorganisms. In spite... 
BACTERIAL SYMBIONT | GENE-CLUSTER | CYTOTOXIC MACROLIDES | NATURAL-PRODUCT DISCOVERY | CYANOBACTERIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYNTHASES | IN-SITU HYBRIDIZATION | SPONGE THEONELLA-SWINHOEI | IDENTIFICATION | ANTIFUNGAL MACROLIDE | Cyanobacteria - genetics | Deltaproteobacteria - metabolism | Multigene Family | Peptides | Actins - metabolism | Bacterial Proteins - chemistry | Cyanobacteria - metabolism | Molecular Sequence Data | Polyketides - chemistry | Small Molecule Libraries - metabolism | Polyketides - metabolism | Polyketide Synthases - metabolism | Macrolides - chemistry | Pyrans - chemistry | Pyrans - metabolism | Base Sequence | Actins - chemistry | Symbiosis | Gene Expression | Bacterial Proteins - genetics | Macrolides - metabolism | Biological Evolution | Small Molecule Libraries - chemistry | Polyketide Synthases - chemistry | Animals | Deltaproteobacteria - genetics | Theonella - microbiology | Protein Binding | Bacterial Proteins - metabolism | Polyketide Synthases - genetics | Enzymes | Bacteria | Biosynthesis | Metabolism | Index Medicus | Polyketide Synthases/metabolism | Actins/metabolism | Macrolides/chemistry | Polyketide Synthases/chemistry | Life Sciences | Cyanobacteria/metabolism | Deltaproteobacteria/genetics | Bacterial Proteins/chemistry | Macrolides/metabolism | Actins/chemistry | Polyketide Synthases/genetics | Deltaproteobacteria/metabolism | Small Molecule Libraries/metabolism | Theonella/microbiology | Cyanobacteria/genetics | Pyrans/metabolism | Small Molecule Libraries/chemistry | Microbiology and Parasitology | Bacterial Proteins/metabolism | Polyketides/chemistry | Polyketides/metabolism | Bacterial Proteins/genetics | Pyrans/chemistry
Journal Article
Science, ISSN 0036-8075, 1/2013, Volume 339, Issue 6118, pp. 452 - 456
Journal Article
Science, ISSN 0036-8075, 12/2007, Volume 318, Issue 5858, pp. 1900 - 1903
Journal Article
The EMBO Journal, ISSN 0261-4189, 06/2011, Volume 30, Issue 12, pp. 2325 - 2335
The Hippo tumour suppressor pathway is a conserved signalling pathway that controls organ size. The core of the Hpo pathway is a kinase cascade, which in... 
hippo signalling | F‐actin | growth regulation | F-actin | TISSUE-GROWTH | BIOCHEMISTRY & MOLECULAR BIOLOGY | YORKIE PHOSPHORYLATION | TEAD/TEF FAMILY | CELL BIOLOGY | REGULATE CELL-PROLIFERATION | SIGNALING PATHWAY | GENE-EXPRESSION | CONTACT INHIBITION | SIZE-CONTROL | TUMOR-SUPPRESSOR PATHWAY | PROMOTES APOPTOSIS | Wings, Animal - cytology | Cell Proliferation | Humans | Drosophila melanogaster - genetics | Actins - genetics | Drosophila Proteins - biosynthesis | Organ Specificity - genetics | Wings, Animal - growth & development | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Actins - chemistry | RNA Caps - antagonists & inhibitors | RNA Caps - chemistry | Intracellular Signaling Peptides and Proteins - genetics | Cytoskeleton - chemistry | RNA Caps - genetics | Actins - biosynthesis | Carrier Proteins - biosynthesis | Cells, Cultured | Cytoskeleton - genetics | Drosophila melanogaster - cytology | Protein-Serine-Threonine Kinases - genetics | Signal Transduction - genetics | Drosophila Proteins - chemistry | Carrier Proteins - genetics | Phenotype | Animals | Drosophila melanogaster - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Wings, Animal - chemistry | Protein-Serine-Threonine Kinases - chemistry | Drosophila Proteins - genetics | HeLa Cells | Proteins | Signal transduction | Tumors | Index Medicus
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 11/2018, Volume 24, Issue 62, pp. 16686 - 16691
An intramolecular Diels–Alder (IMDA) reaction efficiently accelerated by Schreiner's thiourea is reported, to build a functionalized cytochalasin scaffold... 
