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1. Full Text Enteral Omega-3 Fatty Acid, γ-Linolenic Acid, and Antioxidant Supplementation in Acute Lung Injury
by Rice, Todd W and Wheeler, Arthur P and Thompson, B. Taylor and deBoisblanc, Bennett P and Steingrub, Jay and Rock, Peter and NIH NHLBI Acute Respiratory Distress Syndrome Network of Investigators, for the and NHLBI ARDS Clinical Trials Network and NIH NHLBI Acute Respiratory Distress Syndrome Network of Investigators
JAMA, ISSN 0098-7484, 10/2011, Volume 306, Issue 14, pp. 1574 - 1581
CONTEXT The omega-3 (n-3) fatty acids docosahexaenoic acid and eicosapentaenoic acid, along with γ-linolenic acid and antioxidants, may modulate systemic... 
MECHANICALLY VENTILATED PATIENTS | MEDICINE, GENERAL & INTERNAL | PLASMA | CLINICAL-TRIAL | INFLAMMATION | FATTY-ACIDS | FISH-OIL | NUTRITION | CRITICALLY-ILL PATIENTS | EICOSAPENTAENOIC ACID | RESPIRATORY-DISTRESS-SYNDROME | Humans | Middle Aged | Eicosapentaenoic Acid - adverse effects | Male | Sepsis - complications | Inflammation - drug therapy | Adult | Female | Acute Lung Injury - drug therapy | Dietary Supplements - adverse effects | Drug Therapy, Combination | Docosahexaenoic Acids - therapeutic use | Double-Blind Method | gamma-Linolenic Acid - therapeutic use | gamma-Linolenic Acid - adverse effects | Intensive Care Units - utilization | Treatment Outcome | Enteral Nutrition | Biomarkers - blood | Acute Lung Injury - mortality | Eicosapentaenoic Acid - blood | Antioxidants - therapeutic use | Docosahexaenoic Acids - blood | Survival Analysis | Pneumonia - complications | Antioxidants - adverse effects | Aged | Eicosapentaenoic Acid - therapeutic use | Acute Lung Injury - etiology | Docosahexaenoic Acids - adverse effects | Ventilator Weaning | Acute Lung Injury - complications
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2. Full Text Rutin decreases lipopolysaccharide-induced acute lung injury via inhibition of oxidative stress and the MAPK–NF-κB pathway
by Yeh, Chung-Hsin and Yang, Jiann-Jou and Yang, Ming-Ling and Li, Yi-Ching and Kuan, Yu-Hsiang
Free Radical Biology and Medicine, ISSN 0891-5849, 04/2014, Volume 69, pp. 249 - 257
Acute lung injury (ALI) is a serious disease with unacceptably high mortality and morbidity rates. Up to now, no effective therapeutic strategy for ALI has... 
Acute lung injury | NF-κB | Free radicals | CAT | Lipopolysaccharide | SOD | HO-1 | Rutin | MAPK | GPx | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RATS | NEUTROPHILS | MECHANISMS | THERAPEUTIC APPLICATIONS | QUERCETIN | IN-VITRO | NF-kappa B | INFLAMMATION | ENDOCRINOLOGY & METABOLISM | MICE | EXPRESSION | Mitogen-Activated Protein Kinase Kinases - genetics | Heme Oxygenase-1 - biosynthesis | Lipopolysaccharides - toxicity | Rutin - toxicity | Superoxide Dismutase - biosynthesis | Humans | Acute Lung Injury - genetics | Glutathione Peroxidase - biosynthesis | Gene Expression Regulation - drug effects | Animals | Acute Lung Injury - chemically induced | NF-kappa B - genetics | Signal Transduction - drug effects | Rutin - administration & dosage | Acute Lung Injury - drug therapy | Mice | Oxidative Stress - drug effects | Superoxide Dismutase-1 | Catalase - biosynthesis
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3. Full Text Andrographolide Protects against LPS-Induced Acute Lung Injury by Inactivation of NF-κB
by Zhu, Tao and Wang, Dao-xin and Zhang, Wei and Liao, Xiu-qing and Guan, Xian and Bo, Hong and Sun, Jia-yang and Huang, Ni-wen and He, Jing and Zhang, Yun-kun and Tong, Jing and Li, Chang-yi
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, p. e56407
Background: Nuclear factor-kappa B (NF-kappa B) is a central transcriptional factor and a pleiotropic regulator of many genes involved in acute lung injury.... 
