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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2006, Volume 103, Issue 4, pp. 1006 - 1011
Farnesoid X receptor (FXR) plays an important role in maintaining bile acid and cholesterol homeostasis. Here we demonstrate that FXR also regulates glucose... 
Messenger RNA | Diabetes complications | Glycogen | Liver | Adenoviruses | Mice | Liver glycogen | Insulin | Cholesterols | Blood plasma | GW4064 | triglyceride | glucose | TRIGLYCERIDE LEVELS | MYOCARDIAL-INFARCTION | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | GLYCOGEN-SYNTHASE KINASE-3 | farnesoid x receptor-VP16 | INSULIN-RESISTANCE | GENE-EXPRESSION | cholesterol | FARNESOID-X-RECEPTOR | BILE-ACID BIOSYNTHESIS | LIPID HOMEOSTASIS | CARBOHYDRATE-METABOLISM | Hepatocytes - metabolism | Receptors, Cytoplasmic and Nuclear | DNA-Binding Proteins - metabolism | Lipids - chemistry | Glycogen - metabolism | Time Factors | Adenoviridae - genetics | Diabetes Mellitus, Experimental - metabolism | Gluconeogenesis | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Hyperlipidemias - metabolism | Signal Transduction | Liver - metabolism | Mice, Inbred C57BL | Insulin Resistance | Etoposide - metabolism | Mice, Transgenic | Models, Statistical | Cholesterol - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Knockout | Triglycerides - metabolism | Hyperglycemia - metabolism | Isoxazoles - pharmacology | Transcription Factors - metabolism | Blotting, Northern | Insulin - metabolism | Animals | 3-Hydroxybutyric Acid - metabolism | Glucose - metabolism | Blood Glucose - metabolism | Glucose metabolism | Control | Genes | Rattus | Homeostasis | Rats | Physiological aspects | Research | Structure | Lipids | Diabetes | Glucose | Metabolism | Rodents | Cholesterol | Index Medicus | Biological Sciences | farnesoid X receptor-VP16
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2004, Volume 279, Issue 19, pp. 20314 - 20326
Hepatic glucokinase (GK) catalyzes the phosphorylation of glucose to glucose 6-phosphate (G6P), a step which is essential for glucose metabolism in liver as... 
FATTY-ACID-SYNTHASE | GLUCOSE-HOMEOSTASIS | CARBOHYDRATE RESPONSE ELEMENT | RAT HEPATOCYTES | STEROL REGULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ELEMENT-BINDING PROTEIN-1C | PYRUVATE-KINASE GENE | TRANSCRIPTION FACTOR | CARNITINE-PALMITOYLTRANSFERASE-I | TRANSGENIC MICE | Glucokinase - physiology | Liver - enzymology | Fatty Acid Synthases - metabolism | Immunoblotting | Hepatocytes - metabolism | RNA, Messenger - metabolism | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | Glycogen - metabolism | Time Factors | CCAAT-Enhancer-Binding Proteins - physiology | Adenoviridae - genetics | Transcription, Genetic | Pentosephosphates - metabolism | RNA - metabolism | CCAAT-Enhancer-Binding Proteins - metabolism | DNA-Binding Proteins - physiology | Pyruvate Kinase - metabolism | Signal Transduction | Liver - metabolism | Mice, Inbred C57BL | Carbohydrate Metabolism | Cells, Cultured | Gene Expression Regulation | Lipid Metabolism | Mice, Transgenic | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Nuclear Proteins | Transcription Factors - metabolism | Blotting, Northern | Animals | Proteins - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors | Glucose - metabolism | Mice | Kinetics | Sterol Regulatory Element Binding Protein 1 | Glucose-6-Phosphate - metabolism | Acetyl-CoA Carboxylase - metabolism | Microscopy, Fluorescence | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
STEM CELLS, ISSN 1066-5099, 04/2005, Volume 23, Issue 4, pp. 594 - 603
Multipotential stem cells can be selected from the bone marrow by plastic adhesion, expanded, and cultured. They are able to differentiate not only into... 
