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Journal Article
Cell, ISSN 0092-8674, 02/2018, Volume 172, Issue 4, pp. 857 - 868.e15
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2018, Volume 13, Issue 7, pp. e0200633 - e0200633
Purpose Lung cancer is the deadliest known cancer in the world, with the highest number of mutations in proto-oncogenes and tumor suppressor genes. Therefore,... 
MOLECULAR-PATHOLOGY | POLYMERASE-CHAIN-REACTION | METAANALYSIS | JOINT-CONSENSUS-RECOMMENDATION | ADENOCARCINOMA | MULTIDISCIPLINARY SCIENCES | SQUAMOUS-CELL CARCINOMA | SEQUENCE VARIANTS | ASSOCIATION | EXPRESSION | P53 | Adenocarcinoma of Lung - pathology | Proto-Oncogene Proteins p21(ras) - genetics | Carcinoma, Large Cell - pathology | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Tumor Suppressor Protein p53 - genetics | Adenocarcinoma of Lung - genetics | Iran | DNA Mutational Analysis | Aged, 80 and over | Adult | Female | Carcinoma, Large Cell - genetics | Discoidin Domain Receptor 2 - genetics | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Lung - pathology | Carcinoma, Non-Small-Cell Lung - genetics | Exons - genetics | Small Cell Lung Carcinoma - genetics | Small Cell Lung Carcinoma - pathology | Aged | Mutation | Care and treatment | Cancer patients | Gene mutations | Analysis | Genetic research | Genetic aspects | Research | Lung cancer, Non-small cell | Health aspects | Cancer | Adenocarcinoma | Exons | p53 Protein | Genes | Lung | Lung cancer | Oncology | Kinases | Cancer therapies | Gene sequencing | Cell growth | Cell cycle | Medical research | Squamous cell carcinoma | Non-small cell lung carcinoma | Gene expression | Patients | Medicine | Experimental design | Medical prognosis | Stem cells | Tumor suppressor genes | Molecular biology | Variation | Design of experiments | Apoptosis | Proto-oncogenes | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2018, Volume 13, Issue 6, pp. e0198634 - e0198634
In this study, we present the clinicopathological features associated with PD-L1 protein and mRNA expression in a large Asian cohort of patients with non-small... 
PEMBROLIZUMAB | METAANALYSIS | SAFETY | PD-L1 EXPRESSION | MULTIDISCIPLINARY SCIENCES | ANTIBODY | PULMONARY ADENOCARCINOMA | NIVOLUMAB | DOCETAXEL | DRIVER MUTATIONS | IMMUNOHISTOCHEMISTRY | Prognosis | Follow-Up Studies | Adenocarcinoma of Lung - pathology | Lung Neoplasms - mortality | Proto-Oncogene Proteins p21(ras) - genetics | Tissue Array Analysis | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | ErbB Receptors - genetics | Lung Neoplasms - pathology | Male | RNA, Messenger - metabolism | Anaplastic Lymphoma Kinase - genetics | Young Adult | Adenocarcinoma of Lung - mortality | Adenocarcinoma of Lung - genetics | Aged, 80 and over | Adult | Female | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Lung - pathology | Carcinoma, Non-Small-Cell Lung - genetics | B7-H1 Antigen - genetics | Carcinoma, Non-Small-Cell Lung - mortality | B7-H1 Antigen - metabolism | Gene Rearrangement | Survival Analysis | Aged | Mutation | Messenger RNA | Genetic aspects | Research | Gene expression | Lung cancer, Non-small cell | Apoptosis | Adenocarcinoma | Immunohistochemistry | Lung | Lung cancer | Clinical trials | Cancer therapies | Subgroups | Proteins | Medical research | Squamous cell carcinoma | Immunoglobulins | Epidermal growth factor receptors | Tumor cells | Non-small cell lung carcinoma | L1 protein | Histology | Studies | Pathology | Hospitals | Ribonucleic acids | Cell death | MicroRNAs | PD-L1 protein | Biomarkers | Ligands | Cancer | Tumors | Index Medicus
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 04/2019, Volume 10, Issue 1, pp. 1772 - 12
Deep understanding of the genomic and immunological differences between Chinese and Western lung cancer patients is of great importance for target therapy... 
