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Cancer cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 72 - 85
Neoantigens derived from somatic mutations in tumors may provide a critical link between the adaptive immune system and cancer. Here, we describe a system to... 
IMMUNE-RESPONSE | SOLID TUMORS | ONCOLOGY | COLORECTAL-CANCER | IFN-GAMMA | MOUSE MODEL | GENE-EXPRESSION | CHRONIC VIRAL-INFECTION | LOSS VARIANTS | ESTABLISHED TUMORS | LYMPHOCYTES | CELL BIOLOGY | Adenocarcinoma - pathology | Cell Proliferation | Genetic Vectors - administration & dosage | Ovalbumin - immunology | Cell Count | Humans | Lung Neoplasms - metabolism | Transplantation, Isogeneic - pathology | Mice, 129 Strain | T-Lymphocytes - transplantation | Histocompatibility Antigens Class I - metabolism | Adenocarcinoma - metabolism | T-Lymphocytes - metabolism | Time Factors | Peptide Fragments - immunology | Antigens, Neoplasm - metabolism | Antigens, Surface - metabolism | Lentivirus - genetics | B-Lymphocytes - pathology | Graft Rejection - pathology | Peptide Fragments - genetics | Antigens, Neoplasm - immunology | Adenocarcinoma - immunology | Mice, Transgenic | Lymph Nodes - immunology | Antigen Presentation - immunology | CD3 Complex - metabolism | Genetic Vectors - genetics | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Immunity, Cellular - immunology | B-Lymphocytes - immunology | T-Lymphocytes - immunology | Mice | Graft Rejection - immunology | CD8-Positive T-Lymphocytes - immunology | CD8-Positive T-Lymphocytes - pathology | Lymph Nodes - pathology | Adenocarcinoma of Lung | Lentivirus - immunology | Lung Neoplasms - pathology | Adoptive Transfer | Transplantation, Isogeneic - immunology | T-Lymphocytes - pathology | Ovalbumin - genetics | Antigens, Neoplasm - genetics | Lung - pathology | Cytokines - metabolism | Mice, Inbred C57BL | Oligopeptides - genetics | Oligopeptides - immunology | Kaplan-Meier Estimate | Cancer Vaccines - immunology | Lung Neoplasms - immunology | Animals | Apoptosis - immunology | Interleukin-7 Receptor alpha Subunit - metabolism | Programmed Cell Death 1 Receptor | Lung - immunology
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2016, Volume 351, Issue 6280, pp. 1463 - 1469
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2011, Volume 6, Issue 11, p. e27944
Inflammatory mediators in the tumour microenvironment promote tumour growth, vascular development and enable evasion of anti-tumour immune responses, by... 
MIGRATION | ACTIVATION | FUNCTIONAL MATURATION | ANGIOGENESIS | VEGF | MULTIDISCIPLINARY SCIENCES | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | CXC CHEMOKINES | G-CSF | T-CELLS | ENDOTHELIAL GROWTH-FACTOR | Antigens, CD - immunology | Immunoglobulins - immunology | Membrane Glycoproteins - metabolism | Chemokine CCL2 - immunology | Coculture Techniques | Dendritic Cells - immunology | Humans | Culture Media, Conditioned - pharmacology | Male | Vascular Endothelial Growth Factor A - metabolism | Chemokine CXCL5 - metabolism | Interferon-gamma - metabolism | Chemokine CXCL1 - pharmacology | Lipopolysaccharides - immunology | Antigens, CD - metabolism | Immunoglobulins - metabolism | Chemokine CXCL5 - pharmacology | Flow Cytometry | Female | Chemokine CCL2 - metabolism | Membrane Glycoproteins - immunology | B7-2 Antigen - immunology | Chemokine CXCL1 - metabolism | HLA-DR Antigens - metabolism | Vascular Endothelial Growth Factor A - pharmacology | Colorectal Neoplasms - metabolism | Dendritic Cells - metabolism | Tumor Microenvironment - drug