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Cell Metabolism, ISSN 1550-4131, 02/2017, Volume 25, Issue 2, pp. 386 - 399
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 06/2009, Volume 296, Issue 6, pp. 1258 - 1270
Myostatin is a negative regulator of skeletal muscle size, previously shown to inhibit muscle cell differentiation. Myostatin requires both Smad2 and Smad3... 
MAFbx | Mammalian target of rapamycin complex signaling | MuRF1 | S6 kinase | Smad signaling | Human skeletal muscle cells | Transducer of regulated Ca | responsive element-binding protein activity | MuRF-1 | Atrogin | Transforming growth factor-β-like molecules | IGF-I | PHYSIOLOGY | ATROPHY | RAPID DISUSE | human skeletal muscle cells | transforming growth factor-beta-like molecules | SKELETAL-MUSCLE HYPERTROPHY | FOXO TRANSCRIPTION FACTORS | UBIQUITIN LIGASES | transducer of regulated Ca2+-responsive element-binding protein activity | CELL BIOLOGY | atrogin | PATHWAY | GROWTH | GENE-EXPRESSION | mammalian target of rapamycin complex signaling | CONDITIONAL ACTIVATION | Activin Receptors, Type I - antagonists & inhibitors | Protein Kinases - metabolism | Phosphorylation | Protein Kinases - genetics | Humans | Smad3 Protein - metabolism | Muscle Fibers, Skeletal - drug effects | Tripartite Motif Proteins | Smad3 Protein - genetics | Transfection | RNA Interference | Myoblasts, Skeletal - pathology | Smad2 Protein - genetics | Muscle Proteins - metabolism | Dioxoles - pharmacology | Regulatory-Associated Protein of mTOR | Benzamides - pharmacology | Myostatin - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Rapamycin-Insensitive Companion of mTOR Protein | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Signal Transduction | Cell Size - drug effects | Cells, Cultured | Smad2 Protein - metabolism | Ubiquitin-Protein Ligases - metabolism | Organ Size | Activin Receptors, Type I - metabolism | Myoblasts, Skeletal - enzymology | SKP Cullin F-Box Protein Ligases - metabolism | Mice, SCID | Myostatin - antagonists & inhibitors | Adaptor Proteins, Signal Transducing | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Cell Differentiation - drug effects | Follistatin - pharmacology | Muscle Fibers, Skeletal - pathology | Creatine Kinase - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | TOR Serine-Threonine Kinases | Myoblasts, Skeletal - drug effects | Insulin-Like Growth Factor I - metabolism | Muscle Fibers, Skeletal - enzymology | RNA, Small Interfering - metabolism | Abdominal surgery | Musculoskeletal system | Signal transduction | Cell growth | Kinases | Gene expression | Cells | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 2002, Volume 10, Issue 3, pp. 483 - 493
Smad proteins regulate gene expression in response to TGFβ signaling. Here we present evidence that Smad7 interacts with the transcriptional coactivator p300,... 
GROWTH-FACTOR-BETA | SIGNALING PATHWAYS | ACTIVATION | TGF-BETA | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEGRADATION | RECEPTOR | C-TERMINAL DOMAIN | TRANSCRIPTIONAL COACTIVATOR | LIGASE COMPLEX | P53 | CELL BIOLOGY | Receptors, Transforming Growth Factor beta - genetics | Humans | Protein-Serine-Threonine Kinases | Ubiquitin - metabolism | Molecular Sequence Data | Recombinant Fusion Proteins - metabolism | DNA-Binding Proteins - metabolism | Trans-Activators - genetics | Lysine - metabolism | Acetylation | Nuclear Proteins - genetics | Smad7 Protein | Amino Acid Sequence | Cell Line | Ligases - metabolism | Activin Receptors, Type I - metabolism | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Activin Receptors, Type I - genetics | Proto-Oncogene Proteins c-myc - metabolism | Ubiquitin-Protein Ligases | Animals | Receptors, Transforming Growth Factor beta - metabolism | Protein Binding | Recombinant Fusion Proteins - genetics | Signal Transduction - physiology | Trans-Activators - metabolism | Proto-Oncogene Proteins c-myc - genetics | Mutation | Transforming Growth Factor beta - metabolism | Index Medicus | DNA-Binding Proteins/genetics/metabolism | Proto-Oncogene Proteins c-myc/genetics/metabolism | Medical and Health Sciences | Transforming Growth Factor beta/metabolism | Medicin och hälsovetenskap | Lysine/metabolism | Receptors; Transforming Growth Factor beta/genetics/metabolism | Activin Receptors; Type I/genetics/metabolism | Nuclear Proteins/genetics/metabolism | Signal Transduction/physiology | Ligases/metabolism | Trans-Activators/genetics/metabolism | Recombinant Fusion Proteins/genetics/metabolism | Ubiquitin/metabolism
Journal Article
Kidney International, ISSN 0085-2538, 01/2018, Volume 93, Issue 1, pp. 147 - 158
We examined activin receptor type IIA (ActRIIA) activation in chronic kidney disease (CKD) by signal analysis and inhibition in mice with Alport syndrome using... 