B-CELLS | IMMUNE LANDSCAPE | HETEROGENEITY | RESPONSES | STATISTICS | MULTIDISCIPLINARY SCIENCES | ADENOCARCINOMAS | MUTATIONS | BLOCKADE | EXPRESSION | CLINICOPATHOLOGICAL FEATURES | Proto-Oncogene Proteins p21(ras) - genetics | Carcinoma, Squamous Cell - genetics | Genomics | Humans | Middle Aged | Wnt Signaling Pathway - immunology | Asian Continental Ancestry Group - genetics | ErbB Receptors - genetics | Male | Adenocarcinoma of Lung - mortality | Adenocarcinoma of Lung - genetics | Carcinoma, Squamous Cell - mortality | Female | Adenocarcinoma of Lung - immunology | Lung Neoplasms - genetics | T-Lymphocytes, Cytotoxic - immunology | Datasets as Topic | Carcinoma, Non-Small-Cell Lung - genetics | Antigen Presentation - genetics | Antigen Presentation - immunology | Carcinoma, Non-Small-Cell Lung - mortality | Carcinoma, Squamous Cell - immunology | Carcinoma, Non-Small-Cell Lung - immunology | Lung Neoplasms - immunology | Wnt Signaling Pathway - genetics | Aged | Mutation | Lymphocytes, Tumor-Infiltrating - immunology | Adenocarcinoma | Antigen presentation | Squamous cell carcinoma | Cell survival | Profiling | Wnt protein | Epidermal growth factor receptors | Lung | Lung cancer | Non-small cell lung carcinoma | Cytotoxicity | Lymphocytes T | Patients | 1-Phosphatidylinositol 3-kinase | Metastases | Immune systems | Immunology | Lymphocytes | Infiltration | Signatures | Cancer | Index Medicus
Journal Article
Journal Article
Molecular Cancer, ISSN 1476-4598, 02/2019, Volume 18, Issue 1, pp. 24 - 24
Axl receptor tyrosine kinase is involved in the growth and metastasis and is an indicator of poor prognosis in several cancers including lung cancers. Although... 
Non-small-cell lung cancer | Global gene expression array | Immune checkpoint molecules | Chemokine signalling | Axl receptor tyrosine kinase | ACTIVATION | ONCOLOGY | TARGETED-THERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | RNA, Messenger - immunology | RNA, Small Interfering - genetics | Prognosis | Oligonucleotide Array Sequence Analysis | Adenocarcinoma of Lung - pathology | Humans | ErbB Receptors - genetics | Gene Expression Regulation, Neoplastic | Receptor Protein-Tyrosine Kinases - immunology | Epithelial-Mesenchymal Transition - drug effects | Lung Neoplasms - pathology | Gene Expression Profiling | Epithelial-Mesenchymal Transition - genetics | Receptors, CXCR6 - immunology | Signal Transduction - immunology | Adenocarcinoma of Lung - genetics | Proto-Oncogene Proteins - immunology | Antineoplastic Agents - pharmacology | Adenocarcinoma of Lung - immunology | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Benzocycloheptenes - pharmacology | Carcinoma, Non-Small-Cell Lung - genetics | RNA, Messenger - genetics | Proto-Oncogene Proteins - genetics | Signal Transduction - genetics | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Disease Progression | Carcinoma, Non-Small-Cell Lung - immunology | Triazoles - pharmacology | Lung Neoplasms - immunology | Receptors, CXCR6 - genetics | Receptor Protein-Tyrosine Kinases - genetics | ErbB Receptors - immunology | Epithelial-Mesenchymal Transition - immunology | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Cohort Studies | RNA, Small Interfering - metabolism | Tyrosine | Medical research | Medical colleges | RNA | Genes | Development and progression | Lung cancer, Non-small cell | Gene expression | Epidermal growth factor | Analysis | Stem cells | Medicine, Experimental | Genetic research | Mitogens | Protein kinases | Adenocarcinoma | Phosphorylation | Thoracic surgery | Ontology | Mesenchyme | Lung | Lung cancer | Clinical trials | Metastasis | Kinases | Axl protein | Ovarian cancer | Metastases | Proteins | Signal transduction | Receptors | Annotations | Pathways | Protein-tyrosine kinase receptors | Inhibition | Growth factors | Protein-tyrosine kinase | Antigens | Epidermal growth factor receptors | MAP kinase | Pharmacology | Clustering | Chemokine receptors | Medicine | Signaling | Molecular modelling | Medical prognosis | PD-L1 protein | Cell lines | Ligands | Mutation | Chemokines | Apoptosis | Cancer
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2724 - 13
Identifying tumor antigen-specific T cells from cancer patients has important implications for immunotherapy diagnostics and therapeutics. Here, we show that... 
