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Nature Chemical Biology, ISSN 1552-4450, 09/2015, Volume 11, Issue 9, pp. 705 - 712
Actin-targeting macrolides comprise a large, structurally diverse group of cytotoxins isolated from remarkably dissimilar micro- and macroorganisms. In spite... 
BACTERIAL SYMBIONT | GENE-CLUSTER | CYTOTOXIC MACROLIDES | NATURAL-PRODUCT DISCOVERY | CYANOBACTERIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYNTHASES | IN-SITU HYBRIDIZATION | SPONGE THEONELLA-SWINHOEI | IDENTIFICATION | ANTIFUNGAL MACROLIDE | Cyanobacteria - genetics | Deltaproteobacteria - metabolism | Multigene Family | Peptides | Actins - metabolism | Bacterial Proteins - chemistry | Cyanobacteria - metabolism | Molecular Sequence Data | Polyketides - chemistry | Small Molecule Libraries - metabolism | Polyketides - metabolism | Polyketide Synthases - metabolism | Macrolides - chemistry | Pyrans - chemistry | Pyrans - metabolism | Base Sequence | Actins - chemistry | Symbiosis | Gene Expression | Bacterial Proteins - genetics | Macrolides - metabolism | Biological Evolution | Small Molecule Libraries - chemistry | Polyketide Synthases - chemistry | Animals | Deltaproteobacteria - genetics | Theonella - microbiology | Protein Binding | Bacterial Proteins - metabolism | Polyketide Synthases - genetics | Enzymes | Bacteria | Biosynthesis | Metabolism | Index Medicus | Polyketide Synthases/metabolism | Actins/metabolism | Macrolides/chemistry | Polyketide Synthases/chemistry | Life Sciences | Cyanobacteria/metabolism | Deltaproteobacteria/genetics | Bacterial Proteins/chemistry | Macrolides/metabolism | Actins/chemistry | Polyketide Synthases/genetics | Deltaproteobacteria/metabolism | Small Molecule Libraries/metabolism | Theonella/microbiology | Cyanobacteria/genetics | Pyrans/metabolism | Small Molecule Libraries/chemistry | Microbiology and Parasitology | Bacterial Proteins/metabolism | Polyketides/chemistry | Polyketides/metabolism | Bacterial Proteins/genetics | Pyrans/chemistry
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2006, Volume 281, Issue 36, pp. 26391 - 26399
Journal Article
Neuron, ISSN 0896-6273, 08/2012, Volume 75, Issue 4, pp. 618 - 632
Mitochondrial abnormalities have been documented in Alzheimer’s disease and related neurodegenerative disorders, but the causal relationship between... 
ALZHEIMERS-DISEASE BRAIN | DOMINANT OPTIC ATROPHY | MITOCHONDRIAL-FUNCTION | MOUSE MODEL | LIGHT-CHAIN | FRONTOTEMPORAL DEMENTIA | AXONAL-TRANSPORT | NEUROSCIENCES | DYNAMIN-RELATED PROTEIN | PHOSPHORYLATION SITES | TRANSGENIC MICE | Neurons - pathology | Microtubule-Associated Proteins - genetics | Tauopathies - genetics | Cytoskeletal Proteins - genetics | Gelsolin - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Actins - metabolism | Tauopathies - pathology | Cytoplasm - metabolism | MicroRNAs - metabolism | Green Fluorescent Proteins - genetics | Mitochondrial Proteins - genetics | Drosophila Proteins - metabolism | GTP-Binding Proteins - genetics | Nerve Degeneration - metabolism | Neurons - ultrastructure | tau Proteins - genetics | Cell Death - genetics | Mitochondria - genetics | Mitochondrial Proteins - metabolism | ATP Synthetase Complexes - metabolism | Cell Cycle Proteins - genetics | Tauopathies - complications | Cytoskeletal Proteins - metabolism | Myosins - metabolism | Cytoplasm - genetics | RNA Interference - physiology | Disease Models, Animal | In Situ Nick-End Labeling | Green Fluorescent Proteins - metabolism | Animals, Genetically Modified | Gene Expression Regulation - genetics | Drosophila | Cell Cycle Proteins - metabolism | Mitochondria - metabolism | Mitochondria - pathology | Mutation - genetics | Animals | GTP Phosphohydrolases - metabolism | Analysis of Variance | GTP Phosphohydrolases - genetics | Gelsolin - genetics | Mice | Drosophila Proteins - genetics | Nerve Degeneration - etiology | Voltage-Dependent Anion Channels - metabolism | GTP-Binding Proteins - metabolism | Nervous system diseases | Actin | Neurons | Utrophin | Myosin | Mitochondrial DNA | Alzheimer's disease | Proteins | Phosphorylation | Mitochondria | Neurotoxicity | Insects | Microscopy | Neurodegeneration | Pathogenesis | Morphology | Mutation | Defects | Index Medicus | Neurodegenerative diseases | Tau protein | Cell death | Elongation
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 01/2015, Volume 35, Issue 4, pp. 960 - 972
Objective-Marfan's syndrome is characterized by the formation of ascending aortic aneurysms resulting from altered assembly of extracellular matrix... 
