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American Journal of Physiology - Regulatory Integrative and Comparative Physiology, ISSN 0363-6119, 01/2013, Volume 304, Issue 1, pp. R23 - R32
The interaction between adenosine and soluble epoxide hydrolase (sEH) in vascular response is not known. Therefore, we hypothesized that lack of sEH in mice... 
Relaxation | CYP2J5-epoxgenase;ω-hydroxylase | receptor | Soluble epoxide hydrolase | Contraction | Adenosine A | Epoxide Hydrolases - physiology | Adenosine-5'-(N-ethylcarboxamide) - pharmacology | Butyrates - pharmacology | Male | Receptor, Adenosine A2A - physiology | Lauric Acids - pharmacology | Vasodilation - genetics | 8,11,14-Eicosatrienoic Acid - analogs & derivatives | Adenosine A2 Receptor Agonists - pharmacology | Urea - analogs & derivatives | Female | Benzamides - pharmacology | Oxygenases - physiology | Vasodilation - physiology | 8,11,14-Eicosatrienoic Acid - pharmacology | Adamantane - analogs & derivatives | NG-Nitroarginine Methyl Ester - pharmacology | Adamantane - pharmacology | Triazines - pharmacology | Phenethylamines - pharmacology | Vasodilator Agents - pharmacology | Enzyme Inhibitors - pharmacology | Gene Silencing | Adenosine - pharmacology | Pyrimidines - pharmacology | Epoxide Hydrolases - genetics | Triazoles - pharmacology | Adenosine A2 Receptor Antagonists - pharmacology | PPAR gamma - physiology | Animals | Adenosine - analogs & derivatives | Benzoates - pharmacology | Mice | Phenylurea Compounds - pharmacology | Pyridines - pharmacology | Vasodilation - drug effects | Urea - pharmacology | Index Medicus | adenosine A2a receptor | CYP2J5-epoxgenase | ω-hydroxylase | relaxation | contraction | Cardiovascular and Renal Integration | soluble epoxide hydrolase | adenosine A1 receptor
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2014, Volume 58, Issue 11, pp. 6413 - 6423
Journal Article
PSYCHOPHARMACOLOGY, ISSN 0033-3158, 10/2016, Volume 233, Issue 21-22, pp. 3685 - 3709
Rationale AKB48 and its fluorinate derivate 5F-AKB48 are two novel synthetic cannabinoids belonging to a structural class with an indazole core structure. They... 
EXTRACELLULAR DOPAMINE | PRIMARY SOMATOSENSORY CORTEX | SAFETY PHARMACOLOGY | AGGRESSIVE-BEHAVIOR | PREPULSE INHIBITION | PSYCHIATRY | EVOKED ACTIVITY | AKB48 | JWH-018 | NEUROSCIENCES | MASS-SPECTROMETRY | Cannabinoids | NOCICEPTIN/ORPHANIN FQ TRANSMISSION | 5F-AKB48 | Microdialysis | Sensorimotor responses | Synthetic cannabinoids | Delta-THC | PHARMACOLOGY & PHARMACY | NUCLEUS-ACCUMBENS SHELL | Behavior | RECEPTOR AGONIST | Humans | Nucleus Accumbens - metabolism | Motor Activity - drug effects | Male | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Cannabinoid Receptor Agonists - pharmacology | Seizures - chemically induced | Cannabis | Piperidines - pharmacology | Cannabinoid Receptor Antagonists - pharmacology | Catalepsy - chemically induced | Pain Threshold - drug effects | Behavior, Animal - drug effects | Indoles - pharmacology | Reflex, Abnormal - drug effects | Dronabinol - pharmacology | Dopamine - metabolism | Adamantane - analogs & derivatives | Pyrazoles - pharmacology | Binding, Competitive | Adamantane - pharmacology | Naphthalenes - pharmacology | Indazoles - pharmacology | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Mice | In Vitro Techniques | Nucleus Accumbens - drug effects | Aggression - drug effects | Pharmacology, Experimental | Research | Neurochemistry | Psychotropic drugs | Neurology | Pharmacology | Rodents | Index Medicus
Journal Article
Neuropharmacology, ISSN 0028-3908, 06/2016, Volume 105, pp. 630 - 638
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 01/2013, Volume 344, Issue 1, pp. 8 - 14
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2015, Volume 58, Issue 23, pp. 9108 - 9123
Here, we describe the most promising small synthetic organic compounds that act as potent Sortase A inhibitors and cater the potential to be developed as... 
