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Purinergic signalling, ISSN 1573-9546, 2015, Volume 11, Issue 3, pp. 389 - 407
Adenosine receptors (ARs) have emerged as new drug targets. The majority of data on affinity/potency and selectivity of AR ligands described in the literature... 
Neurosciences | Agonist | Biomedicine | Human Physiology | Cancer Research | Selectivity | Potency | Antagonist | Pharmacology/Toxicology | Species differences | Biomedicine general | RADIOLIGAND | XANTHINE DERIVATIVES | NEUROSCIENCES | PROTEIN-COUPLED ADENOSINE | P2Y RECEPTORS | POTENT | INTERNATIONAL UNION | LIGANDS | AFFINITY | A(2A) RECEPTOR | BINDING | Cricetulus | Species Specificity | Humans | DNA, Complementary - genetics | Adenosine A1 Receptor Antagonists - pharmacology | Adenosine A2 Receptor Agonists - metabolism | Receptor, Adenosine A2B - genetics | Structure-Activity Relationship | Adenosine A1 Receptor Antagonists - metabolism | Adenosine A2 Receptor Antagonists - metabolism | Adenosine A2 Receptor Agonists - pharmacology | Adenosine A3 Receptor Agonists - pharmacology | Adenosine A1 Receptor Agonists - pharmacology | Receptor, Adenosine A2B - drug effects | Receptor, Adenosine A2A - genetics | Adenosine A3 Receptor Antagonists - pharmacology | Cell Membrane - metabolism | Adenosine A3 Receptor Agonists - metabolism | Cyclic AMP - metabolism | Arrestin - metabolism | Cell Membrane - drug effects | DNA, Complementary - drug effects | CHO Cells | Cricetinae | Receptors, Purinergic P1 - genetics | Rats | Receptor, Adenosine A2A - metabolism | Receptor, Adenosine A2B - metabolism | Receptor, Adenosine A2A - drug effects | Binding, Competitive - drug effects | Adenosine A2 Receptor Antagonists - pharmacology | Animals | Adenosine A1 Receptor Agonists - metabolism | Adenosine A3 Receptor Antagonists - metabolism | Mice | Receptors, Purinergic P1 - metabolism | Receptors, Purinergic P1 - drug effects | Adenosine | Original
Journal Article
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 2/2016, Volume 389, Issue 2, pp. 233 - 241
Journal Article
Oncogene, ISSN 1476-5594, 2014, Volume 34, Issue 14, pp. 1831 - 1842
Extracellular ATP has been shown to either inhibit or promote cancer growth and migration; however, the mechanism underlying this discrepancy remained elusive.... 
SURVIVAL | MIGRATION | ACTIVATION | 5'-TRIPHOSPHATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | CELL BIOLOGY | HUMAN-TUMOR-CELLS | MODELS | ONCOLOGY | HEMICHANNELS | GENETICS & HEREDITY | RECEPTORS | ATP | Neoplasm Transplantation | Cell Proliferation | Humans | Adenosine Triphosphate - secretion | Bone Neoplasms - secondary | Transplantation, Heterologous | Receptors, Purinergic P2X - genetics | Adenosine Triphosphate - pharmacology | RNA Interference | Apyrase - pharmacology | Adenosine Triphosphate - metabolism | Receptors, Purinergic P2X - metabolism | Female | Receptor, Adenosine A2A - genetics | Osteocytes - metabolism | Signal Transduction | Mice, Inbred C57BL | Receptor, Adenosine A2A - metabolism | Adenosine Triphosphate - analogs & derivatives | Bone Density Conservation Agents - pharmacology | Cell Movement - drug effects | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Mice, Nude | Adenosine - secretion | Alendronate - pharmacology | Adenosine - metabolism | Cell Line, Tumor | Mice | RNA, Small Interfering | Complications and side effects | Bone cancer | Development and progression | Breast cancer | Genetic aspects | Metastasis | Health aspects | Adenosine triphosphate | Bones | Adenosine triphosphatase | Adenosine | Carcinoma | Leukocyte migration | Osteocytes | siRNA | Nucleotides | Bisphosphonates | Purine P2X receptors | Cell adhesion & migration | Metastases | Alendronic acid | Bone growth | Xenografts | Apyrase | Mammary gland | Cell migration | bone metastasis | adenosine nucleotides | breast cancer
Journal Article
American journal of physiology. Heart and circulatory physiology, ISSN 0363-6135, 09/2011, Volume 301, Issue 3, pp. H1183 - H1189
All four adenosine receptor subtypes have been shown to play a role in cardioprotection, and there is evidence that all four subtypes may be expressed in... 