TGF-BETA | MELANOMA | THERAPY | MEMORY | CANCER REGRESSION | INFILTRATING LYMPHOCYTES | MULTIDISCIPLINARY SCIENCES | PD-1 | EXPRESSION | EXHAUSTION | ANTIGEN | Antigens, CD - immunology | CD8-Positive T-Lymphocytes - pathology | Adenocarcinoma of Lung - pathology | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Squamous Cell Carcinoma of Head and Neck - pathology | Ovarian Neoplasms - pathology | Transcriptome | Male | Receptors, Antigen, T-Cell, alpha-beta - immunology | Squamous Cell Carcinoma of Head and Neck - mortality | Ovarian Neoplasms - mortality | Antigens, CD - genetics | Squamous Cell Carcinoma of Head and Neck - immunology | Ovarian Neoplasms - genetics | Adenocarcinoma of Lung - mortality | Adenocarcinoma of Lung - genetics | Carcinoma, Squamous Cell - mortality | Melanoma - genetics | Integrin alpha Chains - immunology | Female | Adenocarcinoma of Lung - immunology | Apyrase - immunology | Immunophenotyping | Melanoma - pathology | Carcinoma, Squamous Cell - immunology | Receptors, Antigen, T-Cell, alpha-beta - genetics | CD8 Antigens - immunology | Squamous Cell Carcinoma of Head and Neck - genetics | Lymphocytes, Tumor-Infiltrating - pathology | Melanoma - immunology | Apyrase - genetics | CD8 Antigens - genetics | Survival Analysis | CD8-Positive T-Lymphocytes - immunology | Integrin alpha Chains - genetics | Lymphocytes, Tumor-Infiltrating - immunology | Melanoma - mortality | Ovarian Neoplasms - immunology | Head | Phenotypes | Tumor cells | CD8 antigen | T cell receptors | Lymphocytes T | Patients | Metastases | T-cell receptor | CD103 antigen | Major histocompatibility complex | Lymphocytes | Immunotherapy | Head and neck cancer | Neck | Solid tumors | Cancer | Tumors | Index Medicus | BASIC BIOLOGICAL SCIENCES
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2732 - 13
Genetic aberrations driving pro-oncogenic and pro-metastatic activity remain an elusive target in the quest of precision oncology. To identify such drivers, we... 
ANAPLASTIC LYMPHOMA KINASE | GENE-EXPRESSION SIGNATURE | CHROMATIN REMODELING COMPLEX | K-RAS | MULTIDISCIPLINARY SCIENCES | PANCREATIC-CANCER | MOUSE MODEL | C-MYC | PROTEIN-PROTEIN INTERACTIONS | MI-2/NURD COMPLEX | GROWTH-FACTOR | RNA, Small Interfering - genetics | Adenocarcinoma of Lung - pathology | Lung Neoplasms - mortality | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Lentivirus - metabolism | Adenocarcinoma of Lung - mortality | GATA Transcription Factors - antagonists & inhibitors | Neoplasm Metastasis | Adenocarcinoma of Lung - genetics | GATA Transcription Factors - metabolism | Female | Integrases - metabolism | Lentivirus - genetics | Proto-Oncogene Proteins p21(ras) - metabolism | Lung Neoplasms - genetics | Genetic Vectors - chemistry | Signal Transduction | Genetic Vectors - metabolism | Lung Neoplasms - therapy | GATA Transcription Factors - genetics | Proto-Oncogene Proteins c-myc - metabolism | Xenograft Model Antitumor Assays | Animals | High-Throughput Screening Assays | Mice, Nude | Survival Analysis | Cell Line, Tumor | Adenocarcinoma of Lung - therapy | Mice | Proto-Oncogene Proteins c-myc - genetics | Integrases - genetics | RNA, Small Interfering - metabolism | Adenocarcinoma | Lung | Lung cancer | Genes | c-Myc protein | Metastasis | Myc protein | Recombinase | Gene expression | Cre recombinase | Metastases | Lungs | Alleles | Dependence | Deoxyribonucleic acid--DNA | Cancer | Index Medicus
Journal Article