X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (137) 137
humans (122) 122
animals (104) 104
cell biology (51) 51
signal transduction (50) 50
activated protein-kinase (48) 48
immunology (48) 48
mice (42) 42
kinases (41) 41
proteins (38) 38
biochemistry & molecular biology (35) 35
insulin resistance (31) 31
inflammation (28) 28
male (28) 28
metabolism (28) 28
phosphorylation (28) 28
review (26) 26
gene-expression (25) 25
physiological aspects (25) 25
oxidative stress (23) 23
phosphoinositide 3-kinase (22) 22
proto-oncogene proteins c-akt - metabolism (22) 22
research (22) 22
article (21) 21
apoptosis (20) 20
cancer (20) 20
gene expression (20) 20
insulin (20) 20
signal transduction - drug effects (20) 20
pharmacology & pharmacy (19) 19
endocrinology & metabolism (18) 18
immunodeficiency (18) 18
phosphatidylinositol 3-kinases - metabolism (18) 18
biology (17) 17
lipids (17) 17
medicine, research & experimental (17) 17
mutation (17) 17
protein kinases (17) 17
analysis (16) 16
female (16) 16
obesity (16) 16
pi3k (16) 16
transcription factors (16) 16
activation (15) 15
fatty acids (15) 15
nf-kappa-b (15) 15
rodents (15) 15
akt (14) 14
article subject (14) 14
cells, cultured (14) 14
diabetes (14) 14
activated phosphoinositide 3-kinase delta syndrome (13) 13
activated phosphoinositide 3-kinase δ syndrome (13) 13
glucose (13) 13
lipid metabolism (13) 13
mitogen-activated protein kinases - metabolism (13) 13
phosphatidylinositol 3-kinase (13) 13
ppar gamma - metabolism (13) 13
activated-receptor-gamma (12) 12
allergy (12) 12
care and treatment (12) 12
cell proliferation (12) 12
development and progression (12) 12
genetic aspects (12) 12
inhibition (12) 12
peroxisome proliferator-activated receptors (12) 12
review article (12) 12
1-phosphatidylinositol 3-kinase (11) 11
abridged index medicus (11) 11
cells (11) 11
cytokines (11) 11
enzymes (11) 11
expression (11) 11
hematology (11) 11
insulin-resistance (11) 11
mutations (11) 11
oncology (11) 11
phosphorylation - drug effects (11) 11
primary immunodeficiency (11) 11
rats (11) 11
research article (11) 11
type 2 diabetes (11) 11
biomedicine (10) 10
cell cycle (10) 10
disease (10) 10
medicine (10) 10
neurosciences (10) 10
pik3cd (10) 10
ppar-gamma (10) 10
signaling (10) 10
skeletal-muscle (10) 10
adipocyte differentiation (9) 9
adipose-tissue (9) 9
allergy and immunology (9) 9
atherosclerosis (9) 9
disease models, animal (9) 9
glucose metabolism (9) 9
health aspects (9) 9
immunology and allergy (9) 9
in-vivo (9) 9
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


by Coulter, Tanya I., MRCPI and Chandra, Anita, PhD, FRCPath and Bacon, Chris M., PhD, FRCPath and Babar, Judith, MRCP, FRCR and Curtis, James, PhD and Screaton, Nick, FRCP, FRCR and Goodlad, John R., MD, FRCPath and Farmer, George, MD and Steele, Cathal Laurence, MB and Leahy, Timothy Ronan, MRCPI and Doffinger, Rainer, PhD, FRCPath and Baxendale, Helen, PhD, FRCPath and Bernatoniene, Jolanta, PhD and Edgar, J. David M., FRCP, FRCPath and Longhurst, Hilary J., PhD, FRCPath and Ehl, Stephan, MD, PhD and Speckmann, Carsten, MD and Grimbacher, Bodo, MD, PhD and Sediva, Anna, MD, PhD and Milota, Tomas, MD and Faust, Saul N., PhD, FRCPCH and Williams, Anthony P., PhD, FRCPath and Hayman, Grant, FRCP, FRCPath and Kucuk, Zeynep Yesim, MD and Hague, Rosie, MRCP, FRCPH and French, Paul, MD, MRCS, DipFMS, FRCPath and Brooker, Richard, FRCPCH and Forsyth, Peter, FRCPath and Herriot, Richard, FRCP, FRCPath and Cancrini, Caterina, MD, PhD and Palma, Paolo, MD, PhD and Ariganello, Paola, MD and Conlon, Niall, PhD, FRCPath and Feighery, Conleth, PhD, FRCPath and Gavin, Patrick J., MD and Jones, Alison, PhD, FRCPCH and Imai, Kohsuke, MD, PhD and Ibrahim, Mohammad A.A., PhD, FRCP, FRCPath and Markelj, Gašper, MD and Abinun, Mario, MD, PhD and Rieux-Laucat, Frédéric, PhD and Latour, Sylvain, PhD and Pellier, Isabelle, MD, PhD and Fischer, Alain, MD, PhD and Touzot, Fabien, MD, PhD and Casanova, Jean-Laurent, MD, PhD and Durandy, Anne, MD, PhD and Burns, Siobhan O., MD, PhD and Savic, Sinisa, PhD, FRCPath and Kumararatne, D.S., FRCPath, DPhil (Oxon) and Moshous, Despina, MD, PhD and Kracker, Sven, PhD and Vanhaesebroeck, Bart, PhD, FMedSci and Okkenhaug, Klaus, PhD and Picard, Capucine, MD, PhD and Nejentsev, Sergey, MD, PhD and Condliffe, Alison M., PhD, FRCP and Cant, Andrew James, MD, FRCP, FRCPH
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 2, pp. 597 - 606.e4
Background Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described combined immunodeficiency resulting from gain-of-function mutations in... 
