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1. Full Text Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria
by Dejea, Christine M and Fathi, Payam and Craig, John M and Boleij, Annemarie and Taddese, Rahwa and Geis, Abby L and Wu, Xinqun and DeStefano Shields, Christina E and Hechenbleikner, Elizabeth M and Huso, David L and Anders, Robert A and Giardiello, Francis M and Wick, Elizabeth C and Wang, Hao and Wu, Shaoguang and Pardoll, Drew M and Housseau, Franck and Sears, Cynthia L
Science, ISSN 0036-8075, 02/2018, Volume 359, Issue 6375, pp. 592 - 597
Individuals with sporadic colorectal cancer (CRC) frequently harbor abnormalities in the composition of the gut microbiome; however, the microbiota associated... 
MUCOSA | MICROBIOTA | INFLAMMATORY-BOWEL-DISEASE | GENE | CANCER | MULTIDISCIPLINARY SCIENCES | Metalloendopeptidases - genetics | Humans | Interleukin-17 - analysis | Peptides - genetics | Metalloendopeptidases - metabolism | Adenomatous Polyposis Coli - pathology | Carcinogenesis | Adenomatous Polyposis Coli - microbiology | Peptides - metabolism | Escherichia coli - pathogenicity | Bacterial Toxins - genetics | Colon - pathology | Gastrointestinal Microbiome | Intestinal Mucosa - microbiology | Intestinal Mucosa - chemistry | Bacteroides fragilis - pathogenicity | Bacteroides fragilis - isolation & purification | Polyketides | Animals | Biofilms | Escherichia coli - genetics | Escherichia coli - isolation & purification | Colonic Neoplasms - pathology | Bacteroides fragilis - genetics | Colon - microbiology | Mice | DNA Damage | Precancerous Conditions - microbiology | Colonic Neoplasms - microbiology | Intestinal Mucosa - pathology | Physiological aspects | Polyposis, Familial | Microbiota (Symbiotic organisms) | Health aspects | Colorectal cancer | Genes | Familial adenomatous polyposis | Mucosa | DNA damage | Interleukin | Colorectal carcinoma | Microbiomes | Microbiota | Carcinogens | Colon cancer | E coli | Bacteria | Colon | Lesions | Deoxyribonucleic acid--DNA | Abnormalities | Benign | Gene expression | Epithelium | Patients | Interleukin 17 | Polyps | Cancer
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2. Full Text Familial adenomatous polyposis
by Half, Elizabeth and Bercovich, Dani and Rozen, Paul
Orphanet Journal of Rare Diseases, ISSN 1750-1172, 2009, Volume 4, Issue 1, pp. 22 - 22
Familial adenomatous polyposis (FAP) is characterized by the development of many tens to thousands of adenomas in the rectum and colon during the second decade... 
MEDICINE, RESEARCH & EXPERIMENTAL | COLORECTAL-CANCER | RESTORATIVE PROCTOCOLECTOMY | MYH-ASSOCIATED POLYPOSIS | ILEAL POUCH | SMALL-BOWEL SURVEILLANCE | MUTY HOMOLOG HMYH | POUCH-ANAL ANASTOMOSIS | RETINAL-PIGMENT EPITHELIUM | DESMOID TUMORS | CAPSULE ENDOSCOPY | Adenomatous Polyposis Coli - etiology | Animals | Humans | Adenomatous Polyposis Coli - epidemiology | Female | Male | Adenomatous Polyposis Coli - pathology | Adenomatous Polyposis Coli - diagnosis | Adenomatous Polyposis Coli - metabolism | Prevention | Development and progression | Care and treatment | Polyposis, Familial | Diagnosis | Risk factors | Disease | Health services | Mortality | Older people | Colorectal cancer | Genetics | Mutation | Clinical medicine | Kinases | Tumors
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3. Full Text Effect of Sulindac and Erlotinib vs Placebo on Duodenal Neoplasia in Familial Adenomatous Polyposis: A Randomized Clinical Trial
by Samadder, N. Jewel and Neklason, Deborah W and Boucher, Kenneth M and Byrne, Kathryn R and Kanth, Priyanka and Samowitz, Wade and Jones, David and Tavtigian, Sean V and Done, Michelle W and Berry, Therese and Jasperson, Kory and Pappas, Lisa and Smith, Laurel and Sample, Danielle and Davis, Rian and Topham, Matthew K and Lynch, Patrick and Strait, Elena and McKinnon, Wendy and Burt, Randall W and Kuwada, Scott K
JAMA, ISSN 0098-7484, 03/2016, Volume 315, Issue 12, pp. 1266 - 1275
IMPORTANCE: Patients with familial adenomatous polyposis (FAP) are at markedly increased risk for duodenal polyps and cancer. Surgical and endoscopic... 