Mesenchymal stem cell | Bone marrow | Transcription factors | Cell differentiation | Insulin | Pancreatic beta cell | Bonemarrow | PROGENITOR CELLS | mesenchymal stem cell | pancreatic beta cell | cell differentiation | insulin | VIVO | transcription factors | BETA-CELLS | NEUROENDOCRINE DIFFERENTIATION | bone marrow | PDX-1 GENE | CELL BIOLOGY | ISLET TRANSPLANTATION | DIABETES-MELLITUS | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | TELOMERASE ACTIVITY | EXPANSION | NUCLEAR FACTOR 3-BETA | HEMATOLOGY | Hepatocyte Nuclear Factor 3-beta - genetics | Coculture Techniques | Homeodomain Proteins - metabolism | Humans | Multipotent Stem Cells - metabolism | Adipocytes - cytology | RNA, Messenger - metabolism | Insulin - biosynthesis | Insulin-Secreting Cells - metabolism | Mesenchymal Stromal Cells - cytology | Trans-Activators - genetics | Adenoviridae - genetics | Cell Differentiation | Insulin-Secreting Cells - cytology | Telomere - metabolism | Trans-Activators - biosynthesis | Insulin - genetics | Biomarkers - metabolism | Hepatocyte Nuclear Factor 3-beta - biosynthesis | Homeodomain Proteins - biosynthesis | Bone Marrow Cells - cytology | Cells, Cultured | Mesenchymal Stromal Cells - metabolism | Transcription Factors - biosynthesis | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Homeodomain Proteins - genetics | Animals | Multipotent Stem Cells - cytology | Adipocytes - metabolism | Mice | Bone Marrow Cells - metabolism | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 12/2004, Volume 6, Issue 6, pp. 611 - 623
ONYX-015 is an adenovirus that lacks the E1B-55K gene product for p53 degradation. Thus, ONYX-015 was conceived as an oncolytic virus that would selectively... 
NUCLEAR-LOCALIZATION | ADENOVIRUS REPLICATION | CHROMOSOME-TRANSLOCATION | MESSENGER-RNA | ONCOLOGY | E1B 55-KILODALTON PROTEIN | INFECTED-CELLS | TIME QUANTITATIVE PCR | SV40-TRANSFORMED CELLS | NUCLEOPORIN GENE | NECK-CANCER | Gene Expression - genetics | Virus Replication - genetics | Humans | Viral Proteins - metabolism | Cytopathogenic Effect, Viral - genetics | Caspase 3 | RNA Transport | Capsid Proteins - metabolism | HCT116 Cells | Cell Cycle Proteins - metabolism | In Situ Hybridization, Fluorescence | Caspase Inhibitors | Blotting, Western | Proto-Oncogene Proteins c-mdm2 | Models, Biological | Adenovirus E1A Proteins - genetics | Epithelial Cells - virology | Viral Nonstructural Proteins - metabolism | Adenoviruses, Human - genetics | Adenoviridae - metabolism | Mutation | Adenoviruses, Human - metabolism | Capsid Proteins - genetics | Neoplasms - metabolism | Epithelial Cells - metabolism | DNA, Viral - biosynthesis | Neoplasms - virology | Caspases - metabolism | Neoplasms - genetics | Adenovirus E1A Proteins - metabolism | Polymerase Chain Reaction | Adenoviridae - genetics | Cell Cycle Proteins - genetics | Protein Biosynthesis - genetics | RNA, Viral - metabolism | Adenovirus E1B Proteins - metabolism | Nuclear Proteins - genetics | Adenovirus E1B Proteins - genetics | Proto-Oncogene Proteins - metabolism | Epithelial Cells - radiation effects | Cyclin-Dependent Kinase Inhibitor p21 | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Viral Nonstructural Proteins - genetics | Viral Plaque Assay | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | bcl-2-Associated X Protein | Poly(ADP-ribose) Polymerases - metabolism | Viral Vaccines | Tumor Suppressor Protein p14ARF - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Index Medicus
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 05/2013, Volume 434, Issue 2, pp. 197 - 202
Journal Article
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 05/2008, Volume 294, Issue 5, pp. 969 - 977
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2003, Volume 278, Issue 48, pp. 48275 - 48282
ABCG5 (G5) and ABCG8 (G8) are ATP-binding cassette (ABC) transporters that limit intestinal absorption and promote biliary excretion of neutral sterols.... 
