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Heteroatom Chemistry, ISSN 1042-7163, 01/2018, Volume 29, Issue 1, pp. e21413 - n/a
We present herein an alternative synthesis route to obtain tetraethyl imidodiphosphate (EtO)2P(O)NH(O)P(OEt)2 (3) and its silylester derivative... 
imidodiphosphate | phosphate silyl ester | Staudinger reaction | ADENYLYL IMIDODIPHOSPHATE | CHEMICAL-SHIFTS | CHEMISTRY, MULTIDISCIPLINARY | Phosphates
Journal Article
Science, ISSN 0036-8075, 9/2006, Volume 313, Issue 5795, pp. 1968 - 1972
In higher eukaryotes, a multiprotein exon junction complex is deposited on spliced messenger RNAs. The complex is organized around a stable core, which serves... 
Hydrolysis | Proteins | Molecules | Messenger RNA | Double stranded RNA | RNA | Exons | Adenosine triphosphatases | Reports | Nucleotides | Binding sites | EIF4A | MESSENGER-RNA | DECAY | HELICASE ACTIVITY | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | DISTINCT | MOLECULAR INSIGHTS | TRANSLATION | MAMMALIAN-CELLS | BINDING | RNA Helicases - metabolism | Humans | Molecular Sequence Data | Crystallography, X-Ray | RNA Helicases - chemistry | Drosophila Proteins - metabolism | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | Adenosine Triphosphate - metabolism | Eukaryotic Initiation Factor-4A - chemistry | Nucleic Acid Conformation | Dimerization | Protein Structure, Tertiary | Amino Acid Sequence | DEAD-box RNA Helicases | Poly U - chemistry | Protein Structure, Secondary | RNA-Binding Proteins - chemistry | Models, Molecular | Neoplasm Proteins - chemistry | Nuclear Proteins - metabolism | Poly U - metabolism | Drosophila Proteins - chemistry | Nuclear Proteins - chemistry | Adenosine Triphosphate - analogs & derivatives | Amino Acid Motifs | Animals | Hydrogen Bonding | Adenylyl Imidodiphosphate - metabolism | Protein Conformation | RNA, Messenger - chemistry | Mutation | Eukaryotic Initiation Factor-4A - metabolism | RNA-Binding Proteins - metabolism | Exon (Molecular genetics) | Analysis | Research | Eukaryotic Initiation Factor-4A | Adenosine Triphosphate | RNA-Binding Proteins | Life Sciences | RNA Helicases | Neoplasm Proteins | Drosophila Proteins | Biochemistry, Molecular Biology | Nuclear Proteins | Adenylyl Imidodiphosphate | Poly U | Molecular biology | RNA, Messenger
Journal Article
The EMBO Journal, ISSN 0261-4189, 03/1993, Volume 12, Issue 3, pp. 849 - 859
The crystal structure of the porcine heart catalytic subunit of cAMP‐dependent protein kinase in a ternary complex with the MgATP analogue MnAMP‐PNP and a... 
Protein kinase a | Nucleotide binding | Phosphotransferase mechanism | Crystal structure | Manganese
Journal Article
FEBS Letters, ISSN 0014-5793, 01/2011, Volume 585, Issue 1, pp. 104 - 110
Protein kinase CK2 (CK2), a constitutively active serine/threonine kinase, is involved in a variety of roles essential to the maintenance of cellular... 
X-ray crystallography | CK2α | Drug discovery | Protein kinase | Cancer | protein kinase CK2 | dithiothreitol | AMPPNP | DMSO | DTT | root mean square deviation | CK2 | adenylyl phosphoramidate | 2-dimethylamino-4,5,6,7-tetrabromo-benzimidazole | adenylyl-imidodiphosphate | adenosine-5′-triphosphate | dimethyl sulfoxide | HEPES | AMPPN | DMAT | ATP | R.M.S.D | N-(2-hydroxyethyl) piperazine-N′-(2-ethanesulfonic acid) | COMPLEX | SMALL MOLECULES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER GENOME | DIFFRACTION DATA | INDUCTION | DISCOVERY | CELL BIOLOGY | IN-VITRO | BIOPHYSICS | CK2 alpha | INHIBITORS | TUMORIGENESIS | INSIGHTS | Protein Structure, Tertiary | Naphthyridines - chemistry | Catalytic Domain | Temperature | Humans | Casein Kinase II - antagonists & inhibitors | Models, Molecular | Crystallography, X-Ray | Adenylyl Imidodiphosphate - chemistry | Protein Subunits - metabolism | Thermodynamics | Casein Kinase II - chemistry | Adenylyl Imidodiphosphate - metabolism | Protein Binding | Calorimetry | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Binding Sites | Circular Dichroism | Casein Kinase II - metabolism | Naphthyridines - pharmacology | Naphthyridines - metabolism | Enzymes | Care and treatment | Oncology, Experimental | Crystals | Research | Analysis | Dimethyl sulfoxide | Chemical properties | Structure | Protein kinases | Musicians | Protein binding | MAINTENANCE | DESIGN | HOMEOSTASIS | THERMODYNAMICS | NEOPLASMS | BASIC BIOLOGICAL SCIENCES | TRANSCRIPTION | CRYSTAL STRUCTURE | PHOSPHOTRANSFERASES | CRYSTALLOGRAPHY | PROTEINS | 60 APPLIED LIFE SCIENCES
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2011, Volume 286, Issue 26, pp. 22875 - 22885
Journal Article
Molecular Cell, ISSN 1097-2765, 03/2015, Volume 57, Issue 5, pp. 836 - 849
Journal Article
Journal Article
FEBS Letters, ISSN 0014-5793, 2007, Volume 581, Issue 5, pp. 935 - 938
Staphylococcus aureus Sav1866 is a bacterial homolog of the human ABC transporter Mdr1 that causes multidrug resistance in cancer cells. We report the crystal... 