focal adhesion | actin | aortic stiffness | myocardin | TGF-β | aortic aneurysms | extracellular matrix | RhoA | TRANSCRIPTION FACTORS | SMAD2 PATHWAY | EPIGENETIC CONTROL | THORACIC AORTIC-ANEURYSMS | SIGNAL-TRANSDUCTION | TGF-beta | GROWTH-FACTOR-BETA | MOUSE MODEL | DISEASE | PERIPHERAL VASCULAR DISEASE | EXTRACELLULAR-MATRIX | DIFFERENTIATION | HEMATOLOGY | Vascular Remodeling | Aortic Aneurysm - metabolism | Muscle, Smooth, Vascular - metabolism | Humans | Actins - metabolism | Myocytes, Smooth Muscle - pathology | rhoA GTP-Binding Protein - metabolism | Aorta - metabolism | Aortic Aneurysm - etiology | Case-Control Studies | Muscle Proteins - metabolism | Cytoskeletal Proteins - metabolism | Cell Differentiation | Marfan Syndrome - complications | Microfilament Proteins - metabolism | Aortic Aneurysm - pathology | Dilatation, Pathologic | Myocytes, Smooth Muscle - metabolism | Biomarkers - metabolism | Calcium-Binding Proteins - metabolism | Collagen Type I - metabolism | Signal Transduction | Nuclear Proteins - metabolism | Aorta - pathology | Muscle, Smooth, Vascular - pathology | Phenotype | Stress Fibers - metabolism | Focal Adhesions - metabolism | Cell Line, Tumor | Marfan Syndrome - metabolism | Marfan Syndrome - pathology | Trans-Activators - metabolism | Transforming Growth Factor beta - metabolism | Index Medicus | Biological Sciences | Medical and Health Sciences | Medicin och hälsovetenskap | Naturvetenskap | Biologiska vetenskaper | Natural Sciences
Journal Article
Laboratory Investigation, ISSN 0023-6837, 05/2012, Volume 92, Issue 5, pp. 713 - 723
Non-alcoholic steatohepatitis (NASH) is typically associated with pro-apoptotic caspase activation. A potential role for pro-inflammatory caspases remains... 
Inflammasome | Inflammation | Caspases | Non-alcoholic fatty liver disease | Non-alcoholic steatohepatitis | Fibrosis | MEDICINE, RESEARCH & EXPERIMENTAL | POPULATION | APOPTOSIS | non-alcoholic fatty liver disease | MICE DEFICIENT | FATTY LIVER-DISEASE | INJURY | NONALCOHOLIC STEATOHEPATITIS | MODEL | PATHOLOGY | inflammation | inflammasome | fibrosis | caspases | HEPATIC STEATOSIS | non-alcoholic steatohepatitis | Tumor Necrosis Factor-alpha - metabolism | Liver - pathology | Clodronic Acid - pharmacology | Fatty Liver - pathology | Actins - metabolism | Caspase 3 - metabolism | Hepatic Stellate Cells - metabolism | Caspase 1 - metabolism | Choline Deficiency - complications | Hepatocytes - pathology | Hepatocytes - metabolism | Fatty Liver - chemically induced | LIM Domain Proteins - metabolism | Liver Cirrhosis - chemically induced | Inflammation - metabolism | Caspase 3 - blood | Interleukin-1beta - metabolism | Choline Deficiency - metabolism | Liver Cirrhosis - metabolism | Muscle Proteins - metabolism | Antigens, Differentiation - metabolism | Kupffer Cells - metabolism | Hepatic Stellate Cells - pathology | Methionine - deficiency | Collagen Type I - metabolism | Fatty Liver - metabolism | Liver - metabolism | Mice, Inbred C57BL | Nuclear Proteins - metabolism | Choline Deficiency - pathology | Kupffer Cells - drug effects | Mice, Knockout | Animals | Caspase 1 - genetics | Caspase 1 - deficiency | Liver Cirrhosis - pathology | Mice | Transforming Growth Factor beta - metabolism | Index Medicus | Nonalcoholic fatty liver disease (NAFLD) | nonalcoholic steatohepatitis (NASH)
Journal Article
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 8/2009, Volume 186, Issue 4, pp. 571 - 587
Invadopodia are matrix-degrading membrane protrusions in invasive carcinoma cells. The mechanisms regulating invadopodium assembly and maturation are not... 
