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Biotechnology and Bioengineering, ISSN 0006-3592, 12/2008, Volume 101, Issue 5, pp. 881 - 893
Journal Article
PLoS Genetics, ISSN 1553-7390, 11/2014, Volume 10, Issue 11, pp. e1004809 - e1004809
Journal Article
Cell Metabolism, ISSN 1550-4131, 05/2012, Volume 15, Issue 5, pp. 665 - 674
Nonalcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular and liver-related mortality. NAFLD is characterized by both triglyceride... 
RAT-LIVER | RISK-FACTORS | MACROPHAGE APOPTOSIS | PROTEIN-KINASE | ENDOCRINOLOGY & METABOLISM | HMG-COA REDUCTASE | STEATOHEPATITIS | 3-HYDROXY-3-METHYLGLUTARYL COENZYME | PREVALENCE | MICRORNA EXPRESSION | MODULATION | CELL BIOLOGY | Sirtuin 1 - metabolism | Up-Regulation | Cholesterol - blood | Humans | Middle Aged | Sterol Esterase - metabolism | Male | MicroRNAs - metabolism | Desmosterol - metabolism | Cardiovascular Diseases - genetics | Cholesterol - genetics | Sirtuin 1 - genetics | Case-Control Studies | Phosphorylation - genetics | Hydroxymethylglutaryl CoA Reductases - metabolism | Adenylate Kinase - metabolism | Non-alcoholic Fatty Liver Disease | Sterol O-Acyltransferase - metabolism | Adult | Female | Lipid Metabolism - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Fatty Liver - genetics | Receptors, LDL - genetics | Gene Expression | Fatty Liver - metabolism | Cardiovascular Diseases - metabolism | Fatty Liver - blood | Liver - metabolism | Receptors, LDL - metabolism | Cholesterol - metabolism | Cholesterol, LDL - genetics | Phenotype | Sterol Esterase - genetics | Desmosterol - blood | Cholesterol, LDL - metabolism | MicroRNAs - genetics | Sterol O-Acyltransferase - genetics | Adenylate Kinase - genetics | Hydroxymethylglutaryl CoA Reductases - genetics | Enzymes | Liver diseases | Low density lipoproteins | Genes | Esters | Triglycerides | Cholesterol | MicroRNA | Fatty liver | Blood cholesterol | Physiological aspects | Hydrolases | Blood lipids | Health aspects | Statins | Index Medicus | atherosclerosis | Nonalcoholic steatohepatitis | cholesterol | Nonalcoholic fatty liver disease | fatty liver | lipogenesis | hypercholesterolemia | HMG CoA reductase
Journal Article
Cell Metabolism, ISSN 1550-4131, 05/2012, Volume 15, Issue 5, pp. 691 - 702
Numerous studies in humans link a nonsynonymous genetic polymorphism (I148M) in adiponutrin (ADPN) to various forms of fatty liver disease and liver cirrhosis.... 
ADIPOSE TRIGLYCERIDE LIPASE | COMPARATIVE GENE IDENTIFICATION-58 | LIPID-METABOLISM | MESSENGER-RNA EXPRESSION | FATTY LIVER-DISEASE | FAMILY-MEMBERS | ENZYMES | ENDOCRINOLOGY & METABOLISM | PNPLA3 | CONGENITAL GENERALIZED LIPODYSTROPHY | CHANARIN-DORFMAN-SYNDROME | CELL BIOLOGY | 1-Acylglycerol-3-Phosphate O-Acyltransferase - genetics | Lysophospholipids - metabolism | Up-Regulation | Lipids - genetics | Humans | Cercopithecus aethiops | Acyl Coenzyme A - genetics | Male | Lipids - biosynthesis | Acyltransferases - metabolism | Acyltransferases - genetics | 1-Acylglycerol-3-Phosphate O-Acyltransferase - metabolism | Cysteine Endopeptidases - metabolism | Liver - drug effects | Lipid Metabolism - genetics | Membrane Proteins - metabolism | Dietary Sucrose - metabolism | Phospholipids - metabolism | Acyl Coenzyme A - metabolism | CHO Cells | Fatty Liver - genetics | Phosphatidic Acids - genetics | Cricetinae | Fatty Liver - metabolism | Membrane Proteins - genetics | Liver - metabolism | Models, Molecular | Phospholipids - genetics | Hep G2 Cells | Mice, Knockout | Polymorphism, Genetic | Triglycerides - metabolism | Lysophospholipids - genetics | Animals | Cysteine Endopeptidases - genetics | Mice | Phosphatidic Acids - metabolism | Triglycerides - genetics | COS Cells | Physiological aspects | Medical colleges | Disease susceptibility | Liver diseases | Liver cirrhosis | Index Medicus
Journal Article
International Journal of Dermatology, ISSN 0011-9059, 12/2017, Volume 56, Issue 12, pp. 1406 - 1413
BackgroundGenodermatoses represent genetic anomalies of skin tissues including hair follicles, sebaceous glands, eccrine glands, nails, and teeth. Ten... 
