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1. Full Text ATP mediates rapid microglial response to local brain injury in vivo
by Gan, Wen-Biao and Davalos, Dimitrios and Yang, Guang and Dustin, Michael L and Kim, Jiyun V and Jung, Steffen and Zuo, Yi and Littman, Dan R and Grutzendler, Jaime
Nature Neuroscience, ISSN 1097-6256, 06/2005, Volume 8, Issue 6, pp. 752 - 758
Parenchymal microglia are the principal immune cells of the brain. Time-lapse two-photon imaging of GFP-labeled microglia demonstrates that the fine termini of... 
HIPPOCAMPAL SLICES | CELLS | ACTIVATION | PROTEIN | MACROPHAGES | CENTRAL-NERVOUS-SYSTEM | RELEASE | RECEPTORS | ASTROCYTES | EXPRESSION | NEUROSCIENCES | Connexins - antagonists & inhibitors | Green Fluorescent Proteins | Microglia - metabolism | Cell Communication - physiology | Receptors, Purinergic P2Y1 | Gliosis - physiopathology | Brain Injuries - metabolism | Brain Injuries - physiopathology | Brain - metabolism | Gliosis - pathology | Adenosine Triphosphate - antagonists & inhibitors | Chemotaxis - physiology | Apyrase - pharmacology | Adenosine Triphosphate - metabolism | Reaction Time - drug effects | Microglia - cytology | Astrocytes - drug effects | Microglia - drug effects | Brain - physiopathology | Gliosis - metabolism | Phagocytosis - physiology | Purinergic P2 Receptor Antagonists | Mice, Transgenic | Chemotaxis - drug effects | Reaction Time - physiology | Connexins - metabolism | Animals | Signal Transduction - drug effects | Receptors, Purinergic P2 - metabolism | Cell Communication - drug effects | Brain - pathology | Signal Transduction - physiology | Mice | Brain Injuries - pathology | Astrocytes - metabolism | Brain | Analysis | Neuroglia | Response bias | Neural transmission | Regulation | Research | Gene expression | Adenosine triphosphate | Injuries | Index Medicus
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2. Full Text Pannexin 1: The Molecular Substrate of Astrocyte "Hemichannels"
by Iglesias, Rodolfo and Dahl, Gerhard and Qiu, Feng and Spray, David C and Scemes, Eliana
Journal of Neuroscience, ISSN 0270-6474, 05/2009, Volume 29, Issue 21, pp. 7092 - 7097
Purinergic signaling plays distinct and important roles in the CNS, including the transmission of calcium signals between astrocytes. Gap junction hemichannels... 
GAP-JUNCTION CHANNELS | COMPLEX | GLUTAMATE RELEASE | PERMEABILITY | P2X RECEPTOR | CALCIUM | CELL-CELL COMMUNICATION | ATP RELEASE | CONNEXIN HEMICHANNELS | EXPRESSION | NEUROSCIENCES | Membrane Potentials - genetics | Embryo, Mammalian | Fluorescent Dyes - metabolism | Cerebral Cortex - cytology | Patch-Clamp Techniques - methods | Adenosine Triphosphate - pharmacology | Benzenesulfonates - pharmacology | Adenosine Triphosphate - antagonists & inhibitors | Adenosine Triphosphate - metabolism | Electric Stimulation - methods | Mefloquine - pharmacology | Membrane Potentials - drug effects | Astrocytes - drug effects | Connexin 43 - metabolism | Mice, Inbred C57BL | RNA, Small Interfering - pharmacology | Cells, Cultured | Connexins - genetics | Down-Regulation - drug effects | Nerve Tissue Proteins - genetics | Adenosine Triphosphate - analogs & derivatives | Connexin 43 - deficiency | Connexins - metabolism | Mice, Knockout | Down-Regulation - physiology | Nerve Tissue Proteins - metabolism | Carbenoxolone - pharmacology | Astrocytes - physiology | Animals | Connexin 43 - antagonists & inhibitors | Mice | Index Medicus
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3. Full Text Cytostatic Activity of Adenosine Triphosphate-Competitive Kinase Inhibitors in BRAF Mutant Thyroid Carcinoma Cells
by Salerno, Paolo and De Falco, Valentina and Tamburrino, Anna and Nappi, Tito Claudio and Vecchio, Giancarlo and Schweppe, Rebecca E and Bollag, Gideon and Santoro, Massimo and Salvatore, Giuliana
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 01/2010, Volume 95, Issue 1, pp. 450 - 455
Context: The V600E mutation accounts for the vast majority of thyroid carcinoma-associated BRAF mutations. Objective: The aim was to study the effects of the... 