Phosphorylation | Quantification | Cell lines | Actin depolymerizing factors | Actins | Polymerization | Small interfering RNA | Antibodies | Protein precursors | Physiological regulation | CARCINOMA-CELLS | TYROSINE PHOSPHORYLATION | EGF | PATHWAY | ACTIN POLYMERIZATION | IN-VIVO | CANCER-CELL INVASION | EXTRACELLULAR-MATRIX DEGRADATION | ARP2/3 COMPLEX | PODOSOME FORMATION | CELL BIOLOGY | Oncogene Proteins - genetics | RNA, Small Interfering - genetics | Oncogene Protein pp60(v-src) - metabolism | Actin Depolymerizing Factors - genetics | Humans | Actins - metabolism | Extracellular Matrix - metabolism | Actin-Related Protein 2-3 Complex - genetics | Recombinant Fusion Proteins - metabolism | Actin Depolymerizing Factors - metabolism | Actin-Related Protein 2-3 Complex - metabolism | Wiskott-Aldrich Syndrome Protein, Neuronal - metabolism | Protein Structure, Tertiary | Neoplasm Invasiveness | Oncogene Proteins - metabolism | Rats | Epidermal Growth Factor - metabolism | Oncogene Protein pp60(v-src) - genetics | Cortactin - metabolism | Matrix Metalloproteinase 14 - metabolism | Mammary Neoplasms, Animal - pathology | Tyrosine - metabolism | Animals | Cortactin - genetics | Mammary Neoplasms, Animal - metabolism | Adaptor Proteins, Signal Transducing - genetics | Matrix Metalloproteinase 14 - genetics | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Wiskott-Aldrich Syndrome Protein, Neuronal - genetics | RNA, Small Interfering - metabolism | Metastasis | Properties | Observations | Actin | Cancer cells | Membrane proteins | Cell growth | Biochemistry | Cells | Cell cycle | Cancer | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 2210 - 20
VEGFR-2/Notch signalling regulates angiogenesis in part by driving the remodelling of endothelial cell junctions and by inducing cell migration. Here, we show... 
TIP CELLS | PERMEABILITY | ELONGATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | RHO | RAC1 | BETA-CATENIN | ENDOCYTOSIS | FLOW | VASCULAR ENDOTHELIAL-CADHERIN | Human Umbilical Vein Endothelial Cells | Neovascularization, Physiologic - drug effects | Vascular Remodeling | Cadherins - metabolism | Humans | Actins - metabolism | rac GTP-Binding Proteins - metabolism | Actins - drug effects | Vascular Endothelial Growth Factor A - metabolism | Cell Movement - physiology | Antigens, CD - metabolism | Pseudopodia - drug effects | Actin-Related Protein 2-3 Complex - metabolism | Microtubules - metabolism | Microtubules - drug effects | Actin-Related Protein 3 - metabolism | Wiskott-Aldrich Syndrome Protein - metabolism | Actin-Related Protein 2 - metabolism | Cell Polarity - drug effects | Vascular Endothelial Growth Factor A - pharmacology | Cardiac Myosins - metabolism | Endothelial Cells - physiology | Signal Transduction | Wiskott-Aldrich Syndrome Protein Family - metabolism | Endothelial Cells - metabolism | Models, Cardiovascular | Intercellular Junctions - metabolism | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Antigens, CD - drug effects | Cadherins - drug effects | Cell Adhesion | Cell Movement - drug effects | Neovascularization, Physiologic - physiology | Pseudopodia - metabolism | Intercellular Junctions - drug effects | Cell Polarity - physiology | Myosin Light Chains - metabolism | Pseudopodia - physiology | Endothelium, Vascular | Endothelial Cells - drug effects | Cell junctions | Pseudopodia | Dephosphorylation | Cadherin | Remodeling | Contraction | Endothelial cells | Cell adhesion & migration | Vascular endothelial growth factor receptors | Prisons | Angiogenesis | Signaling | Cell activation | Actin | Microtubules | Myosin | Notch protein | Vascular endothelial growth factor | Cell migration | Elongation | Index Medicus
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 02/2010, Volume 21, Issue 4, pp. 584 - 596
Vascular endothelial (VE)-cadherin is a cell-cell adhesion molecule involved in endothelial barrier functions. Previously, we reported that cAMP-Epac-Rap1... 
