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International Journal of Antimicrobial Agents, ISSN 0924-8579, 2011, Volume 39, Issue 1, pp. 16 - 21
Journal Article
Cell Death and Disease, ISSN 2041-4889, 02/2014, Volume 5, Issue 2, pp. e1063 - e1063
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, p. e0145940
Short chain fatty acids (SCFA), products of microbial fermentation of dietary fiber, exert multiple metabolic effects in cells. Previously, we had demonstrated... 
PROPIONATE | INHIBITION | CHAIN FATTY-ACIDS | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | RECEPTOR | PEROXISOMAL BETA-OXIDATION | GUT MICROBIOTA | IDENTIFICATION | ADIPOSE-TISSUE | AMP-Activated Protein Kinases - metabolism | Lipolysis - drug effects | Adipogenesis - drug effects | Insulin Resistance | Adipocytes - cytology | Adipokines - metabolism | Mitochondria - metabolism | Adipocytes - drug effects | Mitochondria - drug effects | Peroxisomes - metabolism | Triglycerides - metabolism | Gene Expression Regulation - drug effects | Peroxisomes - drug effects | Animals | Butyric Acid - metabolism | Cell Differentiation - drug effects | Swine | Adipocytes - metabolism | Dietary Fiber | Butyric Acid - pharmacology | Dietary Supplements | Glucose metabolism | Pork industry | Genes | Triglycerides | Glucose | Gene expression | Fatty acids | Dextrose | Cell culture | Phosphorylation | Body fat | Downstream effects | AKT protein | Lipids | Activation | Adipocytes | Kinases | Metabolic syndrome | Accumulation | Adiponectin | Proteins | Microorganisms | Transcription activation | Sterol regulatory element-binding protein | Oxidation | Lipid metabolism | Lipogenesis | Adipogenesis | Community structure | Pigs | Animal sciences | Fermentation | Metabolism | Insulin | Lipolysis | Studies | Hogs | Thioridazine | Diet | Insulin resistance | Dietary fiber | Differentiation | Endocrinology
Journal Article
Molecular Oncology, ISSN 1574-7891, 04/2015, Volume 9, Issue 4, pp. 889 - 905
... potent. Second, we performed RNA expression analysis on 3 dasatinib-resistant and 3 dasatinib–sensitive pancreatic cancer cell lines to profile their gene expression... 
Dasatinib | PP2A | FTY-720 | Pancreatic cancer | Phenothiazine | APOPTOSIS | NAB-PACLITAXEL | PHENOTHIAZINES | DRUG-RESISTANCE | GEMCITABINE | CELL-DEATH | INHIBITION | CISPLATIN | ONCOLOGY | FTY720 | LEUKEMIA | Tumor Suppressor Proteins - metabolism | Apoptosis - drug effects | Humans | Pancreatic Neoplasms - enzymology | Pancreatic Neoplasms - genetics | Antineoplastic Agents - therapeutic use | Enzyme Activation - drug effects | Dasatinib - pharmacology | Pancreatic Neoplasms - drug therapy | Penfluridol - pharmacology | Phenothiazines - pharmacology | Computer Simulation | Protein Phosphatase 2 - metabolism | Cell Line, Tumor | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Penfluridol - therapeutic use | Protein Kinase Inhibitors - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Cell Cycle - drug effects | Drug Evaluation, Preclinical | Care and treatment | Phosphatases | RNA | Developmental biology | Oncology, Experimental | Genes | Research | Gene expression | Digital map services | Cell death | Drug therapy | Cancer | Medical research | Phosphoprotein phosphatase | Therapeutic applications | Tumor cell lines | Ribonucleic acid--RNA | Kinases | Cancer therapies | Cell growth | Thioridazine | Medical prognosis | Cell cycle | Data collection | Tumor suppressor genes | Protein phosphatase | Mutation | Localization | Design of experiments | Apoptosis
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 02/2019, Volume 20, Issue 3
Thioridazine (THD) is a common phenothiazine antipsychotic drug reported to suppress growth in several types of cancer cells... 
SURVIVAL | ACTIVATION | autophagy | catenin | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | apoptosis | BETA-CATENIN | P62 | CHEMISTRY, MULTIDISCIPLINARY | thioridazine | TEMOZOLOMIDE | INVASION | glioblastoma | DEGRADATION | CASPASE-8 | Wnt | RECEPTORS
Journal Article
Current Opinion in Oncology, ISSN 1040-8746, 01/2013, Volume 25, Issue 1, pp. 59 - 65
Journal Article
Journal Article
Journal of Molecular Neuroscience, ISSN 0895-8696, 3/2004, Volume 22, Issue 3, pp. 189 - 198
.... All agents induced a dose-dependent decrease in viability and proliferation, with the highest activity elicited by thioridazine... 
