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1. Full Text Mucosal delivery of antigen‐coated nanoparticles to lungs confers protective immunity against tuberculosis infection in mice
by Stylianou, Elena and Diogo, Gil R and Pepponi, Ilaria and Dolleweerd, Craig and Arias, Mauricio A and Locht, Camille and Rider, Christopher C and Sibley, Laura and Cutting, Simon M and Loxley, Andrew and Ma, Julian K.C and Reljic, Rajko
European journal of immunology, ISSN 0014-2980, 02/2014, Volume 44, Issue 2, pp. 440 - 449
Nanoparticles | Vaccine | Tuberculosis | Mucosal | Immunity | Life Sciences & Biomedicine | Immunology | Science & Technology | Adjuvants, Immunologic - administration & dosage | Cell Proliferation | Vaccines, Subunit - genetics | Antigens, Bacterial - immunology | Mycobacterium tuberculosis - immunology | Pulmonary Alveoli - microbiology | Tuberculosis - microbiology | Acyltransferases - genetics | Antigens, Bacterial - genetics | CD4-Positive T-Lymphocytes - immunology | Respiratory Mucosa - microbiology | Interleukin-2 - immunology | Respiratory Mucosa - immunology | Tumor Necrosis Factor-alpha - immunology | Adjuvants, Immunologic - genetics | Female | Bacterial Proteins - immunology | Tuberculosis Vaccines - immunology | CD4-Positive T-Lymphocytes - virology | Tuberculosis Vaccines - genetics | Lectins - immunology | Bacterial Proteins - genetics | Acyltransferases - immunology | Recombinant Proteins - genetics | Vaccines, Subunit - immunology | Tuberculosis - immunology | Animals | Recombinant Proteins - immunology | CD8-Positive T-Lymphocytes - virology | Bacterial Load - immunology | Epithelial Cells - immunology | Epithelial Cells - microbiology | Interferon-gamma - immunology | BCG Vaccine - immunology | Lectins - genetics | Mice | Mice, Inbred BALB C | Nanoparticles - administration & dosage | CD8-Positive T-Lymphocytes - immunology | Pulmonary Alveoli - immunology | Antigens | Tuberculosis vaccines | Glycosaminoglycans | Immunotherapy | Lectins | Plant lipids | T cells | Health aspects | Protein binding | Lungs | Immune system | Index Medicus
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2. Full Text Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis
by Ballester, Marie and Nembrini, Chiara and Dhar, Neeraj and de Titta, Alexandre and de Piano, Cyntia and Pasquier, Miriella and Simeoni, Eleonora and van der Vlies, André J and McKinney, John D and Hubbell, Jeffrey A and Swartz, Melody A
Vaccine, ISSN 0264-410X, 2011, Volume 29, Issue 40, pp. 6959 - 6966
Allergy and Immunology | Vaccine | Administration route | Adjuvant | T-helper cells | Lung | Intradermal | Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) | Microbiology | Applied microbiology | Spleen - immunology | Nanoparticles - chemistry | Dendritic Cells - immunology | Antigens, Bacterial - immunology | Mycobacterium tuberculosis - immunology | Complement System Proteins - immunology | Vaccines, Synthetic - immunology | Lung - cytology | Th1 Cells - immunology | Immunoconjugates - administration & dosage | Immunoconjugates - immunology | Bacterial Proteins - immunology | Tuberculosis Vaccines - immunology | CpG Islands - immunology | Mice, Inbred C57BL | Tuberculosis Vaccines - administration & dosage | Acyltransferases - immunology | Antigens, Bacterial - administration & dosage | Lymph Nodes - immunology | Immunoconjugates - chemistry | Particle Size | Tuberculosis - immunology | Animals | Tuberculosis - prevention & control | Th17 Cells - immunology | Polypropylenes - chemistry | Mice | Nanoparticles - administration & dosage | Vaccines, Synthetic - administration & dosage | Lung - immunology | Antigens | Tuberculosis | Proteins | Emulsion polymerization | Lymphocytes | Laboratories | Glycerol | Vaccines | Index Medicus
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3. Full Text Down selecting adjuvanted vaccine formulations: A comparative method for harmonized evaluation
by Younis, Sumera Y and Barnier-Quer, Christophe and Heuking, Simon and Sommandas, Vinod and Brunner, Livia and vd.Werff, Nicole and Dubois, Patrice and Friede, Martin and Kocken, Clemens and Collin, Nicolas and Remarque, Ed