BARRIER DYSFUNCTION | F-ACTIN | ADHESION | COMPLEX | EPITHELIAL-CELLS | RAP1 EFFECTOR | VE-CADHERIN | SRC ACTIVITY | ADHERENS JUNCTIONS | EXCHANGE FACTORS | CELL BIOLOGY | RNA, Small Interfering - genetics | Platelet Endothelial Cell Adhesion Molecule-1 - genetics | Thiazolidines - metabolism | Cadherins - metabolism | Fluorescence Recovery After Photobleaching | alpha Catenin - metabolism | Humans | Actins - metabolism | Guanosine Triphosphate - metabolism | Antigens, CD - genetics | Recombinant Fusion Proteins - metabolism | Actins - genetics | Antigens, CD - metabolism | Colforsin - metabolism | Guanine Nucleotide Exchange Factors - metabolism | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Cadherins - genetics | Cyclic AMP - metabolism | Bridged Bicyclo Compounds, Heterocyclic - metabolism | Cell Line | rap1 GTP-Binding Proteins - metabolism | Guanine Nucleotide Exchange Factors - genetics | Endothelial Cells - metabolism | Intercellular Junctions - metabolism | beta Catenin - metabolism | beta Catenin - genetics | Animals | Endothelial Cells - cytology | Cyclic AMP Response Element-Binding Protein - metabolism | Recombinant Fusion Proteins - genetics | Signal Transduction - physiology | alpha Catenin - genetics | rap1 GTP-Binding Proteins - genetics | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2010, Volume 12, Issue 3, pp. 257 - 266
Satellite cells are resident myogenic progenitors in postnatal skeletal muscle involved in muscle postnatal growth and adult regenerative capacity. Here, we... 
P53-MEDIATED APOPTOSIS | MORPHOMETRIC ANALYSIS | SKELETAL-MUSCLE | STEM-CELLS | INTERSTITIAL SPACES | REGENERATION | SOLEUS MUSCLE | BONE-MARROW | MYOGENIC SPECIFICATION | SELF-RENEWAL | CELL BIOLOGY | Paired Box Transcription Factors - genetics | Antigens, CD34 - metabolism | Cell Proliferation | Cell Count | Actins - metabolism | PAX7 Transcription Factor - genetics | Ki-67 Antigen - metabolism | PAX7 Transcription Factor - metabolism | Stem Cells - cytology | Muscle Fibers, Skeletal - metabolism | Muscle, Skeletal - cytology | Stem Cells - metabolism | Myosin Heavy Chains - metabolism | Stem Cell Transplantation | Kruppel-Like Transcription Factors - metabolism | Muscle Proteins - metabolism | Antigens, Ly - metabolism | Membrane Proteins - metabolism | Microfilament Proteins - metabolism | Cell Differentiation - physiology | Myocytes, Smooth Muscle - cytology | Myocytes, Smooth Muscle - metabolism | Animals, Newborn | PAX3 Transcription Factor | Muscle, Skeletal - growth & development | Mice, Inbred C57BL | Muscle Development - physiology | RNA, Untranslated | Satellite Cells, Skeletal Muscle - cytology | Mice, Transgenic | Satellite Cells, Skeletal Muscle - metabolism | MyoD Protein - metabolism | Muscle, Skeletal - physiology | Regeneration - physiology | Mice, Knockout | Proteins - genetics | Cell Lineage | Satellite Cells, Skeletal Muscle - transplantation | Animals | Mice, Nude | Muscle Fibers, Skeletal - cytology | Mice | Physiological aspects | Genetic aspects | Regeneration (Biology) | Research | Stem cells | Index Medicus
Journal Article