INDUCED MITOGENIC FACTOR | IN-VITRO | ACTIVATION | INHIBITION | PI-3K/AKT-NF-KAPPA-B SIGNALING PATHWAY | MULTIDISCIPLINARY SCIENCES | ALVEOLAR FLUID CLEARANCE | EPITHELIAL SODIUM-CHANNEL | PANICULATA | EXPRESSION | RESPIRATORY-DISTRESS-SYNDROME | Bronchoalveolar Lavage Fluid | Protein Binding - genetics | Cell Count | Pneumonia - pathology | Cell Survival - genetics | Acute Lung Injury - genetics | Male | NF-kappa B - metabolism | Vascular Endothelial Growth Factor A - metabolism | Protective Agents - therapeutic use | Vascular Endothelial Growth Factor A - genetics | Lipopolysaccharides | Alveolar Epithelial Cells - pathology | Protective Agents - pharmacology | Protein Binding - drug effects | Pulmonary Edema - complications | Pulmonary Edema - pathology | Vascular Cell Adhesion Molecule-1 - genetics | Acute Lung Injury - drug therapy | Acute Lung Injury - metabolism | Alveolar Epithelial Cells - ultrastructure | Pneumonia - genetics | Diterpenes - pharmacology | Pulmonary Edema - genetics | Cell Survival - drug effects | Diterpenes - therapeutic use | Cytokines - metabolism | DNA - metabolism | Down-Regulation - drug effects | Acute Lung Injury - pathology | Pulmonary Edema - drug therapy | Gene Expression Regulation - drug effects | Animals | Pneumonia - drug therapy | Transcription Factor RelA - metabolism | Pneumonia - complications | Mice | Mice, Inbred BALB C | Vascular Cell Adhesion Molecule-1 - metabolism | Peroxidase - metabolism | Vascular cell adhesion molecule 1 | Phosphorylation | Epithelial cells | Kinases | Macrophages | Inactivation | Cell adhesion & migration | Interleukin 6 | Ultrastructure | Rodents | Inhibition | Alveoli | Vascular endothelial growth factor | Drug dosages | Deoxyribonucleic acid--DNA | Medicinal plants | Pathogens | Edema | NF-κB protein | Deactivation | Therapeutic applications | Traditional Chinese medicine | Leukocytes (neutrophilic) | Inflammation | Tumor necrosis factor-α | Gene expression | Medicine | Hospitals | Lungs | Respiratory distress syndrome | Rheumatoid arthritis | Hypoxia | In vivo methods and tests | Laboratory animals | In vitro methods and tests | Binding sites | Deoxyribonucleic acid | DNA
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4. Full Text Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury
by Caudrillier, Axelle and Kessenbrock, Kai and Gilliss, Brian M and Nguyen, John X and Marques, Marisa B and Monestier, Marc and Toy, Pearl and Werb, Zena and Looney, Mark R
Journal of Clinical Investigation, ISSN 0021-9738, 07/2012, Volume 122, Issue 7, pp. 2661 - 2671
There is emerging evidence that platelets are major contributors to inflammatory processes through intimate associations with innate immune cells. Here, we... 
