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Journal Article
Journal Article
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 4, pp. 398 - 407
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 01/2010, Volume 207, Issue 1, pp. 85 - 100
Members of the transforming growth factor beta (TGF-beta) family have been genetically linked to vascular formation during embryogenesis. However,... 
MEDICINE, RESEARCH & EXPERIMENTAL | HEREDITARY HEMORRHAGIC TELANGIECTASIA | EPITHELIAL-CELLS | BONE MORPHOGENETIC PROTEIN | COLORECTAL-CANCER | ENDOTHELIAL-CELLS | MOUSE MODEL | TRANSFORMING GROWTH-FACTOR-BETA-1 | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | TGF-BETA RECEPTOR | IMMUNOLOGY | RENAL-CELL CARCINOMA | Activin Receptors, Type II - metabolism | Growth Differentiation Factor 2 - metabolism | Recombinant Fusion Proteins - pharmacology | Humans | Growth Differentiation Factor 2 - genetics | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Neovascularization, Pathologic - pathology | Activin Receptors, Type I - pharmacology | Activin Receptors, Type II - pharmacology | Neoplasms, Experimental - genetics | Fibroblast Growth Factor 2 - metabolism | Growth Differentiation Factors - genetics | Transforming Growth Factor beta | Cell Line | Gene Dosage - genetics | Endothelial Cells - metabolism | Activin Receptors, Type I - metabolism | Mice, Transgenic | Signal Transduction - genetics | Activin Receptors, Type I - genetics | Growth Differentiation Factors - metabolism | Animals | Fibroblast Growth Factor 2 - genetics | Signal Transduction - drug effects | Neovascularization, Pathologic - drug therapy | Activin Receptors, Type II - genetics | Immunoglobulin Fc Fragments - pharmacology | Recombinant Fusion Proteins - genetics | Neovascularization, Pathologic - genetics | Mice | Neovascularization, Pathologic - metabolism | Neoplasms, Experimental - metabolism | Endothelial Cells - pathology | Immunoglobulin Fc Fragments - genetics | Neoplasms, Experimental - drug therapy | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Kidney International, ISSN 0085-2538, 01/2018, Volume 93, Issue 1, pp. 147 - 158
We examined activin receptor type IIA (ActRIIA) activation in chronic kidney disease (CKD) by signal analysis and inhibition in mice with Alport syndrome using... 
cardiovascular disease | chronic kidney disease | bone | fibrosis | mineral metabolism | vascular calcification | TGF-BETA | CARDIOVASCULAR EVENTS | RENAL FIBROSIS | ARTERIAL CALCIFICATION | BONE MORPHOGENETIC PROTEIN-7 | GROWTH-FACTOR 23 | UROLOGY & NEPHROLOGY | SMOOTH-MUSCLE-CELLS | LINKED ALPORT-SYNDROME | OSTEOCLAST DIFFERENTIATION | ATHEROSCLEROTIC LESION | Kidney - pathology | Recombinant Fusion Proteins - pharmacology | Blood Vessels - metabolism | Chronic Kidney Disease-Mineral and Bone Disorder - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Chronic Kidney Disease-Mineral and Bone Disorder - genetics | Vascular Calcification - metabolism | Kidney - metabolism | Bone Resorption - genetics | Bone and Bones - metabolism | Myocardium - metabolism | Renal Insufficiency, Chronic - genetics | Bone Resorption - metabolism | Disease Models, Animal | Bone Resorption - physiopathology | Glomerular Filtration Rate | Signal Transduction | Smad2 Protein - metabolism | Cardiomegaly - physiopathology | Nephritis, Hereditary - genetics | Renal Insufficiency, Chronic - physiopathology | Mice, Knockout | Renal Insufficiency, Chronic - prevention & control | Cardiomegaly - prevention & control | Nephritis, Hereditary - metabolism | Collagen Type IV - deficiency | Activin Receptors, Type II - genetics | Fibrosis | Sp7 Transcription Factor - metabolism | Collagen Type IV - genetics | Cardiomegaly - metabolism | Activin Receptors, Type II - metabolism | Bone and Bones - pathology | Phosphorylation | Vascular Remodeling | Blood Vessels - pathology | Vascular Calcification - genetics | Actins - metabolism | Chronic Kidney Disease-Mineral and Bone Disorder - physiopathology | Activin Receptors, Type II - antagonists & inhibitors | Blood Vessels - physiopathology | Renal Insufficiency, Chronic - metabolism | Ventricular Remodeling | Chronic Kidney Disease-Mineral and Bone Disorder - prevention & control | Muscle Proteins - metabolism | Vascular Calcification - physiopathology | Microfilament Proteins - metabolism | Nephritis, Hereditary - physiopathology | Kidney - physiopathology | Vascular Calcification - prevention & control | Myocardium - pathology | Bone Resorption - prevention & control | Bone and Bones - physiopathology | Animals | Nephritis, Hereditary - drug therapy | Cardiomegaly - genetics | Bone Remodeling | Chronic kidney disease
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2016, Volume 291, Issue 7, pp. 3395 - 3410
By non-covalent association after proteolytic cleavage, the pro-domains modulate the activities of the mature growth factor domains across the transforming... 