effects | Enzyme-Linked Immunosorbent Assay | Intercellular Adhesion Molecule-1 - immunology | Tissue Culture Techniques | Cells, Cultured | Vascular Endothelial Growth Factor A - immunology | Tumor Microenvironment - immunology | B7-2 Antigen - metabolism | Cell Differentiation - immunology | Chemokine CXCL1 - immunology | Intercellular Adhesion Molecule-1 - metabolism | Colorectal Neoplasms - immunology | Chemokine CCL2 - pharmacology | Cell Differentiation - drug effects | Chemokine CXCL5 - immunology | Interferon-gamma - immunology | Lipopolysaccharides - pharmacology | Aged | HLA-DR Antigens - immunology | Colorectal Neoplasms - pathology | Culture Media, Conditioned - metabolism | Care and treatment | Dendritic cells | Vascular endothelial growth factor | Colorectal cancer | Tumors | CD86 antigen | Colorectal carcinoma | Biochemistry | Metastasis | Kinases | Lipopolysaccharides | Proteins | Angiogenesis | Signal transduction | Lymphocytes | Inhibition | Pretreatment | Conditioning | Antigens | Immune response | Cytokines | Maturation | Neutrophils | Interleukin 12 | CD80 antigen | Inflammation | CD83 antigen | Interleukin 10 | Ligands | Histocompatibility antigen HLA | Prostate cancer | Chemokines | Monocyte chemoattractant protein 1 | Apoptosis
Journal Article
British journal of cancer, ISSN 1532-1827, 2015, Volume 112, Issue 6, pp. 1067 - 1075
Journal Article
Journal Article
Cancer immunology, immunotherapy, ISSN 1432-0851, 2005, Volume 55, Issue 7, pp. 808 - 818
This study was designed to determine the characteristics of tumour cell-derived microvesicles (TMV) and their interactions with human monocytes. TMV were shed... 
Monocytes | Biomedicine | Immunology | Transfer | Oncology | Cancer Research | mRNA | CCR6 | Tumour-derived microvesicles | CANCER-CELLS | SURVIVAL | monocytes | APOPTOSIS | ACTIVATION | PHAGOCYTOSIS | ADHESION MOLECULES | IMMUNOLOGY | transfer | PLATELET MICROPARTICLES | PLASMA | ONCOLOGY | MEMBRANE-VESICLES | ENDOTHELIAL MICROPARTICLES | tumour-derived microvesicles | RNA, Messenger - immunology | Adenocarcinoma - ultrastructure | Tetradecanoylphorbol Acetate - pharmacology | Humans | Neoplasm Proteins - immunology | RNA, Messenger - analysis | Cell Line, Tumor - drug effects | Gene Expression Profiling | Monocytes - immunology | Membrane Proteins - analysis | Basigin - genetics | Basigin - immunology | Antigens, Neoplasm - analysis | Neoplasm Proteins - genetics | Receptors, Chemokine | Receptors, Cytokine - genetics | Antigens, Neoplasm - immunology | Cell Survival | Adenocarcinoma - immunology | RNA, Messenger - genetics | HLA Antigens - immunology | Pancreatic Neoplasms - ultrastructure | Immunophenotyping | Membrane Proteins - immunology | Cell Membrane - ultrastructure | Neoplasms - ultrastructure | Chemotaxis | Hyaluronan Receptors - genetics | Particle Size | Cell Line, Tumor - ultrastructure | Lung Neoplasms - immunology | Colorectal Neoplasms - immunology | Neoplasms - immunology | Cell Line, Tumor - immunology | Pancreatic Neoplasms - immunology | Colorectal Neoplasms - ultrastructure | Lung Neoplasms - ultrastructure | Neoplasm Proteins - analysis | Receptors, Cytokine - immunology | Cell Membrane - immunology | Genes, MHC Class I | Hyaluronan Receptors - immunology | Apoptosis | Growth factors | Messenger RNA | Tumors
Journal Article
Gastroenterology, ISSN 0016-5085, 2011, Volume 140, Issue 1, pp. 310 - 321.e4
Background & Aims Anti-tumor immunity changes over the course of tumor progression; it is not clear how or when the developing tumor overcomes immune... 
