Development, ISSN 0950-1991, 05/2010, Volume 137, Issue 10, pp. 1645 - 1655
Apical constriction is a major mechanism underlying tissue internalization during development. This cell constriction typically requires actomyosin...
Amnioserosa | Apical constriction | Par proteins | Drosophila | Myosin | PAR proteins | DORSAL CLOSURE | EPITHELIAL-CELL POLARITY | DEVELOPMENTAL BIOLOGY | BAZOOKA | GASTRULATION | DENDRITIC SPINE MORPHOGENESIS | NONMUSCLE MYOSIN-II | CRUMBS | C-ELEGANS | PROTEINS | PLANAR POLARITY | Protein Kinase C - genetics | Actins - metabolism | Multiprotein Complexes - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Cell Movement - genetics | Cell Movement - physiology | Drosophila - physiology | Actomyosin - genetics | Multiprotein Complexes - metabolism | Drosophila Proteins - physiology | Protein Kinase C - metabolism | Protein Multimerization - physiology | Actomyosin - physiology | Protein Multimerization - genetics | Drosophila - embryology | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Drosophila - genetics | Cytoplasmic Streaming - physiology | Protein Kinase C - physiology | Animals, Genetically Modified | Actomyosin - metabolism | Body Patterning - physiology | Multiprotein Complexes - physiology | Cell Polarity - genetics | Animals | Embryo, Nonmammalian | Cell Polarity - physiology | Drosophila - metabolism | Drosophila Proteins - genetics | Intracellular Signaling Peptides and Proteins - physiology | Body Patterning - genetics | Protein Binding - physiology
Amnioserosa | Apical constriction | Par proteins | Drosophila | Myosin | PAR proteins | DORSAL CLOSURE | EPITHELIAL-CELL POLARITY | DEVELOPMENTAL BIOLOGY | BAZOOKA | GASTRULATION | DENDRITIC SPINE MORPHOGENESIS | NONMUSCLE MYOSIN-II | CRUMBS | C-ELEGANS | PROTEINS | PLANAR POLARITY | Protein Kinase C - genetics | Actins - metabolism | Multiprotein Complexes - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Cell Movement - genetics | Cell Movement - physiology | Drosophila - physiology | Actomyosin - genetics | Multiprotein Complexes - metabolism | Drosophila Proteins - physiology | Protein Kinase C - metabolism | Protein Multimerization - physiology | Actomyosin - physiology | Protein Multimerization - genetics | Drosophila - embryology | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Drosophila - genetics | Cytoplasmic Streaming - physiology | Protein Kinase C - physiology | Animals, Genetically Modified | Actomyosin - metabolism | Body Patterning - physiology | Multiprotein Complexes - physiology | Cell Polarity - genetics | Animals | Embryo, Nonmammalian | Cell Polarity - physiology | Drosophila - metabolism | Drosophila Proteins - genetics | Intracellular Signaling Peptides and Proteins - physiology | Body Patterning - genetics | Protein Binding - physiology
Journal Article
Circulation Research, ISSN 0009-7330, 2015, Volume 116, Issue 5, pp. 895 - 908
Vascular stiffness is a mechanical property of the vessel wall that affects blood pressure, permeability, and inflammation. As a result, vascular stiffness is...
