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1. Full Text A randomized clinical trial of hydroxymethylglutaryl-coenzyme a reductase inhibition for acute lung injury (the HARP study)
by Craig, Thelma R and Duffy, Martin J and Shyamsundar, Murali and McDowell, Cliona and O'Kane, Cecilia M and Elborn, J. Stuart and McAuley, Daniel F
American journal of respiratory and critical care medicine, ISSN 1073-449X, 03/2011, Volume 183, Issue 5, pp. 620 - 626
Acute respiratory distress syndrome | Acute lung injury | Simvastatin | Respiratory System | Life Sciences & Biomedicine | Critical Care Medicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | Intensive care medicine | Medical sciences | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy | Emergency and intensive respiratory care | Bronchoalveolar Lavage Fluid | Simvastatin - therapeutic use | Double-Blind Method | Humans | Middle Aged | Male | Treatment Outcome | Inflammation - etiology | Cytokines - drug effects | Multiple Organ Failure - prevention & control | Inflammation - drug therapy | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Female | Acute Lung Injury - drug therapy | C-Reactive Protein - drug effects | Acute Lung Injury - complications | Index Medicus | Abridged Index Medicus
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2. Full Text Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury
by Russell, Clark D and Millar, Jonathan E and Baillie, J Kenneth
The Lancet (British edition), ISSN 0140-6736, 02/2020, Volume 395, Issue 10223, pp. 473 - 475
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Evidence-Based Medicine - methods | Glucocorticoids - therapeutic use | Coronavirus Infections - drug therapy | Humans | Pneumonia, Viral - drug therapy | Betacoronavirus | Glucocorticoids - adverse effects | Corticoids | Epidemics | Mental disorders | Viremia | Clinical trials | Antibodies | Viruses | Infections | Hydrocortisone | Necrosis | Psychosis | Osteoporosis | Biomedical materials | Randomization | Children | Injury analysis | Avascular necrosis | Respiratory therapy | Ventilators | Bacterial infections | Corticosteroids | Complications | Mortality | Diabetes mellitus | Severe acute respiratory syndrome | Inflammation | Coronaviruses | Ribonucleic acid--RNA | Patients | Fever | Respiratory syncytial virus | Lungs | Equivalence | Respiratory distress syndrome | Influenza | Respiratory diseases | Sepsis | Diabetes | Index Medicus | Abridged Index Medicus
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3. Full Text pH-Responsive Nanoparticles Targeted to Lungs for Improved Therapy of Acute Lung Inflammation/Injury
by Zhang, Can Yang and Lin, Wenjing and Gao, Jin and Shi, Xutong and Davaritouchaee, Maryam and Nielsen, Amy E and Mancini, Rock J and Wang, Zhenjia
ACS applied materials & interfaces, ISSN 1944-8244, 05/2019, Volume 11, Issue 18, pp. 16380 - 16390
Research | Science & Technology - Other Topics | Materials Science | Nanoscience & Nanotechnology | Technology | Materials Science, Multidisciplinary | Science & Technology | Nanoparticles - chemistry | Humans | Pneumonia - pathology | Drug Carriers - administration & dosage | Polyethylene Glycols - chemistry | Thiophenes - administration & dosage | Drug Carriers - chemistry | Bacterial Infections - complications | Antibodies, Anti-Idiotypic - administration & dosage | Intercellular Adhesion Molecule-1 - drug effects | Acute Lung Injury - drug therapy | Bacterial Infections - microbiology | Lung - pathology | Bacterial Infections - drug therapy | Rats | Respiratory Distress Syndrome, Adult - drug therapy | Acute Lung Injury - pathology | Animals | Pneumonia - drug therapy | Lung - drug effects | Amides - chemistry | Pneumonia - complications | Antibodies, Anti-Idiotypic - chemistry | Mice | Nanoparticles - administration & dosage | Thiophenes - chemistry | Amides - administration & dosage | Acute Lung Injury - complications | Hydrogen-Ion Concentration | targeted drug delivery | controlled release | nanoparticles | acute lung inflammation | pH-responsive