CELL LUNG-CANCER | COLON-CANCER | MEDICINE, GENERAL & INTERNAL | METAANALYSIS | ADENOCARCINOMA | RISK | CHEMOPREVENTION | LONG-TERM TREATMENT | CELECOXIB | EXPRESSION | CYCLOOXYGENASE-2 INHIBITOR | Erlotinib Hydrochloride - adverse effects | Humans | Middle Aged | Erlotinib Hydrochloride - administration & dosage | Sulindac - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Duodenal Neoplasms - genetics | Male | Antineoplastic Agents - therapeutic use | Adenomatous Polyposis Coli - pathology | Sulindac - adverse effects | Genes, APC | Antineoplastic Agents - adverse effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Duodenal Neoplasms - drug therapy | Adenomatous Polyposis Coli - drug therapy | Adult | Female | Adenomatous Polyposis Coli - genetics | Duodenal Neoplasms - pathology | Treatment outcome | Erlotinib | Sulindac | Analysis | Dosage and administration | Polyposis, Familial | Drug therapy | Drugs | Clinical trials | Placebo effect | Risk factors | Cancer
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4. Full Text Molecular genetics of colorectal cancer
by Fearon, Eric R
Annual Review of Pathology: Mechanisms of Disease, ISSN 1553-4006, 02/2011, Volume 6, Issue 1, pp. 479 - 507
Over the past three decades, molecular genetic studies have revealed some critical mutations underlying the pathogenesis of the sporadic and inherited forms of... 
adenoma-carcinoma sequence | KRAS mutation | adenomatous polyposis coli (APC) | mismatch repair | Wnt signaling | p53 tumor-suppressor gene (TSG) | LYNCH-SYNDROME | DNA METHYLATION | PEUTZ-JEGHERS-SYNDROME | MICROSATELLITE INSTABILITY | PATHOLOGY | FAMILY-HISTORY | ISLAND METHYLATOR PHENOTYPE | COLON-CANCER | adenomatous polyposis (APC) | TUMOR-SUPPRESSOR | ABERRANT CRYPT FOCI | ADENOMATOUS POLYPOSIS | Epigenesis, Genetic - physiology | Adenoma - genetics | Colorectal Neoplasms - genetics | Genes, Tumor Suppressor - physiology | Humans | Adenoma - pathology | Adenomatous Polyposis Coli - genetics | Colorectal Neoplasms - pathology | Adenomatous Polyposis Coli - pathology | Physiology, Pathological | Molecular genetics | Colorectal cancer | Physiological aspects | Development and progression | Genetic aspects | Research | Cancer
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5. Full Text Expanded Extracolonic Tumor Spectrum in MUTYH -Associated Polyposis
by Vogt, Stefanie and Jones, Natalie and Christian, Daria and Engel, Christoph and Nielsen, Maartje and Kaufmann, Astrid and Steinke, Verena and Vasen, Hans F and Propping, Peter and Sampson, Julian R and Hes, Frederik J and Aretz, Stefan
Gastroenterology, ISSN 0016-5085, 2009, Volume 137, Issue 6, pp. 1976 - 1985.e10
Background & Aims MUTYH -associated polyposis (MAP) is characterized by a lifetime risk of colorectal cancer of up to 100%. However, no systematic evaluation... 