RESPONSES | CANCER CELLS | PATHWAY | GROWTH | ENDOCRINOLOGY & METABOLISM | RAF KINASE | SENSITIVITY | MUTATIONS | LINES | Humans | Mutant Proteins - genetics | Extracellular Signal-Regulated MAP Kinases - metabolism | Sulfonamides - pharmacology | Binding, Competitive - drug effects | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Thyroid Neoplasms - genetics | Adenosine Triphosphate - antagonists & inhibitors | Proto-Oncogene Proteins B-raf - genetics | Adenosine Triphosphate - metabolism | Carcinoma - genetics | Indoles - pharmacology | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Serum - physiology | Phosphorylation - drug effects | Tumor Cells, Cultured | Carcinoma - pathology | Cytostatic Agents - pharmacology | Drug Evaluation, Preclinical | Mutant Proteins - antagonists & inhibitors | Thyroid Neoplasms - pathology | Index Medicus | Abridged Index Medicus
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4. Full Text Effects of zidovudine treatment on heart mRNA expression and mitochondrial DNA copy number associated with alterations in deoxynucleoside triphosphate composition in a neonatal rat model
by Snowdin, Jacob W and Hsiung, Chia-Heng and Kesterson, Daniel G and Kamath, Vasudeva G and McKee, Edward E
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 10/2015, Volume 59, Issue 10, pp. 6328 - 6336
The prevention of mother-to-child transmission (MTCT) of HIV is a crucial component in HIV therapy. Nucleoside reverse transcriptase inhibitors (NRTIs),... 
SKELETAL-MUSCLE | 3'-AZIDO-3'-DEOXYTHYMIDINE | TRANSMISSION | CARDIAC MYOCYTES | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | TOXICITY | MICE | AZT | DYSFUNCTION | HIV-POSITIVE MOTHERS | COMBINATION | DNA, Mitochondrial - antagonists & inhibitors | Reverse Transcriptase Inhibitors - toxicity | Anti-HIV Agents - toxicity | Uridine Triphosphate - antagonists & inhibitors | Uridine Triphosphate - biosynthesis | Mitochondrial Proteins - genetics | Cytidine Triphosphate - biosynthesis | Adenosine Triphosphate - biosynthesis | RNA, Messenger - biosynthesis | Adenosine Triphosphate - antagonists & inhibitors | Mitochondrial Proteins - metabolism | RNA, Messenger - antagonists & inhibitors | DNA Copy Number Variations - drug effects | Female | Phosphorylation - drug effects | DNA, Mitochondrial - biosynthesis | Animals, Newborn | Cytidine Triphosphate - antagonists & inhibitors | Guanosine Triphosphate - biosynthesis | Mitochondrial Proteins - antagonists & inhibitors | RNA, Messenger - genetics | Gene Expression Regulation | Rats | Rats, Sprague-Dawley | Pregnancy | Animals | Zidovudine - toxicity | Heart - drug effects | Guanosine Triphosphate - antagonists & inhibitors | Index Medicus | Antiviral Agents
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5. Full Text Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer
by Hao, Yujun and Samuels, Yardena and Li, Qingling and Krokowski, Dawid and Guan, Bo-Jhih and Wang, Chao and Jin, Zhicheng and Dong, Bohan and Cao, Bo and Feng, Xiujing and Xiang, Min and Xu, Claire and Fink, Stephen and Meropol, Neal J and Xu, Yan and Conlon, Ronald A and Markowitz, Sanford and Kinzler, Kenneth W and Velculescu, Victor E and Brunengraber, Henri and Willis, Joseph E and Laframboise, Thomas and Hatzoglou, Maria and Zhang, Guo-Fang and Vogelstein, Bert and Wang, Zhenghe
Nature Communications, ISSN 2041-1723, 06/2016, Volume 7, Issue 1, pp. 11971 - 11971
Cancer cells often require glutamine for growth, thereby distinguishing them from most normal cells. Here we show that PIK3CA mutations reprogram glutamine... 