BMC immunology, ISSN 1471-2172, 01/2018, Volume 19, Issue 1, pp. 6 - 6
Plasmodium falciparum | AMA1 | Squalene-in-water SWE | Tuberculosis | QS21 | Adjuvants | HBsAg | Aluminium oxyhydroxide | Ag85A | Hepatitis B | Life Sciences & Biomedicine | Immunology | Science & Technology | Enzyme-Linked Immunosorbent Assay - methods | Adjuvants, Immunologic - analysis | Immunization | Reproducibility of Results | Antigens, Protozoan - immunology | Spleen - immunology | Immunoglobulin G - blood | Interleukin-5 - metabolism | Mice, Inbred C57BL | Antigens, Bacterial - immunology | Hepatitis B Surface Antigens - immunology | Vaccines - immunology | Acyltransferases - immunology | Membrane Proteins - immunology | Spleen - cytology | Interferon-gamma - metabolism | Enzyme-Linked Immunospot Assay - methods | Interleukin-5 - immunology | Animals | Spleen - metabolism | Immunoglobulin G - immunology | Vaccines - analysis | Interferon-gamma - immunology | Protozoan Proteins - immunology | Immune response | Adjuvants, Pharmaceutic | Dosage and administration | Diagnosis | Research | Comparative analysis | Index Medicus
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4. Full Text Enhanced Immunogenicity and Protective Efficacy Against Mycobacterium tuberculosis of Bacille Calmette-Guerin Vaccine Using Mucosal Administration and Boosting with a Recombinant Modified Vaccinia Virus Ankara
by Goonetilleke, Nilu P and McShane, Helen and Hannan, Carolyn M and Anderson, Richard J and Brookes, Roger H and Hill, Adrian V. S
The Journal of immunology (1950), ISSN 0022-1767, 08/2003, Volume 171, Issue 3, pp. 1602 - 1609
Life Sciences & Biomedicine | Immunology | Science & Technology | Immunodominant Epitopes - immunology | T-Lymphocyte Subsets - immunology | Lung - microbiology | Adjuvants, Immunologic - administration & dosage | Dose-Response Relationship, Immunologic | Spleen - immunology | Viral Vaccines - therapeutic use | Antigens, Bacterial - immunology | Mycobacterium tuberculosis - immunology | Molecular Sequence Data | Vaccines, Synthetic - immunology | Spleen - microbiology | Vaccinia virus - immunology | CD4-Positive T-Lymphocytes - immunology | Acyltransferases - administration & dosage | Female | Immunization Schedule | Adjuvants, Immunologic - therapeutic use | Injections, Intradermal | Amino Acid Sequence | CD4-Positive T-Lymphocytes - microbiology | CD8-Positive T-Lymphocytes - microbiology | Cells, Cultured | Acyltransferases - immunology | Immunization, Secondary - methods | Vaccines, Synthetic - therapeutic use | Antigens, Bacterial - administration & dosage | Lymph Nodes - immunology | Administration, Intranasal | Viral Vaccines - administration & dosage | Immunodominant Epitopes - administration & dosage | Animals | Nasal Mucosa - immunology | BCG Vaccine - immunology | Mice | Mice, Inbred BALB C | T-Lymphocyte Subsets - microbiology | BCG Vaccine - therapeutic use | Vaccines, Synthetic - administration & dosage | CD8-Positive T-Lymphocytes - immunology | Viral Vaccines - immunology | BCG Vaccine - administration & dosage | Lung - immunology | Lymph Nodes - microbiology | Index Medicus | Abridged Index Medicus
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5. Full Text Suboptimal antigen presentation contributes to virulence of mycobacterium tuberculosis in vivo
by Grace, Patricia S and Ernst, Joel D
The Journal of immunology (1950), ISSN 0022-1767, 01/2016, Volume 196, Issue 1, pp. 357 - 364
Life Sciences & Biomedicine | Immunology | Science & Technology | Lung - microbiology | Tuberculosis, Pulmonary - microbiology | Cell Proliferation | Mycobacterium bovis - immunology | Dendritic Cells - immunology | Mice, Inbred C57BL | Antigens, Bacterial - immunology | Mycobacterium tuberculosis - immunology | Acyltransferases - immunology | Virulence Factors - immunology | Antigen Presentation - immunology | Th1 Cells - immunology | Mice, Knockout | Mycobacterium tuberculosis - pathogenicity | Lymphocyte Activation - immunology | Tuberculosis, Pulmonary - immunology | Animals | Dendritic Cells - microbiology | Bacterial Proteins - immunology | Mice | Dendritic Cells - transplantation | Lung - immunology | Macrophages - immunology | Macrophages - microbiology | Index Medicus | Abridged Index Medicus
