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American journal of physiology. Regulatory, integrative and comparative physiology, ISSN 0363-6119, 01/2013, Volume 304, Issue 1, pp. R23 - R32
The interaction between adenosine and soluble epoxide hydrolase (sEH) in vascular response is not known. Therefore, we hypothesized that lack of sEH in mice... 
Relaxation | CYP2J5-epoxgenase;ω-hydroxylase | receptor | Soluble epoxide hydrolase | Contraction | Adenosine A | Epoxide Hydrolases - physiology | Adenosine-5'-(N-ethylcarboxamide) - pharmacology | Butyrates - pharmacology | Male | Receptor, Adenosine A2A - physiology | Lauric Acids - pharmacology | Vasodilation - genetics | 8,11,14-Eicosatrienoic Acid - analogs & derivatives | Adenosine A2 Receptor Agonists - pharmacology | Urea - analogs & derivatives | Female | Benzamides - pharmacology | Oxygenases - physiology | Vasodilation - physiology | 8,11,14-Eicosatrienoic Acid - pharmacology | Adamantane - analogs & derivatives | NG-Nitroarginine Methyl Ester - pharmacology | Adamantane - pharmacology | Triazines - pharmacology | Phenethylamines - pharmacology | Vasodilator Agents - pharmacology | Enzyme Inhibitors - pharmacology | Gene Silencing | Adenosine - pharmacology | Pyrimidines - pharmacology | Epoxide Hydrolases - genetics | Triazoles - pharmacology | Adenosine A2 Receptor Antagonists - pharmacology | PPAR gamma - physiology | Animals | Adenosine - analogs & derivatives | Benzoates - pharmacology | Mice | Phenylurea Compounds - pharmacology | Pyridines - pharmacology | Vasodilation - drug effects | Urea - pharmacology | adenosine A2a receptor | CYP2J5-epoxgenase | ω-hydroxylase | relaxation | contraction | Cardiovascular and Renal Integration | soluble epoxide hydrolase | adenosine A1 receptor
Journal Article
Toxicology and applied pharmacology, ISSN 0041-008X, 2017, Volume 333, pp. 43 - 50
Dipeptidyl peptidase-4 inhibitor (vildagliptin) has been shown to exert beneficial effects on insulin sensitivity and neuroprotection in obese-insulin... 
Obese-insulin resistance | Vildagliptin | Cognitive function | Mitochondrial function | Dapagliflozin | Synaptic plasticity | METFORMIN | OXIDATIVE STRESS | HOMEOSTASIS | COGNITION | DENSITY | PLASMA | CANAGLIFLOZIN | GLUCOSE | PHARMACOLOGY & PHARMACY | TOXICOLOGY | RECEPTOR FUNCTION | Memory - drug effects | Neuroprotective Agents - therapeutic use | Reactive Oxygen Species - metabolism | Insulin - physiology | Nitriles - pharmacology | Obesity - drug therapy | Rats, Wistar | Apoptosis - drug effects | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Cognition Disorders - metabolism | Male | Membrane Potential, Mitochondrial - drug effects | Brain - physiology | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Brain - metabolism | Neuroprotective Agents - pharmacology | Long-Term Potentiation - drug effects | Diet, High-Fat | Malondialdehyde - blood | Adamantane - therapeutic use | Anti-Inflammatory Agents - therapeutic use | Glucosides - therapeutic use | Benzhydryl Compounds - therapeutic use | Adamantane - analogs & derivatives | Malondialdehyde - metabolism | Adamantane - pharmacology | Cognition Disorders - physiopathology | Glucosides - pharmacology | Anti-Inflammatory Agents - pharmacology | Insulin Resistance | Obesity - physiopathology | Mitochondria - metabolism | Mitochondria - drug effects | Cognition Disorders - drug therapy | Maze Learning - drug effects | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Obesity - metabolism | Brain - drug effects | Animals | Benzhydryl Compounds - pharmacology | Oxidative Stress - drug effects | Mitochondria - physiology | Nitriles - therapeutic use | Obesity | Brain | Insulin resistance | Apoptosis | Analysis and chemistry | Low density lipoproteins | Cognition disorders | Glucose tolerance tests | Blood | High performance liquid chromatography | Neurophysiology | Index Medicus | INSULIN | APOPTOSIS | DRUGS | MITOCHONDRIA | RATS | SENSITIVITY | METABOLIC DISEASES | 60 APPLIED LIFE SCIENCES | BRAIN
Journal Article
Science translational medicine, ISSN 1946-6242, 2016, Volume 8, Issue 334, pp. 334ra51 - 334ra51
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 12/2007, Volume 27, Issue 12, pp. 2612 - 2618
OBJECTIVE—An initial step in endothelium-derived hyperpolarizing factor-mediated responses is endothelial cell hyperpolarization. Here we address the... 
