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Life Sciences, ISSN 0024-3205, 11/2017, Volume 188, pp. 1 - 9
The vasorelaxant effects of the anti-diabetic drug, mitiglinide in phenylephrine (Phe)-pre-contracted aortic rings were examined. Arterial tone measurement was... 
Mitiglinide | Voltage-dependent K+ channel | Aortic smooth muscle | SERCA pump | channel | Voltage-dependent K | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | PHYSIOLOGICAL ROLES | ATPASE | ARTERIES | GENES | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | AGENTS | TYPE-2 DIABETES-MELLITUS | EXPRESSION | MODULATION | Potassium Channels, Voltage-Gated - agonists | Endothelium, Vascular - drug effects | Male | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Muscle, Smooth - drug effects | Drug Interactions | Phenylephrine - pharmacology | Glyburide - pharmacology | Oxadiazoles - pharmacology | Aorta, Thoracic - physiology | Indoles - pharmacology | Muscle, Smooth - physiology | Sarcoplasmic Reticulum Calcium-Transporting ATPases - antagonists & inhibitors | Aorta, Thoracic - drug effects | Isoindoles - pharmacology | 4-Aminopyridine - pharmacology | Rabbits | Nifedipine - pharmacology | Adenine - analogs & derivatives | Vasodilator Agents - pharmacology | Vasodilator Agents - antagonists & inhibitors | Adenine - pharmacology | Barium - pharmacology | Sarcoplasmic Reticulum Calcium-Transporting ATPases - physiology | Pyrroles - pharmacology | Animals | Signal Transduction - drug effects | Thapsigargin - pharmacology | Carbazoles - pharmacology | Isoindoles - antagonists & inhibitors | Protein kinase A | Electric potential | Protein kinase G | Smooth muscle | Activation | Potassium conductance | Guanylate cyclase | Channels | Vasodilation | Ca2+-transporting ATPase | Adenylate cyclase | Thapsigargin | Phenylephrine | Measurement methods | Aorta | Life sciences | Potassium channels (voltage-gated) | Inhibition | Pretreatment | Glibenclamide | Diabetes mellitus | Muscles | Cyclopiazonic acid | Endothelium | Nifedipine | Resistance | Signaling | Conductance | Endoplasmic reticulum | Adenosine triphosphatase | Index Medicus
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 05/2016, Volume 117, Issue 5, pp. 1240 - 1249
We demonstrated that in human platelets the endocannabinoid 2-arachidonoylglycerol (2-AG) decreased dose-and time-dependently cAMP intracellular levels. No... 
2‐ARACHIDONOYLGLYCEROL | HUMAN PLATELETS | PHOSPHODIESTERASE 3A | cAMP | 2-ARACHIDONOYLGLYCEROL | CELLS | ACTIVATION | PHOSPHORYLATION | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCANNABINOID SYSTEM | ARACHIDONIC-ACID | CELL BIOLOGY | BLOOD-PLATELETS | CYCLIC-AMP | CB1 | CANNABINOID RECEPTOR-LIGAND | Endocannabinoids - pharmacology | Phosphodiesterase 3 Inhibitors - pharmacology | Humans | Maleimides - pharmacology | Type C Phospholipases - metabolism | Immunoblotting | Phosphatidylinositol 3-Kinases - metabolism | Cannabinoid Receptor Agonists - pharmacology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Type C Phospholipases - antagonists & inhibitors | Dose-Response Relationship, Drug | Blood Platelets - cytology | Protein Kinase C - metabolism | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Receptors, Thromboxane - antagonists & inhibitors | Indoles - pharmacology | Platelet Aggregation - drug effects | Blood Platelets - drug effects | Chromones - pharmacology | Cyclic AMP - metabolism | Milrinone - pharmacology | Hydrazines - pharmacology | Adenine - analogs & derivatives | Intracellular Space - drug effects | Adenylyl Cyclase Inhibitors - pharmacology | Cells, Cultured | Morpholines - pharmacology | Adenine - pharmacology | Protein Kinase C - antagonists & inhibitors | Adenylyl Cyclases - metabolism | Arachidonic Acids - pharmacology | Glycerides - pharmacology | Blood Platelets - metabolism | Intracellular Space - metabolism | Receptors, Thromboxane - metabolism | Index Medicus
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 10/2012, Volume 167, Issue 4, pp. 775 - 786
BACKGROUND AND PURPOSE Patients with chronic obstructive pulmonary disease (COPD) show a poor response to corticosteroids, which has been linked to oxidative... 