STEROL ABSORPTION | MULTIDRUG TRANSPORTER | EYE PIGMENT PRECURSORS | DIETARY-CHOLESTEROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUBCELLULAR-LOCALIZATION | SITOSTEROLEMIA | DROSOPHILA-WHITE GENE | MELANOGASTER | HUMAN HOMOLOG | CANCER RESISTANCE PROTEIN | Bile Ducts - metabolism | Enterocytes - metabolism | Humans | Endoplasmic Reticulum - metabolism | Molecular Sequence Data | Hepatocytes - metabolism | Phylogeny | ATP-Binding Cassette Transporters - chemistry | Transfection | Biological Transport | Adenosine Triphosphate - metabolism | Cloning, Molecular | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Adenoviridae - genetics | Cell Membrane - metabolism | Dimerization | CHO Cells | Recombinant Proteins - metabolism | Amino Acid Sequence | Cholesterol - analogs & derivatives | Cricetinae | Liver - metabolism | Phytosterols | Lipoproteins - chemistry | Cholesterol - metabolism | Hypolipidemic Agents - pharmacology | Precipitin Tests | Protein Transport | Sequence Homology, Amino Acid | Sitosterols - metabolism | Phenotype | Animals | ATP Binding Cassette Transporter, Sub-Family G, Member 8 | Epitopes - chemistry | Mice | Adenoviridae - metabolism | Antibodies, Monoclonal - metabolism | Mutation | DNA, Complementary - metabolism | Microscopy, Fluorescence | ATP Binding Cassette Transporter, Sub-Family G, Member 5 | Evolution, Molecular | ABCG5 protein | ABCG8 protein | sterols | Index Medicus
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2017, Volume 486, Issue 2, pp. 451 - 457
Klotho, an antiaging protein, can extend the lifespan and modulate cellular responses to inflammation and oxidative stress which can ameliorate chronic kidney... 
Cyclosporine A | PDLIM2 | Nephropathy | Klotho | NF-kB p65 | GLOMERULONEPHRITIS | OXIDATIVE STRESS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MODEL | BIOPHYSICS | DISEASE | MICE | KIDNEY | ANTIAGING GENE | RENAL INJURY | EXPRESSION | Tumor Necrosis Factor-alpha - metabolism | RNA, Small Interfering - genetics | Epithelial Cells - metabolism | Interleukin-12 - genetics | Blood Urea Nitrogen | Epithelial Cells - drug effects | Tumor Necrosis Factor-alpha - genetics | Glucuronidase - metabolism | Male | Cyclosporine | LIM Domain Proteins - metabolism | Transcription Factor RelA - genetics | Nephritis, Interstitial - metabolism | Nephritis, Interstitial - pathology | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Adenoviridae - genetics | Chemokine CCL2 - metabolism | Interleukin-6 - metabolism | Nephritis, Interstitial - chemically induced | Cell Line | Kidney Tubules, Proximal - pathology | Genetic Vectors - chemistry | Interleukin-6 - genetics | Macrophages - pathology | Signal Transduction | LIM Domain Proteins - antagonists & inhibitors | Gene Expression Regulation | Genetic Vectors - metabolism | Chemokine CCL2 - genetics | Epithelial Cells - pathology | Interleukin-12 - metabolism | Mice, Inbred ICR | Macrophages - metabolism | Animals | Glucuronidase - genetics | Nephritis, Interstitial - genetics | Nitric Oxide Synthase Type II - genetics | Transcription Factor RelA - metabolism | Adaptor Proteins, Signal Transducing - genetics | Kidney Tubules, Proximal - metabolism | Creatinine - blood | LIM Domain Proteins - genetics | Mice | Adenoviridae - metabolism | Glucuronidase - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Nitric Oxide Synthase Type II - metabolism | RNA, Small Interfering - metabolism | Medical research | Urea | Medical colleges | Chronic kidney failure | RNA | Luciferase | Medicine, Experimental | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 09/2011, Volume 14, Issue 3, pp. 324 - 338
Living in an enriched environment with complex physical and social stimulation leads to improved cognitive and metabolic health. In white fat, enrichment... 