Protein kinase A | Caveolae | Cytochrome P450 | Endothelium-derived hyperpolarizing factor | ACTIVATION | ENTRY | KINASE | RELAXATION | cytochrome P450 | endothelium-derived hyperpolarizing factor | CORONARY-ARTERIES | SYNTHASE | SOLUBLE EPOXIDE HYDROLASE | PERIPHERAL VASCULAR DISEASE | INHIBITORS | protein kinase A | HEMATOLOGY | BINDING | caveolae | BRADYKININ | TRPC Cation Channels - drug effects | Cytochrome P-450 Enzyme Inhibitors | Humans | Cytochrome P-450 Enzyme System - metabolism | Apamin - pharmacology | RNA, Messenger - metabolism | Recombinant Fusion Proteins - metabolism | 8,11,14-Eicosatrienoic Acid - analogs & derivatives | Transfection | Cyclic AMP - analogs & derivatives | Time Factors | Charybdotoxin - pharmacology | Membrane Transport Modulators - pharmacology | Vasodilator Agents - metabolism | Cell Membrane - metabolism | 8,11,14-Eicosatrienoic Acid - pharmacology | Biological Factors - metabolism | Eicosanoic Acids - antagonists & inhibitors | TRPC Cation Channels - genetics | Cyclic AMP - metabolism | Adamantane - analogs & derivatives | Cyclic AMP-Dependent Protein Kinases - metabolism | Adamantane - pharmacology | Bradykinin - metabolism | Endothelial Cells - metabolism | Cells, Cultured | Enzyme Inhibitors - pharmacology | Thionucleotides - pharmacology | Protein Transport | Caveolin 1 - metabolism | Cyclic AMP - pharmacology | Cyclic AMP - antagonists & inhibitors | Membrane Potentials | Ruthenium Red - pharmacology | Calcium Signaling - drug effects | Eicosanoic Acids - metabolism | Miconazole - pharmacology | TRPC Cation Channels - metabolism | Cytochrome P-450 Enzyme System - genetics | Epoxide Hydrolases - metabolism | Endothelial Cells - enzymology | Epoxide Hydrolases - antagonists & inhibitors | Endothelial Cells - drug effects
Journal Article
PloS one, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e46781
Background: Dipeptidyl peptidase 4 (DPP4) and angiotensin-converting enzyme (ACE) are important target enzymes in glycemic control and renovascular protection.... 
