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PloS one, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, pp. e69808 - e69808
Several studies have demonstrated the potential for vector-mediated gene transfer to the brain. Helper-dependent (HD) human (HAd) and canine (CAV-2... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cell Cycle - genetics | Mesencephalon - cytology | Ataxia Telangiectasia Mutated Proteins - metabolism | Humans | Transcriptional Activation | Neurons - cytology | Gene Expression Profiling | Neural Stem Cells - cytology | Wnt Proteins - metabolism | Cell Differentiation - genetics | Wnt Proteins - genetics | DNA Damage - genetics | Endocytosis - genetics | Interferons - genetics | Toll-Like Receptors - metabolism | Neurons - virology | Transduction, Genetic | Neural Stem Cells - virology | Adenoviruses, Human - physiology | Genetic Vectors - metabolism | Signal Transduction - genetics | Transcriptome - genetics | Lentivirus | Down-Regulation - genetics | Genetic Vectors - genetics | Animals | Toll-Like Receptors - genetics | Dogs | Interferons - metabolism | Immunity - genetics | Neural Stem Cells - metabolism | Adenoviruses, Canine - physiology | Viral genetics | Neurons | Genes | Genomics | Genetic transcription | DNA microarrays | Genetic vectors | Adenoviruses | High-definition television | Gene therapy | Tumor proteins | Hyaluronic acid | Health aspects | Brain | Transcription | Toxicity | p53 Protein | DNA damage | Central nervous system | Homeostasis | Genomes | Kinases | Proteins | Morphogenesis | Hyaluronan | Receptors | Pathways | Human immunodeficiency virus--HIV | Toll-like receptors | Biocompatibility | Growth factors | Deoxyribonucleic acid--DNA | Expression vectors | Brain diseases | Immune system | Cell survival | Immune response | Gene transfer | Cloning | Inflammation | Gene expression | Vectors (Biology) | Neural stem cells | In vivo methods and tests | Interferon | Index Medicus | Life Sciences | Biochemistry, Molecular Biology | Deoxyribonucleic acid | HIV | DNA | Human immunodeficiency virus
Journal Article
PloS one, ISSN 1932-6203, 08/2017, Volume 12, Issue 8, pp. e0182974 - e0182974
Phenotypic assays using human primary cells are highly valuable tools for target discovery and validation in drug discovery... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Endonucleases - genetics | Epithelial Cells - metabolism | RNA, Guide - genetics | RNA, Guide - metabolism | Epithelial Cells - drug effects | Humans | Actins - metabolism | Epithelial-Mesenchymal Transition - drug effects | Smad3 Protein - metabolism | Endonucleases - metabolism | Epithelial-Mesenchymal Transition - genetics | INDEL Mutation | Actins - genetics | Smad3 Protein - genetics | Base Sequence | Clustered Regularly Interspaced Short Palindromic Repeats | Adenoviridae - genetics | Bronchi - metabolism | Epithelial Cells - cytology | Bronchi - cytology | Fibroblasts - metabolism | Transduction, Genetic | Genetic Vectors - chemistry | Gene Expression Regulation | Gene Silencing | Genetic Vectors - metabolism | Smad3 Protein - antagonists & inhibitors | Fibronectins - metabolism | Gene Editing | Protein Transport | Transforming Growth Factor beta - pharmacology | Fibroblasts - drug effects | CRISPR-Cas Systems | Fibroblasts - cytology | Fibronectins - genetics | Adenoviridae - metabolism | Primary Cell Culture | Genome, Human | Fibronectins | Drug discovery | Research | Gene expression | Adenoviruses | Biotechnology | Mesenchyme | Epithelial cells | Insertion | Editing | Smooth muscle | Genomes | Smad3 protein | Inactivation | Assaying | gRNA | Fibronectin | Clonal deletion | Actin | Fibroblasts | Protein transport | Deoxyribonucleic acid--DNA | Expression vectors | Translocation | CRISPR | Deactivation | Nuclear transport | Mutagenesis | Lungs | Plasmids | Cell lines | Fibrosis | Stem cells | Genetic engineering | Mutation | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
PloS one, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, pp. e48093 - e48093
.... In this study, we examined whether the viral vector system itself could impact the differentiation capacity of human bone-marrow derived mesenchymal stem cells (hMSCs... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Species Specificity | Homeodomain Proteins - metabolism | Humans | Glucagon - genetics | Adipocytes - cytology | Promoter Regions, Genetic - genetics | Maf Transcription Factors, Large - metabolism | Cell Differentiation - genetics | Mesenchymal Stromal Cells - cytology | Flow Cytometry | Basic Helix-Loop-Helix Transcription Factors - metabolism | Maf Transcription Factors, Large - genetics | Gene Deletion | HEK293 Cells | Trans-Activators - genetics | Adenoviridae - genetics | Lentivirus - genetics | Transcription, Genetic | Osteoblasts - cytology | Insulin - genetics | Cytomegalovirus - genetics | Gene Expression | Basic Helix-Loop-Helix Transcription Factors - genetics | Mesenchymal Stromal Cells - metabolism | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Nerve Tissue Proteins - genetics | Adenovirus E1 Proteins - genetics | Genetic Vectors - genetics | Homeodomain Proteins - genetics | Nerve Tissue Proteins - metabolism | Adipocytes - metabolism | Glucagon - metabolism | Trans-Activators - metabolism | Osteoblasts - metabolism | Chromatin | Glucagon | Genetic vectors | Adenoviruses | Liver | Genes | Genetically modified organisms | Stem cells | DNA binding proteins | Gene expression | Cell differentiation | Health aspects | Regulators | Transcription factors | Mesenchyme | Differentiation (biology) | Homeostasis | Infections | Biology | Hormones | Proteins | Hyperglycemia | Rodents | Bone marrow | Somatostatin | Pancreas | Genetic modification | Expression vectors | Blood & organ donations | Gene transfer | Early region | Insulin | Hepatocytes | In vivo methods and tests | Diabetes | Index Medicus
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 01/2004, Volume 172, Issue 1, pp. 567 - 576
...) STAT3 in human macrophages to broaden the investigation to determine the role of STAT3 in IL-10-mediated anti-inflammatory signaling and gene expression... 