Cellular mechanotransduction | Inflammation | Permeability | Cardiovascular diseases | Cell adhesion | cellular mechanotransduction | DEPENDENT DIABETES-MELLITUS | CARDIAC & CARDIOVASCULAR SYSTEMS | PULMONARY ARTERIAL-HYPERTENSION | FLUID SHEAR-STRESS | permeability | THORACIC AORTIC-ANEURYSMS | ALPHA-CARDIAC ACTIN | cardiovascular diseases | LIGHT-CHAIN PHOSPHORYLATION | ATOMIC-FORCE MICROSCOPY | inflammation | cell adhesion | PERIPHERAL VASCULAR DISEASE | PATENT DUCTUS-ARTERIOSUS | SMOOTH-MUSCLE-CELLS | APICAL HYPERTROPHIC CARDIOMYOPATHY | HEMATOLOGY | rho GTP-Binding Proteins - antagonists & inhibitors | Mechanotransduction, Cellular - drug effects | Pulse Wave Analysis | Humans | Cell Membrane Permeability | NF-kappa B - metabolism | Leukocytes - physiology | Cardiovascular Diseases - enzymology | Hemorheology | Mechanotransduction, Cellular - physiology | rho-Associated Kinases - antagonists & inhibitors | Endothelium, Vascular - ultrastructure | Microcirculation | Myosin-Light-Chain Phosphatase - antagonists & inhibitors | Transendothelial and Transepithelial Migration | Actomyosin - physiology | Myosin-Light-Chain Phosphatase - physiology | Integrins - physiology | rho-Associated Kinases - physiology | Cardiovascular Diseases - physiopathology | Models, Cardiovascular | Endothelium, Vascular - physiopathology | Rats | Cytoskeleton - ultrastructure | rho GTP-Binding Proteins - physiology | Mice, Knockout | Animals | Aging - physiology | Cell Adhesion - physiology | Protein Kinase Inhibitors - therapeutic use | Vascular Stiffness - drug effects | Vascular Stiffness - physiology | Mice | Protein Kinase Inhibitors - pharmacology | Calcinosis - pathology | Calcinosis - physiopathology
Cellular mechanotransduction | Inflammation | Permeability | Cardiovascular diseases | Cell adhesion | cellular mechanotransduction | DEPENDENT DIABETES-MELLITUS | CARDIAC & CARDIOVASCULAR SYSTEMS | PULMONARY ARTERIAL-HYPERTENSION | FLUID SHEAR-STRESS | permeability | THORACIC AORTIC-ANEURYSMS | ALPHA-CARDIAC ACTIN | cardiovascular diseases | LIGHT-CHAIN PHOSPHORYLATION | ATOMIC-FORCE MICROSCOPY | inflammation | cell adhesion | PERIPHERAL VASCULAR DISEASE | PATENT DUCTUS-ARTERIOSUS | SMOOTH-MUSCLE-CELLS | APICAL HYPERTROPHIC CARDIOMYOPATHY | HEMATOLOGY | rho GTP-Binding Proteins - antagonists & inhibitors | Mechanotransduction, Cellular - drug effects | Pulse Wave Analysis | Humans | Cell Membrane Permeability | NF-kappa B - metabolism | Leukocytes - physiology | Cardiovascular Diseases - enzymology | Hemorheology | Mechanotransduction, Cellular - physiology | rho-Associated Kinases - antagonists & inhibitors | Endothelium, Vascular - ultrastructure | Microcirculation | Myosin-Light-Chain Phosphatase - antagonists & inhibitors | Transendothelial and Transepithelial Migration | Actomyosin - physiology | Myosin-Light-Chain Phosphatase - physiology | Integrins - physiology | rho-Associated Kinases - physiology | Cardiovascular Diseases - physiopathology | Models, Cardiovascular | Endothelium, Vascular - physiopathology | Rats | Cytoskeleton - ultrastructure | rho GTP-Binding Proteins - physiology | Mice, Knockout | Animals | Aging - physiology | Cell Adhesion - physiology | Protein Kinase Inhibitors - therapeutic use | Vascular Stiffness - drug effects | Vascular Stiffness - physiology | Mice | Protein Kinase Inhibitors - pharmacology | Calcinosis - pathology | Calcinosis - physiopathology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2018, Volume 115, Issue 50, pp. 12817 - 12822
PIEZO1 is a cation channel that is activated by mechanical forces such as fluid shear stress or membrane stretch. PIEZO1 loss-of-function mutations in patients...