cardiovascular disease | chronic kidney disease | bone | fibrosis | mineral metabolism | vascular calcification | TGF-BETA | CARDIOVASCULAR EVENTS | RENAL FIBROSIS | ARTERIAL CALCIFICATION | BONE MORPHOGENETIC PROTEIN-7 | GROWTH-FACTOR 23 | UROLOGY & NEPHROLOGY | SMOOTH-MUSCLE-CELLS | LINKED ALPORT-SYNDROME | OSTEOCLAST DIFFERENTIATION | ATHEROSCLEROTIC LESION | Kidney - pathology | Recombinant Fusion Proteins - pharmacology | Blood Vessels - metabolism | Chronic Kidney Disease-Mineral and Bone Disorder - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Chronic Kidney Disease-Mineral and Bone Disorder - genetics | Vascular Calcification - metabolism | Kidney - metabolism | Bone Resorption - genetics | Bone and Bones - metabolism | Myocardium - metabolism | Renal Insufficiency, Chronic - genetics | Bone Resorption - metabolism | Disease Models, Animal | Bone Resorption - physiopathology | Glomerular Filtration Rate | Signal Transduction | Smad2 Protein - metabolism | Cardiomegaly - physiopathology | Nephritis, Hereditary - genetics | Renal Insufficiency, Chronic - physiopathology | Mice, Knockout | Renal Insufficiency, Chronic - prevention & control | Cardiomegaly - prevention & control | Nephritis, Hereditary - metabolism | Collagen Type IV - deficiency | Activin Receptors, Type II - genetics | Fibrosis | Sp7 Transcription Factor - metabolism | Collagen Type IV - genetics | Cardiomegaly - metabolism | Activin Receptors, Type II - metabolism | Bone and Bones - pathology | Phosphorylation | Vascular Remodeling | Blood Vessels - pathology | Vascular Calcification - genetics | Actins - metabolism | Chronic Kidney Disease-Mineral and Bone Disorder - physiopathology | Activin Receptors, Type II - antagonists & inhibitors | Blood Vessels - physiopathology | Renal Insufficiency, Chronic - metabolism | Ventricular Remodeling | Chronic Kidney Disease-Mineral and Bone Disorder - prevention & control | Muscle Proteins - metabolism | Vascular Calcification - physiopathology | Microfilament Proteins - metabolism | Nephritis, Hereditary - physiopathology | Kidney - physiopathology | Vascular Calcification - prevention & control | Myocardium - pathology | Bone Resorption - prevention & control | Bone and Bones - physiopathology | Animals | Nephritis, Hereditary - drug therapy | Cardiomegaly - genetics | Bone Remodeling | Index Medicus | Chronic kidney disease
Journal Article
Journal Article
Circulation Research, ISSN 0009-7330, 10/2014, Volume 115, Issue 9, pp. 800 - 809
RATIONALE:Adipose stromal cells (ASC) are therapeutically potent progenitor cells that possess properties of pericytes. In vivo, ASC in combination with... 
