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Molecular Cell, ISSN 1097-2765, 2008, Volume 29, Issue 2, pp. 169 - 179
The ATPase RIG-I senses viral RNAs that contain 5′-triphosphates in the cytoplasm. It initiates a signaling cascade that activates innate immune response by... 
RNA | MOLIMMUNO | RESPONSES | HELICASE LGP2 | VIRUS | ACID | REPLICATION | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTIVIRAL INNATE IMMUNITY | HOST | IDENTIFICATION | ADAPTER PROTEIN | CELL BIOLOGY | RNA Caps - immunology | RNA Helicases - metabolism | Zinc - metabolism | Humans | rab GTP-Binding Proteins - genetics | Structure-Activity Relationship | RNA Helicases - chemistry | Interferons - immunology | RNA Caps - metabolism | Zinc - chemistry | Adenosine Triphosphatases - immunology | Interferon-Induced Helicase, IFIH1 | RNA, Viral - genetics | Immunity, Innate - physiology | RNA Caps - chemistry | Zinc - immunology | RNA Helicases - genetics | RNA, Viral - metabolism | Interferons - genetics | DEAD-box RNA Helicases - metabolism | DEAD-box RNA Helicases - chemistry | Dimerization | RNA Caps - genetics | rab GTP-Binding Proteins - metabolism | Cell Line | DEAD Box Protein 58 | Adenosine Triphosphatases - metabolism | Protein Structure, Tertiary - genetics | Binding Sites - genetics | Substrate Specificity - genetics | Polyphosphates - metabolism | DEAD-box RNA Helicases - genetics | Animals | RNA, Viral - chemistry | Polyphosphates - immunology | rab GTP-Binding Proteins - immunology | DEAD-box RNA Helicases - immunology | Interferons - metabolism | Adenosine Triphosphatases - chemistry | RNA, Viral - immunology | rab GTP-Binding Proteins - chemistry | Adenosine Triphosphatases - genetics | Structural Homology, Protein | RNA Helicases - immunology | Polyphosphates - chemistry | Sensors | G proteins | Biological response modifiers | Adenosine triphosphatase | Index Medicus
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 10/2009, Volume 187, Issue 1, pp. 61 - 70
Inflammasomes activate caspase-1 for processing and secretion of the cytokines interleukin-lβ (IL-1β) and IL-18. Cryopyrin/NALP3/NLRP3 is an essential... 
ATP binding cassette transporters | Receptors | Monocytes | Cytokines | Secretion | Adenosine triphosphatases | Antibodies | Reports | Macrophages | Cell extracts | Vehicles | BINDING CASSETTE TRANSPORTER | CASPASE-1 | P2X RECEPTOR | INSULIN-SECRETION | MOUSE | ATP BINDING | INTERLEUKIN-1-BETA RELEASE | COLD AUTOINFLAMMATORY SYNDROME | SULFONYLUREA RECEPTOR | NALP3 INFLAMMASOME | CELL BIOLOGY | Hypoglycemic Agents - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Lipopolysaccharides - metabolism | Caspase 1 - metabolism | Male | Monocytes - metabolism | Caspase 1 - immunology | Monocytes - immunology | Adenosine Triphosphatases - immunology | Lipopolysaccharides - immunology | Adenosine Triphosphate - pharmacology | Inflammation - metabolism | Glyburide - pharmacology | Salmonella typhimurium - classification | Macrophages - immunology | Interleukin-1beta - secretion | Salmonella typhimurium - physiology | Salmonella typhimurium - genetics | Salmonella typhimurium - immunology | Mice, Inbred C57BL | Carrier Proteins - antagonists & inhibitors | Cells, Cultured | Adenosine Triphosphatases - metabolism | Glyburide - chemistry | Hypoglycemic Agents - chemistry | Inflammation - immunology | Glyburide - metabolism | Random Allocation | Enzyme Activation - drug effects | Hypoglycemic Agents - pharmacology | Mice, Knockout | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Glyburide - immunology | Lipopolysaccharides - pharmacology | Interleukin-18 - secretion | Mice | Mice, Inbred BALB C | Mutation | Inflammation - enzymology | Hypoglycemic Agents - immunology | Physiological aspects | Cellular proteins | Interleukin-1 | Research | Glibenclamide | Health aspects
Journal Article
Nature Immunology, ISSN 1529-2908, 05/2011, Volume 12, Issue 5, pp. 441 - 449
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 04/2012, Volume 21, Issue 8, pp. 1725 - 1743
Mutations in the ATP13A2 gene (PARK9, OMIM 610513) cause autosomal recessive, juvenile-onset Kufor-Rakeb syndrome and early-onset parkinsonism. ATP13A2 is an... 