MEDICINE, RESEARCH & EXPERIMENTAL | PHAGOCYTOSIS | INFLAMMATION | MACROPHAGES | RECEPTOR ACTIVATION | COAGULATION | MICE | DNASE | ARTHRITIS | HISTONES | BINDING | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Deoxyribonuclease I - therapeutic use | Human Umbilical Vein Endothelial Cells - immunology | Antibodies, Monoclonal - therapeutic use | Blood Platelets - physiology | Thromboxanes - metabolism | Acute Lung Injury - drug therapy | Aspirin - therapeutic use | Platelet Aggregation - drug effects | Blood Platelets - drug effects | Platelet Aggregation Inhibitors - therapeutic use | Neutrophils - metabolism | Lung - pathology | Histones - immunology | Neutrophils - drug effects | Cells, Cultured | Neutrophils - physiology | Permeability | Acute Lung Injury - pathology | Transfusion Reaction | Animals | Blood Platelets - metabolism | Lipopolysaccharides - pharmacology | Cell Aggregation | Acute Lung Injury - immunology | Mice | Histones - metabolism | Acute Lung Injury - etiology | Lung - immunology | Peroxidase - metabolism | Aspirin | Blood platelets | Lung diseases | Neutrophils | Physiological aspects | Research | Blood transfusion | Health aspects
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5. Full Text A randomized clinical trial of hydroxymethylglutaryl-coenzyme a reductase inhibition for acute lung injury (the HARP study)
by Craig, Thelma R and Duffy, Martin J and Shyamsundar, Murali and McDowell, Cliona and O'Kane, Cecilia M and Elborn, J. Stuart and McAuley, Daniel F
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 03/2011, Volume 183, Issue 5, pp. 620 - 626
Rationale There is no effective pharmacological treatment for acute lung injury (All). Statins are a potential new therapy because they modify many of the... 
Acute respiratory distress syndrome | Acute lung injury | Simvastatin | PULMONARY | MORTALITY | SPACE | RESPIRATORY SYSTEM | INFLAMMATION | simvastatin | acute respiratory distress syndrome | OUTCOMES | acute lung injury | CRITICAL CARE MEDICINE | Bronchoalveolar Lavage Fluid | Simvastatin - therapeutic use | Double-Blind Method | Humans | Middle Aged | Male | Treatment Outcome | Inflammation - etiology | Cytokines - drug effects | Multiple Organ Failure - prevention & control | Inflammation - drug therapy | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Female | Acute Lung Injury - drug therapy | C-Reactive Protein - drug effects | Acute Lung Injury - complications
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6. Full Text The protective effect of Trillin LPS-induced acute lung injury by the regulations of inflammation and oxidative state
by Jiang, Wenjiao and Luo, Fen and Lu, Qianfeng and Liu, Jingyan and Li, Peijin and Wang, Xiaofan and Fu, Yeliu and Hao, Kun and Yan, Tianhua and Ding, Xuansheng
Chemico-Biological Interactions, ISSN 0009-2797, 01/2016, Volume 243, pp. 127 - 134
Inflammation response and oxidative stress have been reported to be involved in the pathogenesis of acute lung injury (ALI). Accordingly, anti-inflammatory... 
Acute lung injury | NF-κB | HO-1 | Nrf2 | Trillin | Inflammation - pathology | Plant Extracts - chemistry | Antioxidants - chemistry | NF-kappa B - immunology | Male | Lipopolysaccharides - immunology | NF-E2-Related Factor 2 - immunology | Saponins - chemistry | Inflammation - complications | Inflammation - drug therapy | Anti-Inflammatory Agents - therapeutic use | Saponins - therapeutic use | Acute Lung Injury - drug therapy | Cytokines - immunology | Lung - pathology | Dioscoreaceae - chemistry | Inflammation - immunology | Acute Lung Injury - pathology | Antioxidants - therapeutic use | Animals | Anti-Inflammatory Agents - chemistry | Lung - drug effects | Heme Oxygenase-1 - immunology | Acute Lung Injury - immunology | Mice, Inbred BALB C | Oxidative Stress - drug effects | Lung - immunology | Acute Lung Injury - complications | Acute respiratory distress syndrome | Inflammation
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7. Full Text Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury
by Looney, Mark R and Nguyen, John X and Hu, Yongmei and Van Ziffle, Jessica A and Lowell, Clifford A and Matthay, Michael A
Journal of Clinical Investigation, ISSN 0021-9738, 11/2009, Volume 119, Issue 11, pp. 3450 - 3461
Transfusion-related acute lung injury (TRA-LI) is the leading cause of transfusion-associated mortality in the US. Previously, we established an... 