Gastroenterology and Hepatology | Chemokine | Danger Signal | Premalignant Lesion | Multistep Carcinogenesis | DENDRITIC CELLS | IMMUNOSURVEILLANCE | CLASSIFICATION | PAPILLARY-MUCINOUS NEOPLASM | CANCER | IN-VITRO | PROTEIN-1 | GASTROENTEROLOGY & HEPATOLOGY | CARCINOMA | T-CELLS | ANTIGEN | Immunologic Surveillance | Antigens, CD - immunology | Adenocarcinoma, Mucinous - pathology | Dendritic Cells - immunology | Humans | Middle Aged | Carcinoma in Situ - immunology | Male | Gene Expression Profiling | Cell Adhesion Molecules - immunology | T-Lymphocytes, Cytotoxic - pathology | Adenocarcinoma, Mucinous - surgery | Chemokine CCL17 - immunology | Abscess - surgery | Adult | Female | Precancerous Conditions - pathology | Retrospective Studies | Carcinoma, Pancreatic Ductal - immunology | Pancreatic Pseudocyst - pathology | Adenocarcinoma, Papillary - pathology | Pancreatitis, Chronic - immunology | T-Lymphocytes, Cytotoxic - immunology | Adenocarcinoma, Papillary - immunology | Carcinoma in Situ - pathology | Pancreatic Neoplasms - pathology | Adenocarcinoma, Mucinous - immunology | Carcinoma, Pancreatic Ductal - pathology | Pancreatitis, Chronic - pathology | Cell Transformation, Neoplastic - immunology | Abscess - pathology | Animals | Precancerous Conditions - immunology | Lymphocytes, Tumor-Infiltrating - pathology | Pancreatic Neoplasms - immunology | Aged | Mice | Mice, Inbred BALB C | Abscess - immunology | Pancreatic Pseudocyst - immunology | Cell Transformation, Neoplastic - pathology | Neoplasm Staging | Lymphocytes, Tumor-Infiltrating - immunology | Antigens | Chemotherapy | Dendritic cells | Pancreatic cancer | Oncology, Experimental | Development and progression | Research | Carcinogenesis | Cancer | Index Medicus | Abridged Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 07/2011, Volume 71, Issue 14, pp. 4809 - 4820
Journal Article
Nature communications, ISSN 2041-1723, 2018, Volume 9, Issue 1, pp. 2724 - 13
Identifying tumor antigen-specific T cells from cancer patients has important implications for immunotherapy diagnostics and therapeutics. Here, we show that... 
TGF-BETA | MELANOMA | THERAPY | MEMORY | CANCER REGRESSION | INFILTRATING LYMPHOCYTES | MULTIDISCIPLINARY SCIENCES | PD-1 | EXPRESSION | EXHAUSTION | ANTIGEN | Antigens, CD - immunology | CD8-Positive T-Lymphocytes - pathology | Adenocarcinoma of Lung - pathology | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Squamous Cell Carcinoma of Head and Neck - pathology | Ovarian Neoplasms - pathology | Transcriptome | Male | Receptors, Antigen, T-Cell, alpha-beta - immunology | Squamous Cell Carcinoma of Head and Neck - mortality | Ovarian Neoplasms - mortality | Antigens, CD - genetics | Squamous Cell Carcinoma of Head and Neck - immunology | Ovarian Neoplasms - genetics | Adenocarcinoma of Lung - mortality | Adenocarcinoma of Lung - genetics | Carcinoma, Squamous Cell - mortality | Melanoma - genetics | Integrin alpha Chains - immunology | Female | Adenocarcinoma of Lung - immunology | Apyrase - immunology | Immunophenotyping | Melanoma - pathology | Carcinoma, Squamous Cell - immunology | Receptors, Antigen, T-Cell, alpha-beta - genetics | CD8 Antigens - immunology | Squamous Cell Carcinoma of Head and Neck - genetics | Lymphocytes, Tumor-Infiltrating - pathology | Melanoma - immunology | Apyrase - genetics | CD8 Antigens - genetics | Survival Analysis | CD8-Positive T-Lymphocytes - immunology | Integrin alpha Chains - genetics | Lymphocytes, Tumor-Infiltrating - immunology | Melanoma - mortality | Ovarian Neoplasms - immunology | Head | Phenotypes | Tumor cells | CD8 antigen | T cell receptors | Lymphocytes T | Patients | Metastases | T-cell receptor | CD103 antigen | Major histocompatibility complex | Lymphocytes | Immunotherapy | Head and neck cancer | Solid tumors | Cancer | Tumors | BASIC BIOLOGICAL SCIENCES
Journal Article
Cancer cell, ISSN 1535-6108, 2012, Volume 21, Issue 6, pp. 822 - 835
Cancer-associated inflammation is thought to be a barrier to immune surveillance, particularly in pancreatic ductal adenocarcinoma (PDA). Gr-1+ CD11b+ cells... 