Life Sciences & Biomedicine | Immunology | Science & Technology | Protein Binding - genetics | Protein Biosynthesis | Interleukin-6 - antagonists & inhibitors | Humans | Tumor Necrosis Factor-alpha - genetics | Immunoglobulins - genetics | Lipopolysaccharides - antagonists & inhibitors | RNA, Messenger - metabolism | Suppressor of Cytokine Signaling Proteins | Repressor Proteins - antagonists & inhibitors | Antigens, CD - metabolism | Trans-Activators - physiology | Protein Tyrosine Phosphatases - antagonists & inhibitors | RNA, Messenger - biosynthesis | Protein Tyrosine Phosphatases - genetics | Inflammation Mediators - physiology | Glycoproteins - genetics | DNA-Binding Proteins - physiology | Protein Tyrosine Phosphatases - biosynthesis | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction - genetics | DNA - metabolism | Down-Regulation - genetics | Macrophages - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 2 | Repressor Proteins - biosynthesis | Up-Regulation - immunology | Interleukin-10 - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Adenoviruses, Human - genetics | Interleukin-10 - immunology | Tumor Necrosis Factor-alpha - biosynthesis | Phosphorylation | Tissue Inhibitor of Metalloproteinase-1 - biosynthesis | Antigens, CD - biosynthesis | Receptors, Cell Surface | Receptors, IgG - biosynthesis | Receptors, IgG - antagonists & inhibitors | Interleukin-10 - physiology | Signal Transduction - immunology | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Signaling Lymphocytic Activation Molecule Family Member 1 | Receptors, Tumor Necrosis Factor - antagonists & inhibitors | RNA, Messenger - antagonists & inhibitors | Receptors, Tumor Necrosis Factor, Type II | Trans-Activators - genetics | Inflammation Mediators - antagonists & inhibitors | Trans-Activators - biosynthesis | Immunoglobulins - biosynthesis | Macrophages - immunology | Inflammation Mediators - immunology | Receptors, Tumor Necrosis Factor - metabolism | Immune Sera - pharmacology | Proteins - physiology | Cells, Cultured | Glycoproteins - antagonists & inhibitors | Histocompatibility Antigens Class II - biosynthesis | Tissue Inhibitor of Metalloproteinase-1 - antagonists & inhibitors | Transcription Factors - antagonists & inhibitors | Transcription Factors - biosynthesis | Up-Regulation - genetics | DNA-Binding Proteins - genetics | DNA - antagonists & inhibitors | Glycoproteins - biosynthesis | Suppressor of Cytokine Signaling 3 Protein | Down-Regulation - immunology | Interleukin-6 - biosynthesis | Receptors, Tumor Necrosis Factor - biosynthesis | STAT3 Transcription Factor | Trans-Activators - antagonists & inhibitors | Genetic Vectors | DNA-Binding Proteins - biosynthesis | Tumor Necrosis Factor-alpha - antagonists & inhibitors | SOCS-3 protein | Index Medicus | Abridged Index Medicus
Journal Article
Human gene therapy, ISSN 1043-0342, 02/2016, Volume 27, Issue 2, pp. 134 - 147
Retinal degenerative diseases are a leading cause of irreversible blindness. Retinal cell death is the main cause of vision loss in genetic disorders... 
