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Cell, ISSN 0092-8674, 04/2011, Volume 145, Issue 1, pp. 54 - 66
Journal Article
Annual Review of Biochemistry, ISSN 0066-4154, 6/2016, Volume 85, Issue 1, pp. 715 - 742
Molecular chaperones control the cellular folding, assembly, unfolding, disassembly, translocation, activation, inactivation, disaggregation, and degradation... 
Hsp70 | Hsp60 | unfoldases | Hsp104 | sHsps | protein homeostasis | heat-shock proteins | Hsp110 | small heat-shock proteins | Heat-shock proteins | Small heat-shock proteins | SHsps | Unfoldases | Protein homeostasis | BACTERIOPHAGE-LAMBDA | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | SUBUNIT BINDING-PROTEIN | ALPHA-B-CRYSTALLIN | QUALITY-CONTROL | RIBULOSEBISPHOSPHATE-CARBOXYLASE | HEAT-SHOCK-PROTEIN | ATP HYDROLYSIS | LAMBDA-DNA-REPLICATION | RIBULOSE-BISPHOSPHATE CARBOXYLASE | Protein Aggregates | Rhodospirillum rubrum - metabolism | Protein Unfolding | Humans | Mitochondrial Proteins - genetics | HSP110 Heat-Shock Proteins - chemistry | Mitochondrial Proteins - metabolism | Adenosine Triphosphate - metabolism | Escherichia coli - metabolism | Protein Structure, Quaternary | Chaperonin 60 - metabolism | HSP70 Heat-Shock Proteins - chemistry | Rhodospirillum rubrum - chemistry | Chaperonin 60 - chemistry | Chaperonin 60 - genetics | Gene Expression | Heat-Shock Proteins, Small - chemistry | Heat-Shock Proteins, Small - metabolism | Models, Molecular | HSP70 Heat-Shock Proteins - genetics | Escherichia coli - chemistry | Protein Folding | HSP70 Heat-Shock Proteins - metabolism | HSP110 Heat-Shock Proteins - genetics | Heat-Shock Proteins, Small - genetics | Mitochondrial Proteins - chemistry | Adenosine Triphosphate - chemistry | HSP110 Heat-Shock Proteins - metabolism | Molecular chaperones | Observations | Protein folding | Health aspects
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 01/2012, Volume 19, Issue 2, pp. 239 - 280
Triazole compounds containing three nitrogen atoms in the five-membered aromatic azole ring are readily able to bind with a variety of enzymes and receptors in... 
Triazole | Antifungal | Antidiabetic | Triazolium | Anticonvulsant | Antibacterial | Antihistaminic | Antitubercular | Analgesic | Anti-obesitic | Antiparasitic | Antiviral | Anticancer | Anti-inflammatory | Anti-neuropathic | A ADENOSINE RECEPTOR | analgesic | antibacterial | anticancer | triazole | CLICK CHEMISTRY APPROACH | antihistaminic | ANTIBACTERIAL ACTIVITY | anti-inflammatory | BIOLOGICAL EVALUATION | PHARMACOLOGY & PHARMACY | anti-neuropathic | CHEMISTRY, MEDICINAL | INOSINE MONOPHOSPHATE DEHYDROGENASE | anticonvulsant | BIOCHEMISTRY & MOLECULAR BIOLOGY | EFFICIENT SYNTHESIS | PHARMACOLOGICAL IN-VITRO | AZOLE ANTIFUNGAL AGENTS | antitubercular | anti-obesitic | triazolium | antiviral | antiparasitic | antidiabetic | HISTONE DEACETYLASE INHIBITORS | ANTIMICROBIAL ACTIVITY | Antifungal Agents - pharmacology | Analgesics - pharmacology | Antiviral Agents - pharmacology | Antitubercular Agents - chemistry | Anti-Inflammatory Agents - pharmacology | Triazoles - chemistry | Antitubercular Agents - pharmacology | Antifungal Agents - chemistry | Hypoglycemic Agents - chemistry | Antineoplastic Agents - chemistry | Anticonvulsants - pharmacology | Hypoglycemic Agents - pharmacology | Triazoles - pharmacology | Anti-Inflammatory Agents - chemistry | Analgesics - chemistry | Antiviral Agents - chemistry | Anti-Bacterial Agents - chemistry | Anticonvulsants - chemistry | Antiparasitic Agents - pharmacology | Anti-Bacterial Agents - pharmacology | Antineoplastic Agents - pharmacology | Antiparasitic Agents - chemistry
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 497, Issue 7448, pp. 217 - 223
The mammalian target of rapamycin (mTOR), a phosphoinositide 3-kinase-related protein kinase, controls cell growth in response to nutrients and growth factors... 
