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Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2010, Volume 53, Issue 6, pp. 2636 - 2645
The PI3K/Akt signaling pathway is a key pathway in cell proliferation, growth, survival, protein synthesis, and glucose metabolism. It has been recognized... 
CHEMISTRY, MEDICINAL | ZSTK474 | 3-KINASE INHIBITOR | PATHWAY | 3-KINASE/MAMMALIAN TARGET | TUMOR-SUPPRESSOR | MUTATIONS | ANTITUMOR-ACTIVITY | IDENTIFICATION | CANCER | PTEN/MMAC1 | Neoplasms - metabolism | Models, Chemical | Area Under Curve | Humans | Neoplasms - prevention & control | Intracellular Signaling Peptides and Proteins - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Structure-Activity Relationship | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Adenosine Triphosphate - pharmacology | Protein Kinase Inhibitors - chemistry | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Inhibitory Concentration 50 | Female | Triazines - chemistry | Molecular Structure | Protein-Serine-Threonine Kinases - metabolism | Binding, Competitive | Protein Kinase Inhibitors - pharmacokinetics | Protein Structure, Tertiary | Cell Survival - drug effects | Triazines - pharmacology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Models, Molecular | Morpholines - pharmacology | Morpholines - chemistry | Phosphatidylinositol 3-Kinases - genetics | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Survival Analysis | Cell Line, Tumor | Protein Binding | Mice | Protein Kinase Inhibitors - pharmacology | TOR Serine-Threonine Kinases | Morpholines - pharmacokinetics | Mutation | Adenosine Triphosphate - chemistry | Neoplasms - pathology | Triazines - pharmacokinetics | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 09/2009, Volume 461, Issue 7261, pp. 282 - 286
Phagocytic removal of apoptotic cells occurs efficiently in vivo such that even in tissues with significant apoptosis, very few apoptotic cells are detectable.... 
UTP | THYMUS | RECEPTOR SUBTYPES | EPITHELIAL-CELLS | CHEMOTAXIS | INFLAMMATION | ENGULFMENT | ELEGANS | MULTIDISCIPLINARY SCIENCES | DEATH | EXTRACELLULAR NUCLEOTIDES | Uridine Triphosphate - metabolism | Monocytes - cytology | Humans | Culture Media, Conditioned - chemistry | Culture Media, Conditioned - pharmacology | Monocytes - metabolism | Receptors, Purinergic P2Y2 | Adenosine Triphosphate - pharmacology | Chemotactic Factors - pharmacology | Chemotactic Factors - metabolism | Adenosine Triphosphate - metabolism | Receptors, Purinergic P2 - genetics | Phagocytes - cytology | Cell Line | Phagocytosis - drug effects | Jurkat Cells | Phagocytes - drug effects | Mice, Inbred C57BL | Uridine Triphosphate - pharmacology | Cells, Cultured | Phagocytosis - physiology | Thymus Gland - cytology | Purinergic P2 Receptor Antagonists | Chemotaxis - drug effects | Macrophages - cytology | Phagocytes - metabolism | Monocytes - drug effects | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Receptors, Purinergic P2 - metabolism | Macrophages - drug effects | Mice | Apoptosis - physiology | Macrophage Activation - drug effects | Receptors, Purinergic P2 - deficiency | Culture Media, Conditioned - metabolism | Phagocytes | Nucleotides | Research | Properties | Apoptosis | Rodents | Cells | Index Medicus
Journal Article
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 09/2011, Volume 118, Issue 5, pp. 826 - 840
Inflammation contributes to neurodegeneration in post-ischemic brain, diabetes, and Alzheimer's disease. Participants in this inflammatory response include... 