Knockout mice | Adenosine receptor | Myocardial Infarction - genetics | Receptor, Adenosine A1 - drug effects | Adenosine A1 Receptor Antagonists - pharmacology | Male | Receptor, Adenosine A2B - genetics | Myocardial Reperfusion Injury - pathology | Adenosine A2 Receptor Agonists - pharmacology | Time Factors | Adenosine A1 Receptor Agonists - pharmacology | Myocardial Infarction - pathology | Myocardium - metabolism | Myocardial Infarction - physiopathology | Receptor, Adenosine A2A - genetics | Myocardial Reperfusion Injury - genetics | Disease Models, Animal | Receptor Cross-Talk | Receptor, Adenosine A2B - deficiency | Mice, Inbred C57BL | Ventricular Function, Left - drug effects | Ventricular Pressure - drug effects | Myocardium - pathology | Adenosine - pharmacology | Myocardial Infarction - metabolism | Receptor, Adenosine A2A - metabolism | Receptor, Adenosine A1 - metabolism | Myocardial Reperfusion Injury - physiopathology | Receptor, Adenosine A2B - metabolism | Mice, Knockout | Myocardial Reperfusion Injury - metabolism | Animals | Analysis of Variance | Perfusion | Adenosine - analogs & derivatives | Mice | Myocardial Infarction - prevention & control | Receptor, Adenosine A2A - deficiency | Myocardial Reperfusion Injury - prevention & control | A2a adenosine receptor | A2b adenosine receptor | knockout mice | Integrative Cardiovascular Physiology and Pathophysiology
Journal Article
Journal Article
PLoS biology, ISSN 1545-7885, 2019, Volume 17, Issue 3, p. e3000161
Adenosine is a constituent of many molecules of life; increased free extracellular adenosine indicates cell damage or metabolic stress. The importance of... 
HYPOTHERMIA | ACTIVATION | A RECEPTOR | PLASMA | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | INOSINE | MOUSE | BIOLOGY | CAFFEINE | A(2A) RECEPTOR | BLOOD | Blood Pressure - genetics | Male | Receptor, Adenosine A2B - genetics | Hypothermia - chemically induced | Body Temperature - physiology | Hypothermia - metabolism | Receptor, Adenosine A3 - metabolism | Caffeine - pharmacology | Heart Rate - physiology | Female | Receptor, Adenosine A2A - genetics | Blood Pressure - physiology | Uridine - toxicity | Receptor, Adenosine A1 - genetics | Inosine - pharmacology | Heart Rate - genetics | Genotype | Receptor, Adenosine A2A - metabolism | Receptor, Adenosine A1 - metabolism | Receptor, Adenosine A2B - metabolism | Mice, Knockout | Phenotype | Animals | Body Temperature - genetics | Lipopolysaccharides - pharmacology | Receptor, Adenosine A3 - genetics | Mice | Hypothermia - genetics | Physiological aspects | Nucleosides | Adenosine | Temperature requirements | Temperature | Thermoregulation | Kinases | Receptors | Torpor | Temperature effects | Dependence | Physiology | Inhibition | Damage | Supervision | Phenotypes | Adenosine receptors | AMP | Breeding | Body temperature | Hazards | Metabolism | Gene expression | Diurnal | Hypotension | Histamine | Bradycardia | Adenosine kinase | Uridine | Diabetes | Kidney diseases | Endocrinology | Hypothermia
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 09/2014, Volume 34, Issue 9, pp. 2078 - 2085
OBJECTIVE—In a phase III clinical trial (PLATelet inhibition and patient Outcomes, PLATO), ticagrelor provided better clinical outcomes than clopidogrel in... 
adenosine | aspirin | cyclooxygenase | platelet aggregation inhibitors | ISCHEMIA/REPERFUSION INJURY | ACUTE CORONARY SYNDROMES | PLATO | COMBINATION | ATORVASTATIN | ISCHEMIA-REPERFUSION INJURY | CLOPIDOGREL | PLATELET INHIBITION | PERIPHERAL VASCULAR DISEASE | CARDIOPROTECTION | HEMATOLOGY | Receptor, Adenosine A1 - physiology | Ticlopidine - therapeutic use | Nitric Oxide Synthase Type III - biosynthesis | Adenosine A1 Receptor Antagonists - pharmacology | Male | Receptor, Adenosine A2A - physiology | Cardiotonic Agents - therapeutic use | Cyclooxygenase 2 - biosynthesis | Myocardial Reperfusion Injury - pathology | Cyclooxygenase 2 - genetics | Adenosine - therapeutic use | Myocardial Infarction - pathology | Enzyme Induction - drug effects | Nitric Oxide Synthase Type III - physiology | Aspirin - pharmacology | Myocardial Reperfusion Injury - drug therapy | Drug Evaluation, Preclinical | Pyrazoles - pharmacology | Cyclooxygenase 2 Inhibitors - pharmacology | Rats | Cyclooxygenase 2 - physiology | Adenosine - pharmacology | Cardiotonic Agents - pharmacology | Nitric Oxide Synthase Type III - genetics | Rats, Sprague-Dawley | Ticlopidine - analogs & derivatives | Triazoles - pharmacology | Up-Regulation - drug effects | Adenosine A2 Receptor Antagonists - pharmacology | Animals | Myocardial Infarction - drug therapy | Adenosine - analogs & derivatives | Adenosine - physiology | 6-Ketoprostaglandin F1 alpha - metabolism | Quinazolines - pharmacology | Lipoxins - metabolism | Myocardial Reperfusion Injury - prevention & control
Journal Article