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Cell, ISSN 0092-8674, 2007, Volume 129, Issue 4, pp. 723 - 733
Transcriptional activation of the nuclear receptor RAR by retinoic acid (RA) often leads to inhibition of cell growth. However, in some tissues, RA promotes... 
ACUTE-PROMYELOCYTIC-LEUKEMIA | PPAR-BETA | BREAST-CANCER CELLS | TERATOCARCINOMA STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAMMARY-CARCINOMA | SYMPATHETIC NEURONS | E-FABP | FATTY-ACIDS | TARGET GENE | BINDING PROTEIN-II | CELL BIOLOGY | Active Transport, Cell Nucleus - physiology | Apoptosis - drug effects | Humans | Transcriptional Activation - drug effects | Cell Survival - genetics | Apoptosis - genetics | Mammary Neoplasms, Experimental - physiopathology | Fatty Acid-Binding Proteins - metabolism | Mammary Neoplasms, Experimental - metabolism | Mammary Neoplasms, Experimental - genetics | Receptors, Retinoic Acid - genetics | Cell Nucleus - metabolism | Mammary Neoplasms, Animal - physiopathology | Female | Gene Expression Regulation, Neoplastic - physiology | Mammary Neoplasms, Animal - genetics | Tretinoin - pharmacology | Receptors, Retinoic Acid - drug effects | Cell Survival - drug effects | PPAR-beta - metabolism | Keratinocytes | Receptors, Retinoic Acid - metabolism | Cell Transformation, Neoplastic - metabolism | Fatty Acid-Binding Proteins - genetics | Animals | PPAR-beta - drug effects | Active Transport, Cell Nucleus - drug effects | Mammary Neoplasms, Animal - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Transcriptional Activation - physiology | Cell Transformation, Neoplastic - drug effects | Cell Nucleus - drug effects | Growth | Tretinoin | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 514, Issue 7520, pp. 112 - 116
Chemoresistance is a serious limitation of cancer treatment(1). Until recently, almost all the work done to study this limitation has been restricted to tumour... 
CANCER-CELLS | ACTIVATION | METASTASIS | MICROENVIRONMENT | ANGIOGENESIS | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | RESISTANCE | FOCAL ADHESION KINASE | NF-KAPPA-B | EXPRESSION | Doxorubicin - therapeutic use | Apoptosis - drug effects | Apoptosis - radiation effects | Humans | NF-kappa B - metabolism | Cell Nucleus - metabolism | Neoplasms - genetics | DNA Damage - genetics | Neoplasms - radiotherapy | Phosphorylation - drug effects | DNA Damage - drug effects | Endothelial Cells - metabolism | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Focal Adhesion Protein-Tyrosine Kinases - deficiency | Neoplasms - drug therapy | Focal Adhesion Protein-Tyrosine Kinases - genetics | Drug Resistance, Neoplasm - genetics | Animals | Active Transport, Cell Nucleus - drug effects | Cell Proliferation - drug effects | Mice | Cell Nucleus - drug effects | Neoplasms - pathology | Endothelial Cells - enzymology | Cytokines - biosynthesis | Doxorubicin - pharmacology | Cell Proliferation - radiation effects | Drug Resistance, Neoplasm - drug effects | Endothelial Cells - drug effects | Tyrosine | Complications and side effects | Care and treatment | DNA damage | Oncology, Experimental | Genetic research | Genetic aspects | Research | Drug resistance | Phosphotransferases | Health aspects | Cancer | Cell growth | Chemotherapy | Cytokines | Melanoma | Lymphomas | Radiation therapy | Kinases | Cancer therapies | Deoxyribonucleic acid--DNA | Cell adhesion & migration | Tumors | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2014, Volume 289, Issue 4, pp. 2457 - 2468
Journal Article
Journal Article
by Yu, JP and Wang, Y and Yan, F and Zhang, P and Li, H and Zhao, H and Yan, CH and Ren, XB
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 09/2014, Volume 193, Issue 5, pp. 2574 - 2586
Immunotherapy for cancer treatment is achieved through the activation of competent immune effector cells and the inhibition of immunosuppressive cells, such as... 
LUNG-CANCER | STAT3 ACTIVATION | SIGNALING PATHWAYS | DENDRITIC CELLS | SYNERGISTIC INDUCTION | IFN-GAMMA | INDOLEAMINE 2,3-DIOXYGENASE | IKK-ALPHA | TNF-ALPHA | IMMUNOLOGY | BLOOD MONONUCLEAR-CELLS | Cell Nucleus - immunology | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Triterpenes - pharmacology | Breast Neoplasms - immunology | Humans | Transcription Factor RelB - immunology | Neoplasm Proteins - immunology | Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology | Cell Nucleus - pathology | Myeloid Cells - immunology | Female | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Active Transport, Cell Nucleus - genetics | STAT3 Transcription Factor - genetics | Transcription Factor RelB - genetics | Interleukin-6 - genetics | Protein-Serine-Threonine Kinases - genetics | Gene Expression Regulation, Neoplastic - immunology | Up-Regulation - drug effects | Breast Neoplasms - genetics | Cell Nucleus - genetics | Up-Regulation - immunology | Breast Neoplasms - pathology | Active Transport, Cell Nucleus - drug effects | Interleukin-6 - immunology | Protein-Serine-Threonine Kinases - immunology | Active Transport, Cell Nucleus - immunology | Myeloid Cells - pathology | STAT3 Transcription Factor - immunology | Index Medicus | Abridged Index Medicus | MDSCs | Breast cancer | IDO | STAT3 | Noncanonical NF-κB
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2011, Volume 286, Issue 47, pp. 40725 - 40733
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2003, Volume 100, Issue 7, pp. 3878 - 3882
Journal Article
Stem Cells, ISSN 1066-5099, 2004, Volume 22, Issue 5, pp. 770 - 778
Murine embryonic stem (mES) cells remain undifferentiated in the presence of leukemia inhibitory factor (LIF), and activation of signal transducer and... 