PIEZO1 | Lymphatic system | Mechanotransduction | Valve formation | Ion channe | MORPHOGENESIS | FOXC2 | ion channel | STRETCH | mechanotransduction | MULTIDISCIPLINARY SCIENCES | VESSEL MATURATION | valve formation | lymphatic system | FLOW | Lymphatic System - physiology | Cadherins - metabolism | Lymphatic Vessels - physiology | Endothelial Cells - metabolism | NFATC Transcription Factors - metabolism | Intercellular Junctions - metabolism | Lymphangiogenesis - physiology | Actomyosin - metabolism | Cell Movement - physiology | Antigens, CD - metabolism | Transcription Factors - metabolism | Lymphatic Vessels - metabolism | Animals | Ion Channels - metabolism | Cell Adhesion - physiology | Forkhead Transcription Factors - metabolism | Lymphatic System - metabolism | Signal Transduction - physiology | Intercellular Junctions - physiology | Mice | Ion Transport - physiology | Endothelial Cells - physiology | Physiological aspects | Ion channels | Transcription factors | Fluid flow | Pleural effusion | Cell junctions | Valves | Remodeling | Lymphedema | Actin | Rodents | Cell adhesion | Vascular endothelial growth factor | Actomyosin | Effusion | Polymerization | Ions | Cadherin | Endothelial cells | Valve leaflets | Shear stress | Mutation | Mechanical stimuli | Cell migration | Biological Sciences
PIEZO1 | Lymphatic system | Mechanotransduction | Valve formation | Ion channe | MORPHOGENESIS | FOXC2 | ion channel | STRETCH | mechanotransduction | MULTIDISCIPLINARY SCIENCES | VESSEL MATURATION | valve formation | lymphatic system | FLOW | Lymphatic System - physiology | Cadherins - metabolism | Lymphatic Vessels - physiology | Endothelial Cells - metabolism | NFATC Transcription Factors - metabolism | Intercellular Junctions - metabolism | Lymphangiogenesis - physiology | Actomyosin - metabolism | Cell Movement - physiology | Antigens, CD - metabolism | Transcription Factors - metabolism | Lymphatic Vessels - metabolism | Animals | Ion Channels - metabolism | Cell Adhesion - physiology | Forkhead Transcription Factors - metabolism | Lymphatic System - metabolism | Signal Transduction - physiology | Intercellular Junctions - physiology | Mice | Ion Transport - physiology | Endothelial Cells - physiology | Physiological aspects | Ion channels | Transcription factors | Fluid flow | Pleural effusion | Cell junctions | Valves | Remodeling | Lymphedema | Actin | Rodents | Cell adhesion | Vascular endothelial growth factor | Actomyosin | Effusion | Polymerization | Ions | Cadherin | Endothelial cells | Valve leaflets | Shear stress | Mutation | Mechanical stimuli | Cell migration | Biological Sciences
Journal Article
Nature Cell Biology, ISSN 1465-7392, 07/2015, Volume 17, Issue 7, pp. 849 - 855
Mammalian embryos initiate morphogenesis with compaction, which is essential for specifying the first lineages of the blastocyst. The 8-cell-stage mouse embryo...
ORGANIZATION | SURFACE | PROTEIN | MYOSIN | CELL BIOLOGY | Immunohistochemistry | Blastomeres - physiology | Cell Communication - physiology | Male | Green Fluorescent Proteins - genetics | Cdh1 Proteins - genetics | Time-Lapse Imaging | Time Factors | Actomyosin - physiology | Female | Green Fluorescent Proteins - metabolism | Mice, Inbred C57BL | Embryonic Development - physiology | Mice, Transgenic | Mice, Knockout | Embryo, Mammalian - physiology | Animals | Embryo, Mammalian - embryology | Cell Adhesion - physiology | Embryo, Mammalian - cytology | Myosin Light Chains - metabolism | Kinetics | Cell Shape - physiology | Cdh1 Proteins - physiology | Microscopy, Fluorescence | Contractility (Biology) | Cell interaction | Genetic aspects | Properties | Cell adhesion molecules
ORGANIZATION | SURFACE | PROTEIN | MYOSIN | CELL BIOLOGY | Immunohistochemistry | Blastomeres - physiology | Cell Communication - physiology | Male | Green Fluorescent Proteins - genetics | Cdh1 Proteins - genetics | Time-Lapse Imaging | Time Factors | Actomyosin - physiology | Female | Green Fluorescent Proteins - metabolism | Mice, Inbred C57BL | Embryonic Development - physiology | Mice, Transgenic | Mice, Knockout | Embryo, Mammalian - physiology | Animals | Embryo, Mammalian - embryology | Cell Adhesion - physiology | Embryo, Mammalian - cytology | Myosin Light Chains - metabolism | Kinetics | Cell Shape - physiology | Cdh1 Proteins - physiology | Microscopy, Fluorescence | Contractility (Biology) | Cell interaction | Genetic aspects | Properties | Cell adhesion molecules
Journal Article
Science, ISSN 0036-8075, 08/2014, Volume 345, Issue 6200, pp. 1062 - 1065
Cells use actomyosin contractility to move through three-dimensional (3D) extracellular matrices. Contractility affects the type of protrusions cells use to...