SRTA GENE | IN-VITRO | CHEMISTRY, MEDICINAL | CELL-WALL | STREPTOCOCCUS-PNEUMONIAE | ACTIVE-SITE | STAPHYLOCOCCUS-AUREUS SORTASE | SURFACE-PROTEINS | IMIDAZOLIUM ION-PAIR | A INHIBITORS | PROTEIN ANCHORING TRANSPEPTIDASE | Aminoacyltransferases - antagonists & inhibitors | Cysteine Endopeptidases - chemistry | Small Molecule Libraries - pharmacology | Staphylococcus aureus - enzymology | Nitriles - pharmacology | Benzoates - chemistry | Humans | Bacterial Proteins - chemistry | Carbolines - chemistry | Cysteine Endopeptidases - metabolism | Rhodanine - analogs & derivatives | Rhodanine - pharmacology | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Staphylococcal Infections - microbiology | Bacterial Adhesion - drug effects | Adamantane - analogs & derivatives | Aminoacyltransferases - chemistry | Bacterial Proteins - antagonists & inhibitors | Adamantane - pharmacology | Staphylococcal Infections - drug therapy | Thiones - chemistry | Enzyme Inhibitors - pharmacology | Models, Molecular | Staphylococcus aureus - pathogenicity | Small Molecule Libraries - chemistry | Animals | Nitriles - chemistry | Benzoates - pharmacology | Aminoacyltransferases - metabolism | Bacterial Proteins - metabolism | Protein Conformation | Thiazoles - chemistry | Anti-Bacterial Agents - pharmacology | Thiazoles - pharmacology | Thiones - pharmacology | Staphylococcus aureus - drug effects | Carbolines - pharmacology | Index Medicus
Journal Article
American Journal of Therapeutics, ISSN 1075-2765, 2016, Volume 23, Issue 3, pp. e757 - e765
Journal Article
Arteriosclerosis thrombosis and vascular biology, ISSN 1079-5642, 07/2010, Volume 30, Issue 7, pp. 1407 - U356
Objective-Endothelial cell senescence is an important contributor to vascular aging and is increased under diabetic conditions. Here we investigated whether... 
senescence | glucagon-like peptide 1 | endothelium | diabetes mellitus | reactive oxygen species | APOPTOSIS | TRANSCRIPTION | ATHEROSCLEROSIS | ZUCKER RAT | NEPHROPATHY | CARDIOVASCULAR-DISEASE | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | DYSFUNCTION | GLP-1 RECEPTOR | HEMATOLOGY | DIABETIC FATTY RATS | Diabetes Mellitus - enzymology | Diabetes Mellitus - pathology | Heme Oxygenase-1 - metabolism | Oxidants - pharmacology | Reactive Oxygen Species - metabolism | Nitriles - pharmacology | Humans | Cellular Senescence - drug effects | Male | Phosphatidylinositol 3-Kinases - metabolism | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Pyrrolidines - pharmacology | Dose-Response Relationship, Drug | Proto-Oncogene Proteins c-akt - metabolism | Cyclic AMP - metabolism | Adamantane - analogs & derivatives | Disease Models, Animal | Cyclic AMP-Dependent Protein Kinases - metabolism | Adamantane - pharmacology | Glucagon-Like Peptide 1 - metabolism | Signal Transduction | Cells, Cultured | Diabetes Mellitus - drug therapy | Hydrogen Peroxide - pharmacology | Rats | Receptors, Glucagon - metabolism | Hypoglycemic Agents - pharmacology | Peptides - pharmacology | Rats, Zucker | Animals | Glucagon-Like Peptide-1 Receptor | Cyclic AMP Response Element-Binding Protein - metabolism | NAD(P)H Dehydrogenase (Quinone) - metabolism | Venoms - pharmacology | DNA Damage | Enzyme Activation | Oxidative Stress - drug effects | Endothelial Cells - pathology | Endothelial Cells - enzymology | Endothelial Cells - drug effects | Index Medicus
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 12/2012, Volume 696, Issue 1-3, pp. 194 - 202
Dipeptidyl peptidase-4 (DPP-4) inhibitors have been demonstrated to improve glycemic control, in particular postprandial hyperglycemic control, in patients... 