Human embryonic stem cells | Self-renewal | Leukemia inhibitory factor | STAT3 | ACTIVATION | PHOSPHORYLATION | PLURIPOTENCY | HUMAN BLASTOCYSTS | INTERLEUKIN-6 | self-renewal | LINES | POLYPEPTIDES | CELL BIOLOGY | ONCOLOGY | TYROSINE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DIFFERENTIATION | leukemia inhibitory factor | HEMATOLOGY | human embryonic stem cells | Membrane Glycoproteins - metabolism | Humans | Culture Media, Conditioned - pharmacology | Antigens, CD - genetics | Cell Culture Techniques - methods | Protein Subunits - metabolism | Antigens, CD - metabolism | Interleukin-6 | DNA-Binding Proteins - metabolism | Cell Differentiation - genetics | Cell Nucleus - metabolism | Trans-Activators - genetics | Phosphorylation - drug effects | Receptors, Cytokine - metabolism | Active Transport, Cell Nucleus - genetics | Leukemia Inhibitory Factor | Receptors, Cytokine - genetics | Protein Subunits - genetics | Cell Division - genetics | Cell Line | Cytokine Receptor gp130 | Pluripotent Stem Cells - immunology | Gene Expression Regulation - genetics | Signal Transduction - genetics | DNA-Binding Proteins - genetics | Cell Division - drug effects | Leukemia Inhibitory Factor Receptor alpha Subunit | Membrane Glycoproteins - genetics | Gene Expression Regulation - drug effects | Pluripotent Stem Cells - metabolism | Proteins - genetics | Stem Cell Transplantation - methods | Animals | Proteins - metabolism | Cell Nucleus - genetics | Signal Transduction - drug effects | Cell Differentiation - drug effects | Active Transport, Cell Nucleus - drug effects | Pluripotent Stem Cells - drug effects | Trans-Activators - metabolism | Cell Proliferation - drug effects | Mice | Proteins - pharmacology | STAT3 Transcription Factor | Cell Nucleus - drug effects | Receptors, OSM-LIF | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2007, Volume 282, Issue 28, pp. 20621 - 20633
Journal Article
Blood, ISSN 0006-4971, 11/2012, Volume 120, Issue 23, pp. 4621 - 4634
The nuclear export protein XPO1 is overexpressed in cancer, leading to the cytoplasmic mislocalization of multiple tumor suppressor proteins. Existing... 
ANTICANCER ACTIVITY | APOPTOSIS | TRANSPORT | PROTEIN | MECHANISM | RITUXIMAB | DRUG-RESISTANCE | CELL-SURVIVAL | CRM1 | HEMATOLOGY | EXPRESSION | Triazoles - chemistry | Humans | Crystallography, X-Ray | Immunoblotting | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Antineoplastic Agents - metabolism | RNA Interference | T-Lymphocytes - metabolism | Acrylates - metabolism | T-Lymphocytes - drug effects | Acrylates - pharmacology | Receptors, Cytoplasmic and Nuclear - chemistry | Interleukin-10 - metabolism | Antineoplastic Agents - pharmacology | Molecular Structure | Interleukin-6 - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Acrylates - chemistry | Karyopherins - chemistry | Cells, Cultured | Models, Molecular | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Antineoplastic Agents - chemistry | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Triazoles - pharmacology | Microscopy, Confocal | Triazoles - metabolism | Animals | Karyopherins - metabolism | Active Transport, Cell Nucleus - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Cell Line, Tumor | Karyopherins - genetics | Protein Binding | Mice | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus | Abridged Index Medicus | Lymphoid Neoplasia
Journal Article
British Journal of Haematology, ISSN 0007-1048, 04/2013, Volume 161, Issue 1, pp. 117 - 127
This study explored the anti‐leukaemic efficacy of novel irreversible inhibitors of the major nuclear export receptor, chromosome region maintenance 1 ( CRM 1,... 
all | aml | new drugs for leukaemia | new drugs for lymphoma | Acute leukaemia | All | Aml | New drugs for lymphoma | New drugs for leukaemia | NOTCH1 | SIGNALS | RECEPTOR | RESTORATION | CANCER | TRANSPORT | RESISTANCE | MUTATIONS | PROTEINS | HEMATOLOGY | EXPRESSION | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Apoptosis - drug effects | Humans | Leukemia, Myeloid, Acute - metabolism | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Dose-Response Relationship, Drug | Cell Nucleus - metabolism | Leukemia, Myeloid, Acute - drug therapy | Female | Antineoplastic Agents - pharmacology | Blood Cells - drug effects | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Leukemia, Myeloid, Acute - pathology | Nuclear Proteins - metabolism | Mice, SCID | Xenograft Model Antitumor Assays | Animals | Cell Cycle Checkpoints - drug effects | Active Transport, Cell Nucleus - drug effects | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Cell Line, Tumor | Mice, Inbred NOD | Mice | Karyopherins - antagonists & inhibitors | Drug Screening Assays, Antitumor | Models | Enzyme inhibitors | T cells | Tumor proteins | Index Medicus | Drugs | Animal models | Transcription factors | Acute lymphatic leukemia | Toxicity | Immunodeficiency | Antagonists | Lymphocytes T | Mutation | Nuclear transport | p53 protein | Apoptosis
Journal Article