salmeterol | corticosteroid | severe asthma | PI3Kδ | formoterol | oxidative stress | COPD | CELLS | COMBINATION THERAPY | INHALED CORTICOSTEROIDS | AIRWAY INFLAMMATION | BUDESONIDE | ADRENERGIC AGONISTS | INTERLEUKIN-8 | ASTHMA CONTROL | OBSTRUCTIVE PULMONARY-DISEASE | PHARMACOLOGY & PHARMACY | PI3Kd | Ethanolamines - pharmacology | Asthma - metabolism | Formoterol Fumarate | Albuterol - pharmacology | Humans | Middle Aged | Oxidative Stress - physiology | Male | Fluticasone | Adrenergic beta-2 Receptor Agonists - pharmacology | 1-Phosphatidylinositol 4-Kinase - metabolism | Young Adult | Dexamethasone - pharmacology | U937 Cells | Adult | Female | Interleukin-8 - metabolism | Pulmonary Disease, Chronic Obstructive - metabolism | Chromones - pharmacology | Salmeterol Xinafoate | Adenine - analogs & derivatives | Leukocytes, Mononuclear - drug effects | Hydrogen Peroxide - pharmacology | Adrenal Cortex Hormones - pharmacology | Albuterol - analogs & derivatives | Morpholines - pharmacology | 1-Phosphatidylinositol 4-Kinase - antagonists & inhibitors | Adenine - pharmacology | Drug Resistance - drug effects | Receptors, Adrenergic, beta-2 - metabolism | Budesonide - pharmacology | Androstadienes - pharmacology | Aged | Quinazolines - pharmacology | Hydrogen peroxide | Dexamethasone | Asthma | Steroids | Oxidative stress | Chronic obstructive pulmonary disease | Index Medicus | Research Papers
Journal Article
Steroids, ISSN 0039-128X, 03/2011, Volume 76, Issue 4, pp. 409 - 415
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2013, Volume 123, Issue 12, pp. 5119 - 5134
A systems pharmacological approach that capitalizes on the characterization of intracellular signaling networks can transform our understanding of human... 
MEDICINE, RESEARCH & EXPERIMENTAL | VISUAL CYCLE | PHAGOCYTOSIS | OPTICAL COHERENCE TOMOGRAPHY | ABCA4 | RHODOPSIN | MECHANISMS | MICE | DOXAZOSIN | LONG-TERM TREATMENT | CLINICAL-EXPERIENCE | Receptors, Adrenergic, alpha-2 - genetics | Guanabenz - therapeutic use | Reactive Oxygen Species | Receptor, Serotonin, 5-HT2A - genetics | Doxazosin - pharmacology | Humans | Photoreceptor Cells, Vertebrate - drug effects | Adrenergic alpha-Antagonists - therapeutic use | Macaca fascicularis | Adrenergic alpha-Antagonists - pharmacology | Molecular Targeted Therapy | Photoreceptor Cells, Vertebrate - physiology | Macular Degeneration - drug therapy | Adenylyl Cyclase Inhibitors | Adrenergic alpha-Agonists - therapeutic use | Alcohol Oxidoreductases - genetics | ATP-Binding Cassette Transporters - deficiency | Photoreceptor Cells, Vertebrate - radiation effects | ATP-Binding Cassette Transporters - genetics | Adenine - therapeutic use | Doxazosin - therapeutic use | Nerve Tissue Proteins - biosynthesis | Receptors, Adrenergic, alpha-2 - biosynthesis | Drug Evaluation, Preclinical | Disease Models, Animal | Macular Degeneration - prevention & control | Receptor, Serotonin, 5-HT2A - biosynthesis | Adenine - analogs & derivatives | Signal Transduction | Cell Survival | Light - adverse effects | Serotonin Antagonists - therapeutic use | Receptors, G-Protein-Coupled - biosynthesis | Adenine - pharmacology | Serotonin Antagonists - pharmacology | Nerve Tissue Proteins - genetics | Mice, Knockout | Guanabenz - pharmacology | Animals | Macular Degeneration - congenital | Macular Degeneration - genetics | Adrenergic alpha-Agonists - pharmacology | Mice | Mice, Inbred BALB C | Receptors, G-Protein-Coupled - genetics | Photoreceptor Cells, Vertebrate - pathology | Alcohol Oxidoreductases - deficiency | Macular degeneration | Retinal degeneration | Research | Studies | Pathology | Signal transduction | Disease | Genes | Retina | Photoreceptors | Pharmacology | Index Medicus | Abridged Index Medicus