KINDLER-SYNDROME | KINDLIN-1 | PROTEIN | MUTATION | VII COLLAGEN | SPECTRUM | DYSTROPHIC EPIDERMOLYSIS-BULLOSA | IDENTIFICATION | DERMATOLOGY | Rare Diseases - genetics | 1-Acylglycerol-3-Phosphate O-Acyltransferase - genetics | Endonucleases - genetics | Lipid Metabolism, Inborn Errors - genetics | Sjogren-Larsson Syndrome - genetics | Xeroderma Pigmentosum - genetics | Humans | Male | Mitochondrial Proteins - genetics | Ichthyosis Vulgaris - genetics | INDEL Mutation | Skin Diseases, Genetic - genetics | Exome | Epidermolysis Bullosa - genetics | DNA Mutational Analysis | Intermediate Filament Proteins - genetics | Female | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Periodontal Diseases - genetics | Protoporphyrinogen Oxidase - genetics | Porphyria, Variegate - genetics | Photosensitivity Disorders - genetics | Epidermolysis Bullosa Simplex - genetics | Flavoproteins - genetics | Membrane Proteins - genetics | Collagen Type VII - genetics | Aldehyde Oxidoreductases - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Blister - genetics | Keratin-14 - genetics | Homozygote | Phenotype | Ichthyosis, Lamellar - genetics | Pedigree | Lipoxygenase - genetics | Consanguinity | Epidermolysis Bullosa Dystrophica - genetics | Muscular Diseases - genetics | Ichthyosiform Erythroderma, Congenital - genetics | Genetic research | Skin | Nucleotide sequencing | Genes | DNA sequencing | Sebaceous glands | Nails | Glands | Teeth | Disorders | Homozygosity | Tissues | Follicles | Gene sequencing | Genodermatosis | Gene mapping | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 02/2014, Volume 25, Issue 2, pp. 139 - 151
We report that two oncogenes coamplified on chromosome 3q26, and , cooperate to drive a stem-like phenotype in lung squamous cell carcinoma (LSCC). Protein... 
INITIATING CELLS | DETECTS FREQUENT | STEM-CELLS | PROTEIN | CANCER CELLS | EPITHELIUM | ONCOLOGY | TRANSFORMED GROWTH | PKC-IOTA | KINASE-C-IOTA | BASAL-CELLS | CELL BIOLOGY | Acyltransferases - antagonists & inhibitors | Protein Kinase C - genetics | RNA, Small Interfering - genetics | Cell Proliferation | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Lung Neoplasms - metabolism | SOXB1 Transcription Factors - antagonists & inhibitors | Lung Neoplasms - pathology | Acyltransferases - metabolism | Acyltransferases - genetics | Promoter Regions, Genetic - genetics | Immunoenzyme Techniques | SOXB1 Transcription Factors - metabolism | Neoplastic Stem Cells - metabolism | SOXB1 Transcription Factors - genetics | Cell Transformation, Neoplastic - genetics | Isoenzymes - metabolism | Protein Kinase C - metabolism | Neoplastic Stem Cells - pathology | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Isoenzymes - genetics | RNA, Messenger - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Protein Kinase C - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Animals | High-Throughput Nucleotide Sequencing | Mice | Cell Transformation, Neoplastic - pathology | Isoenzymes - antagonists & inhibitors | Apoptosis | Squamous cell carcinoma | Genetic aspects | Cancer | Index Medicus
Journal Article
PLoS Genetics, ISSN 1553-7390, 07/2016, Volume 12, Issue 7, pp. e1006160 - e1006160
While most yeast enzymes for the biosynthesis of glycerophospholipids, sphingolipids and ergosterol are known, genes for several postulated transporters... 