MIGRATION | NESPRIN-3 | BLEBBING CELLS | FORCE | MULTIDISCIPLINARY SCIENCES | Fibroblasts - physiology | Vimentin - metabolism | Humans | Cells, Cultured | Cytoplasm - physiology | Hydrostatic Pressure | Cell Movement - physiology | Cell Nucleus - physiology | Extracellular Matrix - ultrastructure | Microfilament Proteins | Extracellular Matrix - physiology | Actomyosin - physiology | Pseudopodia - physiology | Cell research | Motility | Research | Cells | Cytoplasm | Biophysics | Cell adhesion & migration | Pistons | Myosin | Human behavior | Mammals | Two dimensional | Human tissues | Contracts | Internal pressure
MIGRATION | NESPRIN-3 | BLEBBING CELLS | FORCE | MULTIDISCIPLINARY SCIENCES | Fibroblasts - physiology | Vimentin - metabolism | Humans | Cells, Cultured | Cytoplasm - physiology | Hydrostatic Pressure | Cell Movement - physiology | Cell Nucleus - physiology | Extracellular Matrix - ultrastructure | Microfilament Proteins | Extracellular Matrix - physiology | Actomyosin - physiology | Pseudopodia - physiology | Cell research | Motility | Research | Cells | Cytoplasm | Biophysics | Cell adhesion & migration | Pistons | Myosin | Human behavior | Mammals | Two dimensional | Human tissues | Contracts | Internal pressure
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 07/2011, Volume 22, Issue 14, pp. 2491 - 2508
Integrating individual cell movements to create tissue-level shape change is essential to building an animal. We explored mechanisms of adherens junction (AJ):...
GASTRULATION | ACTIN | CELL-SHAPE CHANGE | ALPHA-CATENIN | FORCES | APICAL CONSTRICTION | E-CADHERIN | ESTABLISHMENT | INTERCALATION | PLANAR POLARITY | CELL BIOLOGY | Drosophila melanogaster - physiology | Cell Shape - genetics | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Adherens Junctions - metabolism | Cell Movement - genetics | Cell Movement - physiology | Actomyosin - genetics | Drosophila Proteins - physiology | Gastrulation - genetics | Actomyosin - physiology | Adherens Junctions - genetics | Morphogenesis - genetics | Cytoskeleton - genetics | Actomyosin - metabolism | Cell Polarity - genetics | Animals | Adherens Junctions - physiology | Mesoderm - growth & development | Cell Polarity - physiology | Cytoskeleton - physiology | Drosophila Proteins - genetics | Mutation | Cell Shape - physiology | Morphogenesis - physiology
GASTRULATION | ACTIN | CELL-SHAPE CHANGE | ALPHA-CATENIN | FORCES | APICAL CONSTRICTION | E-CADHERIN | ESTABLISHMENT | INTERCALATION | PLANAR POLARITY | CELL BIOLOGY | Drosophila melanogaster - physiology | Cell Shape - genetics | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Adherens Junctions - metabolism | Cell Movement - genetics | Cell Movement - physiology | Actomyosin - genetics | Drosophila Proteins - physiology | Gastrulation - genetics | Actomyosin - physiology | Adherens Junctions - genetics | Morphogenesis - genetics | Cytoskeleton - genetics | Actomyosin - metabolism | Cell Polarity - genetics | Animals | Adherens Junctions - physiology | Mesoderm - growth & development | Cell Polarity - physiology | Cytoskeleton - physiology | Drosophila Proteins - genetics | Mutation | Cell Shape - physiology | Morphogenesis - physiology
Journal Article
Development (Cambridge), ISSN 0950-1991, 12/2017, Volume 144, Issue 23, pp. 4249 - 4260
D'Arcy Thompson was a proponent of applying mathematical and physical principles to biological systems, an approach that is becoming increasingly common in...