Gastroenterology and Hepatology | BASE-EXCISION-REPAIR | URINARY-TRACT CANCER | APC GENE MUTATION | MUIR-TORRE-SYNDROME | NONPOLYPOSIS COLORECTAL-CANCER | DUODENAL ADENOMATOSIS | FAMILIAL ADENOMATOUS POLYPOSIS | MYH-ASSOCIATED POLYPOSIS | LYNCH SYNDROME | GASTROENTEROLOGY & HEPATOLOGY | MSH2 MUTATION CARRIERS | Gastrointestinal Neoplasms - genetics | Humans | Middle Aged | Adenomatous Polyposis Coli - epidemiology | Ovarian Neoplasms - pathology | Male | Adenomatous Polyposis Coli - pathology | Incidence | Ovarian Neoplasms - genetics | Young Adult | Gastrointestinal Neoplasms - pathology | Gastrointestinal Neoplasms - epidemiology | Urinary Bladder Neoplasms - genetics | Urinary Bladder Neoplasms - pathology | Adult | Female | Retrospective Studies | Endoscopy | Adenomatous Polyposis Coli - genetics | Child | Urinary Bladder Neoplasms - epidemiology | Breast Neoplasms - epidemiology | Skin Neoplasms - pathology | Genetic Predisposition to Disease | Sebaceous Gland Neoplasms - epidemiology | Risk Assessment | Risk Factors | Sebaceous Gland Neoplasms - genetics | DNA Glycosylases - genetics | Kaplan-Meier Estimate | Europe - epidemiology | Skin Neoplasms - epidemiology | Ovarian Neoplasms - epidemiology | Phenotype | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Sebaceous Gland Neoplasms - pathology | Skin Neoplasms - genetics | Adolescent | Age of Onset | Aged | Medical colleges | Animal pigments | Genetic disorders | Oncology, Experimental | Colorectal cancer | Research | Cancer | Tumors | Medical informatics
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6. Full Text Upper GI Tract Lesions in Familial Adenomatous Polyposis (FAP): Enrichment of Pyloric Gland Adenomas and Other Gastric and Duodenal Neoplasms
by Wood, Laura D and Salaria, Safia N and Cruise, Michael W and Giardiello, Francis M and Montgomery, Elizabeth A
The American Journal of Surgical Pathology, ISSN 0147-5185, 03/2014, Volume 38, Issue 3, pp. 389 - 393
Patients with familial adenomatous polyposis (FAP), an autosomal dominant cancer predisposition syndrome caused by mutations in the APC gene, develop neoplasms... 
fundic gland polyp | cancer screening | familial adenomatous polyposis | pyloric gland adenoma | SURGERY | ADENOCARCINOMA | DISTINCT | DYSPLASIA | RISK | PATHOLOGY | FOVEOLAR | COLI GENE | PATIENT | MUTATIONS | Prognosis | Tertiary Care Centers | Humans | Middle Aged | Endoscopy, Gastrointestinal | Polyps - pathology | Gastric Mucosa - pathology | Male | Stomach Neoplasms - pathology | Adenomatous Polyposis Coli - pathology | Disease Progression | Young Adult | Baltimore | Biopsy | Adolescent | Adenoma - pathology | Adult | Female | Registries | Carcinoma - pathology | Child | Duodenal Neoplasms - pathology
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7. Full Text Adenoma development in familial adenomatous polyposis and MUTYH‐associated polyposis: somatic landscape and driver genes
by Rashid, Mamunur and Fischer, Andrej and Wilson, Cathy H and Tiffen, Jessamy and Rust, Alistair G and Stevens, Philip and Idziaszczyk, Shelley and Maynard, Julie and Williams, Geraint T and Mustonen, Ville and Sampson, Julian R and Adams, David J
The Journal of Pathology, ISSN 0022-3417, 01/2016, Volume 238, Issue 1, pp. 98 - 108
Familial adenomatous polyposis ( FAP ) and MUTYH ‐associated polyposis ( MAP ) are inherited disorders associated with multiple colorectal adenomas that lead... 
adenoma development | exome sequencing | APC | colorectal neoplasms | WTX | somatic landscape | driver genes | MUTYH | MUTATIONAL PROCESSES | EXOME | INSTABILITY | VARIANTS | PATHOLOGY | CANCER | ONCOLOGY | GERMLINE MUTATIONS | PREDISPOSE | Intestinal Polyposis - pathology | DNA Mutational Analysis | Intestinal Polyposis - genetics | Humans | DNA Glycosylases - genetics | Transcriptome | Neoplastic Syndromes, Hereditary - genetics | Adenomatous Polyposis Coli - genetics | Adenomatous Polyposis Coli - pathology | Gene mutations | Analysis | Genes | Colorectal cancer | Genetic research | Genetic aspects | Adenoma | Tumor proteins | Original Papers | Original Paper
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8. Full Text Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli-dependent intestinal tumorigenesis
by Ghaleb, Amr M and McConnell, Beth B and Nandan, Mandayam O and Katz, Jonathan P and Kaestner, Klaus H and Yang, Vincent W
Cancer Research, ISSN 0008-5472, 08/2007, Volume 67, Issue 15, pp. 7147 - 7154
The zinc finger transcription factor Kruppel-like factor 4 (KLF4) is frequently down-regulated in colorectal cancer. previous studies showed that the... 
