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2013, Fifth edition., ISBN 9780199697397, xxiii, 789 pages
... involved in developing an effective drug. 
Pharmacokinetics | Pharmaceutical chemistry | Chemistry, Pharmaceutical | Drug Design
Book
Antimicrobial agents and chemotherapy, ISSN 1098-6596, 2015, Volume 59, Issue 10, pp. 6444 - 6453
There is increasing interest in the use of lipophilic copper (Cu)-containing complexes to combat bacterial infections. In this work, we showed that Cu... 
COPPER HOMEOSTASIS | OXIDATIVE STRESS | EFFLUX SYSTEM | CEFTRIAXONE | ESCHERICHIA-COLI | BIS(THIOSEMICARBAZONATO) COMPLEXES | NEISSERIA-GONORRHOEAE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | MULTIPLE-ANTIBIOTIC-RESISTANCE | MECHANISMS | ANTIMICROBIAL RESISTANCE | Streptococcus pneumoniae - growth & development | Electron Transport - drug effects | Species Specificity | Thiosemicarbazones - toxicity | Haemophilus influenzae - drug effects | Salmonella typhimurium - growth & development | Escherichia coli - drug effects | Lactobacillus acidophilus - drug effects | Cytoplasm - metabolism | Salmonella typhimurium - metabolism | Microbial Sensitivity Tests | Thiosemicarbazones - chemistry | Copper - chemistry | Biological Transport | Streptococcus pneumoniae - metabolism | Anti-Bacterial Agents - chemistry | Escherichia coli - metabolism | Salmonella typhimurium - drug effects | Anti-Bacterial Agents - toxicity | Drug Resistance, Bacterial - drug effects | Escherichia coli - growth & development | Copper - toxicity | Lactobacillus acidophilus - growth & development | Coordination Complexes - toxicity | Haemophilus influenzae - growth & development | Staphylococcus aureus - metabolism | Haemophilus influenzae - metabolism | Streptococcus pneumoniae - drug effects | Microbial Viability - drug effects | Neisseria gonorrhoeae - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Coordination Complexes - chemistry | Neisseria gonorrhoeae - growth & development | Neisseria gonorrhoeae - metabolism | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Cytoplasm - drug effects | Lactobacillus acidophilus - metabolism | Index Medicus | Mechanisms of Action | Physiological Effects
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 09/2011, Volume 301, Issue 3, pp. 587 - 600
Transient receptor potential (TRP) ankyrin 1 (TRPA1) is a Ca2+-permeant, nonselective cationic channel... 
Transient receptor potential vanilloid 1 | Synaptic transmission | Patchclamp | COLD HYPERALGESIA | PROTEIN-KINASE-C | PHYSIOLOGY | ION-CHANNEL TRPA1 | GLUTAMATERGIC SYNAPTIC-TRANSMISSION | GENE-RELATED PEPTIDE | patch-clamp | transient receptor potential vanilloid 1 | SPINAL-CORD | SENSORY NEURONS | DIRECT PHOSPHORYLATION | CELL BIOLOGY | SUBSTANTIA-GELATINOSA NEURONS | COVALENT MODIFICATION | synaptic transmission | Hyperalgesia - chemically induced | Calcium - metabolism | Capsaicin - pharmacology | Nociception - physiology | Ganglia, Spinal - cytology | Nociceptive Pain - chemically induced | Calcium Channels - physiology | Protein Kinase C - metabolism | Oocytes - drug effects | Behavior, Animal - drug effects | Synaptic Transmission - drug effects | Ankyrins - agonists | Membrane Potentials - drug effects | Calcium - pharmacology | TRPC Cation Channels | Colforsin - pharmacology | Oocytes - metabolism | Rats | Rats, Sprague-Dawley | 1-Methyl-3-isobutylxanthine - pharmacology | Tachyphylaxis - physiology | Mice, Knockout | Nociceptive Pain - physiopathology | Spermine - pharmacology | Mice | Inhibitory Postsynaptic Potentials - drug effects | Electrophysiological Phenomena - drug effects | Hydrogen-Ion Concentration | Maleimides - pharmacology | Phorbol 12,13-Dibutyrate - pharmacology | Isocyanates - pharmacology | Miniature Postsynaptic Potentials - drug effects | Excitatory Postsynaptic Potentials - drug effects | Dose-Response Relationship, Drug | Excitatory Postsynaptic Potentials - physiology | Trigeminal Caudal Nucleus - cytology | Neurons - physiology | Transient Receptor Potential Channels - physiology | Neurons - drug effects | Action Potentials - drug effects | Miniature Postsynaptic Potentials - physiology | Cyclic AMP-Dependent Protein Kinases - metabolism | Xenopus laevis | Electrophysiological Phenomena - physiology | Inhibitory Postsynaptic Potentials - physiology | Ankyrins - physiology | Allyl Compounds - pharmacology | Membrane Potentials - physiology | Mice, Inbred Strains | Transient Receptor Potential Channels - agonists | TRPV Cation Channels - genetics | Hyperalgesia - physiopathology | Action Potentials - physiology | Animals | TRPA1 Cation Channel | Ion Channel Gating - drug effects | Nociception | Neural transmission | Ion channels | Research | Properties | Nervous System Cell Biology
Journal Article
Journal Article
eLife, ISSN 2050-084X, 2017, Volume 6
Journal Article
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2007, Volume 56, Issue 4, pp. 701 - 713
Acetylcholine is a ubiquitous cortical neuromodulator implicated in cognition. In order to understand the potential for acetylcholine to play a role in visual attention, we studied nicotinic acetylcholine receptor (nAChR... 