METABOLIC SYNDROME | CYCLOOXYGENASE-2 | GENE-EXPRESSION | INJURY | ANGIOTENSIN-II | INHIBITORS | KIDNEY | UP-REGULATION | NEPHROPATHY | UMCG Approved | DIPEPTIDYL PEPTIDASE-IV | MULTIDISCIPLINARY SCIENCES | DYSFUNCTION | Immunohistochemistry | Dipeptidyl Peptidase 4 - metabolism | Nitriles - pharmacology | Diabetes Mellitus, Type 2 - genetics | Dipeptidyl Peptidase 4 - blood | Endothelium, Vascular - drug effects | Aorta - metabolism | Diabetes Mellitus, Type 2 - metabolism | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Endothelium, Vascular - physiology | Pyrrolidines - pharmacology | Kidney - metabolism | Peptidyl-Dipeptidase A - blood | E-Selectin - genetics | Peptidyl-Dipeptidase A - metabolism | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Blood Pressure - drug effects | Adamantane - analogs & derivatives | Rats, Inbred SHR | Adamantane - pharmacology | Egg Proteins - pharmacology | Kidney - drug effects | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Aorta - drug effects | Diabetes Mellitus, Type 2 - prevention & control | Rats | Reverse Transcriptase Polymerase Chain Reaction | Cell Adhesion Molecules - metabolism | Protein Hydrolysates - pharmacology | Blotting, Western | Rats, Zucker | Animals | Prostaglandin-Endoperoxide Synthases - metabolism | Vasodilation - drug effects | In Vitro Techniques | Aorta - physiology | Type 2 diabetes | Glucagon | RNA | Protein hydrolysates | Angiotensin | Indomethacin | Diabetes therapy | Drinking water | Peptides | Syngeneic grafts | Interleukin | Western blotting | Proteins | Prostaglandins | Metabolites | Peptidyl-dipeptidase A | Rodents | Aorta | Supplementation | Damage | Food | Formulations | Hypertension | Enzymes | Departments | Peptidase | Kidneys | Diabetes mellitus | Dietary supplements | Contractility | Pharmacology | Interleukin 13 | Inflammation | Tumor necrosis factor-α | Metabolism | Gene expression | Insulin | Hydrolysates | Endothelium | Studies | Polymerase chain reaction | p22phox Protein | Cyclooxygenase-1 | Coronary vessels | Fibrosis | Diabetes | Laboratory animals | Endocrinology | metabolic syndrome | up-regulation | angiotensin-ii | kidney | inhibitors | dipeptidyl peptidase-iv | cyclooxygenase-2 | nephropathy | gene-expression | injury
Journal Article
Antimicrobial agents and chemotherapy, ISSN 1098-6596, 2010, Volume 54, Issue 7, pp. 2840 - 2846
Journal Article
Antimicrobial agents and chemotherapy, ISSN 1098-6596, 2014, Volume 58, Issue 11, pp. 6413 - 6423
Journal Article
Journal Article
Psychopharmacology (Berlin, Germany), ISSN 1432-2072, 2016, Volume 233, Issue 21-22, pp. 3685 - 3709
AKB48 and its fluorinate derivate 5F-AKB48 are two novel synthetic cannabinoids belonging to a structural class with an indazole core structure. They are... 
Neurosciences | AKB48 | JWH-018 | Δ 9 -THC | Cannabinoids | Biomedicine | 5F-AKB48 | Microdialysis | Sensorimotor responses | Synthetic cannabinoids | Behavior | Pharmacology/Toxicology | Psychiatry | THC | EXTRACELLULAR DOPAMINE | PRIMARY SOMATOSENSORY CORTEX | SAFETY PHARMACOLOGY | AGGRESSIVE-BEHAVIOR | PREPULSE INHIBITION | PSYCHIATRY | EVOKED ACTIVITY | NEUROSCIENCES | MASS-SPECTROMETRY | NOCICEPTIN/ORPHANIN FQ TRANSMISSION | Delta-THC | PHARMACOLOGY & PHARMACY | NUCLEUS-ACCUMBENS SHELL | RECEPTOR AGONIST | Humans | Nucleus Accumbens - metabolism | Motor Activity - drug effects | Male | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Cannabinoid Receptor Agonists - pharmacology | Seizures - chemically induced | Cannabis | Piperidines - pharmacology | Cannabinoid Receptor Antagonists - pharmacology | Catalepsy - chemically induced | Pain Threshold - drug effects | Behavior, Animal - drug effects | Indoles - pharmacology | Reflex, Abnormal - drug effects | Dronabinol - pharmacology | Dopamine - metabolism | Adamantane - analogs & derivatives | Pyrazoles - pharmacology | Binding, Competitive | Adamantane - pharmacology | Naphthalenes - pharmacology | Indazoles - pharmacology | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Mice | In Vitro Techniques | Nucleus Accumbens - drug effects | Aggression - drug effects | Pharmacology, Experimental | Research | Neurochemistry | Psychotropic drugs | Neurology | Pharmacology | Rodents
Journal Article
Chemical communications (Cambridge, England), ISSN 1364-548X, 2018, Volume 54, Issue 32, pp. 4037 - 4040
A fluorogenic 2D glycoprobe based on poly-cyclodextrin and thin-layer manganese dioxide has been developed for the targeted and stimulus-responsive imaging of... 
