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Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 07/2012, Volume 7, Issue 7, pp. 1086 - 1090
Most clinically available small-molecule kinase inhibitors are multi-targeted and can inhibit multiple kinases. Our driving hypothesis was that one of these... 
ALK | Crizotinib | Non–small-cell lung cancer | Tyrosine kinase | Lung cancer | Kinase inhibitor | Anaplastic lymphoma kinase | ROS1 | Epidermal growth factor receptor | Non-small-cell lung cancer | ONCOLOGY | RESPIRATORY SYSTEM | MUTATIONS | Proto-Oncogene Proteins c-met - metabolism | Activin Receptors, Type II - metabolism | Lung Neoplasms - drug therapy | Translocation, Genetic | Apoptosis - drug effects | Protein-Tyrosine Kinases - metabolism | Humans | Lung Neoplasms - metabolism | Activin Receptors, Type II - antagonists & inhibitors | Lung Neoplasms - pathology | Protein-Tyrosine Kinases - genetics | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Phosphorylation - drug effects | Drug Evaluation, Preclinical | Pyrazoles - pharmacology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Proto-Oncogene Proteins - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Blotting, Western | Cell Line, Tumor | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors | lung cancer | kinase inhibitor | crizotinib | epidermal growth factor receptor | tyrosine kinase | anaplastic lymphoma kinase | EGFR | non-small-cell lung cancer
Journal Article
Cell, ISSN 0092-8674, 2010, Volume 142, Issue 4, pp. 531 - 543
Journal Article
Experimental Hematology, ISSN 0301-472X, 2013, Volume 41, Issue 2, pp. 155 - 166.e17
Red cell production is primarily determined by the action of erythropoietin. Additional erythropoiesis-regulatory factors include molecules and cellular... 
Hematology, Oncology and Palliative Medicine | Advanced Basic Science | GLOBIN GENE-EXPRESSION | SYSTEM | MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN | HEMATOPOIESIS | VEGF | BONE-MARROW | PROLIFERATION | GROWTH-FACTOR | ANEMIA | HEMATOLOGY | ERYTHROID PROGENITORS | Erythroid Precursor Cells - drug effects | Cells, Cultured - cytology | Humans | Culture Media, Conditioned - chemistry | Activin Receptors, Type II - antagonists & inhibitors | Blood Cells - metabolism | Erythropoiesis - drug effects | Gene Expression Profiling | K562 Cells - drug effects | Recombinant Fusion Proteins | RNA, Messenger - biosynthesis | Blood Cells - cytology | Stromal Cells - drug effects | Adult | Bone Marrow Cells - drug effects | Colony-Forming Units Assay | Drug Evaluation, Preclinical | Blood Cells - drug effects | Cytokines - genetics | Cells, Cultured - drug effects | Erythroid Precursor Cells - cytology | Bone Marrow Cells - cytology | Cytokines - secretion | Fetal Blood - cytology | Organ Specificity | Erythropoiesis - physiology | K562 Cells - cytology | K562 Cells - metabolism | Erythroid Precursor Cells - metabolism | Ligands | Cells, Cultured - metabolism | In Vitro Techniques | Stromal Cells - physiology | Bone Marrow Cells - metabolism | Cytokines - biosynthesis | Hemoglobin | Osteoporosis | Medical colleges | Erythropoietin | Transforming growth factors
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 08/2017, Volume 292, Issue 33, pp. 13714 - 13726
Bone morphogenetic proteins 9 and 10 (BMP9/BMP10) are circulating cytokines with important roles in endothelial homeostasis. The aim of this study was to... 