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 07/2009, Volume 8, Issue 7, pp. 1974 - 1984
Journal Article
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 05/2013, Volume 57, Issue 5, pp. 2076 - 2086
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
TRANSIENT EXPRESSION | FC-RECEPTOR | HIV-1 ENVELOPE | CD4-BINDING SITE | RAPID PRODUCTION | IMMUNODEFICIENCY-VIRUS TYPE-1 | NONNEUTRALIZING ANTIBODIES | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | SHIV CHALLENGE | CELL | RATIONAL DESIGN | Antibodies, Monoclonal - biosynthesis | Antiviral Agents - immunology | Cyclohexanes - pharmacology | Humans | HIV Envelope Protein gp120 - antagonists & inhibitors | Neutralization Tests | Antiviral Agents - metabolism | Recombinant Proteins - biosynthesis | HIV Envelope Protein gp120 - metabolism | Tenofovir | Antibodies, Neutralizing - immunology | HIV-1 - growth & development | Tobamovirus - genetics | HIV Antibodies - immunology | Immunoglobulin G - biosynthesis | Immunoglobulin G - immunology | HIV Antibodies - biosynthesis | Immunoglobulin G - pharmacology | HIV Antibodies - pharmacology | Antibodies, Monoclonal - immunology | Antiviral Agents - pharmacology | Adenine - analogs & derivatives | HIV-1 - drug effects | Antibodies, Monoclonal - pharmacology | Antibodies, Neutralizing - pharmacology | Plant Lectins - pharmacology | Adenine - pharmacology | Recombinant Proteins - pharmacology | Drug Synergism | Triazoles - pharmacology | Organophosphonates - pharmacology | Animals | Chromatography, Affinity | Recombinant Proteins - immunology | Antibodies, Neutralizing - biosynthesis | Tobacco - genetics | Genetic Vectors | Drug Combinations | Index Medicus | Antiviral Agents
Journal Article
AIDS, ISSN 0269-9370, 07/2012, Volume 26, Issue 11, pp. 1371 - 1385
Background: The effect of specific antiretrovirals on inflammation is unclear. Methods: A5224s was a substudy of A5202, which randomized HIV-infected... 
endothelial activation markers | abacavir | C-reactive protein | TNF alpha | inflammation markers | interleukin-6 | INTIMA-MEDIA THICKNESS | INFECTIOUS DISEASES | ABACAVIR-LAMIVUDINE | BONE-MINERAL DENSITY | IMMUNOLOGY | HIV-INFECTED PATIENTS | TENOFOVIR-EMTRICITABINE | INDIVIDUAL ANTIRETROVIRAL DRUGS | VIROLOGY | CLINICAL-TRIALS | ACUTE MYOCARDIAL-INFARCTION | Anti-HIV Agents - pharmacology | Humans | Tumor Necrosis Factor-alpha - blood | Deoxycytidine - pharmacology | Male | Inflammation - blood | Tenofovir | Acquired Immunodeficiency Syndrome - immunology | C-Reactive Protein - metabolism | Interleukin-6 - blood | Atazanavir Sulfate | Adult | Female | Ritonavir - pharmacology | C-Reactive Protein - drug effects | Acquired Immunodeficiency Syndrome - blood | Emtricitabine | Dideoxynucleosides - pharmacology | HIV-1 - metabolism | Adenine - analogs & derivatives | Adenine - pharmacology | Inflammation - immunology | Biomarkers - blood | Acquired Immunodeficiency Syndrome - drug therapy | Organophosphonates - pharmacology | Tumor Necrosis Factor-alpha - drug effects | Benzoxazines - pharmacology | Lamivudine - pharmacology | Pyridines - pharmacology | Oligopeptides - pharmacology | Deoxycytidine - analogs & derivatives | Drug Combinations | Antiviral agents | nucleoside reverse transcriptase inhibitors | RNA | Ritonavir | tenofovir | Lamivudine | Inflammation | Efavirenz | CD4 antigen | Cell adhesion molecules | Interleukin 6 | Abacavir | Age | Tumor necrosis factor- alpha | Index Medicus | AIDS/HIV
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, pp. e59281 - e59281
Platelets play an important role in thrombosis and in neo-vascularisation as they release and produce factors that both promote and suppress angiogenesis.... 
