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Cancer Cell, ISSN 1535-6108, 09/2013, Volume 24, Issue 3, pp. 289 - 304
Proteasome inhibitor (PI) resistance mechanisms in multiple myeloma (MM) remain controversial. We report the existence of a progenitor organization in primary... 
BORTEZOMIB RESISTANCE | OVEREXPRESSION | DEXAMETHASONE | BLIMP-1 | UNFOLDED PROTEIN RESPONSE | ONCOLOGY | FACTOR XBP-1 | MECHANISMS | DIFFERENTIATION | CANCER | GENOME | CELL BIOLOGY | eIF-2 Kinase - metabolism | Humans | Precursor Cells, B-Lymphoid - metabolism | Transcription Factors - deficiency | Pyrazines - therapeutic use | Boronic Acids - therapeutic use | DNA-Binding Proteins - deficiency | X-Box Binding Protein 1 | Plasma Cells - pathology | DNA-Binding Proteins - metabolism | Multiple Myeloma - drug therapy | Precursor Cells, B-Lymphoid - pathology | Plasma Cells - metabolism | Membrane Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Cell Survival - drug effects | Bortezomib | Endoribonucleases - metabolism | Proteasome Inhibitors - pharmacology | Signal Transduction | Immunophenotyping | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Multiple Myeloma - metabolism | Regulatory Factor X Transcription Factors | Proteasome Inhibitors - therapeutic use | Transcription Factors - metabolism | Activating Transcription Factor 6 - metabolism | Drug Resistance, Neoplasm - genetics | Endoplasmic Reticulum Stress | Mutation | Pyrazines - pharmacology | Multiple Myeloma - genetics | Boronic Acids - pharmacology | Immunoglobulins | Care and treatment | Multiple myeloma | Genetic research | Health aspects | Tumors | Cancer
Journal Article
The EMBO Journal, ISSN 0261-4189, 08/2013, Volume 32, Issue 17, pp. 2348 - 2361
Mitofusin 2 (Mfn2) is a key protein in mitochondrial fusion and it participates in the bridging of mitochondria to the endoplasmic reticulum (ER). Recent data... 
cell death and autophagy | mitochondria | cell metabolism | CANCER-CELLS | OXIDATIVE STRESS | FUSION | MITOFUSIN 2 | CA2+ PUMP | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUSCLE-CELL APOPTOSIS | ENDOPLASMIC-RETICULUM STRESS | CELL BIOLOGY | UNFOLDED PROTEIN RESPONSE | GENE-EXPRESSION | Reactive Oxygen Species - metabolism | eIF-2 Kinase - metabolism | Humans | Apoptosis - genetics | Activating Transcription Factor 6 - genetics | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Mitochondria - genetics | Membrane Proteins - metabolism | Autophagy - genetics | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | eIF-2 Kinase - genetics | Membrane Proteins - genetics | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Mitochondria - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Fibroblasts - pathology | Gene Knockout Techniques | Regulatory Factor X Transcription Factors | Transcription Factors - metabolism | Activating Transcription Factor 6 - metabolism | Animals | GTP Phosphohydrolases - metabolism | GTP Phosphohydrolases - genetics | Endoplasmic Reticulum Stress | Fibroblasts - drug effects | Mice | Unfolded Protein Response - physiology | Proteins | Signal transduction | Mitochondria | Cellular biology | Gene expression | Stress response
Journal Article
Gastroenterology, ISSN 0016-5085, 2008, Volume 134, Issue 2, pp. 568 - 576
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2010, Volume 54, Issue 4, pp. 795 - 809
The unfolded protein response (UPR) is activated upon the accumulation of misfolded proteins in the endoplasmic reticulum (ER) that are sensed by the binding... 
Gastroenterology and Hepatology | Hepatosteatosis | Endoplasmic reticulum stress | Unfolded protein response | Liver injury | MESSENGER-RNA TRANSLATION | UNFOLDED-PROTEIN RESPONSE | TRANSCRIPTION FACTOR XBP-1 | NECROSIS-FACTOR-ALPHA | ISCHEMIA-REPERFUSION INJURY | PROGRAMMED CELL-DEATH | GLUCOSE-REGULATED PROTEINS | HEPATITIS-C VIRUS | HUMAN HEPATOCELLULAR-CARCINOMA | GASTROENTEROLOGY & HEPATOLOGY | NF-KAPPA-B | Hepatitis C, Chronic - metabolism | Fatty Liver - metabolism | Cholestasis - metabolism | eIF-2 Kinase - metabolism | Humans | Liver Diseases - pathology | Stress, Physiological | Endoplasmic Reticulum - metabolism | Hyperhomocysteinemia - metabolism | Hepatocytes - pathology | Hepatocytes - metabolism | Unfolded Protein Response | Liver Diseases, Alcoholic - metabolism | Activating Transcription Factor 6 - metabolism | Inflammation - metabolism | Animals | Models, Biological | Liver Neoplasms - metabolism | Non-alcoholic Fatty Liver Disease | Protein Conformation | Liver Diseases - metabolism | Reperfusion Injury - metabolism | Apoptosis | Carcinoma, Hepatocellular - metabolism | Inositol | Immunoglobulins | Stress (Physiology) | Ribonuclease | Glucose | Genetic translation | Dextrose | Messenger RNA | Proteases | Proteolysis | Analysis | Hepatitis C | Adenylic acid | Hepatitis C virus | Health aspects | Protein binding | Tumors
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