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Angewandte Chemie International Edition, ISSN 1433-7851, 01/2014, Volume 53, Issue 2, pp. 582 - 585
Journal Article
Science, ISSN 0036-8075, 11/2008, Volume 322, Issue 5905, pp. 1211 - 1217
The adenosine class of heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) mediates the important role of extracellular... 
Triazoles - chemistry | Humans | Tryptophan - chemistry | Crystallography, X-Ray | Structure-Activity Relationship | Adenosine A2 Receptor Antagonists | Turkeys | Animals | Protein Binding | Receptor, Adenosine A2A - chemistry | Ligands | Protein Conformation | Triazines - chemistry | Binding Sites | Proteins | Adenosine | Molecular biology | Binding sites | Crystal structure
Journal Article
Science, ISSN 0036-8075, 7/2012, Volume 337, Issue 6091, pp. 232 - 236
Pharmacological responses of G protein-coupled receptors (GPCRs) can be fine-tuned by allosteric modulators. Structural studies of such effects have been... 
Molecules | Receptors | Sodium | Molecular structure | REPORTS | Lipids | Ligands | Cell membranes | Cholesterols | Water channels | Crystal structure | ANGSTROM CRYSTAL-STRUCTURE | COMPLEX | ANTAGONIST | OPIOID RECEPTOR | MULTIDISCIPLINARY SCIENCES | RHODOPSIN | PROTEIN-COUPLED RECEPTORS | ADENOSINE A(2A) RECEPTOR | ALPHA-2-ADRENERGIC RECEPTORS | MODULATION | MUSCARINIC ACETYLCHOLINE-RECEPTOR | Allosteric Regulation | Humans | Crystallography, X-Ray | Adenosine A2 Receptor Agonists - metabolism | Recombinant Fusion Proteins - metabolism | Cholesterol - chemistry | Adenosine A2 Receptor Antagonists - metabolism | Lipids - chemistry | Lipid Bilayers | Sodium - analysis | HEK293 Cells | Protein Engineering | Water - chemistry | Triazines - metabolism | Protein Structure, Secondary | Models, Molecular | Receptor, Adenosine A2A - metabolism | Recombinant Fusion Proteins - chemistry | Triazoles - metabolism | Hydrogen Bonding | Receptor, Adenosine A2A - chemistry | Protein Conformation | Cytochrome b Group - chemistry | Escherichia coli Proteins - chemistry | Chemistry | G proteins | Chemical properties | Research | Receptor-mediated endocytosis | Proteins | Ions | Adenosine | Pharmacology | Binding | Control | Stabilization | Strategy | Channels | BASIC BIOLOGICAL SCIENCES | STABILIZATION | CLATHRATES | RESOLUTION | ADENOSINE | REGULATIONS | 60 APPLIED LIFE SCIENCES | RESIDUES | SODIUM IONS | LIPIDS | WATER
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 10, pp. e108492 - e108492
Journal Article
Journal of Pharmacy and Pharmacology, ISSN 0022-3573, 01/2013, Volume 65, Issue 1, pp. 30 - 34
Objectives  With the aim of finding the structural features governing binding activity and selectivity against adenosine receptors (ARs), several 3‐subtituted... 
binding affinity | adenosine receptor ligands | amide derivatives | carbamate derivatives | coumarins | SERIES | 3-PHENYLCOUMARINS | DISCOVERY | MEDICINAL CHEMISTRY | POTENT | LIGANDS | PHARMACOLOGY | PHARMACOLOGY & PHARMACY | MAO | INHIBITORS | ANTAGONISTS | Coumarins - metabolism | Cricetulus | Amides - chemical synthesis | Humans | Adenosine A1 Receptor Antagonists - pharmacology | Structure-Activity Relationship | Adenosine A1 Receptor Antagonists - metabolism | Carbamates - chemistry | Carbamates - metabolism | Receptors, Purinergic P1 - chemistry | Adenosine A2 Receptor Antagonists - metabolism | Receptor, Adenosine A3 - metabolism | Amides - metabolism | Receptor, Adenosine A2A - genetics | Adenosine A3 Receptor Antagonists - pharmacology | Receptor, Adenosine A1 - genetics | CHO Cells | Carbamates - pharmacology | Amides - pharmacology | Binding, Competitive | Recombinant Proteins - metabolism | Cricetinae | Recombinant Proteins - antagonists & inhibitors | Hydroxylation | Receptors, Purinergic P1 - genetics | Receptor, Adenosine A1 - chemistry | Receptor, Adenosine A2A - metabolism | Receptor, Adenosine A1 - metabolism | Coumarins - pharmacology | Adenosine A2 Receptor Antagonists - pharmacology | Carbamates - chemical synthesis | Receptor, Adenosine A3 - chemistry | Animals | Coumarins - chemical synthesis | Amides - chemistry | Receptor, Adenosine A2A - chemistry | Receptor, Adenosine A3 - genetics | Adenosine A3 Receptor Antagonists - metabolism | Kinetics | Receptors, Purinergic P1 - metabolism | Adenosine A1 Receptor Antagonists - chemistry | Adenosine A2 Receptor Antagonists - chemistry | Adenosine A3 Receptor Antagonists - chemistry | Carbamates | Coumarins | Hydroxides | Chemical properties | Derivatives (Financial instruments) | Adenosine
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2014, Volume 57, Issue 9, pp. 3623 - 3650
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 12/2013, Volume 21, Issue 23, pp. 7435 - 7452
Adenosine receptors and monoamine oxidases are drug targets for neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease. In the present study we... 
Caffeine derivatives | Monoamine oxidase B inhibitors | Anellated xanthines | Synthesis | Alzheimer’s disease | Tetrahydropyrimido[2,1-f]purinediones | Adenosine A1 receptor antagonists | Adenosine A2A receptor antagonists | Parkinson’s disease | Tricyclic compounds | Parkinson's disease | receptor antagonists | Tetrahydropyrimido[2,1-f] purinediones | Alzheimer's disease | Adenosine A | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CAFFEINE | CHEMISTRY, ORGANIC | ADENOSINE A(2A) RECEPTOR | Adenosine A(2A) receptor antagonists | BIOLOGICAL-ACTIVITY | MOTOR | MONOAMINE-OXIDASE-B | ANIMAL-MODELS | Adenosine A receptor antagonists | INHIBITORS | ANTAGONIST RADIOLIGAND | PARKINSONS-DISEASE | Monoamine Oxidase Inhibitors - pharmacology | Cricetulus | Purines - pharmacology | Humans | Adenosine A1 Receptor Antagonists - pharmacology | Neurodegenerative Diseases - drug therapy | Xanthines - pharmacology | Purinergic P1 Receptor Antagonists - pharmacology | Adenosine A2 Receptor Antagonists - pharmacology | Xanthines - chemistry | Animals | Purines - chemistry | Caffeine - chemistry | Caffeine - pharmacology | Monoamine Oxidase Inhibitors - chemistry | Adenosine A1 Receptor Antagonists - chemistry | Adenosine A2 Receptor Antagonists - chemistry | CHO Cells | Monoamine Oxidase - metabolism | Neurodegenerative Diseases - enzymology | Purinergic P1 Receptor Antagonists - chemistry | Drug therapy | Nervous system diseases
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2016, Volume 24, Issue 21, pp. 5462 - 5480
Journal Article