OBESITY | COLD-EXPOSURE | ADAPTIVE THERMOGENESIS | NEUROTROPHIC FACTOR | ENDOCRINOLOGY & METABOLISM | DIET-INDUCED THERMOGENESIS | ADULT HUMANS | MICE LACKING | REGULATES ENERGY-BALANCE | ADIPOSE-TISSUE | VENTROMEDIAL HYPOTHALAMUS | CELL BIOLOGY | Brain-Derived Neurotrophic Factor - antagonists & inhibitors | Brain-Derived Neurotrophic Factor - genetics | Adenoviridae | Adipose Tissue, White - metabolism | Ion Channels - genetics | Adipocytes - cytology | Male | Gene Expression Profiling | Mitochondrial Proteins - genetics | Receptor, trkB - genetics | MicroRNAs - pharmacology | Obesity - genetics | Brain-Derived Neurotrophic Factor - deficiency | DNA-Binding Proteins - metabolism | Thermogenesis - physiology | Adipose Tissue, White - cytology | Mitochondria - genetics | Mitochondrial Proteins - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Mitochondria - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Gene Knockout Techniques | Obesity - metabolism | Transcription Factors - metabolism | Motor Activity - genetics | Adipose Tissue, Brown - cytology | Phenotype | Animals | Hypothalamus - metabolism | Maze Learning | Hypothalamus - cytology | Ion Channels - metabolism | Adipocytes - metabolism | Adipose Tissue, Brown - metabolism | Mice | Uncoupling Protein 1 | Receptor, trkB - metabolism | Obesity | Neurosciences | Public health | Medical genetics | Enrichment | Brain-derived neurotrophic factor | Thermogenesis | Cognitive ability | Data processing | TrkB receptors | Adipocytes | Hypothalamus | Environmental effects | Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2005, Volume 280, Issue 11, pp. 9887 - 9894
Insulin resistance and increased cytochrome P450 2E1 (CYP2E1) expression are both associated with and mechanistically implicated in the development of... 
DIABETES-MELLITUS | NONALCOHOLIC FATTY LIVER | METABOLIC SYNDROME | OXIDATIVE STRESS | EXPRESSION SENSITIZES HEPATOCYTES | CYTOCHROME-P450 2E1 | TRANSCRIPTION FACTOR FOXO1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | C-JUN | MICE LACKING | RECEPTOR SUBSTRATE-1 | Up-Regulation | Phosphorylation | Immunoprecipitation | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | Hepatocytes - metabolism | Cytochrome P-450 CYP2E1 - biosynthesis | DNA-Binding Proteins - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Glutathione Peroxidase | MAP Kinase Kinase 4 | Time Factors | Hepatitis - metabolism | Adenoviridae - genetics | Protein-Serine-Threonine Kinases - metabolism | Cytochrome P-450 CYP2E1 - chemistry | RNA - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Line | Fatty Liver - metabolism | Signal Transduction | Down-Regulation | Mice, Inbred C57BL | Rats | Choline - chemistry | Glycogen Synthase Kinase 3 - metabolism | Serine - chemistry | Subcellular Fractions - metabolism | Blotting, Western | Proto-Oncogene Proteins c-akt | Transcription Factors - metabolism | Blotting, Northern | Insulin - metabolism | Tyrosine - metabolism | Animals | Proteins - metabolism | Methionine - chemistry | Glucose - metabolism | Forkhead Box Protein O1 | Mice | Forkhead Transcription Factors | Index Medicus
Journal Article