SEQUESTRATION | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | TOLL-LIKE RECEPTOR-4 | PLASMA | GLYCOPROTEIN IB-ALPHA | RESPIRATORY-DISTRESS SYNDROME | NEUTROPHILS | ANIMAL-MODEL | INTEGRIN MAC-1 | BLOOD | Thrombocytopenia - etiology | Neutrophils - drug effects | Genes, MHC Class I - genetics | Lung - physiology | Cyclooxygenase Inhibitors - pharmacology | Transfusion Reaction | Gene Expression Regulation - drug effects | Platelet Aggregation | Animals | Blood Platelets - metabolism | Fibrinolytic Agents - therapeutic use | Lipopolysaccharides - pharmacology | Acute Lung Injury - drug therapy | Mice | Mice, Inbred BALB C | Blood Platelets - drug effects | Acute Lung Injury - etiology | Cyclooxygenase Inhibitors - therapeutic use | Acute Lung Injury - complications | Acute respiratory distress syndrome | Complications and side effects | Aspirin | Usage | Care and treatment | Research | Diagnosis | Health aspects | Blood transfusion | Risk factors
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8. Full Text Fluid Balance, Diuretic Use, and Mortality in Acute Kidney Injury
by Morgan E. Grams and Michelle M. Estrella and Josef Coresh and Roy G. Brower and Kathleen D. Liu and for the National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network and Natl Heart Lung & Blood Inst and National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network and for the National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network
Clinical Journal of the American Society of Nephrology, ISSN 1555-9041, 05/2011, Volume 6, Issue 5, pp. 966 - 973
Background and objectives Management of volume status in patients with acute kidney injury (AKI) is complex, and the role of diuretics is controversial. The... 
SURVIVAL | MANAGEMENT | THERAPY | FUROSEMIDE | UROLOGY & NEPHROLOGY | ACUTE-RENAL-FAILURE | PULMONARY-ARTERY | ALBUMIN | CRITICALLY-ILL PATIENTS | DIALYSIS | HYPOPROTEINEMIC PATIENTS | Multicenter Studies as Topic - statistics & numerical data | Randomized Controlled Trials as Topic - statistics & numerical data | Water-Electrolyte Balance - physiology | Acute Kidney Injury - drug therapy | Fluid Therapy - mortality | Fluid Therapy - statistics & numerical data | Humans | Middle Aged | Proportional Hazards Models | Male | Water-Electrolyte Balance - drug effects | Acute Lung Injury - mortality | Furosemide - therapeutic use | Acute Kidney Injury - mortality | Critical Illness - mortality | Fluid Therapy - methods | Critical Illness - therapy | Diuretics - therapeutic use | Female | Acute Lung Injury - drug therapy | Acute Lung Injury - metabolism | Acute Kidney Injury - metabolism | Original
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9. Full Text Inhaled Anticoagulation Regimens for the Treatment of Smoke Inhalation–Associated Acute Lung Injury: A Systematic Review
by Miller, Andrew C and Elamin, Elamin M and Suffredini, Anthony F
Critical Care Medicine, ISSN 0090-3493, 02/2014, Volume 42, Issue 2, pp. 413 - 419
OBJECTIVE:Inhaled anticoagulation regimens are increasingly being used to manage smoke inhalation–associated acute lung injury. We systematically reviewed... 