MAMMALIAN TARGET | RAPAMYCIN | RAPTOR | BINDING PARTNER | RAG GTPASES | RHEB | PATHWAY | TOR | MULTIDISCIPLINARY SCIENCES | CELL-GROWTH | P70 S6 KINASE | Adaptor Proteins, Signal Transducing - chemistry | Catalytic Domain - drug effects | TOR Serine-Threonine Kinases - metabolism | Pyridines - chemistry | Furans - pharmacology | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Pyrimidines - chemistry | TOR Serine-Threonine Kinases - antagonists & inhibitors | Indoles - metabolism | Furans - chemistry | Adenosine Triphosphate - metabolism | Indoles - pharmacology | Tacrolimus Binding Protein 1A - pharmacology | Naphthyridines - chemistry | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Purines - metabolism | Purines - pharmacology | MTOR Associated Protein, LST8 Homolog | Tacrolimus Binding Protein 1A - chemistry | Models, Molecular | Magnesium - metabolism | Pyrimidines - pharmacology | Sirolimus - metabolism | Sirolimus - pharmacology | Magnesium - chemistry | Purines - chemistry | TOR Serine-Threonine Kinases - chemistry | Tacrolimus Binding Protein 1A - metabolism | Pyridines - pharmacology | Sirolimus - chemistry | Adaptor Proteins, Signal Transducing - metabolism | Adenosine Triphosphate - chemistry | Indoles - chemistry | Naphthyridines - pharmacology | Naphthyridines - metabolism | Protein Structure, Tertiary - drug effects | Proteins | Enzymes | Kinases | Crystal structure
Journal Article
Journal Article
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 3/2019, Volume 68, Issue 3, pp. 467 - 478
The tumor-expressed CD73 ectonucleotidase generates immune tolerance and promotes invasiveness via adenosine production from degradation of AMP. While... 
Immunohistochemistry | CD73 | Immunology | Pancreatic carcinoma | Medicine & Public Health | Oncology | Cancer Research | Hepatocellular carcinoma | Ecto-5′-nucleotidase | Cholangiocarcinoma | TARGET | CANCER CELLS | Ecto-5 '-nucleotidase | ADENOSINE | IMMUNOLOGY | OVEREXPRESSION | MELANOMA | PROGNOSTIC BIOMARKER | ONCOLOGY | IMMUNOTHERAPY | GROWTH | CD39 | DIFFERENTIATION | 5'-Nucleotidase - antagonists & inhibitors | Carcinoma, Hepatocellular - mortality | Pancreatic Neoplasms - chemistry | Prognosis | Humans | Liver Neoplasms - chemistry | Liver Neoplasms - mortality | Biliary Tract - chemistry | Bile Duct Neoplasms - chemistry | Epithelial-Mesenchymal Transition | Carcinoma, Pancreatic Ductal - mortality | Liver Neoplasms - pathology | Carcinoma, Hepatocellular - chemistry | Pancreatic Neoplasms - mortality | GPI-Linked Proteins - antagonists & inhibitors | GPI-Linked Proteins - analysis | Pancreatic Neoplasms - pathology | Cholangiocarcinoma - mortality | 5'-Nucleotidase - analysis | Carcinoma, Pancreatic Ductal - pathology | Liver - chemistry | Carcinoma, Pancreatic Ductal - chemistry | Cholangiocarcinoma - pathology | Cholangiocarcinoma - chemistry | Bile Duct Neoplasms - mortality | Carcinoma, Hepatocellular - pathology | Bile Duct Neoplasms - pathology | Pancreas - chemistry | Liver cancer | Adenylic acid | Immunotherapy | Pancreatic cancer | Nucleotidases | Adenocarcinoma | Biliary tract | Adenosine | Carcinoma | AMP | Tumor cells | Invasiveness | Immunological tolerance | Patients | E-cadherin | Hepatocytes | CD73 antigen | Ectonucleotidase | Pancreas | Tumors
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 04/2013, Volume 135, Issue 16, pp. 5998 - 6001
Journal Article
eLife, ISSN 2050-084X, 08/2014, Volume 3, Issue 2014, pp. 1 - 17
The Cdc45/Mcm2-7/GINS ( CMG) helicase separates DNA strands during replication in eukaryotes. How the CMG is assembled and engages DNA substrates remains... 