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6. Full Text Aerosol vaccination with AERAS-402 elicits robust cellular immune responses in the lungs of rhesus macaques but fails to protect against high-dose mycobacterium tuberculosis challenge
by Darrah, Patricia A and Bolton, Diane L and Lackner, Andrew A and Kaushal, Deepak and Aye, Pyone Pyone and Mehra, Smriti and Blanchard, James L and Didier, Peter J and Roy, Chad J and Rao, Srinivas S and Hokey, David A and Scanga, Charles A and Sizemore, Donata R and Sadoff, Jerald C and Roederer, Mario and Seder, Robert A
The Journal of immunology (1950), ISSN 0022-1767, 08/2014, Volume 193, Issue 4, pp. 1799 - 1811
Life Sciences & Biomedicine | Immunology | Science & Technology | Lung - microbiology | Mycobacterium tuberculosis - virology | Mycobacterium bovis - immunology | Antigens, Bacterial - immunology | Mycobacterium tuberculosis - immunology | Bronchoalveolar Lavage Fluid - immunology | Male | Macaca mulatta | Vaccines, Synthetic - immunology | CD4-Positive T-Lymphocytes - immunology | Vaccination - methods | Bacterial Proteins - immunology | Tuberculosis Vaccines - immunology | Tuberculosis Vaccines - administration & dosage | Administration, Inhalation | Acyltransferases - immunology | Tuberculosis, Pulmonary - prevention & control | Tuberculosis, Pulmonary - immunology | Animals | Vaccines, Synthetic - administration & dosage | CD8-Positive T-Lymphocytes - immunology | Interleukin-2 - biosynthesis | Immunity, Cellular | Tumor Necrosis Factor-alpha - biosynthesis | Interferon-gamma - biosynthesis | Lung - immunology | Index Medicus | Abridged Index Medicus
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7. Full Text The RNA-binding protein HuR is essential for the B cell antibody response
by Diaz-Munoz, Manuel D and Bell, Sarah E and Fairfax, Kirsten and Monzon-Casanova, Elisa and Cunningham, Adam F and Gonzalez-Porta, Mar and Anews, Simon R and Bunik, Victoria I and Zarnack, Kathi and Curk, Tomaz and Heggermont, Ward A and Heymans, Stephane and Gibson, Gary E and Kontoyiannis, Dimitris L and Ule, Jernej and Turner, Martin
Nature immunology, ISSN 1529-2908, 04/2015, Volume 16, Issue 4, pp. 415 - 425
Life Sciences & Biomedicine | Immunology | Science & Technology | RNA, Messenger - immunology | Cell Proliferation | Reactive Oxygen Species - metabolism | Germinal Center - immunology | Germinal Center - drug effects | Mitochondria - immunology | Acyltransferases - genetics | Antigens - administration & dosage | Immunity, Humoral | Mitochondria - genetics | Reactive Oxygen Species - immunology | Cell Death | Cell Differentiation | Germinal Center - cytology | ELAV Proteins - immunology | Immunoglobulin Class Switching | Immunoglobulins - biosynthesis | Erythrocytes - immunology | B-Lymphocytes - cytology | Immunization | Mice, Inbred C57BL | RNA, Messenger - genetics | Acyltransferases - immunology | Mice, Knockout | Alternative Splicing - immunology | B-Lymphocytes - drug effects | Animals | B-Lymphocytes - immunology | Lipopolysaccharides - pharmacology | Antigens - immunology | Sheep | Mice | ELAV Proteins - genetics | Index Medicus
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8. Full Text Ag85B–ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naïve human volunteers
by van Dissel, Jaap T and Arend, Sandra M and Prins, Corine and Bang, Peter and Tingskov, Pernille Nyholm and Lingnau, Karen and Nouta, Jan and Klein, Michèl R and Rosenkrands, Ida and Ottenhoff, Tom H.M and Kromann, Ingrid and Doherty, T. Mark and Andersen, Peter
Vaccine, ISSN 0264-410X, 2010, Volume 28, Issue 20, pp. 3571 - 3581