Activin A | Adipose tissue | Coculture techniques | Smooth muscle | Neovascularization | Endothelial cells | Mesenchymal stem cells | PROGENITOR CELLS | CARDIAC-FUNCTION | endothelial cells | VASCULAR NETWORK FORMATION | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | neovascularization | HEPATOCYTE GROWTH-FACTOR | CORD BLOOD | TISSUE | adipose tissue | smooth muscle | MESENCHYMAL STEM-CELLS | IFATS COLLECTION | coculture techniques | mesenchymal stem cells | activin A | IN-VIVO | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Up-Regulation | Phosphorylation | Coculture Techniques | Humans | Transforming Growth Factor beta1 - metabolism | Actins - metabolism | Adipose Tissue - cytology | Follistatin - metabolism | Activins - metabolism | Adipose Tissue - metabolism | Time Factors | Muscle Proteins - metabolism | Cell Differentiation | Microfilament Proteins - metabolism | Myocytes, Smooth Muscle - metabolism | Protein-Serine-Threonine Kinases - metabolism | Calcium-Binding Proteins - metabolism | Signal Transduction | Endothelial Cells - metabolism | Cells, Cultured | Smad2 Protein - metabolism | Cell Communication | Mesenchymal Stromal Cells - metabolism | Activin Receptors, Type I - metabolism | Cell Lineage | Receptors, Transforming Growth Factor beta - metabolism | Neovascularization, Physiologic | Cell Movement | Index Medicus
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 01/2013, Volume 33, Issue 1, pp. 121 - 130
OBJECTIVE—Inflammatory activation of valve endothelium is an early phase of aortic valve disease pathogenesis, but subsequent mechanisms are poorly understood.... 
calcification | invasion | transforming growth factor-β | smooth muscle actin | tumor necrosis factor-α | PROGENITOR CELLS | ENDOCARDIAL CUSHION TISSUE | SWINE | AORTIC-VALVE | FACTOR-KAPPA-B | INTERSTITIAL-CELLS | transforming growth factor-beta | tumor necrosis factor-alpha | ARTERIAL | CONGENITAL HEART-DISEASE | RECEPTOR ACTIVATOR | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Heart Valve Diseases - pathology | Humans | Transforming Growth Factor beta1 - metabolism | NF-kappa B - metabolism | Epithelial-Mesenchymal Transition - genetics | Heart Valve Diseases - immunology | Aortic Valve - pathology | Inflammation - metabolism | Transfection | Time Factors | Swine | Inflammation Mediators - metabolism | Calcinosis - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-6 - metabolism | Protein-Serine-Threonine Kinases - metabolism | Aortic Valve - immunology | Recombinant Proteins - metabolism | Signal Transduction | Endothelial Cells - metabolism | Aortic Valve - embryology | Cells, Cultured | Gene Expression Regulation | Activin Receptors, Type I - metabolism | Inflammation - immunology | Quail | Aortic Valve - metabolism | Chick Embryo | Endothelial Cells - immunology | Animals | NF-kappa B - genetics | Receptors, Transforming Growth Factor beta - metabolism | Heart Valve Diseases - metabolism | Heart Valve Diseases - genetics | Inflammation - genetics | Calcinosis - immunology | Primary Cell Culture | Calcinosis - pathology | Endothelial Cells - pathology | Cell Movement | Index Medicus
Journal Article
Cell Stem Cell, ISSN 1934-5909, 2011, Volume 9, Issue 5, pp. 433 - 446
Journal Article
Journal Article
Osteoarthritis and Cartilage, ISSN 1063-4584, 2015, Volume 24, Issue 2, pp. 315 - 324
Summary Objective The aetiology of OA is not fully understood although several adipokines such as leptin are known mediators of disease progression. Since... 