SYSNEURO | SIGNALING | ACETYLCHOLINE-RECEPTORS | CORTICAL-NEURONS | CAT VISUAL-CORTEX | MONKEY STRIATE CORTEX | CHOLINERGIC MODULATION | CONTRAST RESPONSE FUNCTIONS | SPATIAL ATTENTION | NEUROSCIENCES | CEREBRAL-CORTEX | GABAERGIC NEURONS | MACACA-FASCICULARIS | Pyramidal Cells - metabolism | Synaptic Transmission - physiology | Visual Perception - drug effects | gamma-Aminobutyric Acid - metabolism | Visual Pathways - metabolism | Macaca fascicularis | Male | Acetylcholine - metabolism | Geniculate Bodies - drug effects | Nicotine - pharmacology | Neural Inhibition - physiology | Neurons - ultrastructure | Synapses - metabolism | Synaptic Transmission - drug effects | Neurons - metabolism | Pyramidal Cells - drug effects | Neurons - drug effects | Pyramidal Cells - ultrastructure | Action Potentials - drug effects | Nicotinic Agonists - pharmacology | Microscopy, Electron, Transmission | Synapses - drug effects | Receptors, Nicotinic - drug effects | Receptors, Nicotinic - metabolism | Contrast Sensitivity - physiology | Visual Perception - physiology | Geniculate Bodies - metabolism | Interneurons - ultrastructure | Geniculate Bodies - ultrastructure | Interneurons - drug effects | Synapses - ultrastructure | Animals | Interneurons - metabolism | Visual Pathways - drug effects | Visual Pathways - ultrastructure | Contrast Sensitivity - drug effects | Visual Cortex - ultrastructure | Visual Cortex - drug effects | Visual Cortex - metabolism | Neural Inhibition - drug effects | GABA | Neurons | Nicotine | Brain | Rodents
Journal Article
Neuropsychopharmacology (New York, N.Y.), ISSN 0893-133X, 06/2013, Volume 38, Issue 7, pp. 1221 - 1233
.... Consistent with these effects, Ro25 reduced GABAergic responses in pyramidal neurons and hence could affect circuit functions by altering the excitation/inhibition balance in the brain... 
oscillation | interneuron | LTP | memory | Down syndrome | GluN2B | TS65DN MOUSE | RO 25-6981 | PSYCHIATRY | NR2B SUBUNIT | HIPPOCAMPAL | NEUROSCIENCES | PREFRONTAL CORTEX | IN-VITRO | NR2B-CONTAINING NMDA RECEPTORS | GABA-A | DOWN-SYNDROME | PHARMACOLOGY & PHARMACY | GAMMA OSCILLATIONS | Memory - drug effects | Interneurons - physiology | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Neuronal Plasticity - drug effects | GABAergic Neurons - physiology | Male | Hippocampus - drug effects | Excitatory Postsynaptic Potentials - drug effects | Mice, Neurologic Mutants | Excitatory Postsynaptic Potentials - physiology | Neuronal Plasticity - physiology | Long-Term Potentiation - drug effects | Piperidines - pharmacology | Pyramidal Cells - physiology | Long-Term Potentiation - physiology | Brain Waves - drug effects | Pyramidal Cells - drug effects | Action Potentials - drug effects | Brain Waves - physiology | Maze Learning - physiology | Interneurons - drug effects | GABAergic Neurons - drug effects | Maze Learning - drug effects | Receptors, N-Methyl-D-Aspartate - physiology | Action Potentials - physiology | Animals | Down Syndrome - drug therapy | Phenols | Mice | Hippocampus - physiology | Memory - physiology | learning & memory | GABA | neurophysiology | Original | glutamate
Journal Article
Nature communications, ISSN 2041-1723, 2016, Volume 7, Issue 1, p. 12199
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