gap junctions | Alzheimer’s disease | amyloid β‐peptide | cytokines | diabetes mellitus | pannexin | stroke | connexin | amyloid β-peptide | Alzheimer's disease | BRAIN-INJURY | GAP JUNCTIONAL COMMUNICATION | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMYLOID PLAQUES | ASTROCYTES | NEUROTOXICITY | NEUROSCIENCES | BETA | IN-VIVO | CHANNELS | RECEPTORS | amyloid beta-peptide | Tumor Necrosis Factor-alpha - metabolism | Oxygen - pharmacology | Cell Hypoxia - physiology | Amyloid beta-Peptides - pharmacology | Microtubule-Associated Proteins - pharmacology | Culture Media, Conditioned - pharmacology | Lanthanum - pharmacology | Peptide Fragments - pharmacology | Cerebral Cortex - cytology | Adenosine Triphosphate - pharmacology | Time Factors | Interleukin-1beta - metabolism | Adenosine Triphosphate - metabolism | Neuropeptides - pharmacology | Nerve Tissue Proteins - pharmacology | Neurons - physiology | Astrocytes - chemistry | Female | Cell Death - drug effects | Connexins - pharmacology | Neurons - drug effects | Animals, Newborn | Astrocytes - drug effects | Cell Hypoxia - drug effects | Connexin 43 - metabolism | Glutamic Acid - pharmacology | Cells, Cultured | Fluoresceins | Coculture Techniques - methods | Connexin 43 - deficiency | Connexins - metabolism | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Biotinylation - methods | Glutamic Acid - metabolism | Mice | Astrocytes - metabolism | Methyl aspartate | Neurosciences | Peptides | Neurons | Diabetes | Glucose | Glutamate | Dextrose | Index Medicus
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, pp. e0136080 - e0136080
Extracellular adenosine 5'-triphosphate (ATP) is a signaling molecule that induces a plethora of effects ranging from the regulation of cell proliferation to... 
EXTRACELLULAR ATP | COLON-CANCER | ATP-BINDING CASSETTE | SIGNALING PATHWAYS | TRANSPORT | MRP2 | EPITHELIAL-CELLS | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | PURINERGIC RECEPTORS | Caco-2 Cells | Cell Survival - drug effects | RNA, Small Interfering - genetics | Signal Transduction | Humans | Gene Expression Regulation, Neoplastic | Receptors, Purinergic P2Y - metabolism | Etoposide - pharmacology | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Cisplatin - pharmacology | Adenosine Triphosphate - pharmacology | Drug Resistance, Neoplasm - genetics | HEK293 Cells | Multidrug Resistance-Associated Proteins - genetics | Transcription, Genetic | Antineoplastic Agents - pharmacology | Multidrug Resistance-Associated Proteins - metabolism | Doxorubicin - pharmacology | Drug Resistance, Neoplasm - drug effects | RNA, Small Interfering - metabolism | Receptors, Purinergic P2Y - genetics | Chemotherapy | Usage | Colorectal cancer | Physiological aspects | Genetic aspects | Research | Drug therapy | Drug resistance | Adenosine triphosphate | Cancer | Cell proliferation | Adenocarcinoma | Drugs | Epithelial cells | Colorectal carcinoma | Chemoresistance | Stimulation | Biology | mRNA | Kinases | Cancer therapies | Doxorubicin | Western blotting | Proteins | Signal transduction | Receptors | Cell growth | Intestine | Purine P2 receptors | Adenosine | Cell survival | Multidrug resistance | Extracellular signal-regulated kinase | Etoposide | Hazards | Gene expression | Cisplatin | Molecular chains | Signaling | Medical prognosis | ATP | Index Medicus
Journal Article
Kidney International, ISSN 0085-2538, 08/2017, Volume 92, Issue 2, pp. 415 - 431
Journal Article
Journal Article
Oncogene, ISSN 0950-9232, 04/2015, Volume 34, Issue 14, pp. 1831 - 1842
Extracellular ATP has been shown to either inhibit or promote cancer growth and migration; however, the mechanism underlying this discrepancy remained elusive.... 
SURVIVAL | ACTIVATION | 5'-TRIPHOSPHATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | MASS-SPECTROMETRY | CELL BIOLOGY | HUMAN-TUMOR-CELLS | ONCOLOGY | HEMICHANNELS | GENETICS & HEREDITY | MICE | RECEPTORS | ATP | Neoplasm Transplantation | Cell Proliferation | Humans | Adenosine Triphosphate - secretion | Bone Neoplasms - secondary | Transplantation, Heterologous | Receptors, Purinergic P2X - genetics | Adenosine Triphosphate - pharmacology | RNA Interference | Apyrase - pharmacology | Adenosine Triphosphate - metabolism | Receptors, Purinergic P2X - metabolism | Female | Receptor, Adenosine A2A - genetics | Osteocytes - metabolism | Signal Transduction | Mice, Inbred C57BL | Receptor, Adenosine A2A - metabolism | Adenosine Triphosphate - analogs & derivatives | Bone Density Conservation Agents - pharmacology | Cell Movement - drug effects | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Mice, Nude | Adenosine - secretion | Alendronate - pharmacology | Adenosine - metabolism | Cell Line, Tumor | Mice | RNA, Small Interfering | Complications and side effects | Bone cancer | Development and progression | Breast cancer | Genetic aspects | Metastasis | Health aspects | Adenosine triphosphate | Bones | Adenosine triphosphatase | Index Medicus | bone metastasis | adenosine nucleotides | breast cancer
Journal Article