Morphogenesis | Tension | Actin | Contractility | Myosin | F-ACTIN | FISSION YEAST | CADHERIN JUNCTIONS | VENTRAL FURROW | DEVELOPMENTAL BIOLOGY | MYOSIN-II | NEURAL-TUBE CLOSURE | BLEBBISTATIN INHIBITION | EPITHELIAL MORPHOGENESIS | APICAL CONSTRICTION | CELL-CELL ADHESION | Epithelial Cells - physiology | Biomechanical Phenomena | Animals | Models, Biological | Humans | Muscle Contraction - physiology | Intercellular Junctions - physiology | Myosins - physiology | Actins - physiology | Cell Movement - physiology | Morphogenesis - physiology | Molecular Motor Proteins - physiology | Actomyosin | Spatial discrimination | Cytoskeleton | Mathematical models | Contraction | Review
Morphogenesis | Tension | Actin | Contractility | Myosin | F-ACTIN | FISSION YEAST | CADHERIN JUNCTIONS | VENTRAL FURROW | DEVELOPMENTAL BIOLOGY | MYOSIN-II | NEURAL-TUBE CLOSURE | BLEBBISTATIN INHIBITION | EPITHELIAL MORPHOGENESIS | APICAL CONSTRICTION | CELL-CELL ADHESION | Epithelial Cells - physiology | Biomechanical Phenomena | Animals | Models, Biological | Humans | Muscle Contraction - physiology | Intercellular Junctions - physiology | Myosins - physiology | Actins - physiology | Cell Movement - physiology | Morphogenesis - physiology | Molecular Motor Proteins - physiology | Actomyosin | Spatial discrimination | Cytoskeleton | Mathematical models | Contraction | Review
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2012, Volume 109, Issue 27, pp. 10891 - 10896
Fundamental biological processes such as morphogenesis and wound healing involve the closure of epithelial gaps. Epithelial gap closure is commonly attributed...
Cell culture techniques | Epithelial cells | Cell lines | Actins | Pseudopodia | Kidney cells | Stiffness | Stencils | Curvature | Cells | Epithelial cell migration | Wound model assay | Microfabrication | Madin-Darby canine kidney cells | STRING WOUND CLOSURE | DELAMINATION | MULTIDISCIPLINARY SCIENCES | epithelial cell migration | MECHANISMS | MODEL | ADHESION | REPAIR | wound model assay | JUNCTIONS | DYNAMICS | RHO | microfabrication | MOTILITY | Cell Line | rho-Associated Kinases - physiology | Cell Culture Techniques - instrumentation | Cell Count | Stress, Mechanical | Kidney - cytology | Cell Culture Techniques - methods | Cell Movement - physiology | Myosin-Light-Chain Kinase - physiology | Epithelial Cells - physiology | Animals | Actomyosin - physiology | Dogs | Intercellular Junctions - physiology | Wound Healing - physiology | Pseudopodia - physiology | Epithelial Cells - cytology | Physiological aspects | Kidneys | Research | Health aspects | Cell migration | Biological Sciences
Cell culture techniques | Epithelial cells | Cell lines | Actins | Pseudopodia | Kidney cells | Stiffness | Stencils | Curvature | Cells | Epithelial cell migration | Wound model assay | Microfabrication | Madin-Darby canine kidney cells | STRING WOUND CLOSURE | DELAMINATION | MULTIDISCIPLINARY SCIENCES | epithelial cell migration | MECHANISMS | MODEL | ADHESION | REPAIR | wound model assay | JUNCTIONS | DYNAMICS | RHO | microfabrication | MOTILITY | Cell Line | rho-Associated Kinases - physiology | Cell Culture Techniques - instrumentation | Cell Count | Stress, Mechanical | Kidney - cytology | Cell Culture Techniques - methods | Cell Movement - physiology | Myosin-Light-Chain Kinase - physiology | Epithelial Cells - physiology | Animals | Actomyosin - physiology | Dogs | Intercellular Junctions - physiology | Wound Healing - physiology | Pseudopodia - physiology | Epithelial Cells - cytology | Physiological aspects | Kidneys | Research | Health aspects | Cell migration | Biological Sciences
Journal Article
Brain Research, ISSN 0006-8993, 2012, Volume 1487, pp. 78 - 87
Abstract The intracellular calcium concentration ([Ca2+ ] i ) is an important factor determining the permeability of endothelial barriers including the...