Rheumatology | Smad1 | Human chondrocytes | Hip osteoarthritis | β-Catenin | Dedifferentiation | Leptin | COLLAGEN | RHEUMATOLOGY | DIFFERENTIATED PHENOTYPE | HYPERTROPHY | IN-VITRO | SYNOVIAL FIBROBLASTS | HUMAN OSTEOARTHRITIC CARTILAGE | SIGNALING PATHWAY | beta-Catenin | ARTICULAR CHONDROCYTES | ORTHOPEDICS | KNEE OSTEOARTHRITIS | EXPRESSION | Receptors, Transforming Growth Factor beta - genetics | Humans | Leptin - metabolism | Middle Aged | Male | Lymphotoxin-alpha - metabolism | RNA, Messenger - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Lymphotoxin-alpha - genetics | Cartilage, Articular - metabolism | Smad5 Protein - metabolism | Smad2 Protein - genetics | Aged, 80 and over | Smad2 Protein - drug effects | Protein-Serine-Threonine Kinases - metabolism | Collagen Type X - drug effects | SOX9 Transcription Factor - metabolism | Matrix Metalloproteinase 13 - genetics | Smad2 Protein - metabolism | Prednisolone - pharmacology | beta Catenin - metabolism | Matrix Metalloproteinase 13 - metabolism | Glycogen Synthase Kinase 3 - genetics | Receptors, Transforming Growth Factor beta - drug effects | Activin Receptors, Type II - genetics | Protein-Serine-Threonine Kinases - drug effects | Activin Receptors, Type II - metabolism | Osteoarthritis, Hip - metabolism | Glycogen Synthase Kinase 3 - drug effects | Activin Receptors, Type II - drug effects | Chondrocytes - drug effects | Collagen Type X - metabolism | beta Catenin - drug effects | Smad1 Protein - genetics | Adult | Female | Smad5 Protein - genetics | Chondrocytes - metabolism | RNA, Messenger - drug effects | Cell Dedifferentiation - drug effects | Cartilage, Articular - cytology | Lymphotoxin-alpha - drug effects | Protein-Serine-Threonine Kinases - genetics | Collagen Type X - genetics | SOX9 Transcription Factor - drug effects | Matrix Metalloproteinase 13 - drug effects | Glycogen Synthase Kinase 3 - metabolism | beta Catenin - genetics | Osteoarthritis, Hip - genetics | Smad5 Protein - drug effects | Core Binding Factor Alpha 1 Subunit - drug effects | Wnt Signaling Pathway - drug effects | Receptors, Transforming Growth Factor beta - metabolism | Wnt Signaling Pathway - genetics | Glucocorticoids - pharmacology | Smad1 Protein - metabolism | Aged | Smad1 Protein - drug effects | Cartilage, Articular - drug effects | In Vitro Techniques | Cell Dedifferentiation - genetics | Core Binding Factor Alpha 1 Subunit - genetics | Index Medicus
Journal Article
Molecular Endocrinology, ISSN 0888-8809, 03/2004, Volume 18, Issue 3, pp. 653 - 665
Growth differentiation factor-9 (GDF-9) is an oocyte-derived growth factor and a member of the TGF-β superfamily that includes TGF-β, activin, and bone... 
ALK7 SIGNALS | BONE MORPHOGENETIC PROTEIN | MAD-RELATED PROTEIN | ENDOCRINOLOGY & METABOLISM | OSTEOGENIC PROTEIN-1 | FOLLICULAR-GROWTH | TGF-BETA RECEPTOR | OVARIAN GRANULOSA-CELLS | IDENTIFICATION | HOMOLOG GDF-9B | LUTEAL CELLS | Phosphorylation | Receptors, Transforming Growth Factor beta - genetics | Trans-Activators - drug effects | Protein-Serine-Threonine Kinases | Activin Receptors - drug effects | Activins - metabolism | COS Cells - drug effects | Activin Receptors - genetics | Granulosa Cells - drug effects | Granulosa Cells - metabolism | COS Cells - metabolism | DNA-Binding Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Bone Morphogenetic Proteins - metabolism | Growth Differentiation Factor 9 | Trans-Activators - genetics | Female | Smad7 Protein | Promoter Regions, Genetic | Signal Transduction | Smad6 Protein | Cells, Cultured | DNA-Binding Proteins - drug effects | Rats | Activin Receptors, Type I - metabolism | DNA-Binding Proteins - genetics | Activin Receptors, Type I - genetics | Rats, Sprague-Dawley | Activin Receptors, Type I - drug effects | Transforming Growth Factor beta - pharmacology | Bone Morphogenetic Protein 15 | Smad3 Protein | Activin Receptors - metabolism | Animals | Activins - pharmacology | Receptors, Transforming Growth Factor beta - drug effects | Receptors, Transforming Growth Factor beta - metabolism | Intercellular Signaling Peptides and Proteins - pharmacology | Smad Proteins | Trans-Activators - metabolism | RNA, Small Interfering | Transforming Growth Factor beta - metabolism | Smad2 Protein | Index Medicus
Journal Article
Journal of Cell Science, ISSN 0021-9533, 10/2005, Volume 118, Issue 19, pp. 4495 - 4509
Journal Article