SUPPRESSES TUMOR-GROWTH | HEREDITARY HEMORRHAGIC TELANGIECTASIA | ANGIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PRODOMAIN | bone morphogenetic protein (BMP) | surface plasmon resonance (SPR) | BMP9 | protein complex | IDENTIFICATION | MESENCHYMAL STEM-CELLS | homeostasis | transforming growth factor (TGF-B) | KINASE 1 ALK1 | MUTATIONS | TGF-BETA-1 | Activin Receptors, Type II - metabolism | Growth Differentiation Factor 2 - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Protein Precursors - blood | Protein Precursors - chemistry | Humans | Growth Differentiation Factors - blood | Antigens, CD - genetics | Recombinant Fusion Proteins - metabolism | Antigens, CD - metabolism | Endoglin | Human Umbilical Vein Endothelial Cells - cytology | HEK293 Cells | Female | Growth Differentiation Factors - genetics | Receptors, Cell Surface - chemistry | Antigens, CD - chemistry | Protein Interaction Domains and Motifs | Dimerization | Growth Differentiation Factor 2 - blood | Peptide Fragments - genetics | Activin Receptors, Type II - chemistry | Recombinant Proteins - metabolism | Growth Differentiation Factor 2 - isolation & purification | Peptide Fragments - metabolism | Protein Precursors - genetics | Specific Pathogen-Free Organisms | Bone Morphogenetic Protein Receptors, Type II - genetics | Signal Transduction | Peptide Fragments - isolation & purification | Cells, Cultured | Models, Molecular | Receptors, Cell Surface - metabolism | Recombinant Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Bone Morphogenetic Protein Receptors, Type II - metabolism | Protein Precursors - metabolism | Growth Differentiation Factors - metabolism | Animals | Peptide Fragments - agonists | Activin Receptors, Type II - genetics | Mice, Inbred BALB C | Bone Morphogenetic Protein Receptors, Type II - chemistry | Growth Differentiation Factors - chemistry | Receptors, Cell Surface - genetics | transforming growth factor β (TGF-B) | Cell Biology
Journal Article
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 08/2012, Volume 359, Issue 1-2, pp. 2 - 12
Journal Article
STEM CELLS, ISSN 1066-5099, 05/2014, Volume 32, Issue 5, pp. 1289 - 1300
Bone morphogenetic protein (BMP) signaling is a critical regulator of cartilage differentiation and endochondral ossification. Gain‐of‐function mutations in... 
Fibrodysplasia ossificans progressiva | Bone morphogenetic protein signaling | Chondrogenesis | Endochondral ossification | Alk2 | PROGENITOR CELLS | STEM-CELLS | R206H MUTATION | I RECEPTOR | OSTEOGENIC DIFFERENTIATION | CHONDROCYTE DIFFERENTIATION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | CARTILAGE FORMATION | MOUSE EMBRYONIC FIBROBLASTS | ONCOLOGY | BONE-FORMATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | STROMAL CELLS | HEMATOLOGY | Chondrocytes - cytology | Chondrogenesis - drug effects | Chondrogenesis - genetics | Immunoblotting | Embryo, Mammalian - metabolism | Cell Differentiation - genetics | Mesenchymal Stromal Cells - cytology | Time Factors | Ossification, Heterotopic - metabolism | Myositis Ossificans - pathology | Chondrocytes - metabolism | Fibroblasts - metabolism | Myositis Ossificans - metabolism | Bone Morphogenetic Protein Receptors, Type II - genetics | Ossification, Heterotopic - pathology | Mice, Inbred C57BL | Cells, Cultured | Bone Morphogenetic Protein Receptors, Type I - genetics | Mesenchymal Stromal Cells - metabolism | Activin Receptors, Type I - metabolism | Mice, Transgenic | Signal Transduction - genetics | Bone Morphogenetic Protein Receptors, Type I - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Activin Receptors, Type I - genetics | Bone Morphogenetic Protein 4 - pharmacology | Bone Morphogenetic Protein Receptors, Type II - metabolism | Mice, Knockout | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Embryo, Mammalian - cytology | Myositis Ossificans - genetics | Fibroblasts - cytology | Ossification, Heterotopic - genetics | Bone morphogenetic proteins | Stem cells | Rodents | Mutation
Journal Article
Journal Article