CELL-WALL | HEDGEHOG ACYLTRANSFERASE | CHAIN FATTY-ACIDS | GENETIC INTERACTION MAP | GENETICS & HEREDITY | BOUND O-ACYLTRANSFERASES | ENDOPLASMIC-RETICULUM | GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE | PLASMA-MEMBRANE | RAFT ASSOCIATION | GPI-ANCHORED PROTEINS | Ergosterol - genetics | Ergosterol - metabolism | Saccharomyces cerevisiae - genetics | Glycosylphosphatidylinositols - genetics | Saccharomyces cerevisiae - metabolism | Fatty Acids - genetics | Membrane Transport Proteins - genetics | Lipid Metabolism - genetics | Membrane Transport Proteins - metabolism | Phosphatidylinositols - metabolism | Fatty Acids - metabolism | Chromosome Deletion | Phosphatidylinositols - genetics | Amino Acid Sequence | Ceramides - metabolism | Membrane Proteins - genetics | Mutant Proteins - genetics | Cell Wall - genetics | Sphingolipids - metabolism | Saccharomyces cerevisiae Proteins - genetics | Ceramides - genetics | Sphingolipids - genetics | Glycosylphosphatidylinositols - metabolism | Cell Wall - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Crosses, Genetic | Physiological aspects | Genetic aspects | Lipid metabolism | Brewer's yeast | Gene expression | Observations | Mitogen-activated protein kinases | Proteins | Enzymes | Membranes | Maps | Biomedical research | Sterols | Genes | Glycerol | Lipids | Biosynthesis | Mutation | Metabolism | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2017, Volume 12, Issue 6, pp. e0178685 - e0178685
Hepatic steatosis can occur with any antiretroviral therapy (cART). Although single nucleotide polymorphisms (SNPs) have been identified to predispose to... 
TRANSIENT ELASTOGRAPHY | CONFERS SUSCEPTIBILITY | NONINVASIVE EVALUATION | CIRRHOSIS | MULTIDISCIPLINARY SCIENCES | CONTROLLED ATTENUATION PARAMETER | PNPLA3 | MORBID-OBESITY | NONALCOHOLIC STEATOHEPATITIS | WIDE ASSOCIATION | HEPATIC STEATOSIS | Chondroitin Sulfate Proteoglycans - genetics | Humans | Middle Aged | HIV Seropositivity - drug therapy | Male | Acyltransferases - genetics | HIV Seropositivity - genetics | Young Adult | Lysophospholipase - genetics | Protein Phosphatase 1 - genetics | Aged, 80 and over | Adult | Female | Liver Cirrhosis - genetics | Body Mass Index | Fatty Liver - genetics | Anti-Retroviral Agents - therapeutic use | Genetic Predisposition to Disease - genetics | Membrane Proteins - genetics | Proportional Hazards Models | Reverse Transcriptase Polymerase Chain Reaction | Bilirubin - blood | Adaptor Proteins, Signal Transducing - genetics | Triglycerides - blood | Polymorphism, Single Nucleotide - genetics | Aged | Lipase - genetics | Highly active antiretroviral therapy | Care and treatment | Usage | Fatty liver | HIV patients | Research | Single nucleotide polymorphisms | Genetic polymorphisms | Therapy | Liver | Medical services | Infections | Single-nucleotide polymorphism | Bilirubin | Risk factors | Alcohol use | Hepatitis | Acquired immune deficiency syndrome--AIDS | Antiretroviral agents | Human immunodeficiency virus--HIV | Attenuation | Drug therapy | Antiretroviral drugs | Obesity | Liver diseases | Internal medicine | Blood & organ donations | Complications | Abnormalities | Triglycerides | Regression analysis | Metabolism | Risk analysis | Patients | Antiretroviral therapy | Steatosis | Carriers | Polymerase chain reaction | Medicine | Gene frequency | Body mass | Fibrosis | Diabetes | Index Medicus | Acquired immune deficiency syndrome | AIDS | HIV | Human immunodeficiency virus
Journal Article
Journal Article
Journal of the American Academy of Dermatology, ISSN 0190-9622, 08/2017, Volume 77, Issue 2, pp. 268 - 273.e6
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, pp. e85757 - e85757
Journal Article