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Journal Article
Toxicology, ISSN 0300-483X, 2005, Volume 216, Issue 2, pp. 154 - 167
Many adverse drug reactions are caused by the cytochrome P450 (CYP) dependent activation of drugs into reactive metabolites. In order to reduce attrition due... 
Reactive metabolites | Cytotoxicity | Metabolism-mediated toxicity | CYP3A4 | In vitro screening | Adverse drug reactions (ADRs) | CYTOCHROME-P450 | MEDIATED CYTOTOXICITY | HUMAN HEPATOCYTE CULTURES | in vitro screening | CARBAMAZEPINE | adverse drug reactions (ADRs) | STABLE EXPRESSION | INDUCTION | metabolism-mediated toxicity | IDIOSYNCRATIC DRUG-REACTIONS | CHINESE-HAMSTER CELLS | HEPG2 CELLS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | reactive metabolites | HUMAN-LIVER-MICROSOMES | cytotoxicity | Microsomes - metabolism | Thiazoles - metabolism | Cytochrome P-450 Enzyme Inhibitors | Cytochrome P-450 CYP3A | Coculture Techniques | Humans | Thiazolidinediones - toxicity | Cytochrome P-450 Enzyme System - metabolism | Isoniazid - toxicity | Xenobiotics - toxicity | Chromans - metabolism | Flutamide - metabolism | Triazolam - toxicity | Microsomes - drug effects | Triazolam - metabolism | Adenosine Triphosphate - metabolism | Carbamazepine - toxicity | Toxicity Tests - methods | Xenobiotics - metabolism | Cell Culture Techniques | Cell Survival - drug effects | Albendazole - toxicity | Tamoxifen - toxicity | Dapsone - metabolism | Dapsone - toxicity | Cell Line, Tumor | Glutathione - chemistry | Troglitazone | Buthionine Sulfoximine - pharmacology | Quinidine - toxicity | Amitriptyline - toxicity | Glutathione - metabolism | Flutamide - toxicity | Substrate Specificity | Piperazines - metabolism | Piperazines - toxicity | Ochratoxins - metabolism | Xenobiotics - chemistry | Tetrazolium Salts - metabolism | Carbamazepine - metabolism | Quinidine - metabolism | Tamoxifen - metabolism | Amitriptyline - metabolism | Glutathione - antagonists & inhibitors | Enzyme Activation - drug effects | Thiazolidinediones - metabolism | Ochratoxins - toxicity | Thiazoles - toxicity | Animals | Albendazole - metabolism | Chromans - toxicity | Isoniazid - metabolism | Phosphates | Metabolites | Ketoconazole | Cytochrome P-450 | Control systems | Xenobiotics | Glutathione
Journal Article
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 2010, Volume 20, Issue 2, pp. S609 - S631
The purpose of our study was to investigate the effects of the mitochondria-targeted antioxidants, MitoQ and SS31, and the anti-aging agent resveratrol on... 
mitochondria-targeted antioxidants | amyloid-β protein precursor | cyclophilin D | Amyloid-β | peroxiredoxins | TRANSCRIPTION FACTORS | OXIDATIVE DAMAGE | MEMORY DEFICITS | amyloid-beta protein precursor | NEUROSCIENCES | COGNITIVE FUNCTION | NEURODEGENERATIVE DISEASES | MOUSE MODEL | A-BETA | GENE-EXPRESSION | PRECURSOR PROTEIN | Amyloid-beta | TRANSGENIC MICE | Neurons - pathology | Microscopy, Electron, Transmission - methods | Peptide Fragments - toxicity | Humans | Peroxiredoxins - metabolism | Mitochondrial Proteins - genetics | Membrane Potential, Mitochondrial - drug effects | RNA, Messenger - metabolism | Mitochondria - ultrastructure | Alzheimer Disease - pathology | Electron Transport Complex IV - metabolism | Drug Interactions | Neurons - ultrastructure | Peroxiredoxins - genetics | Mitochondrial Proteins - metabolism | Adenosine Triphosphate - metabolism | Lipid Peroxidation - drug effects | Neurons - metabolism | Neurons - drug effects | Disease Models, Animal | Cell Survival - drug effects | Amyloid beta-Peptides - toxicity | Alzheimer Disease - drug therapy | Mice, Transgenic | Antioxidants - pharmacology | Cell Line, Transformed - ultrastructure | Mitochondria - drug effects | Hydrogen Peroxide - metabolism | Gene Expression Regulation - drug effects | Animals | Analysis of Variance | Mice | Amyloid beta-Protein Precursor | Index Medicus
Journal Article
Journal of Hazardous Materials, ISSN 0304-3894, 10/2012, Volume 235-236, pp. 343 - 351
Journal Article
Journal Article
Journal Article