PHOSPHOINOSITIDE 3-KINASE PATHWAY | CELLS | DEPRIVATION | PHOSPHORYLATION | GLUCOSE | MULTIDISCIPLINARY SCIENCES | KRAS | PROLIFERATION | OPPORTUNITIES | TUMOR-GROWTH | EXPRESSION | Adenocarcinoma - pathology | Class I Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases - metabolism | Colorectal Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Glutamine - metabolism | Adenosine Triphosphate - biosynthesis | Adenosine Triphosphate - antagonists & inhibitors | Colorectal Neoplasms - drug therapy | Ketoglutaric Acids - antagonists & inhibitors | Transaminases - metabolism | Female | Adenocarcinoma - genetics | Antineoplastic Agents - pharmacology | Ketoglutaric Acids - metabolism | Protein-Serine-Threonine Kinases - metabolism | Colorectal Neoplasms - enzymology | Signal Transduction | Transaminases - genetics | HCT116 Cells | Adenocarcinoma - enzymology | Citric Acid Cycle - drug effects | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Activating Transcription Factor 4 - genetics | Adenocarcinoma - drug therapy | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | HT29 Cells | Xenograft Model Antitumor Assays | Animals | Glutamine - antagonists & inhibitors | Activating Transcription Factor 4 - metabolism | Tumor Burden - drug effects | Mice, Nude | Cell Line, Tumor | Aminooxyacetic Acid - pharmacology | Mice | Mutation | Colorectal Neoplasms - pathology | Index Medicus
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6. Full Text A Novel P2X7 Receptor Activator, the Human Cathelicidin-Derived Peptide LL37, Induces IL-1β Processing and Release
by Elssner, Andreas and Duncan, Michelle and Gavrilin, Mikhail and Wewers, Mark D
Journal of Immunology, ISSN 0022-1767, 04/2004, Volume 172, Issue 8, pp. 4987 - 4994
The release of IL-1 beta is a tightly controlled process that requires induced synthesis of the precursor pro-IL-1 beta and a second stimulus that initiates... 
Antimicrobial Cationic Peptides - antagonists & inhibitors | Cathelicidins | Antimicrobial Cationic Peptides - physiology | Humans | Receptors, Lipoxin - physiology | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Caspase 1 - metabolism | Monocytes - metabolism | Monocytes - immunology | Enzyme Activation - immunology | Adenosine Triphosphate - pharmacology | Adenosine Triphosphate - antagonists & inhibitors | Apyrase - pharmacology | Adenosine Triphosphate - metabolism | Interleukin-1 - antagonists & inhibitors | Adenosine Triphosphate - physiology | Protein Processing, Post-Translational - immunology | Receptors, Formyl Peptide - physiology | Binding Sites - drug effects | Interleukin-1 - metabolism | Cells, Cultured | Purinergic P2 Receptor Antagonists | Adenosine Triphosphate - analogs & derivatives | Receptors, Purinergic P2X7 | Cell Membrane Permeability - immunology | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Cell Membrane Permeability - drug effects | Receptors, Purinergic P2 - metabolism | Lipopolysaccharides - pharmacology | Index Medicus | Abridged Index Medicus
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7. Full Text A Tool for the Import of Natural and Unnatural Nucleoside Triphosphates into Bacteria
by Feldman, Aaron W and Fischer, Emil C and Ledbetter, Michael P and Liao, Jen-Yu and Chaput, John C and Romesberg, Floyd E
Journal of the American Chemical Society, ISSN 0002-7863, 01/2018, Volume 140, Issue 4, pp. 1447 - 1454
Nucleoside triphosphates play a central role in biology, but efforts to study these roles have proven difficult because the levels of triphosphates are tightly... 
DEOXYRIBONUCLEOSIDE KINASES | BASE-PAIR | SEMISYNTHETIC ORGANISM | DNA | ESCHERICHIA-COLI | GENETIC ALPHABET | POLYMERASE | I KLENOW FRAGMENT | NUPG GENE | CHEMISTRY, MULTIDISCIPLINARY | MINOR-GROOVE | Polyphosphates - pharmacology | Nucleotides - metabolism | Polyphosphates - metabolism | Diatoms - metabolism | Nucleotides - chemistry | Biological Products - chemistry | Adenosine Triphosphate - antagonists & inhibitors | Adenosine Triphosphate - pharmacokinetics | Nucleotides - pharmacology | Biological Products - metabolism | Molecular Structure | Diatoms - chemistry | Polyphosphates - chemistry | Phosphates | Nucleosides | Chemical properties | Structure | Analysis | Index Medicus
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8. Full Text Thrombin-induced ATP release from human umbilical vein endothelial cells
by Stefanie Gödecke and Claudia Roderigo and Christine R. Rose and Bernhard H. Rauch and Axel Gödecke and Jürgen Schrader
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 03/2012, Volume 302, Issue 6, pp. 915 - 923
ATP and its degradation products play an important role as signaling molecules in the vascular system, and endothelial cells are considered to be an important... 