Mdr1 | Outward-facing conformation | Transport protein | Multidrug ABC transporter | ATP-bound state | AMP-PNP | ABC | TMD | multidrug resistance 1 gene | sodium dodecyl sulfate polyacrylamide electrophoresis | ATP binding cassette | SDS–PAGE | ADP | NBD | nucleotide binding domain | adenosine-5′-(β,γ-imido)triphosphate | transmembrane domain | adenosine diphosphate | adenosine triphosphate | ATP | transport protein | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | outward-facing conformation | MODEL | ATP-BINDING | CELL BIOLOGY | BIOPHYSICS | multidrug ABC transporter | HUMAN P-GLYCOPROTEIN | Recombinant Proteins - metabolism | Staphylococcus aureus - genetics | Drug Stability | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Adenosine Triphosphatases - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Crystallography, X-Ray | Recombinant Proteins - genetics | Adenylyl Imidodiphosphate - chemistry | ATP-Binding Cassette Transporters - chemistry | ATP-Binding Cassette Transporters - genetics | Adenylyl Imidodiphosphate - metabolism | ATP-Binding Cassette Transporters - metabolism | Protein Binding | Adenosine Triphosphatases - chemistry | Bacterial Proteins - metabolism | Protein Conformation | Adenosine Triphosphatases - genetics | Staphylococcus aureus - metabolism | Staphylococcus aureus | Television broadcasting industry
Journal Article
Molecular Cell, ISSN 1097-2765, 02/2019, Volume 73, Issue 4, pp. 738 - 748.e9
A class of translation inhibitors, exemplified by the natural product rocaglamide A (RocA), isolated from Aglaia genus plants, exhibits antitumor activity by... 
ribosome profiling | Rocaglamide | translation | crystal structure | FMO | sequence specificity | X-ray | evolution | Ribo-Seq | eIF4A | SYSTEM | SITE | INITIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | GENOME-WIDE ANALYSIS | SENSITIVITY | DYNAMICS | MECHANISMS | PHENIX | HELICASE | CELL BIOLOGY | Protein Synthesis Inhibitors - chemistry | Protein Synthesis Inhibitors - isolation & purification | Humans | Ribosomes - metabolism | Benzofurans - pharmacology | Structure-Activity Relationship | Adenylyl Imidodiphosphate - chemistry | Benzofurans - chemistry | Aglaia - genetics | Plant Proteins - chemistry | HEK293 Cells | Aglaia - metabolism | Eukaryotic Initiation Factor-4A - chemistry | Molecular Structure | Plant Proteins - metabolism | Protein Biosynthesis - genetics | Protein Interaction Domains and Motifs | Protein Synthesis Inhibitors - pharmacology | Benzofurans - isolation & purification | Binding Sites | Eukaryotic Initiation Factor-4A - genetics | RNA - metabolism | Aglaia - chemistry | Ribosomes - chemistry | Models, Molecular | Protein Synthesis Inhibitors - metabolism | RNA - chemistry | Drug Resistance - genetics | Plant Proteins - genetics | Ribosomes - genetics | Adenylyl Imidodiphosphate - metabolism | Ribosomes - drug effects | Protein Binding | Protein Biosynthesis - drug effects | Mutation | Eukaryotic Initiation Factor-4A - metabolism | Amino Acid Substitution | Benzofurans - metabolism | Amino acids | Messenger RNA | Structure | Genetic translation | Cells | Crystals
Journal Article
Journal Article