Type 2 diabetes | Glucagon-like peptide-1 | Postprandial hyperglycemia | Teneligliptin | Dyslipidemia | Dipeptidyl peptidase-4 | MYOCARDIAL-INFARCTION | ENDOTHELIAL DYSFUNCTION | PRECLINICAL PROFILE | ISCHEMIC-HEART-DISEASE | IMPROVED GLUCOSE-TOLERANCE | IV INHIBITOR | CARDIOVASCULAR-DISEASE | BETA-CELL DYSFUNCTION | PHARMACOLOGY & PHARMACY | SLOW-BINDING INHIBITOR | Hypertriglyceridemia - drug therapy | Pyrazoles - therapeutic use | Nitriles - pharmacology | Rats, Wistar | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Dipeptidyl Peptidase 4 - blood | Glucagon-Like Peptide 1 - blood | Male | Insulin - blood | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Hyperglycemia - drug therapy | Pyrrolidines - pharmacology | Sitagliptin Phosphate | Thiazolidines - pharmacology | Adamantane - analogs & derivatives | Pyrazoles - pharmacology | Hypoglycemic Agents - therapeutic use | Adamantane - pharmacology | Blood Glucose - analysis | Rats | Hypolipidemic Agents - pharmacology | Hypertriglyceridemia - blood | Hypoglycemic Agents - pharmacology | Thiazolidines - therapeutic use | Rats, Zucker | Triazoles - pharmacology | Animals | Hyperglycemia - blood | Hypolipidemic Agents - therapeutic use | Diabetes Mellitus, Type 2 - drug therapy | Pyrazines - pharmacology | Hyperglycemia | Peptides | Triglycerides | Glucose | Fatty acids | Dextrose | Index Medicus
Journal Article
Journal Article
Science Translational Medicine, ISSN 1946-6234, 04/2016, Volume 8, Issue 334, pp. 334ra51 - 334ra51
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 12/2007, Volume 27, Issue 12, pp. 2612 - 2618
OBJECTIVE—An initial step in endothelium-derived hyperpolarizing factor-mediated responses is endothelial cell hyperpolarization. Here we address the... 
Protein kinase A | Caveolae | Cytochrome P450 | Endothelium-derived hyperpolarizing factor | ACTIVATION | ENTRY | KINASE | RELAXATION | cytochrome P450 | endothelium-derived hyperpolarizing factor | CORONARY-ARTERIES | SYNTHASE | SOLUBLE EPOXIDE HYDROLASE | PERIPHERAL VASCULAR DISEASE | INHIBITORS | protein kinase A | HEMATOLOGY | BINDING | caveolae | BRADYKININ | TRPC Cation Channels - drug effects | Cytochrome P-450 Enzyme Inhibitors | Humans | Cytochrome P-450 Enzyme System - metabolism | Apamin - pharmacology | RNA, Messenger - metabolism | Recombinant Fusion Proteins - metabolism | 8,11,14-Eicosatrienoic Acid - analogs & derivatives | Transfection | Cyclic AMP - analogs & derivatives | Time Factors | Charybdotoxin - pharmacology | Membrane Transport Modulators - pharmacology | Vasodilator Agents - metabolism | Cell Membrane - metabolism | 8,11,14-Eicosatrienoic Acid - pharmacology | Biological Factors - metabolism | Eicosanoic Acids - antagonists & inhibitors | TRPC Cation Channels - genetics | Cyclic AMP - metabolism | Adamantane - analogs & derivatives | Cyclic AMP-Dependent Protein Kinases - metabolism | Adamantane - pharmacology | Bradykinin - metabolism | Endothelial Cells - metabolism | Cells, Cultured | Enzyme Inhibitors - pharmacology | Thionucleotides - pharmacology | Protein Transport | Caveolin 1 - metabolism | Cyclic AMP - pharmacology | Cyclic AMP - antagonists & inhibitors | Membrane Potentials | Ruthenium Red - pharmacology | Calcium Signaling - drug effects | Eicosanoic Acids - metabolism | Miconazole - pharmacology | TRPC Cation Channels - metabolism | Cytochrome P-450 Enzyme System - genetics | Epoxide Hydrolases - metabolism | Endothelial Cells - enzymology | Epoxide Hydrolases - antagonists & inhibitors | Endothelial Cells - drug effects | Index Medicus
Journal Article