Calcium | Nucleotide release | ACTIVATION | PHYSIOLOGY | calcium | PROTEIN | INTRACELLULAR CALCIUM | nucleotide release | CONNEXIN HEMICHANNELS | ASTROCYTES | MONOLAYERS | CELL BIOLOGY | PANNEXIN-1 CHANNELS | PROSTACYCLIN PRODUCTION | SENSITIVE CHANNELS | RECEPTORS | Connexins - antagonists & inhibitors | Nerve Tissue Proteins - antagonists & inhibitors | Gadolinium - pharmacology | Human Umbilical Vein Endothelial Cells - drug effects | Histamine - pharmacology | Human Umbilical Vein Endothelial Cells - metabolism | Calcium - metabolism | Receptor, PAR-1 - metabolism | Humans | RNA, Small Interfering - pharmacology | Receptor, PAR-1 - agonists | Cells, Cultured | Adenosine Triphosphate - agonists | Calcimycin - pharmacology | Calcium - antagonists & inhibitors | Carbenoxolone - pharmacology | Adenosine Triphosphate - antagonists & inhibitors | Egtazic Acid - pharmacology | Thrombin - pharmacology | Adenosine Triphosphate - metabolism | Egtazic Acid - analogs & derivatives | Connexin 43 - antagonists & inhibitors | Oligopeptides - pharmacology | Physiological aspects | Thrombin | Adenosine triphosphate | Umbilical arteries | Endothelium | Signal transduction | Physiology | Peptides | Adenosine triphosphatase | Cells | Index Medicus
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9. Full Text Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation
by Matsukawa, Toshihiro and Izawa, Kumi and Isobe, Masamichi and Takahashi, Mariko and Maehara, Akie and Yamanishi, Yoshinori and Kaitani, Ayako and Okumura, Ko and Teshima, Takanori and Kitamura, Toshio and Kitaura, Jiro
Gut, ISSN 0017-5749, 05/2016, Volume 65, Issue 5, pp. 777 - 787
ObjectiveExtracellular ATP mediates mast cell-dependent intestinal inflammation via P2X7 purinoceptors. We have previously shown that CD300f (also called the... 
INTESTINAL INFLAMMATION | RESPONSES | CMRF-35-LIKE MOLECULE-1 | INFLAMMATORY-BOWEL-DISEASE | RECOGNITION | RECEPTOR LMIR3 | GASTROENTEROLOGY & HEPATOLOGY | ANTIGEN | Adenosine Triphosphate - antagonists & inhibitors | Animals | Receptors, Immunologic - physiology | Mice, Inbred C57BL | Mast Cells - physiology | Mice | Ceramides - physiology | Colitis - prevention & control | Disease Models, Animal | Care and treatment | Ceramides | Inflammation | Dosage and administration | Research | Colitis | Risk factors | Adenosine triphosphate | Immunoglobulins | Cytokines | Pathogenesis | Allergies | Molecular weight | Crohns disease | Studies | Inflammatory bowel disease | Histamine | Rodents | Bone marrow | Ligands | Colon | Index Medicus | Abridged Index Medicus | Inflammatory Bowel Disease | IBD MODELS | EXPERIMENTAL COLITIS | GASTROINTESTINAL IMMUNE RESPONSE | 1506
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10. Full Text Advanced Glycation End Products Inhibit Glucose-Stimulated Insulin Secretion through Nitric Oxide-Dependent Inhibition of Cytochrome c Oxidase and Adenosine Triphosphate Synthesis
by Zhao, Zhengshan and Zhao, Chunying and Zhang, Xu Hannah and Zheng, Feng and Cai, Weijing and Vlassara, Helen and Ma, Zhongmin Alex
Endocrinology, ISSN 0013-7227, 06/2009, Volume 150, Issue 6, pp. 2569 - 2576
Advanced glycation end products (AGEs) are implicated in diabetic complications. However, their role in β-cell dysfunction is less clear. In this study we... 
