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Neuron (Cambridge, Mass.), ISSN 0896-6273, 2013, Volume 79, Issue 6, pp. 1086 - 1093
Dynamic changes in 5-methylcytosine (5mC) have been implicated in the regulation of gene expression critical for consolidation of memory. However, little is... 
GLYCOSYLASE | METHYLATION | CHROMATIN | CONVERSION | 5-HYDROXYMETHYLCYTOSINE | NEUROGENESIS | PROTEINS | EXPRESSION | NEUROSCIENCES | BRAIN | PLASTICITY | Male | Seizures - metabolism | Seizures - chemically induced | Central Nervous System - physiology | Mixed Function Oxygenases | Time Factors | Cytosine - metabolism | Potassium Chloride - pharmacology | Neurons - physiology | Adenoviridae - genetics | Neurons - drug effects | Animals, Newborn | DNA-Binding Proteins - physiology | Transduction, Genetic | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Cells, Cultured | Proto-Oncogene Proteins - genetics | DNA Methylation - genetics | Flurothyl - toxicity | DNA-Binding Proteins - genetics | Hippocampus - cytology | Mutation - genetics | Conditioning, Classical - physiology | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Chrysenes - metabolism | Motor Activity - genetics | Animals | Analysis of Variance | Hydroxylation - genetics | Convulsants - toxicity | Proto-Oncogene Proteins - physiology | Luminescent Proteins - genetics | Mice | Transcription, Genetic - genetics | Luminescent Proteins - metabolism | Memory - physiology | Enzymes | Neurosciences | Pyrimidines | Hydroxylation | Neurons | Genes | DNA | Memory | Genetic aspects | Genetic transcription | Methylation | Brain-derived neurotrophic factor | Brain research | Rodents | DNA methylation | Epigenetics | Gene expression | Binding sites | Deoxyribonucleic acid--DNA
Journal Article
Cancer research (Chicago, Ill.), ISSN 1538-7445, 2009, Volume 69, Issue 17, pp. 6951 - 6959
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e48093
Viral gene carriers are being widely used as gene transfer systems in (trans) differentiation and reprogramming strategies. Forced expression of key regulators... 
IN-VITRO | PROTEIN | REPLICATION | MULTIDISCIPLINARY SCIENCES | ISLET-LIKE CLUSTERS | BETA-CELLS | LIVER | INSULIN-PRODUCING CELLS | GENERATION | STROMAL CELLS | PRECURSOR CELLS | Species Specificity | Homeodomain Proteins - metabolism | Humans | Glucagon - genetics | Adipocytes - cytology | Promoter Regions, Genetic - genetics | Maf Transcription Factors, Large - metabolism | Cell Differentiation - genetics | Mesenchymal Stromal Cells - cytology | Flow Cytometry | Basic Helix-Loop-Helix Transcription Factors - metabolism | Maf Transcription Factors, Large - genetics | Gene Deletion | HEK293 Cells | Trans-Activators - genetics | Adenoviridae - genetics | Lentivirus - genetics | Transcription, Genetic | Osteoblasts - cytology | Insulin - genetics | Cytomegalovirus - genetics | Gene Expression | Basic Helix-Loop-Helix Transcription Factors - genetics | Mesenchymal Stromal Cells - metabolism | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Nerve Tissue Proteins - genetics | Adenovirus E1 Proteins - genetics | Genetic Vectors - genetics | Homeodomain Proteins - genetics | Nerve Tissue Proteins - metabolism | Adipocytes - metabolism | Glucagon - metabolism | Trans-Activators - metabolism | Osteoblasts - metabolism | Chromatin | Glucagon | Genetic vectors | Adenoviruses | Liver | Genes | Genetically modified organisms | Stem cells | DNA binding proteins | Gene expression | Cell differentiation | Health aspects | Regulators | Transcription factors | Mesenchyme | Differentiation (biology) | Homeostasis | Infections | Biology | Hormones | Proteins | Hyperglycemia | Rodents | Bone marrow | Somatostatin | Pancreas | Genetic modification | Expression vectors | Blood & organ donations | Gene transfer | Early region | Insulin | Hepatocytes | In vivo methods and tests | Diabetes
Journal Article
Blood, ISSN 1528-0020, 2007, Volume 110, Issue 6, pp. 1916 - 1923
CD8+ T cell-numbers rapidly expand and then contract after exposure to their cognate antigen. Here we show that the sustained frequencies of transgene... 
NONHUMAN-PRIMATES | PROTECTIVE IMMUNITY | VIRUS-INFECTION | REPLICATION | HIV | RHESUS-MONKEYS | IMMUNE-RESPONSES | CENTRAL-MEMORY | HEMATOLOGY | VIRAL VECTORS | LYMPHOCYTES | Lymphocytic choriomeningitis virus - immunology | Adenoviridae Infections - genetics | Adenoviridae Infections - virology | Peptide Fragments | Genetic Vectors - administration & dosage | Ovalbumin - immunology | Humans | Viral Vaccines - genetics | Antigens, Viral - genetics | Green Fluorescent Proteins - genetics | CD4-Positive T-Lymphocytes - immunology | Kidney - metabolism | T-Lymphocytes - metabolism | Adenoviridae - genetics | Primates | Immunologic Memory - immunology | Glycoproteins - genetics | Ovalbumin - genetics | Gene Products, gag - immunology | Immunization | Gene Products, gag - genetics | Genetic Vectors - immunology | Lymphocyte Activation | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Adenoviridae Infections - immunology | Kidney - cytology | Chromium - metabolism | Genetic Vectors - genetics | Viral Vaccines - administration & dosage | Antigens, Viral - immunology | Glycoproteins - immunology | Animals | Green Fluorescent Proteins - immunology | Egg Proteins - immunology | Lymphocytic choriomeningitis virus - genetics | Mice | Mice, Inbred BALB C | HeLa Cells | CD8-Positive T-Lymphocytes - immunology | Egg Proteins - genetics | Viral Vaccines - immunology | Immunobiology
Journal Article
Nature cell biology, ISSN 1476-4679, 2013, Volume 15, Issue 9, pp. 1056 - 1066
Journal Article
Molecular therapy, ISSN 1525-0016, 2017, Volume 25, Issue 11, pp. 2440 - 2451
In solid tumors, chimeric antigen receptor (CAR)-modified T cells must overcome the challenges of the immunosuppressive tumor microenvironment. We hypothesized... 