Neurology | Calcium oscillation | Tight junction | Calcium wave | Gap junction | Blood–brain barrier | Blood-brain barrier | PROTEIN-KINASE-C | INTRACELLULAR CALCIUM | BARRIER PERMEABILITY | K1 INVASION | CONNEXIN HEMICHANNELS | NEUROSCIENCES | TIGHT JUNCTIONS | GAP-JUNCTIONS | MECHANICAL STIMULATION | ATP RELEASE | Extracellular Space - physiology | Neuroimaging | Protein Kinase C - physiology | Calcium Signaling - physiology | Electrophoresis, Polyacrylamide Gel | Cells, Cultured | Extracellular Space - drug effects | Rats | Permeability | Brain - physiology | Blotting, Western | Endothelium, Vascular - physiology | Animals | Calcium - physiology | Egtazic Acid - pharmacology | Biological Transport, Active - physiology | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - physiology | Actomyosin - physiology | Egtazic Acid - analogs & derivatives | Cytoskeleton - physiology | Connexins - pharmacology | Gap Junctions - drug effects | Bradykinin - pharmacology
Neurology | Calcium oscillation | Tight junction | Calcium wave | Gap junction | Blood–brain barrier | Blood-brain barrier | PROTEIN-KINASE-C | INTRACELLULAR CALCIUM | BARRIER PERMEABILITY | K1 INVASION | CONNEXIN HEMICHANNELS | NEUROSCIENCES | TIGHT JUNCTIONS | GAP-JUNCTIONS | MECHANICAL STIMULATION | ATP RELEASE | Extracellular Space - physiology | Neuroimaging | Protein Kinase C - physiology | Calcium Signaling - physiology | Electrophoresis, Polyacrylamide Gel | Cells, Cultured | Extracellular Space - drug effects | Rats | Permeability | Brain - physiology | Blotting, Western | Endothelium, Vascular - physiology | Animals | Calcium - physiology | Egtazic Acid - pharmacology | Biological Transport, Active - physiology | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - physiology | Actomyosin - physiology | Egtazic Acid - analogs & derivatives | Cytoskeleton - physiology | Connexins - pharmacology | Gap Junctions - drug effects | Bradykinin - pharmacology
Journal Article
Science, ISSN 0036-8075, 3/2012, Volume 335, Issue 6073, pp. 1232 - 1235
Apical constriction changes cell shapes, driving critical morphogenetic events, including gastrulation in diverse organisms and neural tube closure in...
Neurons | Lasers | Drosophila | REPORTS | Cell lines | Particle decay | Actins | Cell membranes | Gene expression regulation | Particle tracks | Embryos | DORSAL CLOSURE | POLARITY | INTEGRATION | MULTIDISCIPLINARY SCIENCES | FORCES | APICAL CONSTRICTION | INVAGINATION | TISSUE MORPHOGENESIS | CORTICAL FLOWS | C-ELEGANS GASTRULATION | DROSOPHILA | Drosophila melanogaster - embryology | Embryo, Nonmammalian - cytology | Gastrulation | Actomyosin - chemistry | Fluorescence Recovery After Photobleaching | Drosophila melanogaster - cytology | Cell Membrane - ultrastructure | Cytoskeleton - ultrastructure | Caenorhabditis elegans - embryology | Cell Membrane - physiology | Myosins - chemistry | Morphogenesis | Animals | Caenorhabditis elegans - cytology | Models, Biological | Cell Shape | Computer Simulation | Actomyosin - physiology | Cytoskeleton - physiology | Intercellular Junctions - physiology | Mechanical Phenomena | Myosins - physiology | Embryo, Nonmammalian - physiology | Intercellular Junctions - ultrastructure | Physiological aspects | Caenorhabditis elegans | Cell physiology | Research | Proteins | Cellular biology | Developmental biology | Morphology
Neurons | Lasers | Drosophila | REPORTS | Cell lines | Particle decay | Actins | Cell membranes | Gene expression regulation | Particle tracks | Embryos | DORSAL CLOSURE | POLARITY | INTEGRATION | MULTIDISCIPLINARY SCIENCES | FORCES | APICAL CONSTRICTION | INVAGINATION | TISSUE MORPHOGENESIS | CORTICAL FLOWS | C-ELEGANS GASTRULATION | DROSOPHILA | Drosophila melanogaster - embryology | Embryo, Nonmammalian - cytology | Gastrulation | Actomyosin - chemistry | Fluorescence Recovery After Photobleaching | Drosophila melanogaster - cytology | Cell Membrane - ultrastructure | Cytoskeleton - ultrastructure | Caenorhabditis elegans - embryology | Cell Membrane - physiology | Myosins - chemistry | Morphogenesis | Animals | Caenorhabditis elegans - cytology | Models, Biological | Cell Shape | Computer Simulation | Actomyosin - physiology | Cytoskeleton - physiology | Intercellular Junctions - physiology | Mechanical Phenomena | Myosins - physiology | Embryo, Nonmammalian - physiology | Intercellular Junctions - ultrastructure | Physiological aspects | Caenorhabditis elegans | Cell physiology | Research | Proteins | Cellular biology | Developmental biology | Morphology
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2011, Volume 286, Issue 4, pp. 2375 - 2381
Cdc42 is a member of the Rho GTPase family of intracellular molecular switches regulating multiple signaling pathways involved in actomyosin organization and...