Allergy and Immunology | Activated phosphoinositide 3-kinase δ syndrome | hematopoietic stem cell transplantation | phosphoinositide 3-kinase δ | immunodeficiency | phosphoinositide 3-kinase inhibitor | PIK3CD gene | bronchiectasis | p110δ-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency | Recurrence | Humans | Middle Aged | Child, Preschool | Infant | Male | Antibiotic Prophylaxis | Class I Phosphatidylinositol 3-Kinases/antagonists & inhibitors | Young Adult | Immunoglobulins, Intravenous/therapeutic use | Enzyme Inhibitors/therapeutic use | Lymphoproliferative Disorders/genetics | Adult | Female | Surveys and Questionnaires | Child | Respiratory Tract Infections/genetics | Mutation/genetics | Hematopoietic Stem Cell Transplantation | International Cooperation | Herpesviridae Infections/genetics | Animals | Adolescent | Survival Analysis | Mice | Immunologic Deficiency Syndromes/genetics | Cohort Studies | Activated phosphoinositide 3-kinase delta syndrome | IMMUNOLOGICAL FEATURES | HYPER-IGM SYNDROME | p110 delta-activating mutation causing senescent T cells | hematopoietic stem cell | COMMON VARIABLE IMMUNODEFICIENCY | PIK3CD | IMMUNOLOGY | lymphadenopathy | REFERENCE VALUES | P110-DELTA | phosphoinositide 3-kinase delta | P110 DELTA | B-CELL | ALLERGY | transplantation | MUTATIONS | Class I Phosphatidylinositol 3-Kinases - genetics | Herpesviridae Infections - mortality | Respiratory Tract Infections - genetics | Lymphoproliferative Disorders - therapy | Respiratory Tract Infections - mortality | Respiratory Tract Infections - therapy | Immunologic Deficiency Syndromes - mortality | Herpesviridae Infections - genetics | Immunologic Deficiency Syndromes - therapy | Lymphoproliferative Disorders - genetics | Mutation - genetics | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Lymphoproliferative Disorders - mortality | Herpesviridae Infections - therapy | Immunoglobulins, Intravenous - therapeutic use | Immunologic Deficiency Syndromes - genetics | Immune Deficiencies, Infection, and Systemic Immune Disorders | HSCT, Hematopoietic stem cell transplantation | BALF, Bronchoalveolar lavage fluid | CT, Computed tomography | APDS, Activated phosphoinositide-3 kinase δ syndrome | GOF, Gain of function | PI3K, Phosphoinositide 3-kinase | HSV, Herpes simplex virus | CMV, Cytomegalovirus | OR, Odds ratio | PPV, Pneumococcal polysaccharide vaccine | CNS, Central nervous system
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 138, Issue 1, pp. 210 - 218.e9
Background Activated phosphoinositide 3-kinase δ syndrome (APDS) 2 (p110δ-activating mutations causing senescent T cells, lymphadenopathy, and immunodeficiency... 