CELLS | DEMENTIA | PROTEIN | CHAPERONE-MEDIATED AUTOPHAGY | P-TYPE ATPASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | PYRAMIDAL DEGENERATION | KUFOR-RAKEB SYNDROME | ALPHA-SYNUCLEIN | MUTATIONS | PARKINSONS-DISEASE | Lewy Bodies - ultrastructure | Pyramidal Cells - metabolism | Neurites - physiology | Proton-Translocating ATPases - immunology | Substantia Nigra - pathology | Calcium - metabolism | Humans | Substantia Nigra - metabolism | Adenosine Triphosphatases - immunology | Autophagy | Mitochondria - ultrastructure | Brain - metabolism | Proton-Translocating ATPases - metabolism | Neurons - ultrastructure | RNA Interference | Neurites - ultrastructure | Dopaminergic Neurons - metabolism | Cytoplasmic Vesicles - metabolism | Neurons - physiology | Dopaminergic Neurons - physiology | Membrane Proteins - metabolism | Neurons - metabolism | Parkinson Disease - metabolism | Parkinson Disease - pathology | Cells, Cultured | Adenosine Triphosphatases - metabolism | Rats | Membrane Proteins - immunology | Animals | Brain - pathology | Mice | Hydrogen-Ion Concentration | Brain | Cadmium | Neuroprotection | Basal ganglia | Calcium (intracellular) | Dopamine | Mesencephalon | Neurodegenerative diseases | Axonogenesis | Neurons | Substantia nigra | Adenosinetriphosphatase | Cortex | pH effects | Lewy bodies | Mitochondria | Pyramidal cells | Kinetics | Movement disorders
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2011, Volume 108, Issue 24, pp. 9933 - 9938
The molecular mechanisms regulating noncanonical protein transport across cellular membranes are poorly understood. Cross-presentation of exogenous antigens on... 
T lymphocytes | Antigens | Cross priming | Receptors | Dendritic cells | Ubiquitins | Antibodies | Ova | Physiological regulation | Endosomes | ACTIVATION | DENDRITIC CELLS | UBIQUITIN | MULTIDISCIPLINARY SCIENCES | RETRO-TRANSLOCATION | PROTEASOME | DEGRADATION | ENDOPLASMIC-RETICULUM | EXOGENOUS ANTIGENS | PROTEIN DISLOCATION | ER | Ovalbumin - immunology | Dendritic Cells - immunology | Endosomal Sorting Complexes Required for Transport - genetics | Green Fluorescent Proteins - genetics | Adenosine Triphosphatases - immunology | Endosomes - metabolism | Endosomal Sorting Complexes Required for Transport - immunology | Lectins, C-Type - metabolism | Protein Transport - immunology | RNA Interference | Bone Marrow Cells - immunology | Transcription Factors - immunology | Endocytosis - immunology | DNA-Binding Proteins - immunology | Adenosine Triphosphatases - metabolism | Receptors, Cell Surface - immunology | Blotting, Western | Mice, Knockout | Mannose-Binding Lectins - immunology | Cytosol - metabolism | Adenosine Triphosphatases - genetics | Mice | Receptors, Cell Surface - genetics | Mannose-Binding Lectins - metabolism | Endosomes - immunology | Cytosol - immunology | Lectins, C-Type - immunology | Lectins, C-Type - genetics | DNA-Binding Proteins - metabolism | Ovalbumin - metabolism | Flow Cytometry | Nuclear Proteins - genetics | Dendritic Cells - metabolism | Polyubiquitin - metabolism | Green Fluorescent Proteins - metabolism | Endosomal Sorting Complexes Required for Transport - metabolism | Receptors, Cell Surface - metabolism | Nuclear Proteins - metabolism | Antigens - metabolism | Ubiquitination - immunology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nuclear Proteins - immunology | Transcription Factors - metabolism | Animals | Mannose-Binding Lectins - genetics | Antigens - immunology | Cross-Priming | Bone Marrow Cells - metabolism | Microscopy, Fluorescence | Physiological aspects | Cell receptors | Research | Translocation (Genetics) | Biological transport | Biological Sciences
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 05/2012, Volume 71, Issue 5, pp. 710 - 713
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2014, Volume 289, Issue 48, pp. 33098 - 33108
The transporter associated with antigen processing (TAP) constitutes a focal element in the adaptive immune response against infected or malignantly... 
ABC TRANSPORTER | PHOSPHOLIPID-BILAYER NANODISCS | PEPTIDE-BINDING-SITE | VIRUS PROTEIN ICP47 | TAPASIN BINDING | ACTIVE DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | VALIDATION | FORCE-FIELD | CONFORMATION | MICROSCALE THERMOPHORESIS | Membrane Lipids - genetics | Humans | Peptides - genetics | Adenosine Triphosphate - genetics | Multiprotein Complexes - genetics | Adenosine Triphosphatases - immunology | Histocompatibility Antigens Class I - metabolism | Immediate-Early Proteins - metabolism | Multiprotein Complexes - metabolism | Protein Transport - immunology | Peptides - metabolism | Antigen Presentation | Adenosine Triphosphate - metabolism | Membrane Lipids - immunology | Proteasome Endopeptidase Complex - immunology | Immediate-Early Proteins - immunology | Peptides - immunology | Histocompatibility Antigens Class I - immunology | Adenosine Triphosphatases - metabolism | Adenosine Triphosphate - immunology | Histocompatibility Antigens Class I - genetics | Protein Transport - genetics | Proteasome Endopeptidase Complex - genetics | Immediate-Early Proteins - genetics | Cell Line, Tumor | Membrane Lipids - metabolism | Adenosine Triphosphatases - genetics | Proteasome Endopeptidase Complex - metabolism | Multiprotein Complexes - immunology | Antigen Processing | Lipid Bilayer | Peptide Transport | Membrane Biology | Membrane Transport | Membrane Protein | ATP-binding Cassette Transporter | Transporter | Herpesvirus | Membrane Transporter Reconstitution
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 2/2017, Volume 74, Issue 4, pp. 715 - 730
Journal Article
Vaccine, ISSN 0264-410X, 2007, Volume 25, Issue 37, pp. 6721 - 6729
Journal Article