Allergy and Immunology | First-time-in-human | Clinical trial | Vaccine | Tuberculosis | Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Fundamental and applied biological sciences. Psychology | Miscellaneous | Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) | Microbiology | Applied microbiology | Biological and medical sciences | Bacteriology | Oligodeoxyribonucleotides - immunology | Immunoglobulin G - blood | Adjuvants, Immunologic | Humans | Oligopeptides - immunology | Antigens, Bacterial - immunology | Mycobacterium tuberculosis - immunology | Acyltransferases - immunology | Male | Young Adult | Recombinant Proteins - immunology | Interferon-gamma - immunology | Adolescent | BCG Vaccine - immunology | Adult | T-Lymphocytes - immunology | Bacterial Proteins - immunology | Antibodies, Bacterial - blood | Immunity, Cellular | BCG Vaccine - administration & dosage | Drug Combinations | Proteins | Studies | Pain | Lymphocytes | Vaccines | Immune system | Index Medicus | Adjuvants
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9. Full Text Multifunctional, High-Level Cytokine-Producing Th1 Cells in the Lung, but Not Spleen, Correlate with Protection against Mycobacterium tuberculosis Aerosol Challenge in Mice
by Forbes, Emily K and Sander, Clare and Ronan, Edward O and McShane, Helen and Hill, Adrian V. S and Beverley, Peter C. L and Tchilian, Elma Z
The Journal of immunology (1950), ISSN 0022-1767, 10/2008, Volume 181, Issue 7, pp. 4955 - 4964
Life Sciences & Biomedicine | Immunology | Science & Technology | Lung - microbiology | Tuberculosis, Pulmonary - microbiology | Mycobacterium bovis - immunology | Spleen - immunology | Humans | Antigens, Bacterial - immunology | Mycobacterium tuberculosis - immunology | Molecular Sequence Data | Lung - cytology | Th1 Cells - immunology | Cytokines - physiology | Spleen - microbiology | Th1 Cells - metabolism | Acyltransferases - administration & dosage | Female | Lung - metabolism | Injections, Intradermal | Amino Acid Sequence | Adenoviruses, Human - immunology | Acyltransferases - immunology | Immunization, Secondary - methods | Antigens, Bacterial - administration & dosage | Spleen - cytology | Administration, Intranasal | Tuberculosis, Pulmonary - prevention & control | Th1 Cells - microbiology | Tuberculosis, Pulmonary - immunology | Animals | Spleen - metabolism | BCG Vaccine - immunology | Aerosols | Adenoviruses, Human - genetics | Mice | Mice, Inbred BALB C | Mycobacterium bovis - growth & development | BCG Vaccine - administration & dosage | Cytokines - biosynthesis | Lung - immunology | Index Medicus | Abridged Index Medicus
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10. Full Text Adjuvant potential of poly-α-L-Glutamine from the cell wall of mycobacterium tuberculosis
by Mani, Rajesh and Gupta, Manish and Malik, Anshu and Tandon, Ravi and Prasad, Rajendra and Bhatnagar, Rakesh and Banerjee, Nirupama
Infection and immunity, ISSN 0019-9567, 10/2018, Volume 86, Issue 10
ESAT-6 | Th1/Th2/Th17 responses | Adjuvants | Vaccines | Poly-a-lglutamine | Cell wall | Mycobacterium tuberculosis H37Rv | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Science & Technology | Cell Wall - immunology | Adjuvants, Immunologic - administration & dosage | Humans | Antigens, Bacterial - immunology | Interleukin-17 - immunology | Mycobacterium tuberculosis - immunology | Tuberculosis - microbiology | Th1 Cells - immunology | Acyltransferases - genetics | Antigens, Bacterial - genetics | Antibodies, Bacterial | Freund's Adjuvant - immunology | Interleukin-2 - immunology | Acyltransferases - administration & dosage | Female | Bacterial Proteins - immunology | Tuberculosis Vaccines - immunology | Tuberculosis Vaccines - genetics | Mice, Inbred C57BL | Peptides - immunology | Tuberculosis Vaccines - administration & dosage | Bacterial Proteins - genetics | Cell Wall - genetics | Interleukin-17 - genetics | Acyltransferases - immunology | Antigens, Bacterial - administration & dosage | Bacterial Proteins - administration & dosage | Tuberculosis - immunology | Interleukin-2 - genetics | Animals | Tuberculosis - genetics | Tuberculosis - prevention & control | Mice | Mycobacterium tuberculosis - genetics | Index Medicus
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