OVEREXPRESSION | MICROENVIRONMENT | ONCOLOGY | DUCTAL ADENOCARCINOMA | INTERLEUKIN-1-BETA | MICE | SUPPRESSOR-CELLS | INDUCTION | DIFFERENTIATION | MAMMARY CARCINOMAS | MOUSE MODELS | CELL BIOLOGY | Immunohistochemistry | Adenocarcinoma - pathology | CD8-Positive T-Lymphocytes - pathology | Pancreatic Neoplasms - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | Inflammation - metabolism | Adenocarcinoma - metabolism | RNA Interference | T-Lymphocytes - metabolism | Myeloid Cells - immunology | CD8-Positive T-Lymphocytes - metabolism | T-Lymphocytes - pathology | Carcinoma, Pancreatic Ductal - immunology | CD11b Antigen - immunology | Adenocarcinoma - immunology | Pancreatic Neoplasms - pathology | Receptors, Chemokine - metabolism | Mice, Transgenic | Inflammation - immunology | Receptors, Chemokine - immunology | Carcinoma, Pancreatic Ductal - pathology | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Mice, Knockout | Tumor Microenvironment - immunology | Models, Immunological | Animals | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Pancreatic Neoplasms - immunology | Cell Line, Tumor | Myeloid Cells - metabolism | T-Lymphocytes - immunology | Mice | CD11b Antigen - metabolism | Myeloid Cells - pathology | CD8-Positive T-Lymphocytes - immunology | Medical colleges | Analysis | Pancreatic cancer | Oncology, Experimental | Genetically modified organisms | Inflammation | Macrophage colony stimulating factor | Research | T cells | Tumors | Cancer | granulocyte-macrophage colony stimulating factor | myeloid cells | T lymphocyte | carcinoma | pancreas
Journal Article
Nature (London), ISSN 1476-4687, 2019, Volume 565, Issue 7741, pp. 600 - 605
... Affiliations: (1) Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan (2) JSR-Keio University Medical and Chemical Innovation... 
MELANOMA | DENDRITIC CELLS | EFFICACY | ANTI-CTLA-4 | MULTIDISCIPLINARY SCIENCES | MICROBIOME | TUMOR | DISTINCT POPULATION | COLONIZATION | HUMAN GUT | INDUCTION | CD8-Positive T-Lymphocytes - cytology | Adenocarcinoma - pathology | Dendritic Cells - immunology | Humans | Symbiosis - immunology | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Listeria monocytogenes - immunology | Healthy Volunteers | Listeriosis - prevention & control | Antigens, CD - metabolism | Feces - microbiology | Bacteria - immunology | Listeriosis - immunology | Bacteria - classification | Female | Adenocarcinoma - immunology | Histocompatibility Antigens Class I - immunology | Integrin alpha Chains - metabolism | Xenograft Model Antitumor Assays | Bacteria - isolation & purification | Animals | Adenocarcinoma - therapy | Interferon-gamma - immunology | Cell Line, Tumor | Listeriosis - microbiology | Mice | Gastrointestinal Microbiome - immunology | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | Interferon-gamma - biosynthesis | Prevention | Care and treatment | Bacterial infections | Microbiota (Symbiotic organisms) | Physiological aspects | T cells | Health aspects | Cancer | Consortia | Dendritic cells | Interferon | Biological response modifiers | Animal models | CD8 antigen | Genes | Microbiomes | Lymphocytes T | Metastasis | Immunity | Microbiota | CD103 antigen | Listeria | Lymphocytes | Intestine | Immunotherapy | Strains (organisms) | Therapeutic applications | Melanoma | T cell receptors | Major histocompatibility complex | Immune checkpoint | γ-Interferon | Production capacity | Colonization | Tumors
Journal Article