NANOPARTICLES | THERAPY | MANNOSE RECEPTOR | DRUG-DELIVERY | GLUTATHIONE | MOLECULAR RECOGNITION | THERANOSTICS | METAL-IONS | CHEMISTRY, MULTIDISCIPLINARY | FLUORESCENT-PROBE | LIVING CELLS | Fluorescent Dyes - chemical synthesis | Mannose-Binding Lectins - metabolism | Humans | Oxides - chemistry | Manganese Compounds - chemical synthesis | Macromolecular Substances - pharmacology | beta-Cyclodextrins - pharmacology | Lectins, C-Type - metabolism | Macromolecular Substances - chemistry | Naphthalimides - chemical synthesis | Asialoglycoprotein Receptor - metabolism | Fluorescent Dyes - pharmacology | Naphthalimides - chemistry | beta-Cyclodextrins - chemical synthesis | Acrylamides - pharmacology | Manganese Compounds - chemistry | Adamantane - analogs & derivatives | Oxides - chemical synthesis | Fluorescent Dyes - chemistry | Adamantane - pharmacology | Drug Stability | Receptors, Cell Surface - metabolism | Neoplasms - diagnostic imaging | Acrylamides - chemistry | Oxides - pharmacology | Naphthalimides - pharmacology | beta-Cyclodextrins - chemistry | Adamantane - chemical synthesis | Cell Line, Tumor | Ligands | Adamantane - chemistry | Manganese Compounds - pharmacology | Acrylamides - chemical synthesis | Macromolecular Substances - chemical synthesis | Manganese dioxide | Fluorescence | Cyclodextrins | Medical imaging
Journal Article
Medicinal chemistry (Shp-sariqah, United Arab Emirates), ISSN 1573-4064, 2018, Volume 14, Issue 6, pp. 641 - 649
Background: Black carrot is known to be effective against Type 2 diabetes. The phenolic compounds present in black carrot are responsible for this property,... 
Black carrot | Autodock vina | α-glucosidase | α-amylase | Anthocyanins | Dipeptidyl peptidase IV | Diabetes | CHEMISTRY, MEDICINAL | anthocyanins | LIPID-PEROXIDATION | DNA-DAMAGE | ACARBOSE | CANCER | ANTIOXIDANT CAPACITY | PHYTOCHEMICALS | alpha-glucosidase | HEART-DISEASE | CYANIDIN | alpha-amylase | dipeptidyl peptidase IV | diabetes | Acarbose - pharmacology | Phenols - isolation & purification | Anthocyanins - isolation & purification | Daucus carota - chemistry | Nitriles - pharmacology | Glycoside Hydrolase Inhibitors - isolation & purification | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Pyrrolidines - pharmacology | Enzyme Inhibitors - chemistry | Adamantane - analogs & derivatives | Phenols - pharmacology | alpha-Amylases - antagonists & inhibitors | Dipeptidyl-Peptidase IV Inhibitors - isolation & purification | Adamantane - pharmacology | Anthocyanins - pharmacology | Enzyme Inhibitors - pharmacology | Dipeptidyl-Peptidase IV Inhibitors - chemistry | Hypoglycemic Agents - chemistry | Glycoside Hydrolase Inhibitors - chemistry | Glycoside Hydrolase Inhibitors - pharmacology | Anthocyanins - chemistry | Enzyme Inhibitors - isolation & purification | Hypoglycemic Agents - pharmacology | Hypoglycemic Agents - isolation & purification | Hydrogen Bonding | Molecular Docking Simulation | Encapsulation | Enzymes | Acarbose | CD26 antigen | Peptidase | Target recognition | Molecular interactions | Diabetes mellitus | Glucosidase | Cyclodextrins | Glucose | Metabolism | Phenolic compounds | Glucose metabolism | Amylases | Cyclodextrin | Inhibitors | Phenols | Docking | Inhibition | In vitro methods and tests | Diabetes mellitus (non-insulin dependent)
Journal Article