Reviews | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Leber Congenital Amaurosis - pathology | Cell- and Tissue-Based Therapy - methods | Dependovirus - genetics | Retina - metabolism | Optogenetics - methods | Blindness - metabolism | Humans | Blindness - pathology | Leber Congenital Amaurosis - metabolism | Lentivirus - genetics | cis-trans-Isomerases - metabolism | Blindness - therapy | Leber Congenital Amaurosis - therapy | Genetic Vectors - chemistry | Genetic Vectors - metabolism | Retinitis Pigmentosa - genetics | Retinitis Pigmentosa - metabolism | Clinical Trials as Topic | Leber Congenital Amaurosis - genetics | Blindness - genetics | Macular Degeneration - metabolism | Macular Degeneration - congenital | cis-trans-Isomerases - genetics | Macular Degeneration - genetics | Macular Degeneration - therapy | Retinitis Pigmentosa - therapy | CRISPR-Cas Systems | Adenoviruses, Human - genetics | Retina - pathology | Retinitis Pigmentosa - pathology | Genetic Therapy - methods | Macular Degeneration - pathology | Macular degeneration | Therapy | Cell death | Retinal cells | Retinitis pigmentosa | Blindness | Disorders | Retinal degeneration | Retina | Retinitis | Age | Index Medicus | Life Sciences
Journal Article
PloS one, ISSN 1932-6203, 09/2007, Volume 2, Issue 9, pp. e924 - e924
Bacterial and viral upper respiratory infections (URI) produce highly variable clinical symptoms that cannot be used to identify the etiologic agent. Proper... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Humans | Influenza A virus - genetics | Coronavirus OC43, Human - isolation & purification | Mycoplasma pneumoniae - genetics | Virus Diseases - virology | DNA, Bacterial - chemistry | Parainfluenza Virus 3, Human - isolation & purification | Respiratory System - microbiology | Chlamydophila pneumoniae - genetics | Chlamydophila pneumoniae - isolation & purification | Streptococcus pyogenes - genetics | Influenza B virus - genetics | Parainfluenza Virus 3, Human - genetics | Respiratory System - virology | Adenoviridae - isolation & purification | Sensitivity and Specificity | Polymerase Chain Reaction | Adenoviridae - genetics | Coronavirus 229E, Human - genetics | Coronavirus 229E, Human - isolation & purification | Bacterial Infections - microbiology | Reproducibility of Results | Influenza B virus - isolation & purification | Oligonucleotide Array Sequence Analysis - methods | Parainfluenza Virus 1, Human - genetics | Parainfluenza Virus 1, Human - isolation & purification | Bordetella pertussis - genetics | Respiratory Syncytial Viruses - isolation & purification | Influenza A virus - isolation & purification | Sequence Analysis, DNA | DNA, Viral - chemistry | Streptococcus pyogenes - isolation & purification | Parainfluenza Virus 2, Human - isolation & purification | DNA, Bacterial - genetics | Virus Diseases - diagnosis | Respiratory Syncytial Viruses - genetics | Coronavirus OC43, Human - genetics | Parainfluenza Virus 2, Human - genetics | Bacterial Infections - diagnosis | Mycoplasma pneumoniae - isolation & purification | DNA, Viral - genetics | Electrochemistry - methods | Bordetella pertussis - isolation & purification | Virus diseases | Whooping-cough | Pneumonia | Pathogenic microorganisms | Antibiotics | Analysis | Bacterial pneumonia | Adenoviruses | Health aspects | Health care | Multiplexing | Electrochemical analysis | Sexually transmitted diseases--STD | Image processing | Viruses | Identification | Genomes | Infections | Hybridization | Assaying | Streptococcus infections | Respiratory tract | Pertussis | Microorganisms | Etiology | Bacteria | Influenza A | Probes | Pathogens | Semiconductors | Health promotion | Feasibility studies | Preventive medicine | Coronaviruses | Gene expression | Image analysis | Genotyping | Influenza | Electrochemistry | Viral infections | Index Medicus | STD | Sexually transmitted diseases
Journal Article
Journal of Virology, ISSN 0022-538X, 02/2012, Volume 86, Issue 4, pp. 2239 - 2250
OA  Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+... 
Life Sciences & Biomedicine | Science & Technology | Virology | HIV Infections - prevention & control | Gene Products, env - immunology | Gene Products, env - administration & dosage | Humans | AIDS Vaccines - immunology | Male | Gene Products, nef - genetics | HIV - immunology | Macaca mulatta | HIV Infections - immunology | Simian Acquired Immunodeficiency Syndrome - virology | Simian Immunodeficiency Virus - genetics | Gene Products, env - genetics | Disease Models, Animal | Gene Products, nef - administration & dosage | Simian Immunodeficiency Virus - immunology | Gene Products, gag - immunology | Immunization | Gene Products, gag - genetics | SAIDS Vaccines - administration & dosage | HIV Infections - virology | Defective Viruses - genetics | Adenoviruses, Human - physiology | Genetic Vectors - metabolism | HIV-1 - genetics | Genetic Vectors - genetics | Simian Acquired Immunodeficiency Syndrome - prevention & control | Defective Viruses - physiology | SAIDS Vaccines - genetics | HIV-1 - immunology | Animals | SAIDS Vaccines - immunology | Simian Acquired Immunodeficiency Syndrome - immunology | AIDS Vaccines - genetics | Antibodies, Viral - immunology | HIV - genetics | Adenoviruses, Human - genetics | Gene Products, gag - administration & dosage | AIDS Vaccines - administration & dosage | Gene Products, nef - immunology | Index Medicus | Pathogenesis and Immunity
Journal Article