DIABETIC COMPLICATIONS | HUMAN PANCREATIC-ISLETS | CHRONIC EXPOSURE | ADVANCED GLYCOSYLATION | RISK-FACTOR | CYCLIC-GMP FORMATION | ENDOCRINOLOGY & METABOLISM | BETA-CELL FAILURE | DIETARY GLYCOTOXINS | UNCOUPLING PROTEIN-2 | GLYCOXIDATION PRODUCTS | Glycation End Products, Advanced - physiology | Electron Transport Complex IV - antagonists & inhibitors | Mice, Inbred C57BL | Cells, Cultured | Diabetes Mellitus - metabolism | Male | Electron Transport Complex IV - metabolism | Insulin - metabolism | Insulin-Secreting Cells - metabolism | Adenosine Triphosphate - antagonists & inhibitors | Animals | Glucose - physiology | Adenosine Triphosphate - metabolism | Female | Insulin-Secreting Cells - cytology | Mice | Nitric Oxide - metabolism | Insulin Secretion | Disease Models, Animal | Nitric Oxide Synthase Type II - metabolism | Index Medicus | Abridged Index Medicus
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11. Full Text Disruption of quercetin metabolism by fungicide affects energy production in honey bees (Apis mellifera)
by Mao, Wenfu and Schuler, Mary A and Berenbaum, May R
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2017, Volume 114, Issue 10, pp. 2538 - 2543
Cytochrome P450 monooxygenases (P450) in the honey bee, Apis mellifera, detoxify phytochemicals in honey and pollen. The flavonol quercetin is found... 
Apis mellifera | Mitochondria | Flavonol | Cytochrome P450 | Myclobutanil | DETOXIFICATION | IN-VITRO | flavonol | mitochondria | PACKAGE | MULTIDISCIPLINARY SCIENCES | myclobutanil | cytochrome P450 | EXPRESSION | FLAVONOLS | Nitriles - toxicity | Pollen - metabolism | Triazoles - chemistry | Cytochrome P-450 Enzyme System - metabolism | Fungicides, Industrial - toxicity | Honey - analysis | Adenosine Triphosphate - biosynthesis | Oxidative Phosphorylation - drug effects | Adenosine Triphosphate - antagonists & inhibitors | Triazoles - toxicity | Inactivation, Metabolic - drug effects | Electron Transport Chain Complex Proteins - antagonists & inhibitors | Pollen - chemistry | Insect Proteins - metabolism | Quercetin - chemistry | Bees - metabolism | Quercetin - antagonists & inhibitors | Gene Expression Regulation | Insect Proteins - genetics | Quercetin - biosynthesis | Electron Transport Chain Complex Proteins - genetics | Electron Transport Chain Complex Proteins - chemistry | Fungicides, Industrial - chemistry | Insect Proteins - antagonists & inhibitors | Cytochrome P-450 Enzyme System - chemistry | Animals | Electron Transport Chain Complex Proteins - metabolism | Insect Proteins - chemistry | Nitriles - chemistry | Bees - drug effects | Cytochrome P-450 Enzyme System - genetics | Bees - genetics | Molecular Docking Simulation | Phosphorylation | Phytochemicals | Pesticides | Genetics | Metabolism | Bees | Adenosine triphosphatase | Index Medicus | Biological Sciences
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12. Full Text Arrested Protein Synthesis Increases Persister-Like Cell Formation
by Brian W. Kwan and John A. Valenta and Michael J. Benedik and Thomas K. Wood
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 03/2013, Volume 57, Issue 3, pp. 1468 - 1473
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
BACTERIAL PERSISTENCE | THERAPY | RNA | TOXIN | TOLERANCE | ESCHERICHIA-COLI | BIOFILMS | RESISTANCE | GENERAL STRESS-RESPONSE | BETA-LACTAM ANTIBIOTICS | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | Biofilms - drug effects | Transcription, Genetic - drug effects | Nucleic Acid Synthesis Inhibitors - pharmacology | Escherichia coli - drug effects | Tetracycline - pharmacology | Adaptation, Physiological - drug effects | Biofilms - growth & development | Escherichia coli Proteins - metabolism | Adenosine Triphosphate - biosynthesis | Microbial Sensitivity Tests | Adenosine Triphosphate - antagonists & inhibitors | Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology | Escherichia coli - metabolism | Proton Ionophores - pharmacology | Protein Biosynthesis - drug effects | Escherichia coli - growth & development | Escherichia coli Proteins - antagonists & inhibitors | Protein Synthesis Inhibitors - pharmacology | Rifampin - pharmacology | Drug Resistance, Multiple, Bacterial - drug effects | Index Medicus | Infection | Cyanide | Translation | Biofilms | Antibiotics | Transcription | Tetracyclines | Protein biosynthesis | carbonyls | Toxins | ATP | Rifampin | Mechanisms of Resistance
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13. Full Text The P2X7 receptor antagonist, oxidized adenosine triphosphate, ameliorates renal ischemia-reperfusion injury by expansion of regulatory T cells
by Koo, Tai Yeon and Lee, Jae-Ghi and Yan, Ji-Jing and Jang, Joon Young and Ju, Kyung Don and Han, Miyeun and Oh, Kook-Hwan and Ahn, Curie and Yang, Jaeseok
Kidney International, ISSN 0085-2538, 08/2017, Volume 92, Issue 2, pp. 415 - 431
Extracellular adenosine triphosphate (ATP) binds to purinergic receptors and, as a danger molecule, promotes inflammatory responses. Here we tested whether... 