Neurology | Neurosciences | Biomedicine | Phenothiazines | neuroblastoma | apoptosis | glioma | thioridazine | GROWTH-INHIBITION | VITAMIN-E | MUSTARD TYPE PHENOTHIAZINES | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSCIENCES | SIGMA-RECEPTOR | IN-VITRO | CALMODULIN | ATYPICAL NEUROLEPTICS | ANTIPSYCHOTIC-DRUGS | DIFFERENTIATION | phenothiazines | CASPASE ACTIVATION | Apoptosis - drug effects | Humans | Phenothiazines - therapeutic use | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - toxicity | Dose-Response Relationship, Drug | Caspases - metabolism | Up-Regulation - physiology | Caspase 3 | Caspases - drug effects | Fluphenazine - toxicity | DNA Fragmentation - drug effects | Receptors, sigma - metabolism | Cell Survival - physiology | Thioridazine - toxicity | Cell Survival - drug effects | DNA Fragmentation - physiology | Receptors, sigma - drug effects | Calmodulin - metabolism | Rats | Brain Neoplasms - drug therapy | Cell Division - drug effects | Mice, Inbred ICR | Cell Division - physiology | Up-Regulation - drug effects | Phenazocine - analogs & derivatives | Phenothiazines - toxicity | Animals | Phenazocine - pharmacology | Neuroblastoma - drug therapy | Cell Line, Tumor | Calmodulin - drug effects | Mice | Apoptosis - physiology | Glioma - drug therapy | Knowledge-based systems | Neuroblastoma | Gliomas | Brain tumors | Apoptosis | Brain cancer | Cancer cells | Dosage and administration | Research | Drug therapy | Health aspects | Phenothiazine | Rodents | Cells
Journal Article
Biochemical journal, ISSN 1470-8728, 2007, Volume 406, Issue 1, pp. 105 - 114
...) and thioridazine inhibited the enzyme efficiently... 
NOX4 | NADPH oxidase (NOX) | Superoxide | Hydrogen peroxide | NOX4 inhibitor | Reactive oxygen species (ROS) | APOPTOSIS | OXYGEN SPECIES PRODUCTION | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | hydrogen peroxide | TRANSCRIPTION | reactive oxygen species (ROS) | NADPH OXIDASE ACTIVITY | NAD(P)H OXIDASE | INHIBITION | DIFFERENTIATION | superoxide | EXPRESSION | DIPHENYLENEIODONIUM | Gene Expression Regulation, Enzymologic - drug effects | Reactive Oxygen Species - metabolism | Humans | Cytosol - drug effects | RNA, Messenger - metabolism | Cytosol - enzymology | Time Factors | Superoxides - metabolism | Enzyme Induction - drug effects | NADPH Oxidases - genetics | NADP - metabolism | Ethidium - analogs & derivatives | Cell Membrane - drug effects | NAD - metabolism | Cell Line | Electron Spin Resonance Spectroscopy | RNA, Messenger - genetics | Tetracycline - pharmacology | Enzyme Inhibitors - pharmacology | Hydrogen Peroxide - pharmacology | Nitroblue Tetrazolium - pharmacology | Mitochondria - drug effects | NADPH Oxidase 4 | Cell Membrane - enzymology | Animals | Ethidium - pharmacology | Mice | Cell Membrane | Enzyme Inhibitors | Reactive Oxygen Species | Hydrogen Peroxide | Cytosol | Life Sciences | Mitochondria | Biomolecules | NADP | Ethidium | Biochemistry, Molecular Biology | Enzyme Induction | Nitroblue Tetrazolium | Tetracycline | NAD | Gene Expression Regulation, Enzymologic | Superoxides | RNA, Messenger | NADPH Oxidase | tet, tetracycline | PKC, protein kinase C | NOX, NADPH oxidase | HEK-293, human embryonic kidney | ACP, 1-acetoxy-3-carboxy-2,2,5,5-tetramethylpyrrolidine | HRP, horseradish peroxidase | HBSS, Hanks balanced salt solution | DMEM, Dulbecco's modified Eagle's medium | TGF, transforming growth factor | DHE, dihydroethidium | CMV, cytomegalovirus | NBT, Nitro Blue Tetrazolium | ROS, reactive oxygen species | DPI, diphenyleneiodonium chloride
Journal Article