COLONIC CELL-GROWTH | ONCOLOGY | APC GENE | COLORECTAL-CANCER | DNA-DAMAGE | TUMOR-SUPPRESSOR GENE | DOWN-REGULATION | S-PHASE | KRUPPEL-LIKE FACTOR | TRANSCRIPTION FACTOR KLF4 | BETA-CATENIN | Adenoma - genetics | Cyclins - genetics | Male | Loss of Heterozygosity | RNA, Messenger - metabolism | Adenomatous Polyposis Coli - pathology | Immunoenzyme Techniques | Adenoma - metabolism | Intestinal Polyps - genetics | Cyclins - metabolism | Cell Transformation, Neoplastic - genetics | Kruppel-Like Transcription Factors - metabolism | Female | Cyclin D | Adenomatous Polyposis Coli - genetics | Intestinal Neoplasms - genetics | Intestinal Neoplasms - metabolism | Mice, Inbred C57BL | Cell Transformation, Neoplastic - metabolism | beta Catenin - metabolism | Adenomatous Polyposis Coli - metabolism | Intestinal Neoplasms - pathology | Animals | Intestinal Polyps - pathology | Adenoma - pathology | Mice | Cell Transformation, Neoplastic - pathology | Intestinal Polyps - metabolism | Kruppel-Like Transcription Factors - genetics
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9. Full Text Surveillance of Duodenal Polyposis in Familial Adenomatous Polyposis: Should the Spigelman Score Be Modified?
by Sourrouille, Isabelle and Lefèvre, Jérémie H and Shields, Conor and Colas, Chrystelle and Bellanger, Jerôme and Desaint, Benoît and Paye, Francois and Tiret, Emmanuel and Parc, Yann
Diseases of the Colon and Rectum, ISSN 0012-3706, 11/2017, Volume 60, Issue 11, pp. 1137 - 1146
BACKGROUND: Duodenal polyposis is a manifestation of adenomatous polyposis that predisposes to duodenal or ampullary adenocarcinoma. Duodenal polyposis is... 
Adenomatous polyposis | Adenomatous Familial Polyposis | Prognosis | MYH | Duodenal polyposis | SURGERY | PYLORUS-PRESERVING PANCREATICODUODENECTOMY | PLACEBO | MANAGEMENT | PREVALENCE | ILEAL POUCH | TRIAL | DISEASE | RESTORATIVE PROCTOCOLECTOMY | UPPER GASTROINTESTINAL CANCER | GASTROENTEROLOGY & HEPATOLOGY | PANCREAS-SPARING DUODENECTOMY | Aftercare - methods | Duodenum - pathology | Humans | Endoscopy, Gastrointestinal | Duodenum - diagnostic imaging | Duodenal Neoplasms - diagnosis | Neoplasm Staging | Adenomatous Polyposis Coli - pathology | Duodenal Neoplasms - pathology | Adenomatous Polyposis Coli - diagnosis
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10. Full Text Delineating the Phenotypic Spectrum of the NTHL1 -Associated Polyposis
by Belhadj, Sami and Mur, Pilar and Navarro, Matilde and González, Sara and Moreno, Victor and Capellá, Gabriel and Valle, Laura
Clinical Gastroenterology and Hepatology, ISSN 1542-3565, 2016, Volume 15, Issue 3, pp. 461 - 462
A causal association of NTHL1 biallelic mutations with predisposition to colorectal cancer (CRC) and adenomatous polyposis has been recently reported, 1... 
Gastroenterology and Hepatology | GASTROENTEROLOGY & HEPATOLOGY | TUMORS | Adenomatous Polyposis Coli - genetics | Genotyping Techniques | Adenomatous Polyposis Coli - pathology | Humans | Deoxyribonuclease (Pyrimidine Dimer) - genetics | Medical colleges
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11. Full Text The Role of the Surgical Pathologist in the Diagnosis of Gastrointestinal Polyposis Syndromes
by Rosty, Christophe
Advances In Anatomic Pathology, ISSN 1072-4109, 01/2018, Volume 25, Issue 1, pp. 1 - 13
Polyps of the gastrointestinal tract are very common lesions and most frequently sporadic in nature. Some polyp subtypes are associated with rare hereditary... 