ischemia-reperfusion injury | regulatory T cells | purinergic receptor | innate immunity | periodate-oxidized adenosine triphosphate | ACUTE KIDNEY INJURY | ACTIVATION | DENDRITIC CELLS | periodateoxidized adenosine triphosphate | EXPERIMENTAL GLOMERULONEPHRITIS | DEFICIENCY | NUCLEOTIDES | P2X RECEPTORS | INFLAMMATION | DISEASE | UROLOGY & NEPHROLOGY | ATP | Kidney - drug effects | Immunity, Innate - drug effects | Kidney - pathology | Reperfusion Injury - pathology | Acute Kidney Injury - pathology | Mice, Inbred C57BL | Male | Purinergic P2X Receptor Antagonists - pharmacology | Acute Kidney Injury - prevention & control | Adenosine Triphosphate - analogs & derivatives | Genes, RAG-1 | Mice, Knockout | Adenosine Triphosphate - pharmacology | Adenosine Triphosphate - therapeutic use | T-Lymphocytes, Regulatory - drug effects | Animals | Reperfusion Injury - prevention & control | Reperfusion Injury - immunology | Fibrosis | Receptors, Purinergic P2X7 - metabolism | Acute Kidney Injury - immunology | Drug Evaluation, Preclinical | Purinergic P2X Receptor Antagonists - therapeutic use | Index Medicus
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14. Full Text Disruption of mitochondrial electron transport chain function potentiates the pro-apoptotic effects of MAPK inhibition
by Trotta, Andrew P and Gelles, Jesse D and Serasinghe, Madhavika N and Loi, Patrick and Arbiser, Jack L and Chipuk, Jerry E
Journal of Biological Chemistry, ISSN 0021-9258, 07/2017, Volume 292, Issue 28, pp. 11727 - 11739
The mitochondrial network is a major site of ATP production through the coupled integration of the electron transport chain (ETC) with oxidative... 
SUBCHRONIC TOXICITY | MAGNOLIA PLANT | ACTIVATION | MEK INHIBITION | CANCER CELLS | HONOKIOL | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESISTANCE | BRAF | VEMURAFENIB | CDC2 Protein Kinase | Mitochondria - enzymology | Cyclin-Dependent Kinases - metabolism | Reactive Oxygen Species - metabolism | Uncoupling Agents - pharmacology | Apoptosis - drug effects | Humans | Neoplasm Proteins - antagonists & inhibitors | G1 Phase - drug effects | Electron Transport Complex II - antagonists & inhibitors | Membrane Potential, Mitochondrial - drug effects | Neoplasm Proteins - metabolism | Electron Transport Complex I - metabolism | Lignans - pharmacology | Reactive Oxygen Species - agonists | Oxidative Phosphorylation - drug effects | Adenosine Triphosphate - antagonists & inhibitors | Biphenyl Compounds - pharmacology | Protein Processing, Post-Translational - drug effects | Adenosine Triphosphate - metabolism | Electron Transport Chain Complex Proteins - antagonists & inhibitors | Cyclin-Dependent Kinases - antagonists & inhibitors | Phosphorylation - drug effects | Cyclin-Dependent Kinase 2 - metabolism | Electron Transport Complex I - antagonists & inhibitors | Mitochondria - drug effects | MAP Kinase Signaling System - drug effects | Electron Transport Complex II - metabolism | Electron Transport Chain Complex Proteins - metabolism | Cell Line, Tumor | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Index Medicus | mitochondrial respiratory chain complex | targeted therapy | mitochondria | apoptosis | respiration | oncogene | Cell Biology | mitochondrial dynamics
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