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Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2016, Volume 59, Issue 4, pp. 1271 - 1298
Bromodomains, small protein modules that recognize acetylated lysine on histones, play a significant role in the epigenome, where they function as “readers”... 
CHEMISTRY, MEDICINAL | SWI/SNF COMPLEXES | SMALL-MOLECULE INHIBITORS | PROSTATE-CANCER | SELECTIVE INHIBITORS | GENE-EXPRESSION | CHEMICAL PROBE | TUMOR-SUPPRESSOR | BET INHIBITORS | HISTONE ACETYLTRANSFERASE | PHD FINGER | Small Molecule Libraries - pharmacology | Antigens, Nuclear - metabolism | Humans | Drug Discovery - methods | CREB-Binding Protein - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - antagonists & inhibitors | DNA-Binding Proteins - metabolism | CREB-Binding Protein - metabolism | Protein Processing, Post-Translational - drug effects | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lysine - metabolism | Protein-Serine-Threonine Kinases - metabolism | RNA-Binding Proteins - antagonists & inhibitors | Nerve Tissue Proteins - antagonists & inhibitors | ATPases Associated with Diverse Cellular Activities | DNA-Binding Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Carrier Proteins - antagonists & inhibitors | Adenosine Triphosphatases - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Adenosine Triphosphatases - antagonists & inhibitors | DNA Helicases - metabolism | Small Molecule Libraries - chemistry | Acetylation - drug effects | Animals | Carrier Proteins - metabolism | Nuclear Proteins - antagonists & inhibitors | DNA Helicases - antagonists & inhibitors | Histones - metabolism | Adaptor Proteins, Signal Transducing - metabolism | RNA-Binding Proteins - metabolism
Journal Article
Journal Article
PSYCHOPHARMACOLOGY, ISSN 0033-3158, 07/2011, Volume 216, Issue 2, pp. 173 - 186
Adenosine A(2A) antagonists can reverse many of the behavioral effects of dopamine antagonists, including actions on instrumental behavior. However, little is... 
Dopamine | RECEPTOR ANTAGONISTS | PSYCHIATRY | CAFFEINE | Depression | Activation | Anergia | SCHEDULE-CONTROLLED BEHAVIOR | NEUROSCIENCES | NUCLEUS-ACCUMBENS | Parkinsonism | SYMPATHOMIMETIC AMINES | LOCOMOTOR SUPPRESSION | DECISION-MAKING | Psychomotor slowing | PHARMACOLOGY & PHARMACY | D-AMPHETAMINE | MSX-3 REVERSES | Adenosine | Analysis | Theophylline | Caffeine
Journal Article
Parkinsonism and Related Disorders, ISSN 1353-8020, 2009, Volume 15, Issue 6, pp. 406 - 413
Abstract Adenosine derived from the degradation of ATP/AMP functions as a signalling molecule in the nervous system through the occupation of A1, A2, and A3... 
Neurology | Adenosine | Adenosine antagonists | Parkinson's disease
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 10/2010, Volume 363, Issue 15, pp. 1419 - 1428
Journal Article
SCIENCE, ISSN 0036-8075, 11/2008, Volume 322, Issue 5905, pp. 1211 - 1217
The adenosine class of heterotrimeric guanine nucleotide- binding protein ( G protein)- coupled receptors ( GPCRs) mediates the important role of extracellular... 
MUTAGENESIS | PROTEIN-COUPLED RECEPTOR | LIGAND RECOGNITION | PHARMACOLOGY | MULTIDISCIPLINARY SCIENCES | RHODOPSIN | THERAPEUTIC TARGETS | MECHANISMS | RESIDUES | PARKINSONS-DISEASE | INSIGHTS | Adenosine | G proteins | Research | Structure
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 12/2013, Volume 21, Issue 23, pp. 7435 - 7452
Adenosine receptors and monoamine oxidases are drug targets for neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease. In the present study we... 
Caffeine derivatives | Monoamine oxidase B inhibitors | Anellated xanthines | Synthesis | Alzheimer’s disease | Tetrahydropyrimido[2,1-f]purinediones | Adenosine A1 receptor antagonists | Adenosine A2A receptor antagonists | Parkinson’s disease | Tricyclic compounds | Parkinson's disease | receptor antagonists | Tetrahydropyrimido[2,1-f] purinediones | Alzheimer's disease | Adenosine A | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CAFFEINE | CHEMISTRY, ORGANIC | ADENOSINE A(2A) RECEPTOR | Adenosine A(2A) receptor antagonists | BIOLOGICAL-ACTIVITY | MOTOR | MONOAMINE-OXIDASE-B | ANIMAL-MODELS | Adenosine A receptor antagonists | INHIBITORS | ANTAGONIST RADIOLIGAND | PARKINSONS-DISEASE | Monoamine Oxidase Inhibitors - pharmacology | Cricetulus | Purines - pharmacology | Humans | Adenosine A1 Receptor Antagonists - pharmacology | Neurodegenerative Diseases - drug therapy | Xanthines - pharmacology | Purinergic P1 Receptor Antagonists - pharmacology | Adenosine A2 Receptor Antagonists - pharmacology | Xanthines - chemistry | Animals | Purines - chemistry | Caffeine - chemistry | Caffeine - pharmacology | Monoamine Oxidase Inhibitors - chemistry | Adenosine A1 Receptor Antagonists - chemistry | Adenosine A2 Receptor Antagonists - chemistry | CHO Cells | Monoamine Oxidase - metabolism | Neurodegenerative Diseases - enzymology | Purinergic P1 Receptor Antagonists - chemistry | Drug therapy | Nervous system diseases
Journal Article