Cowden syndrome | Polymerase proofreadingassociated polyposis | Juvenile polyposis syndrome | MUTYHassociated polyposis | Familial adenomatous polyposis | NTHL1-associated polyposis | Serrated polyposis syndrome | Peutz-Jeghers syndrome | MUTYH-associated polyposis | serrated polyposis syndrome | GENOTYPE-PHENOTYPE CORRELATIONS | juvenile polyposis syndrome | PEUTZ-JEGHERS-SYNDROME | polymerase proofreading-associated polyposis | PATHOLOGY | SERRATED POLYPOSIS | HIGH CANCER-RISK | COWDEN-SYNDROME | COLORECTAL-CANCER | JUVENILE POLYPOSIS | familial adenomatous polyposis | HAMARTOMA TUMOR SYNDROME | Colorectal Neoplasms - surgery | Neoplastic Syndromes, Hereditary - pathology | Pathology, Surgical - methods | Peutz-Jeghers Syndrome - pathology | Intestinal Polyposis - pathology | Intestinal Polyposis - genetics | Humans | Adenomatous Polyposis Coli - surgery | Neoplastic Syndromes, Hereditary - diagnosis | Neoplastic Syndromes, Hereditary - surgery | Intestinal Polyposis - diagnosis | Peutz-Jeghers Syndrome - genetics | Adenomatous Polyposis Coli - pathology | Colorectal Neoplasms - diagnosis | Gastrointestinal Tract - pathology | Gastrointestinal Tract - surgery | Intestinal Polyposis - congenital | Peutz-Jeghers Syndrome - diagnosis | Neoplastic Syndromes, Hereditary - genetics | Colorectal Neoplasms - pathology | Intestinal Polyposis - surgery | Adenomatous Polyposis Coli - diagnosis
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12. Full Text Recent Discoveries in the Genetics of Familial Colorectal Cancer and Polyposis
by Valle, Laura
Clinical Gastroenterology and Hepatology, ISSN 1542-3565, 2016, Volume 15, Issue 6, pp. 809 - 819
The development of genome-wide massively parallel sequencing, ie, whole-genome and whole-exome sequencing, and copy number approaches has raised high... 
Gastroenterology and Hepatology | Cancer Predisposition | Serrated Polyposis | Hereditary Non-polyposis Colorectal Cancer | Adenomatous Polyposis | Mixed Polyposis | GERMLINE MUTYH MUTATIONS | MISMATCH REPAIR-DEFICIENCY | DNA-DAMAGE | LYNCH SYNDROME | E3 LIGASE | RARE VARIANTS | HEREDITARY MIXED POLYPOSIS | GENES | EARLY-ONSET | CASE-SERIES | GASTROENTEROLOGY & HEPATOLOGY | Genetic Predisposition to Disease | Adenomatous Polyposis Coli - genetics | Adenomatous Polyposis Coli - pathology | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Genetic research | Genetic aspects | Multiprocessing | Genomics | Colorectal cancer | Cancer | Anopheles | Genes
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13. Full Text Accumulation of driver and passenger mutations during tumor progression
by Ivana Bozic and Tibor Antal and Hisashi Ohtsuki and Hannah Carter and Dewey Kim and Sining Chen and Rachel Karchin and Kenneth W. Kinzler and Bert Vogelstein and Martin A. Nowak
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 43, pp. 18545 - 18550
Major efforts to sequence cancer genomes are now occurring throughout the world. Though the emerging data from these studies are illuminating, their... 
Passengers | Evolution | Tumor suppressor genes | Stop codon | Genomes | Genetic mutation | Modeling | Oncogenes | Tumors | Cancer | Genetics | Mathematical biology | PATHWAYS | HUMAN BREAST | WAITING TIME | MULTIDISCIPLINARY SCIENCES | COLON | MODEL | CANCER | SOMATIC MUTATIONS | genetics | EVOLUTION | GENES | RESISTANCE | mathematical biology | Adenomatous Polyposis Coli - etiology | Genetics, Population | Neoplasms - etiology | Molecular Biology | Genomics | Humans | Adenomatous Polyposis Coli - pathology | Disease Progression | Genes, APC | Neoplastic Processes | Neoplasms - genetics | Stochastic Processes | Time Factors | Computer Simulation | Models, Genetic | Mutation | Adenomatous Polyposis Coli - genetics | Neoplasms - pathology | Genes, Tumor Suppressor | Development and progression | Biomathematics | Research | Gene mutations | Identification and classification | Oncology | Mathematical models | Quantitative Biology - Populations and Evolution | Biological Sciences | Physical Sciences
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