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4. Full Text Rutin decreases lipopolysaccharide-induced acute lung injury via inhibition of oxidative stress and the MAPK-NF-κB pathway
by Yeh, Chung-Hsin and Yang, Jiann-Jou and Yang, Ming-Ling and Li, Yi-Ching and Kuan, Yu-Hsiang
Free radical biology & medicine, ISSN 0891-5849, 04/2014, Volume 69, pp. 249 - 257
Acute lung injury | NF-κB | Free radicals | CAT | Lipopolysaccharide | SOD | HO-1 | MAPK | Rutin | GPx | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Mitogen-Activated Protein Kinase Kinases - genetics | Heme Oxygenase-1 - biosynthesis | Lipopolysaccharides - toxicity | Rutin - toxicity | Superoxide Dismutase - biosynthesis | Humans | Acute Lung Injury - genetics | Glutathione Peroxidase - biosynthesis | Gene Expression Regulation - drug effects | Animals | Acute Lung Injury - chemically induced | NF-kappa B - genetics | Signal Transduction - drug effects | Rutin - administration & dosage | Acute Lung Injury - drug therapy | Mice | Oxidative Stress - drug effects | Superoxide Dismutase-1 | Catalase - biosynthesis | Index Medicus
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5. Full Text Enteral Omega-3 Fatty Acid, γ-Linolenic Acid, and Antioxidant Supplementation in Acute Lung Injury
by Rice, Todd W and Wheeler, Arthur P and Thompson, B. Taylor and deBoisblanc, Bennett P and Steingrub, Jay and Rock, Peter and NIH NHLBI Acute Respiratory Distress Syndrome Network of Investigators, for the and NHLBI ARDS Clinical Trials Network and NIH NHLBI Acute Respiratory Distress Syndrome Network of Investigators
JAMA : the journal of the American Medical Association, ISSN 0098-7484, 10/2011, Volume 306, Issue 14, pp. 1574 - 1581
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | General aspects | Medical sciences | Humans | Middle Aged | Eicosapentaenoic Acid - adverse effects | Male | Sepsis - complications | Inflammation - drug therapy | Adult | Female | Acute Lung Injury - drug therapy | Dietary Supplements - adverse effects | Drug Therapy, Combination | Docosahexaenoic Acids - therapeutic use | Double-Blind Method | gamma-Linolenic Acid - therapeutic use | gamma-Linolenic Acid - adverse effects | Intensive Care Units - utilization | Treatment Outcome | Enteral Nutrition | Biomarkers - blood | Acute Lung Injury - mortality | Eicosapentaenoic Acid - blood | Antioxidants - therapeutic use | Docosahexaenoic Acids - blood | Survival Analysis | Pneumonia - complications | Antioxidants - adverse effects | Aged | Eicosapentaenoic Acid - therapeutic use | Acute Lung Injury - etiology | Docosahexaenoic Acids - adverse effects | Ventilator Weaning | Acute Lung Injury - complications | Index Medicus | Abridged Index Medicus
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6. Full Text Circulating histones are mediators of trauma-associated lung injury
by Abrams, Simon T and Zhang, Nan and Manson, Joanna and Liu, Tingting and Dart, Caroline and Baluwa, Florence and Wang, Susan Siyu and Brohi, Karim and Kipar, Anja and Yu, Weiping and Wang, Guozheng and Toh, Cheng-Hock
American journal of respiratory and critical care medicine, ISSN 1073-449X, 01/2013, Volume 187, Issue 2, pp. 160 - 169
Histones | Trauma | Lung | Respiratory System | Life Sciences & Biomedicine | Critical Care Medicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | Intensive care medicine | Medical sciences | Emergency and intensive care: injuries, diseases due to physical agents. Diving. Drowning. Disaster medicine | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy | Index Medicus | Abridged Index Medicus | lung | trauma | histones
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7. Full Text Randomized, placebo-controlled clinical trial of an aerosolized β2-agonist for treatment of acute lung injury
by Matthay, Michael A and Brower, Roy G and Carson, Shannon and Douglas, Ivor S and Eisner, Mark and Hite, Duncan and Holets, Steven and Kallet, Richard H and Liu, Kathleen D and MacIntyre, Neil and Moss, Marc and Schoenfeld, David and Steingrub, Jay and Thompson, B. Taylor and National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network and The National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network