RHO-FAMILY GTPASES | DIRECTED MIGRATION | NEURONAL DEVELOPMENT | DENDRITIC CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIAC-HYPERTROPHY | ACTIN RING FORMATION | EPITHELIAL MORPHOGENESIS | SPINDLE ORIENTATION | GTP-BINDING PROTEINS | CELL POLARITY | Gene Targeting | Animals | Cell Proliferation | cdc42 GTP-Binding Protein - genetics | Humans | Signal Transduction - physiology | cdc42 GTP-Binding Protein - metabolism | Mice | Mutation | Actomyosin - metabolism | Actomyosin - genetics | Organ Specificity - physiology | Minireviews | Mouse Genetics | Rho | Cellular Regulation | Signal Transduction | Cdc42
RHO-FAMILY GTPASES | DIRECTED MIGRATION | NEURONAL DEVELOPMENT | DENDRITIC CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIAC-HYPERTROPHY | ACTIN RING FORMATION | EPITHELIAL MORPHOGENESIS | SPINDLE ORIENTATION | GTP-BINDING PROTEINS | CELL POLARITY | Gene Targeting | Animals | Cell Proliferation | cdc42 GTP-Binding Protein - genetics | Humans | Signal Transduction - physiology | cdc42 GTP-Binding Protein - metabolism | Mice | Mutation | Actomyosin - metabolism | Actomyosin - genetics | Organ Specificity - physiology | Minireviews | Mouse Genetics | Rho | Cellular Regulation | Signal Transduction | Cdc42
Journal Article
Cell, ISSN 0092-8674, 2006, Volume 125, Issue 7, pp. 1361 - 1374
Cells exhibit a biphasic migration-velocity response to increasing adhesion strength, with fast migration occurring at intermediate extracellular matrix (ECM)...
INTEGRIN-LIGAND BINDING | SMOOTH-MUSCLE | TURNOVER | CONTRACTILITY | MICROTUBULE | LEADING-EDGE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FLUORESCENT SPECKLE MICROSCOPY | EARLY MOLECULAR EVENTS | ACTIN-FILAMENTS | LIVING CELLS | CELL BIOLOGY | Cell Line | Biomechanical Phenomena | Myosin Type II - physiology | Animals | Feedback | Models, Biological | Extracellular Matrix - physiology | Actomyosin - physiology | Cytoskeleton - physiology | Focal Adhesions - physiology | Actins - physiology | Cell Movement - physiology | Cell migration | Cell adhesion | Research | Muscle proteins | Actin | Analysis | Myosin
INTEGRIN-LIGAND BINDING | SMOOTH-MUSCLE | TURNOVER | CONTRACTILITY | MICROTUBULE | LEADING-EDGE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FLUORESCENT SPECKLE MICROSCOPY | EARLY MOLECULAR EVENTS | ACTIN-FILAMENTS | LIVING CELLS | CELL BIOLOGY | Cell Line | Biomechanical Phenomena | Myosin Type II - physiology | Animals | Feedback | Models, Biological | Extracellular Matrix - physiology | Actomyosin - physiology | Cytoskeleton - physiology | Focal Adhesions - physiology | Actins - physiology | Cell Movement - physiology | Cell migration | Cell adhesion | Research | Muscle proteins | Actin | Analysis | Myosin
Journal Article
Cancer Research, ISSN 0008-5472, 08/2011, Volume 71, Issue 15, pp. 5075 - 5080
Cancer cells are defined by their ability to invade through the basement membrane, a critical step during metastasis. While increased secretion of proteases,...