ADHESION | LEUKOCYTE RECRUITMENT | INHIBITION | GENE | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CALCIFICATION | TNF-ALPHA | HYPERTENSION | EXPRESSION | ALK1 | Activin Receptors, Type I - antagonists & inhibitors | Endothelium, Vascular - cytology | Tumor Necrosis Factor-alpha - metabolism | Activin Receptors, Type II - metabolism | Monocytes - cytology | Humans | Activin Receptors, Type II - antagonists & inhibitors | Endothelium, Vascular - drug effects | Monocytes - metabolism | Monocytes - immunology | Tumor Necrosis Factor-alpha - agonists | Bone Morphogenetic Proteins - metabolism | Protein Processing, Post-Translational - drug effects | RNA Interference | E-Selectin - genetics | Aorta | Vascular Cell Adhesion Molecule-1 - genetics | Phosphorylation - drug effects | Endothelium, Vascular - immunology | Pyrazoles - pharmacology | Cells, Cultured | Activin Receptors, Type I - metabolism | E-Selectin - metabolism | Pyrimidines - pharmacology | Cell Adhesion - drug effects | Activin Receptors, Type I - genetics | Vascular Cell Adhesion Molecule-1 - chemistry | Monocytes - drug effects | Up-Regulation - drug effects | Growth Differentiation Factors - metabolism | Intercellular Adhesion Molecule-1 - metabolism | Intercellular Adhesion Molecule-1 - chemistry | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Intercellular Adhesion Molecule-1 - genetics | Activin Receptors, Type II - genetics | E-Selectin - chemistry | Protein Kinase Inhibitors - pharmacology | Kinetics | Vascular Cell Adhesion Molecule-1 - metabolism | atherosclerosis | monocyte | SMAD transcription factor | bone morphogenetic protein (BMP) | endothelial cell | Cell Biology
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 07/2017, Volume 23, Issue 14, pp. 3557 - 3565
Purpose: Activin receptor-like kinase 1 (ALK1) is a novel target in angiogenesis. Concurrent targeting of ALK1 and VEGF signaling results in augmented... 
INTERFERON-ALPHA | HEREDITARY HEMORRHAGIC TELANGIECTASIA | EVEROLIMUS | ONCOLOGY | KINASE-1 LIGAND TRAP | SUNITINIB | RECEPTOR | OPEN-LABEL | PHASE-2 | ANTITUMOR-ACTIVITY | ALK1 | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Recombinant Fusion Proteins - adverse effects | Humans | Middle Aged | Activin Receptors, Type II - antagonists & inhibitors | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Carcinoma, Renal Cell - genetics | Imidazoles - administration & dosage | Male | Indazoles - administration & dosage | Protein Kinase Inhibitors - adverse effects | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Immunoglobulin Fc Fragments - administration & dosage | Vascular Endothelial Growth Factor A - genetics | Dose-Response Relationship, Drug | Angiogenesis Inhibitors - administration & dosage | Activin Receptors, Type II - administration & dosage | Female | Carcinoma, Renal Cell - drug therapy | Angiogenesis Inhibitors - adverse effects | Immunoglobulin Fc Fragments - adverse effects | Recombinant Fusion Proteins - administration & dosage | Carcinoma, Renal Cell - pathology | Imidazoles - adverse effects | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Activin Receptors, Type II - genetics | Aged | Indazoles - adverse effects | Neoplasm Staging | Activin Receptors, Type II - adverse effects | Cell culture | Toxicity | Syngeneic grafts | Medical services | Kinases | Anticancer properties | Proteins | Angiogenesis | Allografts | Quality | Safety engineering | Xenografts | Bone morphogenetic proteins | Safety | Fusion protein | Vascular endothelial growth factor | Protein-tyrosine kinase | Tyrosine | Edema | Pharmacodynamics | Effusion | Diarrhea | Fatigue | Pharmacology | Patients | Vascular endothelial growth factor receptors | Intolerance | Signaling | Experimental design | Antitumor activity | Pharmacokinetics | Activin | Clear cell-type renal cell carcinoma | Cancer | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 02/2011, Volume 71, Issue 4, pp. 1362 - 1373
Journal Article
Neurology, ISSN 0028-3878, 12/2014, Volume 83, Issue 24, pp. 2239 - 2246
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 05/2017, Volume 41, Issue 2, pp. 439 - 450
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 07/2012, Volume 32, Issue 14, pp. 2871 - 2879
Journal Article
Biochemical Society Transactions, ISSN 0300-5127, 08/2016, Volume 44, Issue 4, pp. 1142 - 1149