replication fork | DNA replication | helicase | motor proteins | AAA+ ATPase | Mcm2-7 | MCM2-7 HELICASE | HEXAMERIC HELICASE | MINICHROMOSOME MAINTENANCE PROTEIN | ARCHAEAL MCM | BUDDING YEAST | STRUCTURAL BASIS | BIOLOGY | REPLICATIVE HELICASE | ELECTRON-MICROSCOPY | 26S PROTEASOME | CRYO-EM STRUCTURE | Minichromosome Maintenance Proteins - metabolism | Protein Multimerization | Eukaryotic Cells - metabolism | Drosophila Proteins - metabolism | Minichromosome Maintenance Proteins - chemistry | Protein Subunits - metabolism | Cell Cycle Proteins - chemistry | DNA-Binding Proteins - metabolism | Drosophila melanogaster - metabolism | Multiprotein Complexes - metabolism | Adenosine Triphosphate - metabolism | Protein Structure, Quaternary | Repressor Proteins - metabolism | Protein Structure, Tertiary | Repressor Proteins - chemistry | Chromosomal Proteins, Non-Histone - metabolism | DNA, Single-Stranded - metabolism | RNA-Binding Proteins - chemistry | Cell Cycle Proteins - metabolism | RNA Splicing Factors | Adenosine Triphosphatases - metabolism | Models, Molecular | DNA Replication | DNA - metabolism | Drosophila Proteins - chemistry | Microscopy, Electron | DNA-Binding Proteins - chemistry | Adenosine Triphosphate - analogs & derivatives | DNA, Single-Stranded - chemistry | Multiprotein Complexes - ultrastructure | DNA - chemistry | Multiprotein Complexes - chemistry | Animals | Protein Binding | Adenosine Triphosphatases - chemistry | Protein Subunits - chemistry | Adenosine Triphosphate - chemistry | Chromosomal Proteins, Non-Histone - chemistry | RNA-Binding Proteins - metabolism | Medical research | Single-stranded DNA | Hexamers | Electron microscopy | DNA biosynthesis | DNA helicase | Handedness | Microscopy | Insects | Cdc45 protein | Cell cycle | Polarity | Dimerization | Deoxyribonucleic acid--DNA | Adenosine triphosphatase
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 03/2011, Volume 7, Issue 3, pp. 182 - 188
Triptolide (1) is a structurally unique diterpene triepoxide isolated from a traditional Chinese medicinal plant with anti-inflammatory, immunosuppressive,... 
RNA-POLYMERASE-II | TRIPTERYGIUM-WILFORDII | INHIBITION | PROTEIN | INITIATION | COMMON TARGET | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR IIH | TRANSLATION | CYTOTOXICITY | CHEMOTHERAPY | Humans | Drugs, Chinese Herbal - pharmacology | Biological Products - pharmacology | Transcription Factor TFIIH - chemistry | RNA Polymerase II - metabolism | Phenanthrenes - isolation & purification | Protein Subunits - metabolism | DNA-Binding Proteins - metabolism | Dose-Response Relationship, Drug | Phenanthrenes - chemistry | Epoxy Compounds - pharmacology | Antineoplastic Agents - isolation & purification | Antineoplastic Agents - pharmacology | Drugs, Chinese Herbal - isolation & purification | Diterpenes - chemistry | Epoxy Compounds - isolation & purification | Diterpenes - pharmacology | Cell Survival - drug effects | DNA Helicases - chemistry | Diterpenes - isolation & purification | Adenosine Triphosphatases - metabolism | Antineoplastic Agents - chemistry | DNA-Binding Proteins - chemistry | Biological Products - isolation & purification | DNA Helicases - metabolism | Phenanthrenes - pharmacology | Biological Products - chemistry | Drugs, Chinese Herbal - chemistry | Epoxy Compounds - chemistry | Transcription Factor TFIIH - metabolism | Protein Binding | Adenosine Triphosphatases - chemistry | RNA Polymerase II - genetics | Protein Subunits - chemistry | HeLa Cells | Chinese medicine | Eukaryotes | Biochemistry | Flowers & plants | Adenosine triphosphatase
Journal Article