Allergy and Immunology | and immunodeficiency | p110δ-activating mutations causing senescent T cells | hyper-IgM | adenopathy | p110δ | activated phosphoinositide 3-kinase δ syndrome | p85α | antibody deficiency | immunodeficiency | lymphadenopathy | phosphoinositide 3-kinase | Primary immunodeficiency | Class I Phosphatidylinositol 3-Kinases/genetics | RNA Splice Sites | Gene Frequency | Humans | Middle Aged | Immunologic Deficiency Syndromes/diagnosis | Child, Preschool | Genotype | Male | Young Adult | CD8-Positive T-Lymphocytes/immunology | Phenotype | T-Lymphocyte Subsets/immunology | Biopsy | Adolescent | Alleles | Adult | Female | Mutation | Child | Cohort Studies | p110 delta-activating mutations causing senescent T cells | CELLS | HUMAN IMMUNODEFICIENCY | KINASE | p85 alpha | IMMUNOLOGY | p110 delta | ALLERGY | MUTATIONS | activated phosphoinositide 3-kinase delta syndrome | T-Lymphocyte Subsets - immunology | Class I Phosphatidylinositol 3-Kinases - genetics | Immunologic Deficiency Syndromes - etiology | Immunologic Deficiency Syndromes - mortality | CD8-Positive T-Lymphocytes - metabolism | Immunologic Deficiency Syndromes - diagnosis | T-Lymphocyte Subsets - metabolism | CD8-Positive T-Lymphocytes - immunology | Life Sciences | Human health and pathology | Economics and Finance | Psychology | Santé publique et épidémiologie | Humanities and Social Sciences | Psychiatrics and mental health
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 03/2018, Volume 9, p. 543
Activated phosphoinositide 3-kinase (PI3K) δ Syndrome (APDS), caused by autosomal dominant mutations in (APDS1) or (APDS2), is a heterogeneous primary... 
PIK3CD | Rapamycin | PIK3R1 | Registry | Natural history | Activated phosphoinositide 3-kinase δ syndrome | Life Sciences | Genetics | Santé publique et épidémiologie | Immunology | Human genetics | registry | activated phosphoinositide 3-kinase δ syndrome | natural history | rapamycin
Journal Article
Clinical Immunology, ISSN 1521-6616, 2016, Volume 171, pp. 38 - 40
Highlights • Activated phosphoinositide 3-kinase δ syndrome may be complicated by refractory autoimmune hemolytic anemia. • Sirolimus presents a precision... 
Allergy and Immunology | Sirolimus | Autoimmune hemolytic anemia | Activated phosphoinositide 3-kinase δ syndrome | Activated phosphoinositide 3-kinase delta syndrome | GENOMICS | IMMUNOLOGY
Journal Article
Journal of Clinical Immunology, ISSN 0271-9142, 11/2018, Volume 38, Issue 8, pp. 854 - 863
Journal Article
Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 04/2016, Volume 138, Issue 1, p. 9
Journal Article
Clinical Immunology, ISSN 1521-6616, 12/2018, Volume 197, pp. 60 - 67
Activated phosphoinositide 3-kinase δ (PI3Kδ) syndrome is a newly defined and relatively common primary immunodeficiency, which is caused by heterozygous... 
PIK3CD | Lymphoproliferation | Activated phosphoinositide 3-kinase δ syndrome | Immunodeficiency | Activated phosphoinositide 3-kinase delta syndrome | MAMMALIAN TARGET | IMMUNOLOGY | MATURATION | IMMUNODEFICIENCY MUTATIONS | P110-DELTA | RESPONSES | PI3K-DELTA | T FOLLICULAR HELPER | DISEASE | CELL DIFFERENTIATION
Journal Article
Journal Article
Genes & Diseases, ISSN 2352-3042, 10/2019
Journal Article
03/2018, Volume 9, Issue MAR
Activated phosphoinositide 3-kinase (PI3K) δ Syndrome (APDS), caused by autosomal dominant mutations in PIK3CD (APDS1) or PIK3R1 (APDS2), is a heterogeneous... 
Immunology | Activated phosphoinositide 3-kinase δ syndrome | PIK3CD | Rapamycin | PIK3R1 | Registry | Immunology and Allergy | Natural history
Report
Frontiers in Immunology, ISSN 1664-3224, 03/2018, Volume 9, Issue MAR, p. 446
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 03/2018, Volume 9, Issue MAR
Pathogenic gain-of-function mutations in the gene encoding phosphoinositide 3-kinase delta (PI3Kδ) cause activated PI3Kδ syndrome (APDS), a disease... 
Activated phosphoinositide 3-kinase delta syndrome | Immunology | PI3K | Exhaustion | Programmed death receptor-1 | Checkpoint inhibition | P110δ | Immunology and Allergy | CD8 T cells
Journal Article