ACTIVATION | ALPHA-GRANULES | PROSTACYCLIN | MULTIDISCIPLINARY SCIENCES | NITRIC-OXIDE | GROWTH-FACTOR | ANGIOGENESIS INHIBITOR | PROTEINS | PLASMINOGEN | CARCINOMA | ENDOSTATIN | Endothelium, Vascular - cytology | Humans | Culture Media, Conditioned - pharmacology | Endothelium, Vascular - drug effects | Valerates - pharmacology | Cell Hypoxia | S-Nitrosoglutathione - pharmacology | Platelet Aggregation Inhibitors - pharmacology | Epoprostenol - pharmacology | Collagen - pharmacology | Platelet Aggregation - drug effects | Aspirin - pharmacology | Blood Platelets - drug effects | Vascular Endothelial Growth Factor A - pharmacology | Cell Line | Adenine - analogs & derivatives | Angiogenesis Inhibitors - pharmacology | Adenine - pharmacology | Peptides - pharmacology | Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors | Cell Movement - drug effects | Blood Platelets - metabolism | Endothelial Cells - cytology | Angiostatins - pharmacology | Endothelial Cells - drug effects | Aspirin | Collagen | Hostages | Comparative analysis | Vascular endothelial growth factor | Thrombosis | Blood clot | Endothelium | Prostacyclin | Acetylsalicylic acid | Cell adhesion & migration | Vascularization | Proteins | Angiogenesis | Cell growth | Blood platelets | Thromboembolism | Pharmaceutical sciences | Glutathione | Gold | Immunoglobulins | Research & development--R&D | Pharmacology | Platelet aggregation | Electron microscopy | Organelles | Endothelial cells | Blood clots | Inhibitors | Acids | Microscopy | Granular materials | Nitric oxide | Pharmacy | Hypoxia | Granules | Kinetics | Angiostatin | Immunofluorescence | Platelets | Cell migration | Cancer | Index Medicus | Research & development | R&D
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 01/2016, Volume 60, Issue 1, pp. 316 - 322
Journal Article
Circulation, ISSN 0009-7322, 2006, Volume 113, Issue 18, pp. 2221 - 2228
Background - Cyclic guanosine monophosphate (cGMP) is the common second messenger for the cardiovascular effects of nitric oxide (NO) and natriuretic peptides,... 
Sildenafil | Phosphodiesterases | Cyclic GMP | Nitric oxide | Natriuretic peptides | nitric oxide | CARDIAC & CARDIOVASCULAR SYSTEMS | cyclic GMP | CALCIUM CURRENT | DEPENDENT PROTEIN-KINASE | sildenafil | natriuretic peptides | SOLUBLE GUANYLYL CYCLASE | CGMP-SPECIFIC PHOSPHODIESTERASE | CA2+ CURRENT | phosphodiesterases | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | ADENOVIRUS-MEDIATED EXPRESSION | FROG VENTRICULAR MYOCYTES | NUCLEOTIDE-GATED CHANNELS | HEMATOLOGY | HUMAN ATRIAL MYOCYTES | Cyclic GMP - pharmacology | Heart Ventricles - cytology | Rats, Wistar | Cyclic Nucleotide Phosphodiesterases, Type 5 | Cyclic Nucleotide Phosphodiesterases, Type 2 | Humans | Recombinant Fusion Proteins - analysis | Recombinant Fusion Proteins - physiology | Male | Ion Channels - physiology | Natriuretic Peptide, Brain - pharmacology | Phosphoric Diester Hydrolases - physiology | Cell Compartmentation | Sildenafil Citrate | Purines | Biological Transport | Cell Membrane - metabolism | Atrial Natriuretic Factor - pharmacology | Nitric Oxide Donors - pharmacology | Sarcolemma - metabolism | Second Messenger Systems | Sulfones | Isoenzymes - physiology | Adenine - analogs & derivatives | 3',5'-Cyclic-GMP Phosphodiesterases - physiology | Solubility | Phosphodiesterase Inhibitors - pharmacology | Rats | Adenine - pharmacology | Myocytes, Cardiac - chemistry | Piperazines - pharmacology | 1-Methyl-3-isobutylxanthine - pharmacology | Ion Channels - antagonists & inhibitors | Cyclic AMP - pharmacology | Animals | Ion Channels - analysis | Myocytes, Cardiac - drug effects | Cyclic GMP - metabolism | Cyclic Nucleotide-Gated Cation Channels | Myocytes, Cardiac - ultrastructure | Isoenzymes - antagonists & inhibitors | Ion Channel Gating - drug effects | Index Medicus | Abridged Index Medicus | Life Sciences | Cellular Biology | Cell Membrane | cytology | Ion Channels | cGMP | Recombinant Fusion Proteins | Heart Ventricles | Nitric Oxide Donors | Natriuretic Peptide, Brain | Atrial Natriuretic Factor | pharmacology | 3',5'-Cyclic-GMP Phosphodiesterase | chemistry | Sarcolemma | Phosphodiesterase Inhibitors | Myocytes, Cardiac | Piperazines | Isoenzymes | physiology | Adenine | Cyclic AMP | 1-Methyl-3-isobutylxanthine | drug effects | analysis | ultrastructure | antagonists & inhibitors | Phosphoric Diester Hydrolases | analogs & derivatives | metabolism | Ion Channel Gating
Journal Article