Articles

Bone | Proliferation | Mechanical loading | Ageing | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Adaptation, Physiological | Cell Cycle - genetics | Cell Proliferation - genetics | Osteocytes - metabolism | Humans | Mice, Inbred C57BL | Transcriptome | Carbohydrate Metabolism - genetics | Signal Transduction - genetics | Gene Regulatory Networks | Tibia - pathology | Aging - pathology | Weight-Bearing - physiology | Extracellular Matrix - genetics | Animals | Aging - genetics | Aging - physiology | Female | Osteocytes - pathology | Mice | E2F1 Transcription Factor - genetics | Energy Metabolism - genetics | Tibia - physiopathology | DNA microarrays | Analysis | Cell cycle | Physiological aspects | Carbohydrate metabolism | Genetic transcription | DNA binding proteins | Transforming growth factors | Index Medicus | NADH, Nicotinamide adenine dinucleotide | EGF, epidermal growth factor | Sp7, Sp7 transcription factor 7 | Ezh2, enhancer of zeste 2 polycomb repressive complex 2 subunit | Gtse, G2 and S-phase expressed 1 | Cdk6, cyclin dependent kinase 6 | Cdca3, cell division cycle associated 3 | RNA, Ribonucleic acid | BMD, bone mineral density | Research Paper | E2F1, E2F transcription factor 1 | CO2, Carbon dioxide | BMP, bone morphogenetic protein | Ttn, titin | DAVID, Database for Annotation, Visualization and Integrated Discovery | Bcl212, Bcl-2-like protein 2 | Itgb1, integrin subunit beta 1 | Bcl11a, B-cell CLL | Sox9, SRY-box 9 | Gnas, GNAS complex locus | Grb10, growth factor receptor bound protein 10 | ATP, Adenosine triphosphate | EGR2, early growth response 2 | Wnt16, Wnt family member 16 | Vcam1, vascular cell adhesion molecule 1 | Mark3, microtubule affinity regulating kinase 3 | Fzd7, frizzled class receptor 7 | b2MG, Beta-2-microglobulin | KEGG, Kyoto Encyclopaedia of Genes and Genomes | Phex, phosphate regulating endopeptidase homolog, X-linked | RarB, retinoic acid receptor beta | SPEED, Signalling Pathway Enrichment using Experimental Datasets | BiNGO, A Biological Network Gene Ontology tool | PASTAA, Predicted Association of Transcription factors from Annotated Affinities | lymphoma 11A | TGFb, transforming growth factor beta 1 | Tcf15, transcription factor 15 | Igf1, insulin like growth factor 1 | Dkk1, dickkopf WNT signalling pathway inhibitor 1 | Des, desmin | MAPK, mitogen-activated protein kinase | Dab2IP, disabled 2 interacting protein | Mmp25, matrix metallopeptidase 25 | Actn2, actinin alpha 2 | qRT-PCR, quantitative real time polymerase chain reaction | Mef2c, myocyte enhancer factor 2C | Mki67, marker of proliferation Ki-67 | Pitx2, paired-like homeodomain transcription factor 2 | MCM, Minichromosome maintenance protein complex | Cdc20, cell division cycle 20 | MEPE, matrix extracellular phosphoglycoprotein | QTC, Quality Threshold Clustering | TNFa, tumor necrosis factor a | Fgf7, fibroblast growth factor 7 | Igf2, insulin like growth factor 2 | Ccna2, cyclin A2 | Fgfr1, fibroblast growth factor receptor 1 | Pkia, protein kinase (cAMP-dependent, catalytic) inhibitor alpha | Ccnd3, cyclin D3 | Myf6, myogenic factor 6 | Sost, sclerostin | Sox6, SRY-box 6 | Atf3, activating transcription factor 3 | MMP13, matrix metallopeptidase 13 | AMPK, adenosine monophosphate-activated protein kinase | Mapt, microtubule associated protein tau | Scyl1, SCY1 like pseudokinase 1 | Insig2, insulin induced gene 2 | PBS, Phosphate buffered saline | Kcnma1, potassium calcium-activated channel subfamily M alpha 1 | FDR, false discovery rate | VegfA, vascular endothelial growth factor A | Nusap1, nucleolar and spindle associated protein 1 | ECM, Extracellular matrix | PdgfA, platelet derived growth factor, alpha