Anticoagulants | Antithrombins | Heparin | Fibrinolytic Agents | Acute Lung Injury | Smoke Inhalation Injury | MORTALITY | COMBINED BURN | SHEEP | PULMONARY-FUNCTION | N-ACETYLCYSTEINE | fibrinolytic agents | AIRWAY-OBSTRUCTION | acute lung injury | FAILURE | heparin | antithrombins | anticoagulants | BRONCHIAL BLOOD-FLOW | NEBULIZED HEPARIN | smoke inhalation injury | TRAUMA | CRITICAL CARE MEDICINE | Anticoagulants - administration & dosage | Smoke Inhalation Injury - complications | Humans | Administration, Inhalation | Acute Lung Injury - drug therapy | Acute Lung Injury - etiology | Smoke Inhalation Injury - drug therapy
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10. Full Text Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: A systematic review and meta-analysis
by Tang, Benjamin M. P and Craig, Jonathan C and Eslick, Guy D and Seppelt, Ian and McLean, Anthony S
Critical Care Medicine, ISSN 0090-3493, 05/2009, Volume 37, Issue 5, pp. 1594 - 1603
OBJECTIVE:Controversy remains as to whether low-dose corticosteroids can reduce the mortality and morbidity of acute lung injury (ALI) or the acute respiratory... 
Acute respiratory distress syndrome | Acute lung injury | Steroids | MORTALITY | INFUSION | RANDOMIZED CONTROLLED-TRIAL | METHYLPREDNISOLONE | acute lung injury | FAILURE | acute respiratory distress syndrome | SEPTIC SHOCK | steroids | STEROID-THERAPY | OUTCOMES | ARDS | EPIDEMIOLOGY | CRITICAL CARE MEDICINE | Morbidity - trends | Severity of Illness Index | Drug Administration Schedule | Follow-Up Studies | Risk Assessment | Humans | Middle Aged | Male | Treatment Outcome | Respiratory Distress Syndrome, Adult - mortality | Respiratory Distress Syndrome, Adult - drug therapy | Respiratory Distress Syndrome, Adult - diagnosis | Randomized Controlled Trials as Topic | Dose-Response Relationship, Drug | Hospital Mortality - trends | Acute Lung Injury - mortality | Acute Lung Injury - diagnosis | Survival Analysis | Adult | Female | Acute Lung Injury - drug therapy | Aged | Adrenal Cortex Hormones - administration & dosage
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11. Full Text Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) in children and adults
by Gebistorf, Fabienne and Karam, Oliver and Wetterslev, Jørn and Afshari, Arash
Cochrane Database of Systematic Reviews, ISSN 1469-493X, 06/2016, Volume 2016, Issue 6, p. CD002787
Background Acute hypoxaemic respiratory failure (AHRF) and mostly acute respiratory distress syndrome (ARDS) are critical conditions. AHRF results from several... 
RANDOMIZED-TRIALS | PEROXYNITRITE | Humans | METAANALYSES | Anoxia [drug therapy; mortality] | ACUTE LUNG INJURY | Respiratory Distress Syndrome, Adult [drug therapy | MEDICINE, GENERAL & INTERNAL | THERAPY | RIGHT-VENTRICULAR FUNCTION | Adult | Child | Length of Stay | Acute Disease | Nitric Oxide [administration & dosage; adverse effects] | RISK-FACTORS | Administration, Inhalation | Vasodilator Agents [adverse effects; therapeutic use] | FAILURE | Respiratory Insufficiency [drug therapy; mortality] | Randomized Controlled Trials as Topic | Acute Lung Injury [drug therapy; mortality] | mortality | OUTCOMES | SEQUENTIAL MONITORING BOUNDARIES | Hypoxia - drug therapy | Vasodilator Agents - therapeutic use | Respiratory Insufficiency - mortality | Hypoxia - mortality | Nitric Oxide - adverse effects | Respiratory Distress Syndrome, Adult - mortality | Nitric Oxide - administration & dosage | Respiratory Distress Syndrome, Adult - drug therapy | Acute Lung Injury - mortality | Acute Lung Injury - drug therapy | Vasodilator Agents - adverse effects | Respiratory Insufficiency - drug therapy
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