MIGRATION | CYTOSKELETON | ONCOLOGY | MYOSIN | MAGNETIC TWEEZERS | BIOLOGY | MUSCLE | QUANTITATIVE-ANALYSIS | Myosin Type II - physiology | Compliance | Myosin Type II - antagonists & inhibitors | Humans | Neoplasm Proteins - physiology | Ovarian Neoplasms - pathology | Neoplasm Proteins - antagonists & inhibitors | Receptors, Transforming Growth Factor beta - physiology | Molecular Targeted Therapy | Heterocyclic Compounds, 4 or More Rings - pharmacology | Magnetics - instrumentation | Microspheres | Laminin | Micromanipulation - instrumentation | Neoplasm Invasiveness - pathology | Actomyosin - physiology | Drug Design | Microscopy, Atomic Force | Female | Cell Shape - drug effects | Cell Movement - drug effects | Cell Line, Tumor - cytology | Neoplasm Metastasis - pathology | Proteoglycans - physiology | Collagen | Cell Shape - physiology | Ascites - pathology | Drug Combinations | Tumor Cells, Cultured - cytology
MIGRATION | CYTOSKELETON | ONCOLOGY | MYOSIN | MAGNETIC TWEEZERS | BIOLOGY | MUSCLE | QUANTITATIVE-ANALYSIS | Myosin Type II - physiology | Compliance | Myosin Type II - antagonists & inhibitors | Humans | Neoplasm Proteins - physiology | Ovarian Neoplasms - pathology | Neoplasm Proteins - antagonists & inhibitors | Receptors, Transforming Growth Factor beta - physiology | Molecular Targeted Therapy | Heterocyclic Compounds, 4 or More Rings - pharmacology | Magnetics - instrumentation | Microspheres | Laminin | Micromanipulation - instrumentation | Neoplasm Invasiveness - pathology | Actomyosin - physiology | Drug Design | Microscopy, Atomic Force | Female | Cell Shape - drug effects | Cell Movement - drug effects | Cell Line, Tumor - cytology | Neoplasm Metastasis - pathology | Proteoglycans - physiology | Collagen | Cell Shape - physiology | Ascites - pathology | Drug Combinations | Tumor Cells, Cultured - cytology
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1402 - 12
Forces play diverse roles in vascular development, homeostasis and disease. VE-cadherin at endothelial cell-cell junctions links the contractile acto-myosin...
VASCULAR DEVELOPMENT | MORPHOGENESIS | FLUID SHEAR-STRESS | MECHANICAL TENSION | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | DYNAMICS | FRET MICROSCOPY | FLOW | MECHANOSENSORY COMPLEX | Tensile Strength - physiology | Neovascularization, Physiologic - genetics | Aorta - embryology | Molecular Imaging | Cadherins - physiology | Mechanotransduction, Cellular - physiology | Zebrafish - embryology | Antigens, CD - genetics | Zebrafish - genetics | Zebrafish Proteins - physiology | Biomechanical Phenomena | Animals | Actomyosin - physiology | Fluorescence Resonance Energy Transfer | Zebrafish - physiology | Antigens, CD - physiology | Intercellular Junctions - physiology | Mutation | Zebrafish Proteins - genetics | Cadherins - genetics | Contractility | Homeostasis | Cell junctions | Zebrafish | Cadherin | Endothelial cells | Cell adhesion & migration | Embryonic growth stage | Embryogenesis | Myosin | Aorta | Tension | Fluorescence resonance energy transfer | Biosensors | Localization
VASCULAR DEVELOPMENT | MORPHOGENESIS | FLUID SHEAR-STRESS | MECHANICAL TENSION | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | DYNAMICS | FRET MICROSCOPY | FLOW | MECHANOSENSORY COMPLEX | Tensile Strength - physiology | Neovascularization, Physiologic - genetics | Aorta - embryology | Molecular Imaging | Cadherins - physiology | Mechanotransduction, Cellular - physiology | Zebrafish - embryology | Antigens, CD - genetics | Zebrafish - genetics | Zebrafish Proteins - physiology | Biomechanical Phenomena | Animals | Actomyosin - physiology | Fluorescence Resonance Energy Transfer | Zebrafish - physiology | Antigens, CD - physiology | Intercellular Junctions - physiology | Mutation | Zebrafish Proteins - genetics | Cadherins - genetics | Contractility | Homeostasis | Cell junctions | Zebrafish | Cadherin | Endothelial cells | Cell adhesion & migration | Embryonic growth stage | Embryogenesis | Myosin | Aorta | Tension | Fluorescence resonance energy transfer | Biosensors | Localization
Journal Article