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JAMA, ISSN 0098-7484, 03/2016, Volume 315, Issue 12, pp. 1266 - 1275
Journal Article
Science Signaling, ISSN 1945-0877, 10/2015, Volume 8, Issue 397, pp. ra98 - ra98
Yes-associated protein 1 (YAP1) is a transcriptional coactivator in the Hippo signaling pathway. Increased YAP1 activity promotes the growth of tumors,... 
PHOTODYNAMIC THERAPY | PATHWAY | COLORECTAL-CANCER | BIOCHEMISTRY & MOLECULAR BIOLOGY | HIPPO | GROWTH | MACULAR DEGENERATION | CELL-PROLIFERATION | CHOROIDAL NEOVASCULARIZATION | TEAD/TEF FAMILY | TUMORIGENESIS | CELL BIOLOGY | Transcription, Genetic - drug effects | Phosphorylation | Adenocarcinoma - pathology | Molecular Weight | Apoptosis - drug effects | Colonic Neoplasms - drug therapy | Humans | Neoplasm Proteins - physiology | Colonic Neoplasms - chemically induced | Neoplasm Proteins - antagonists & inhibitors | Phosphoproteins - antagonists & inhibitors | Adenomatous Polyposis Coli - pathology | Autophagy - drug effects | Genes, APC | Neoplasm Proteins - drug effects | Proteasome Endopeptidase Complex - drug effects | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Adenoma - drug therapy | HEK293 Cells | Antineoplastic Agents - pharmacology | Phosphoproteins - physiology | Adenomatous Polyposis Coli - genetics | Mice, Inbred C57BL | Transcription Factors - antagonists & inhibitors | Porphyrins - pharmacology | Adenocarcinoma - drug therapy | Cell Division - drug effects | Mice, Knockout | Xenograft Model Antitumor Assays | Adaptor Proteins, Signal Transducing - physiology | Animals | Adenomatous Polyposis Coli - drug therapy | Colonic Neoplasms - pathology | Adenoma - pathology | Cell Line, Tumor | Mice | Protein Processing, Post-Translational | STAT3 Transcription Factor - antagonists & inhibitors | Protein Multimerization - drug effects
Journal Article
Journal Article
Life Sciences, ISSN 0024-3205, 10/2015, Volume 139, pp. 145 - 152
Colorectal cancer (CRC) is the third leading cause of death in both men and women in North America. Despite chemotherapeutic efforts, CRC is associated with a... 
Colorectal carcinogenesis | Base excision repair | DNA damage | Adenomatous polyposis coli | CANCER-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | BREAST EPITHELIAL-CELLS | LONG-PATCH | NUCLEAR ANTIGEN | MISMATCH REPAIR | DNA-POLYMERASE-BETA | APC TUMOR-SUPPRESSOR | ALKYLATING-AGENTS | APURINIC APYRIMIDINIC SITES | PHARMACOLOGY & PHARMACY | STRAND DISPLACEMENT SYNTHESIS | Dacarbazine - therapeutic use | Rectum - pathology | Humans | Colon - drug effects | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Adenomatous Polyposis Coli - pathology | Carcinogenesis - metabolism | Adenomatous Polyposis Coli Protein - analysis | Rectum - drug effects | Dacarbazine - analogs & derivatives | DNA Polymerase beta - metabolism | Adenomatous Polyposis Coli - genetics | Adenomatous Polyposis Coli Protein - genetics | DNA Repair - drug effects | Colon - pathology | Rectum - metabolism | Carcinogenesis - genetics | Models, Molecular | Flap Endonucleases - analysis | Flap Endonucleases - metabolism | Colon - metabolism | Adenomatous Polyposis Coli - metabolism | Carcinogenesis - drug effects | Carcinogenesis - pathology | DNA Polymerase beta - analysis | Animals | Adenomatous Polyposis Coli - drug therapy | Adenomatous Polyposis Coli Protein - metabolism | Mutation | Chemotherapy | Colon cancer | Mortality | Development and progression | Polyposis, Familial | Carcinogenesis | Cancer | Index Medicus | base excision repair | colorectal carcinogenesis
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 11/2013, Volume 17, Issue 11, pp. 1484 - 1493
As a traditional anti‐inflammatory Chinese herbal medicine, Alkaloid berberine has been recently reported to exhibit anti‐tumour effects against a wide... 
Wnt | familial adenomatous polyposis | signal transduction | colon cancer | berberine | Berberine | Signal transduction | Colon cancer | Familial adenomatous polyposis | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | STEM-CELLS | CYCLOOXYGENASE-2 | CELL-GROWTH | BETA-CATENIN | HUMAN COLORECTAL-CANCER | CELL BIOLOGY | CARCINOGENESIS | PATHWAY | RECEPTORS | TUMORIGENESIS | Cell Proliferation | Humans | Mice, Inbred C57BL | Male | Mice, Transgenic | Adenomatous Polyposis Coli - pathology | beta Catenin - metabolism | Protein Transport | Up-Regulation - drug effects | Young Adult | Berberine - pharmacology | Animals | Wnt Signaling Pathway - drug effects | Adenomatous Polyposis Coli - drug therapy | Adenomatous Polyposis Coli Protein - metabolism | Adolescent | Cell Line, Tumor | Adult | Female | Mice | Berberine - therapeutic use | Anticarcinogenic Agents - pharmacology | Anticarcinogenic Agents - therapeutic use | Drug Screening Assays, Antitumor | Polyps (Pathology) | Polyposis, Familial | Genetic aspects | Analysis | Phosphorylation | Wnt protein | Genes | Colorectal cancer | Clinical trials | Myc protein | Cyclin D1 | Kinases | Polyposis coli | Proteins | Cell growth | Intestine | Tumor necrosis factor-TNF | Colon | Inhibition | Catenin | Adenomatous polyposis coli protein | Immunoglobulins | Oral administration | Inflammation | Grants | Gene expression | Patients | Adenomatous polyposis coli | Studies | Herbal medicine | Signaling | Polyps | Cancer | Tumors | Apoptosis | Original
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 06/2000, Volume 342, Issue 26, pp. 1946 - 1952
Journal Article
Journal Article