American journal of respiratory and critical care medicine, ISSN 1073-449X, 09/2011, Volume 184, Issue 5, pp. 561 - 568
Acute respiratory distress syndrome | Alveolar epithelium | Pulmonary edema | Biological and medical sciences | Intensive care medicine | Medical sciences | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy | Emergency and intensive respiratory care | Adrenergic beta-2 Receptor Agonists - pharmacokinetics | United States - epidemiology | Survival Rate - trends | Double-Blind Method | Drug Administration Schedule | Enzyme-Linked Immunosorbent Assay | Follow-Up Studies | Acute Lung Injury - therapy | Humans | Middle Aged | Administration, Inhalation | Albuterol - pharmacokinetics | Male | Treatment Outcome | Respiration, Artificial | Acute Lung Injury - blood | Dose-Response Relationship, Drug | Acute Lung Injury - mortality | Disease-Free Survival | Albuterol - administration & dosage | Adrenergic beta-2 Receptor Agonists - administration & dosage | Female | Retrospective Studies | Index Medicus | Abridged Index Medicus | pulmonary edema | acute respiratory distress syndrome | alveolar epithelium
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8. Full Text Inhaled Anticoagulation Regimens for the Treatment of Smoke Inhalation–Associated Acute Lung Injury: A Systematic Review
by Miller, Andrew C and Elamin, Elamin M and Suffredini, Anthony F
Critical care medicine, ISSN 0090-3493, 02/2014, Volume 42, Issue 2, pp. 413 - 419
Anticoagulants | Antithrombins | Heparin | Fibrinolytic Agents | Acute Lung Injury | Smoke Inhalation Injury | Life Sciences & Biomedicine | Critical Care Medicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | Intensive care medicine | Medical sciences | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy | Anticoagulants - administration & dosage | Smoke Inhalation Injury - complications | Humans | Administration, Inhalation | Acute Lung Injury - drug therapy | Acute Lung Injury - etiology | Smoke Inhalation Injury - drug therapy | Index Medicus | Abridged Index Medicus
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9. Full Text Hypoxia-induced inflammation in the lung: A potential therapeutic target in acute lung injury?
by Fröhlich, Stephen and Boylan, John and Mcloughlin, Paul
American journal of respiratory cell and molecular biology, ISSN 1044-1549, 03/2013, Volume 48, Issue 3, pp. 271 - 279
Hypoxia | Inflammation | CREB | HIF | ARDS | Respiratory System | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Hypoxia - drug therapy | Lung - pathology | Humans | Pneumonia - pathology | Acute Lung Injury - pathology | Hypoxia - metabolism | Animals | Pneumonia - drug therapy | Hypoxia - pathology | Lung - drug effects | Acute Lung Injury - drug therapy | Acute Lung Injury - metabolism | Lung - metabolism | Pneumonia - metabolism | Index Medicus
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10. Full Text Risk factors for physical impairment after acute lung injury in a national, multicenter study
by Needham, Dale M and Wozniak, Amy W and Hough, Catherine L and Morris, Peter E and Dinglas, Victor D and Jackson, James C and Mendez-Tellez, Pedro A and Shanholtz, Carl and Ely, E. Wesley and Colantuoni, Elizabeth and Hopkins, Ramona O and Natl Inst Hlth NHLBI ARDS Network and National Institutes of Health NHLBI ARDS Network
American journal of respiratory and critical care medicine, ISSN 1073-449X, 05/2014, Volume 189, Issue 10, pp. 1214 - 1224
Acute lung injury | Muscle strength | Exercise test | Follow-up studies | Risk factors | Respiratory System | Life Sciences & Biomedicine | Critical Care Medicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | Intensive care medicine | Medical sciences | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy | Pneumology | Neuromuscular Blocking Agents - adverse effects | Glucocorticoids - therapeutic use | Prospective Studies | Respiratory Distress Syndrome, Adult - physiopathology | Follow-Up Studies |