orthotopic animal model | head and neck cancer | adenovirotherapy | oncolytic virus | CAR T cell therapy | CAR T cell therapy | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNOTHERAPY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EXPANSION | GENETICS & HEREDITY | EX-VIVO | IL-12 | HER2 | ONCOLYTIC ADENOVIRUS | VECTORS | Recombinant Fusion Proteins - immunology | Receptor, ErbB-2 - genetics | Interleukin-12 - genetics | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | T-Lymphocytes - transplantation | Antibodies, Neutralizing - immunology | Adenoviridae - genetics | Female | Receptors, Antigen, T-Cell - immunology | Receptor, ErbB-2 - immunology | Lymphocyte Transfusion | Adenoviridae - immunology | Antibodies, Neoplasm - immunology | Gene Expression | Immunotherapy, Adoptive - methods | Head and Neck Neoplasms - therapy | Carcinoma, Squamous Cell - therapy | Antibodies, Neutralizing - genetics | Tumor Burden | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Carcinoma, Squamous Cell - immunology | Head and Neck Neoplasms - pathology | Xenograft Model Antitumor Assays | Oncolytic Virotherapy - methods | Head and Neck Neoplasms - immunology | Animals | T-Lymphocytes - cytology | Interleukin-12 - immunology | Survival Analysis | Recombinant Fusion Proteins - genetics | Head and Neck Neoplasms - genetics | T-Lymphocytes - immunology | Antibodies, Neoplasm - genetics | Combined Modality Therapy - methods | Mice | Receptors, Antigen, T-Cell - genetics | Cell culture | Phosphorylation | Disease | Blocking antibodies | Clinical trials | Lymphocytes T | Metastasis | Metastases | Human papillomavirus | Lymphocytes | Immunotherapy | Xenografts | Oncolysis | Deoxyribonucleic acid--DNA | Medical research | Squamous cell carcinoma | Immunoglobulins | Cell survival | Immunostimulation | Cytokines | Interleukin 12 | ErbB-2 protein | Medicine | Immune checkpoint | Medical prognosis | PD-L1 protein | Head and neck cancer | Antitumor activity | Ligands | Genetic testing | Solid tumors | Gene therapy | Tumors | Original
Journal Article
Cell metabolism, ISSN 1550-4131, 2011, Volume 14, Issue 3, pp. 324 - 338
.... Inhibition of BDNF signaling by genetic knockout or dominant-negative trkB reversed this phenotype... 
OBESITY | COLD-EXPOSURE | ADAPTIVE THERMOGENESIS | NEUROTROPHIC FACTOR | ENDOCRINOLOGY & METABOLISM | DIET-INDUCED THERMOGENESIS | ADULT HUMANS | MICE LACKING | REGULATES ENERGY-BALANCE | ADIPOSE-TISSUE | VENTROMEDIAL HYPOTHALAMUS | CELL BIOLOGY | Brain-Derived Neurotrophic Factor - antagonists & inhibitors | Brain-Derived Neurotrophic Factor - genetics | Adenoviridae | Adipose Tissue, White - metabolism | Ion Channels - genetics | Adipocytes - cytology | Male | Gene Expression Profiling | Mitochondrial Proteins - genetics | Receptor, trkB - genetics | MicroRNAs - pharmacology | Obesity - genetics | Brain-Derived Neurotrophic Factor - deficiency | DNA-Binding Proteins - metabolism | Thermogenesis - physiology | Adipose Tissue, White - cytology | Mitochondria - genetics | Mitochondrial Proteins - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Mitochondria - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Gene Knockout Techniques | Obesity - metabolism | Transcription Factors - metabolism | Motor Activity - genetics | Adipose Tissue, Brown - cytology | Phenotype | Animals | Hypothalamus - metabolism | Maze Learning | Hypothalamus - cytology | Ion Channels - metabolism | Adipocytes - metabolism | Adipose Tissue, Brown - metabolism | Mice | Uncoupling Protein 1 | Receptor, trkB - metabolism | Obesity | Neurosciences | Public health | Medical genetics | Enrichment | Brain-derived neurotrophic factor | Thermogenesis | Cognitive ability | Data processing | TrkB receptors | Adipocytes | Hypothalamus | Environmental effects
Journal Article
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 31, pp. 30675 - 30703
The emergence of genetic engineering at the beginning of the 1970's opened the era of biomedical technologies, which aims to improve human health using genetic manipulation techniques in a clinical context... 
Viral vectors | Non-viral vectors | AAVP | Gene therapy | Hybrid vectors | VESICULAR GLUTAMATE TRANSPORTER-1 | LONG-TERM EXPRESSION | gene therapy | MUTANT AAV VECTORS | INACTIVATING LENTIVIRAL VECTOR | CENTRAL POLYPURINE TRACT | non-viral vectors | viral vectors | hybrid vectors | HYBRID ADENORETROVIRAL VECTOR | CELL BIOLOGY | HERPES-SIMPLEX-VIRUS | MELANOGASTER DEOXYRIBONUCLEOSIDE KINASE | HUMAN FOAMY VIRUS | PACKAGING CELL-LINES
Journal Article