organocatalysis | medium-ring compounds | density functional calculations | natural products | antitumor agents | FUNGUS PERICONIA SP | ROUTE | DIELS-ALDER REACTIONS | ACTIN | ACIDS | OLEFIN CROSS-METATHESIS | CHEMISTRY, MULTIDISCIPLINARY | SYNTHASE | KETONES | METAL-FREE | Cell Survival - drug effects | Cytochalasins - chemical synthesis | Stereoisomerism | Antineoplastic Agents - chemical synthesis | Humans | Molecular Conformation | Crystallography, X-Ray | Thiourea - chemistry | Antineoplastic Agents - chemistry | Cycloaddition Reaction | Cytochalasins - chemistry | Thermodynamics | Copper - chemistry | Hydrogen Bonding | Actin Cytoskeleton - drug effects | Cell Line, Tumor | Cytochalasins - pharmacology | Antineoplastic Agents - pharmacology | Catalysis | Palladium - chemistry | Polymerization | Care and treatment | Muscle proteins | Cancer | Index Medicus | Actin Cytoskeleton/drug effects | Thiourea/chemistry | Cell Survival/drug effects | Cellular Biology | Chemical Sciences | Theoretical and | or physical chemistry | Life Sciences | Antineoplastic Agents/pharmacology | Cytochalasins/pharmacology | Copper/chemistry | Cytochalasins/chemistry | Quantitative Methods | Biochemistry, Molecular Biology | Antineoplastic Agents/chemistry | Antineoplastic Agents/chemical synthesis | Palladium/chemistry | Cytochalasins/chemical synthesis | Organic chemistry | Molecular biology
Journal Article
Molecules, ISSN 1420-3049, 05/2017, Volume 22, Issue 5, p. 754
Amarogentin, a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots, has been suggested to exhibit many biological effects, including... 
Mitogen-activated protein kinase | Liver fibrosis | α-smoothmuscle actin | Carbon tetrachloride | Amarogentin | amarogentin | OXIDATIVE STRESS | ACTIVATION | RATS | CHEMISTRY, ORGANIC | carbon tetrachloride | MODEL | MESSENGER-RNA LEVELS | mitogen-activated protein kinase | liver fibrosis | HEPATIC STELLATE CELLS | INHIBITION | COLCHICINE | alpha-smoothmuscle actin | SIGNAL-REGULATED KINASE | MODULATION | Albumins - chemistry | Plant Extracts - chemistry | Antioxidants - chemistry | Oxidative Stress | Carbon Tetrachloride | Humans | Malondialdehyde - chemistry | Liver Cirrhosis - chemically induced | Dose-Response Relationship, Drug | Tissue Distribution | Iridoids - chemistry | Actins - chemistry | Phytotherapy | Glycosides - chemistry | Hydroxyproline - chemistry | Cell Line | Liver Cirrhosis - drug therapy | Down-Regulation | Gentiana - chemistry | Mice, Inbred C57BL | Swertia - chemistry | Nucleotides, Cyclic - chemistry | Animals | Iridoids - pharmacology | Plant Roots - chemistry | Iridoids - therapeutic use | Mice | Transcription factors | Liver | Roots | Hydroxyproline | Guanosine | Smooth muscle | Superoxide dismutase | Biochemistry | Kinases | Assaying | Signal transduction | Biological effects | Actin | Cyclic GMP | Peroxidase | Glutathione | Glutathione peroxidase | Retarding | Alanine | Diabetes mellitus | c-Jun protein | Albumin | MAP kinase | Olive oil | Carbon | Malondialdehyde | Signaling | Protein kinase | Fibrosis | Alanine transaminase | Aspartate aminotransferase | Fats and oils | Colchicine | Tumors | Index Medicus
Journal Article
Journal Article
Science, ISSN 0036-8075, 1/2004, Volume 303, Issue 5657, pp. 495 - 499
The BAR (Bin/amphiphysin/Rvs) domain is the most conserved feature in amphiphysins from yeast to human and is also found in endophilins and nadrins. We solved... 
Proteins | String theory | Drosophila | Liver | Lipids | Cell membranes | Dimers | Liposomes | Curvature | Research Article | P branes | CLATHRIN-MEDIATED ENDOCYTOSIS | ADP-RIBOSYLATION FACTORS | LYSOPHOSPHATIDIC ACID | TERMINAL DOMAIN | DROSOPHILA AMPHIPHYSIN | SYNAPTIC VESICLE ENDOCYTOSIS | MULTIDISCIPLINARY SCIENCES | ACTIN CYTOSKELETON | GTPASE-ACTIVATING PROTEIN | BINDING | SH3 DOMAIN | Cytoskeletal Proteins | Coated Vesicles - metabolism | Drosophila - chemistry | Molecular Sequence Data | Crystallography, X-Ray | GTPase-Activating Proteins - metabolism | Drosophila Proteins - metabolism | Phosphoproteins - metabolism | Clathrin-Coated Vesicles - metabolism | Phosphoproteins - chemistry | Cell Membrane - chemistry | Coated Vesicles - chemistry | Nerve Tissue Proteins - chemistry | Carrier Proteins - chemistry | Cell Membrane - metabolism | ADP-Ribosylation Factors - metabolism | ADP-Ribosylation Factors - genetics | Dimerization | Protein Structure, Tertiary | Amino Acid Sequence | Protein Structure, Secondary | COP-Coated Vesicles - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Drosophila Proteins - chemistry | GTPase-Activating Proteins - chemistry | Nuclear Proteins - chemistry | Nerve Tissue Proteins - genetics | Clathrin - metabolism | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | ADP-Ribosylation Factors - chemistry | Adaptor Proteins, Signal Transducing | Liposomes - chemistry | Animals | Carrier Proteins - metabolism | Protein Binding | Liposomes - metabolism | Mutation | Synapses | Chemical properties | Membranes | Yeast | Cellular biology | Cells | BAR domains | amphiphysin | endophilins | nadrins | Index Medicus
Journal Article